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液体微小流量测量技术研究进展

力学学报 2024年第6期56卷 1573-1584页

作者：侯立凯范旭金羽卓刘铭扬包福兵中国计量大学浙江省流量计量技术研究重点实验室杭州310018 中国计量大学计量测试工程学院杭州310018

随着流体力学与生命科学、材料科学、医疗健康、能源环境和先进制造等多学科领域的交叉融合,微量液体与微流控技术逐渐在这些领域取得了广泛的应用.与此同时,液体微小流量(每分钟几微升、几纳升,甚至更低)的测量需求逐渐凸显出来.随着... 详细信息

随着流体力学与生命科学、材料科学、医疗健康、能源环境和先进制造等多学科领域的交叉融合,微量液体与微流控技术逐渐在这些领域取得了广泛的应用.与此同时,液体微小流量(每分钟几微升、几纳升,甚至更低)的测量需求逐渐凸显出来.随着特征尺度的减小,原有的液体流量测量技术已经无法满足测量准确度的要求,因此,需要流量测量技术的进一步发展来满足微小流量测量和传感器微尺度集成的需求.文章介绍了液体微小流量的应用背景和面临的主要问题,首先,根据测量过程中是否引入外界能量(例如电能、热能等),将现有的和正在开发的液体微小流量测量技术分为有源流量测量技术和无源流量测量技术;其次,分别对其包含的具体测量技术展开论述,主要包括质量流量测量技术(科里奥利和微谐振器)、热式流量测量技术(热损失型、热分布型和热脉冲型)、光流控流量测量技术(光致褪色)、压力转换流量测量技术(压差式、悬臂式和柔性膜形变)、粒子测速技术、重力测量技术和弯月面追踪技术等,并讨论了上述测量技术的传感测量原理、测量性能指标和优缺点;最后,结合液体微小流量测量技术的发展和先进测量体系的建设,总结了液体微小流量测量的应用前景和有待解决的挑战.

关键词：微小流量测量流量计微量液体传感器

Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第6期11卷 739-745页

作者： Jingyuan Wang likai qia.chenzhi hou Tingting Zhang Mengyi Chen Haitao Meng Mengxiang Su Hui Xu Zhendong Hua Youmei Wang Bin Di Department of Pharmacy China Pharmaceutical UniversityNanjing210009China China National Narcotics Control Commission-China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control Nanjing210009China Key Laboratory of Drug Monitoring and Control The Ministry of Public Security of the People's Republic of ChinaBeijing100741China Analytical Applications Center Analytical Instruments DivisionShimadzu(China)Co.Ltd.Nanjing BranchBeijing100741China Drug Control Information and Technology Center The Ministry of Public Security of the People's Republic of ChinaNanjing210000China

In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater *** analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 *** isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE *** analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix *** limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,*** linearity was between 0.5 ng/L and250 ng/L,except for that of *** intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line *** difference rate was between 19.91%and-20.44%,and the error range could be considered *** findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples.

关键词： Illicit drugs and metabolites Wastewater analysis On-line solid phase extraction Ultra-high-performance liquid chromatography Mass spectrometry

2018-2022年甘肃省庆阳市流行性感冒流行病学及病原学监测分析

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疾病监测 2024年第1期39卷 26-31页

作者：朱圭娜王文军侯怀哲刘宸志梁姿萱庆阳市疾病预防控制中心甘肃庆阳745000 庆阳市人民医院甘肃庆阳745000

目的分析甘肃省庆阳市2018—2022年流行性感冒(流感)哨点医院监测的流感样病例(ILI)及病原学监测情况,掌握庆阳市流感流行趋势及病原学变化规律,为今后流感的科学防控提供数据支撑。方法ILI资料来源于中国疾病预防控制信息系统的子系统... 详细信息

