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Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

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Science China(Life Sciences) 2024年第5期67卷 913-939页

作者： Chinese Society of Cardiology,Chinese Medical Association,Writing Group Jiangang Jiang Hongyang Shu Dao Wen Wang Rutai Hui Chenze Li Xiao Ran Hong Wang Jing Zhang Shaoping Nie Guanglin Cui Dingcheng Xiang Qun Shao Shengyong Xu Discussion experts:Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping Wang Liming Xia Yan Wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan Wang Shaoliang Chen Hong Jiang Jing Chen Xianjin Du mao Chen Yinxian Sun Sheng Li Hu Ding Xueping ma Hesong Zeng Li Lin Shenghua Zhou likun ma Ling Tao Juan Chen Yiwu Zhou Xiaomei Guo 不详 Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Zhongnan Hospital of Wuhan University Wuhan 430062China Fuwai Huazhong Cardiovascular Hospital Zhengzhou 450003China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010China Harbin Medical University Cancer Hospital Harbin 150081China Union Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Taida Hospital Tianjin 300457China Peking University Third Hospital Beijing 100191China Qilu Hospital of Shandong University Jinan 250012China Kanghua Hospital DongguanGuangzhou 523080China Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003China Nanjing First Hospital Nanjing Medical UniversityNanjing 210006China Renmin Hospital of Wuhan University Wuhan 430060Wuhan West China Hospital Sichuan UniversityChengdu 610044China First Hospital of China Medical University Shenyang 110002China General Hospital of Ningxia Medical University Yinchuan 750003China The Second Xiangya Hospital Central South UniversityChangsha 410012China The First Affiliated Hospital of USTC University of Science and Technology of ChinaHefei 230002China The First Affiliated Hospital of Air Force Medical University Xi’an 710032China Central Hospital of Wuhan City Wuhan 430014China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term prognosis.Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

关键词： fulminant myocarditis guidelines life support-based comprehensive treatment regimen diagnosis treatment cytokine storm overactivation of immunity

Effect of carbon dioxide concentration on the combustion characteristics of boron agglomerates in oxygen-containing atmospheres

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第11期24卷 949-959页

作者： Lian DUAN Zhixun XIA Yunchao FENG Binbin CHEN Jiarui ZHANG likun ma College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

In ramjet combustion chambers,carbon dioxide(CO_(2))produced by the combustion of carbonaceous fuel enters the chamber together with boron agglomerates.In order to investigate the effect of CO_(2)concentration present in an oxygen-containing atmosphere on the combustion characteristics and oxidation mechanisms of boron agglomerates,we used a laser ignition system,an X-ray diffractometer(XRD),and a thermogravimetric-differential scanning calorimetry(TG-DSC)combined thermal analysis system.Single-particle boron was tested in the laser-ignition experiments as the control group.The ignition experiment results showed that with a fixed O2 concentration of 20%,when the particle temperature reaches the melting point of boron,increasing CO_(2)content causes the combustion process of boron agglomerates to transition from single-particle molten droplet combustion to porous-particle combustion.Furthermore,XRD analysis results indicated that the condensed-phase combustion products(CCPs)of boron particles in a mixed atmosphere of O2 and CO_(2)contained B4C,which is responsible for the porous structure of the particles.At temperatures below 1200℃,the addition of CO_(2)has no obvious promotion effect on boron exothermic reaction.However,in the laser-ignition experiment,when the oxygen concentration was fixed at 20%while the CO_(2)concentration increased from 0%to 80%,the maximum temperature of boron agglomerates rose from 2434 to 2573 K,the self-sustaining combustion time of single-particle boron decreased from 396 to 169 ms,and the self-sustaining combustion time of boron agglomerates decreased from 198 to 40 ms.This study conclusively showed that adding CO_(2)to an oxygen-containing atmosphere facilitates boron reaction and consumption pathways,which is beneficial to promoting exothermic reaction of boron agglomerates at relatively high temperatures.

