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NMDA受体拮抗剂APV抑制福尔马林诱导的大鼠伤害性行为反应

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药学学报 1999年第4期34卷 251-254页

作者：李富春丁丽君任民峰中国医学科学院中国协和医科大学基础医学研究所药理学教研室中国科学院生物物理所生物大分子实验室

目的：检测ＮＭＤＡ受体拮抗剂ＤＬ２ａｍｉｎｏ５ｐｈｏｓｐｈｏｎｏｖａｌｅｒｉｃａｃｉｄ（ＡＰＶ）对福尔马林诱导的大鼠伤害性行为反应的镇痛效应。方法：在大鼠左足趾部ｓｃ福尔马林诱导化学损伤性行为反应，经蛛网膜下... 详细信息

目的：检测ＮＭＤＡ受体拮抗剂ＤＬ２ａｍｉｎｏ５ｐｈｏｓｐｈｏｎｏｖａｌｅｒｉｃａｃｉｄ（ＡＰＶ）对福尔马林诱导的大鼠伤害性行为反应的镇痛效应。方法：在大鼠左足趾部ｓｃ福尔马林诱导化学损伤性行为反应，经蛛网膜下腔引入药物，观察对此行为反应的抑制效应。结果：ＡＰＶ剂量依赖地抑制福尔马林诱导的持续性伤害性行为反应并有时间作用特点；ＡＰＶ对其中的反射性缩腿反应也有抑制作用，但没有时间作用特点。结论：ＮＭＤＡ受体在脊髓痛觉传递和疼痛反应过程中起重要作用；但ＮＭＤＡ受体拮抗剂ＡＰＶ是否有直接的镇痛效应仍需进一步分析。

关键词： NMDA受体拮抗剂伤害性行为反应疼痛大鼠

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高校实验室化学废液处理方法的比较研究

中国现代教育装备 2018年第23期 26-29页

作者：李春田军丁立军张超盛显良内蒙古农业大学理学院内蒙古呼和浩特010018 内蒙古农业大学教务处内蒙古呼和浩特010018 神华鄂尔多斯煤制油分公司内蒙古鄂尔多斯017209

高校实验室产生的大量化学废液是主要的环境污染源之一,因此必须对高校实验室的化学废液进行有效处理,防止污染环境和安全事故的发生。介绍了国内高校实验室一些常见无机类废液和有机类废液的实验室处理方法,阐述了新型的废液处理装置... 详细信息

高校实验室产生的大量化学废液是主要的环境污染源之一,因此必须对高校实验室的化学废液进行有效处理,防止污染环境和安全事故的发生。介绍了国内高校实验室一些常见无机类废液和有机类废液的实验室处理方法,阐述了新型的废液处理装置在高校实验室化学废液中的应用实践。对废液处理装置不但详细介绍了其工艺流程,而且还对新型的废液处理装置方案与现行的请有资质公司处理废液方案及传统的高校实验室自行处理废液方案在处理高校实验室化学废液方面的优缺点和经济性进行了比较研究,希望能为高校实验室化学废液处理提供新思路和借鉴。

关键词：高校化学实验室化学废液方法处理装置

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乳腺专用PET在乳腺癌中的临床应用进展

南京医科大学学报（自然科学版） 2024年第5期44卷 726-731页

作者：陈锦泉丁紫藤唐立钧李天女南京医科大学第一附属医院核医学科江苏南京210029

乳腺癌是目前世界范围内发病率最高的肿瘤,早发现、早诊断对于乳腺癌患者的治疗及预后具有重要意义。乳腺专用PET(dedicated breast PET,dbPET)是一种新兴的分子成像设备,在临床实践中用于乳腺癌的检测和肿瘤生物学的评估,具有比传统影... 详细信息

乳腺癌是目前世界范围内发病率最高的肿瘤,早发现、早诊断对于乳腺癌患者的治疗及预后具有重要意义。乳腺专用PET(dedicated breast PET,dbPET)是一种新兴的分子成像设备,在临床实践中用于乳腺癌的检测和肿瘤生物学的评估,具有比传统影像学手段更高的空间分辨率,可以识别乳房内放射性示踪剂摄取的详细形态学模式。鉴于国内外对dbPET的综合性分析较少,文章从dbPET在乳腺癌的筛查、诊断、摄取模式、新辅助化疗后评估及PET显像剂等方面的应用进行综述。

关键词：乳腺癌正电子放射性药物乳腺专用PET

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活血止痛膏外敷治疗带状疱疹105例

中国现代医生 2008年第9期46卷 83-84页

作者：丁丽君朱运喜王海涛河北省邯郸市中医院河北邯郸056002

目的观察活血止痛膏外敷对带状疱疹的治疗效果。方法将205例随机分为两组,治疗组用活血止痛膏外敷患处,对照组用阿昔洛韦软膏外敷患处,均每日1次,10d为一个疗程,观察疗效。结果与对照组相比,治疗组有效率明显优于对照组,两组比较有显著... 详细信息

目的观察活血止痛膏外敷对带状疱疹的治疗效果。方法将205例随机分为两组,治疗组用活血止痛膏外敷患处,对照组用阿昔洛韦软膏外敷患处,均每日1次,10d为一个疗程,观察疗效。结果与对照组相比,治疗组有效率明显优于对照组,两组比较有显著性差异(P<0.05);止痛、止疱、结痂、疗程也明显优于对照组,差异有极显著性(P<0.01),且未有一例留有后遗神经痛。结论活血止痛膏治疗带状疱疹的止痛、止新生疱疹、结痂疗效明显,见效快,无后遗神经痛,疗效确切。