目的分析甘肃省庆阳市2018—2022年流行性感冒(流感)哨点医院监测的流感样病例(ILI)及病原学监测情况,掌握庆阳市流感流行趋势及病原学变化规律,为今后流感的科学防控提供数据支撑。方法ILI资料来源于中国疾病预防控制信息系统的子系统中国流感监测信息系统2018—2022年庆阳市的流感监测数据。ILI病原学监测标本来源于哨点医院,对病例标本进行核酸提取,采用实时荧光定量PCR方法进行分型,对核酸检测阳性的标本同时进行犬肾细胞培养和鸡胚培养,分离、鉴定病毒。利用Excel 2007软件对数据进行汇总、整理和绘图,用SPSS 22.0软件对数据进行统计分析。结果2018—2022年度共监测ILI 6473例,年平均流感样病例百分比(ILI%)为1.34%,ILI%总体呈下降趋势(趋势χ^(2)=1165.377,P<0.001)。ILI以0~4岁组最多,占60.68%;其次为5~14岁组,占26.30%。2020—2022年平均ILI%为0.85%,呈明显下降趋势;各年龄组ILI%也呈明显降低趋势,高年龄组的降低幅度高于低年龄组。流行病学和病原学监测结果显示,流感的流行具有季节性特征,每年的冬春季出现一个流行高峰。2018—2022年度共检测ILI标本3574份,流感病毒阳性标本621份,阳性率为17.38%,不同监测年度流感阳性率差异有统计学意义(χ^(2)=55.778,P<0.001)。不同型别阳性标本中,甲、乙型流感分别占46.38%、52.66%,混合型占0.97%,在2021年的常规监测中检出2份欧亚类禽H1N1猪流感病例标本。不同年份呈现单一型别交替流行或多种型别共同流行的特征,监测年度中乙型流感的流行强度总体高于甲型流感。结论庆阳市ILI和流感病毒的流行趋势、流行特点提示,要持续加强流感病毒监测力度,提高检测水平,及时掌握流感流行和病毒变异情况,制定科学有效的防控策略,为季节性流感疫情做出知情预测及精准防控。

关键词：流行性感冒流行病学病原学监测

Effects of Chip Geometries on Dielectrophoresis and Electrorotation Investigation

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Chinese Journal of Mechanical Engineering 2014年第1期27卷 103-110页

作者： REN Yukun WU Hongchi FENG Guojing hou likai JIANG Hongyuan School of Mechatronics Engineering Harbin Institute of Technology State Key Laboratory of Fluid Power Transmission and Control Zhejiang University The First Affiliated Hospital Harbin Medical University

The electric fields employed for such work are generated using chips, such as planar linear interdigitated arrays or two parallel arrays. However, chip geometries usually affect the investigation of dielectrophoresis （DEP） and electrorotation （ER） significantly, and even may misdirect the theoretical prediction. In order to understand the electrodes geometries effect and provide a suitable range of parameters, three-dimensional simulations for the DEP and ER characterizations on the quadrupolar hyperbolical electrodes are carried out. Influences of the electrodes gaps, cell height, work region, energized voltage and frequencies for the DEP and ER manipulations are analyzed, and the analysis results show that the gaps of the electrodes and the cell height have enormous effects, but the work region is not so important. Moreover, depending on the theoretical analysis, ER experiments for polystyrene microspheres with the diameter of 20 ~m are carried out on two kinds of chips. The experimental results show that the microspheres rotate in the counter-field direction and the maximum rotation speed appears in the megahertz range. In addition, the experimental results are compared with the simulation results, showing that the three-dimensional simulations considering the chip geometries are more accurate than the two-dimensional predictions. This paper provides a new understanding for the theoretical predictions of DEP and ER manipulations, which decreases the difference of the theoretical and experimental results significantly, and will be significant for the lab chip research.

关键词： dielectrophoresis electrorotation chip geometries

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多气源格局下天然气计量体系国内外进展

计量科学与技术 2024年第1期68卷 3-9,75页

作者：成伟杨添波李长武侯立凯包福兵倪金春苏州市计量测试院江苏省市场监管重点实验室(能源计量在线评估) 苏州215128 中国计量大学浙江省流量计量技术研究重点实验室杭州310018

随着人们对环境问题的重视度越来越高,天然气作为一种清洁能源在我国化石能源消费体系中的占比也正在提升。近年来,在天然气消费过程中出现了不同气源的天然气增多、进口天然气比例上升等问题,形成了天然气管网多气源的格局。由于不同... 详细信息