关键词： Boron combustion Amorphous boron Boron-containing propellant Solid fuel ramjet

Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

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Science China Life Sciences 2024年

作者： Jiangang Jiang Hongyang Shu Dao Wen Wang Rutai Hui Chenze Li Xiao Ran Hong Wang Jing Zhang Shaoping Nie Guanglin Cui Dingcheng Xiang Qun Shao Shengyong Xu Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping Wang Liming Xia Yan Wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan Wang Shaoliang Chen Hong Jiang Jing Chen Xianjin Du mao Chen Yinxian Sun Sheng Li Hu Ding Xueping ma Hesong Zeng Li Lin Shenghua Zhou likun ma Ling Tao Juan Chen Yiwu Zhou Xiaomei Guo Peking University Third Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Air Force Medical University Zhongnan Hospital of Wuhan University First Hospital of China Medical University General Hospital of Ningxia Medical University The First Affiliated Hospital of USTC University of Science and Technology of China Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Anzhen Hospital Capital Medical University Chinese Medical Association Harbin Medical University Cancer Hospital Union Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Renmin Hospital of Wuhan University Central Hospital of Wuhan City Taida Hospital Guangzhou General Hospital of Guangzhou Military Command West China Hospital Sichuan University Nanjing First Hospital Nanjing Medical University Chinese Society of Cardiology Kanghua Hospital Dongguan Fuwai Huazhong Cardiovascular Hospital Tongji Hospital Tongji Medical College Huazhong University of Science and Technology The Second Xiangya Hospital Central South University Second Affiliated Hospital Zhejiang University School of Medicine

Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience, the adoption of the “life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core) can significantly improve the survival rate and long-term prognosis. Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

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Research progress on solid-fueled Scramjet

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Chinese Journal of Aeronautics 2022年第1期35卷 398-415页

作者： Xiang ZHAO Zhixun XIA likun ma Chaolong LI Chuanbo FANG Benveniste NATAN Alon GANY Department of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Qinghe Building Ding-3 Beijing 100085China Faculty of Aerospace Engineering Technion-Israel Institute of TechnologyHaifa 32000Israel

The solid-fueled Scramjet is an interesting option for supersonic combustion ramjet.It shows significant advantages such as simple fuel supply and compactness,avoiding the complex system of tanks and pipelines that encountered in liquid-fueled Scramjets.The solid-fueled Scramjet could be the simplest air-breathing engine for the hypersonic flight regime.This paper presents a comprehensive and systematic review of the research progress on solid-fueled Scramjet in various institutes and universities.It summarizes a progress overview of three types of the solid-fueled Scramjet,which covers a wealth of landmark numerical and experimental results.Based on this,several relevant key technologies are proposed.Several inherent scientific issues are refined,such as the mixing mechanism of multi-phase flow and supersonic airflow,ignition and combustion mechanism of the condensed phase in a supersonic airflow,and coupling mechanism of gas and solid phase in a supersonic flow.Finally,the historical development trend is clarified,and some recommendations are provided for future solid-fueled Scramjet.

关键词： Combustor performance Flame stabilization Self-ignition Solid-fueled Scramjet Supersonic combustion ramjet

Detailed modeling of aluminum particle combustion——From single particles to cloud combustion in Bunsen flames

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Chinese Journal of Aeronautics 2022年第5期35卷 319-332页

作者： Jiarui ZHANG Oliver T.STEIN Tien D.LUU Ali SHAMOONI Zhixun XIA Zhenbing LUO likun ma Yunchao FENG Andreas KRONENBURG College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Institut für Technische Verbrennung Universitat StuttgartStuttgart 70174Germany

A numerical model for aluminum cloud combustion which includes the effects of interphase heat transfer,phase change,heterogeneous surface reactions,homogeneous combustion,oxide cap growth and radiation within the Euler–Lagrange framework is proposed.The model is validated in single particle configurations with varying particle diameters.The combustion process of a single aluminum particle is analyzed in detail and the particle consumption rates as well as the heat release rates due to the various physical/chemical sub-models are presented.The combustion time of single aluminum particles predicted by the model are in very good agreement with empirical correlations for particles with diameters larger than 10μm.The prediction error for smaller particles is noticeably reduced when using a heat transfer model that is capable of capturing the transition regime between continuum mechanics and molecular dynamics.The predictive capabilities of the proposed model framework are further evaluated by simulating the aluminum/air Bunsen flames of Mc Gill University for the first time.Results show that the predicted temperature distribution of the flame is consistent with the experimental data and the double-front structure of the Bunsen flame is reproduced well.The burning rates of aluminum in both single particle and particle cloud configurations are calculated and compared with empirical correlations.Results show that the burning rates obtained from the present model are more reasonable,while the correlations,when embedded in the Euler–Lagrange context,tend to underestimate the burning rate in the combustion stage,particularly for the considered fuel-rich flames.

关键词： Aluminum particle combustion Bunsen flame Burning time Burning rate Particle cloud

LES of the Sandia flame series D-F using the Eulerian stochastic field method coupled with tabulated chemistry

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Chinese Journal of Aeronautics 2020年第1期33卷 116-133页

作者： Yifan DUAN Zhixun XIA likun ma Zhenbing LUO Xu HUANG Xiong DENG College of Aerospace Science and Technology National University of Defense TechnologyChangsha 410073China

In this paper,the Eulerian Stochastic Field(ESF)model in the Transported Probability Density Function(TPDF)class model is combined with the Flamelet Generated manifolds(FGM)model.This method solves the joint probability density function transport equation by ESF method that considers the interaction mechanism between flame and turbulence with high precision.At the same time,by making use of the advantage of the FGM model,this model is able to incorporate the detailed chemical reaction mechanism(GRI 3.0)with acceptable computational cost.The new model has been implemented in the open source CFD suite-Open FOAM.Validation of the model has been carried out by simulating the Sandia flame series(three turbulent piloted methane jet flames)issued by the National Laboratory of the United States.The accuracy and advancement of the ESF/FGM turbulent combustion model are verified by comparing the LES results of the new model with the rich experimental data as well as the RANS results.The results demonstrate that the model has a strong ability in capturing combustion phenomena such as extinction and re-ignition in turbulent flame,which is essential in the accurate prediction of the combustion process in real combustion devices,for example,aircraft engines.

关键词： Eulerian Stochastic Field(ESF) Flamelet Generated manifolds(FGM) Large Eddy Simulation(LES) Open FOAM Turbulent combustion

Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)C_(2)T_(x) heterojunction with robust sodium storage at low temperature

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Journal of Energy Chemistry 2024年第2期89卷 635-645,I0014页

作者： Jiabao Li Shaocong Tang Jingjing Hao Quan Yuan Tianyi Wang likun Pan Jinliang Li Shenbo Yang Chengyin Wang College of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Shanghai Key Laboratory of magnetic Resonance School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Nanophotonic ManipulationDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina Hongzhiwei Technology(Shanghai)CO.LTD Shanghai 200241China

Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also challenging.Besides,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold climates.Herein,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical activity.Particularly,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous interface.Besides,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure coupling.Consequently,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 ma h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.

关键词： WS_(2)/Ti_(3)C_(2)T_(x)heterojunction Built-in electric field Ion reservoir Reaction kinetics Sodium storage performance at low temperature

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei ma Lin Li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental conflicts.This study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical enterprises.In the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing compounds.Ketones were the main components of waste gases,accounting for 44.13%-77.85%of the overall VOCs.Process-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC emissions.Dimethyl heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation system.Ground level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km downwind.Furthermore,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of SOAs.Our results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

Nuclear phylogenomics of angiosperms and insights into their relationships and evolution

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Journal of Integrative Plant Biology 2024年第3期66卷 546-578页

作者： Guojin Zhang Hong ma College of Life Sciences Hunan Normal UniversityChangsha 410081China Department of Biology 510 Mueller LaboratoryHuck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

Angiosperms(flowering plants) are by far the most diverse land plant group with over 300,000 species. The sudden appearance of diverse angiosperms in the fossil record was referred to by Darwin as the “abominable mystery,”hence contributing to the heightened interest in angiosperm evolution. Angiosperms display wide ranges of morphological, physiological,and ecological characters, some of which have probably influenced their species richness. The evolutionary analyses of these characteristics help to address questions of angiosperm diversification and require well resolved phylogeny. Following the great successes of phylogenetic analyses using plastid sequences,dozens to thousands of nuclear genes from next-generation sequencing have been used in angiosperm phylogenomic analyses, providing well resolved phylogenies and new insights into the evolution of angiosperms. In this review we focus on recent nuclear phylogenomic analyses of large angiosperm clades, orders, families,and subdivisions of some families and provide a summarized Nuclear Phylogenetic Tree of Angiosperm Families. The newly established nuclear phylogenetic relationships are highlighted and compared with previous phylogenetic results. The sequenced genomes of Amborella,Nymphaea, Chloranthus, Ceratophyllum, and species of monocots, magnoliids, and basal eudicots, have facilitated the phylogenomics of relationships among five major angiosperms clades. All but one of the 64 angiosperm orders were included in nuclear phylogenomics with well resolved relationships except the placements of several orders. Most families have been included with robust and highly supported placements, especially for relationships within several large and important orders and families.Additionally, we examine the divergence time estimation and biogeographic analyses of angiosperm on the basis of the nuclear phylogenomic frameworks and discuss the differences compared with previous analyses. Furthermore,we discuss the implications of nuclear phylogenomic analyses on ancestral

关键词： angiosperms evolution flowering plants nuclear gene phylogenomics phylogeny