随着人们对环境问题的重视度越来越高,天然气作为一种清洁能源在我国化石能源消费体系中的占比也正在提升。近年来,在天然气消费过程中出现了不同气源的天然气增多、进口天然气比例上升等问题,形成了天然气管网多气源的格局。由于不同气源的天然气发热量存在明显差异,我国目前实行的天然气计量体系难以进行准确的贸易计量以及碳排放核算,需积极推进新型计量体系的建设。基于此,该文主要围绕国内外天然气计量体系的发展现状进行研究,介绍了体积计量、质量计量和能量计量3种计量方式及其测量原理,从技术标准、计量仪器、量值溯源方面对比分析了国内外现行的天然气计量技术,阐述我国在计量体系建设上开展的一系列工作,指出能量计量法从天然气的发热量出发,结合天然气的体积或质量流量,面对不同气源、不同品质的天然气能进行高效、准确的计量,是多气源天然气格局下的更公平、合理的计量方式。同时,指出我国在天然气气质分析设备、构建天然气分析溯源、管网中的核查技术等方面存在不足。

关键词：计量学天然气计量体系能量计量发热量测量仪器多气源

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 202-208页

作者： Huiyan Shi chenzhi hou Liqiang Gu Zhe Wei Hang Xing Meiyu Zhang Shixiao Wang Longshan Zhao Kaishun Bi Xiaohui Chen School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China

The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat *** and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with *** analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for *** parameters were all within the acceptance *** validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/*** suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine *** method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.

关键词： Methotrexate Piperazine ferulate Pharmacokinetic parameters HPLC-MS

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社会主义城市概念的演变中国式发展道路综论

时代建筑 2024年第3期 20-33页

作者：菲奥多尔·库德利亚夫采夫卡玉德杨力恺莫斯科建筑设计学院莫斯科国立测绘大学清华大学建筑学院

中华人民共和国早期的社会主义城市规划遗产正在日益引起学者的关注。然而,对苏联的社会主义城市概念在转移到中国过程中的跨国演变的研究仍然很少。彼时中国城市规划的成果在某种程度上是没有明确背景与起源的产物。两者在1917年以来... 详细信息

中华人民共和国早期的社会主义城市规划遗产正在日益引起学者的关注。然而,对苏联的社会主义城市概念在转移到中国过程中的跨国演变的研究仍然很少。彼时中国城市规划的成果在某种程度上是没有明确背景与起源的产物。两者在1917年以来社会主义城市规划演变中的重要性仍然不明确。文章从苏联相似规划及其原型的早期演变角度,介绍了西安、武汉、洛阳和长春“156项重点工程”的城市及其工业区布局的分析结果,揭示出城市布局和模式的多样性,以及与苏联起源不同的新的工业区空间模型,证明了在这一时期社会主义城市概念复合的新演变路线,即中国的发展道路。

关键词： 156项重点工程社会主义城市城市规划演变规划历史

Discussion on Feasibility of Adjustment Program for Jiangmen Chinese White Dolphin Provincial Nature Reserve

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Agricultural Science & Technology 2010年第5期11卷 144-147页

作者：吴洽儿李纯厚孙典荣 qia-er Chun-hou Dian-rong 中国水产科学研究院南海水产研究所广东广州510300

From the protection of Chinese white dolphin and living environment,and considering the industrial development in coastal areas,we put forward adjustment program for Jiangmen Chinese White Dolphin Provincial Nature Reserve. Meanwhile we analyzed the feasibility of this program by systematically focusing the effect of adjusted functional regions on Chinese white dolphin.

关键词： Chinese white dolphin Reserve Adjustment Feasibility

Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

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World Journal of Gastroenterology 2017年第10期23卷 1891-1898页

作者： Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang qia-qia Li xue-Ying Zhang Yun-Feng Zhang hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei School of Public Health Guangzhou Medical University Longgang Central Hospital of Shenzhen Department of Thoracic Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Xiangya School of Medicine Central South University Department of Gastrointestinal Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Tianjin Medical University School of Medicine Georgetown University Department of Radiation Oncology Tumor HospitalXiangya School of Medicine of Central South University Longgang District Peoples Hospital of Shenzhen1 Cancer Center of Guangzhou Medical University

AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.

关键词： Colorectal cancer Health-related quality of life EORTC QLQ-CR29 China's Mainland