关键词：中药外敷带状疱疹

主动风险护理程序在新生儿缺氧缺血性脑病中的应用效果

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中华现代护理杂志 2021年第26期27卷 3587-3590页

作者：孙巧洪婷金志敏陈昕丁丽君浙江省金华市妇幼保健院新生儿科 321000 浙江省金华市中心医院新生儿科 321000

目的探讨主动风险护理程序在新生儿缺氧缺血性脑病(HIE)中的应用效果。方法选取2017年8月—2019年8月在金华市妇幼保健院就诊的78例HIE患儿作为研究对象,按照不同的护理方案分为对照组和观察组,各39例。对照组采用常规护理,观察组针对... 详细信息

目的探讨主动风险护理程序在新生儿缺氧缺血性脑病(HIE)中的应用效果。方法选取2017年8月—2019年8月在金华市妇幼保健院就诊的78例HIE患儿作为研究对象,按照不同的护理方案分为对照组和观察组,各39例。对照组采用常规护理,观察组针对常规护理中存在的潜在风险因素进行目标分析,设计并执行主动风险护理程序。比较两组HIE患儿临床症状改善时间、住院时间、家属护理总满意度评分及并发症总发生率。结果观察组患儿脑水肿消失时间、肌张力恢复时间、住院时间均短于对照组,差异均有统计学意义(P<0.05);干预后,观察组患儿家属护理总满意度评分高于对照组,差异有统计学意义(P<0.05);观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论主动风险护理程序能有效缩短HIE患儿临床症状改善时间,缩短住院时间,提高家属护理总满意度,降低并发症的总发生率,并能提高护理质量。

关键词：婴儿,新生缺氧缺血性脑病主动风险护理程序护理满意度

Upper mantle anisotropy in the Ordos Block and its margins

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Science China Earth Sciences 2011年第6期54卷 888-900页

作者： CHANG lijun WANG ChunYong ding ZhiFeng Institute of Geophysics China Earthquake Administration Beijing 100081 China

Based on the polarization analysis of teleseismic data,SKS (SKKS) fast-wave directions and delay times between fast and slow shear waves were determined for each of the 111 seismic stations from both permanent and temporary broadband seismograph networks deployed in the Ordos Block and its *** the Silver and Chan and stacking analysis methods were *** this way,an image of upper mantle anisotropy in the Ordos Block and its margins was *** the western and northern margins of the Ordos Block,the fast-wave directions are consistently *** fast-wave directions are mainly NWW-SEE and EW in the southern margin of the Ordos *** the eastern margin of the Ordos Block,the fast-wave directions are generally EW,although some run NEE-SWW or *** the Ordos Block,the fast-wave directions trend near N-S in the north,but switch to near EW in the *** delay time between fast and slow waves falls into the interval 0.48-1.50 s,and the average delay time at the stations in the Ordos Block is less than that in its *** suggest that the anisotropy of the stable Ordos Block is mainly caused by "fossil" anisotropy frozen in the ancient North China *** NE-trending push of the northeastern margin of the Tibetan Plateau has caused NW-SE-trending lithospheric extension in the western and northern margins of the Ordos Block,and made the upper mantle flow *** in turn has resulted in the alignment of the upper mantle peridotite lattice with the direction of material *** the southern margin of the Ordos Block,the collision between the North China and Yangtze blocks resulted in the fast-wave direction running parallel to the collision boundary and the Qinling *** this with the APM and velocity structure of the Qinling Orogen,we propose that eastward-directed asthenospheric-mantle channel flow may have occurred beneath the Qinling *** the eastern margin of the Ordos Block,the complex anisotropic charac

关键词： Ordos Block upper mantle anisotropy SKS wave fast-wave direction lithosphere deformation

Seismic anisotropy of upper mantle in Sichuan and adjacent regions

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Science China Earth Sciences 2008年第12期51卷 1683-1693页

作者： CHANG lijun WANG ChunYong ding ZhiFeng Institute of Geophysics China Earthquake AdministrationBeijing 100081China

Based on the polarization analysis of teleseismic SKS waveform data recorded at 94 broadband seis-mic stations in Sichuan and adjacent regions, the SKS fast-wave direction and the delay time between the fast and slow shear waves were determined at each station using the grid searching method of minimum transverse energy and the stacking analysis method, and the image of upper mantle anisot-ropy was acquired. The fast-wave polarization directions are mainly NW-SE in the study area, NWW-SEE to its northeast and NS to its west. The delay time falls into the interval [0.47 s, 1.68 s]. The spatial variation of the fast-wave directions is similar to the variation of GPS velocity directions. The anisotropic image indicates that the regional tectonic stress field has resulted in deformation and flow of upper mantle material, and made the alignment of upper mantle peridotite lattice parallel to the di-rection of material deformation. The crust-upper mantle deformation in Sichuan and adjacent regions accords with the mode of vertically coherent deformation. In the eastern Tibetan Plateau, the crustal material was extruded to east or southeast due to SE traction force of the upper mantle material. The extrusion might be obstructed by a rigid block under the Sichuan Basin and the crust has been de-formed. After a long-term accumulation of tectonic strain energy, the accumulative energy suddenly released in Yingxiu town of the Longmenshan region, and Wenchuan MS8.0 earthquake occurred.

关键词： upper mantle anisotropy SKS wave fast-wave polarization direction lithospheric deformation Wenchuan MS8.0 earthquake

Seismic anisotropy of upper mantle in eastern China

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Science China Earth Sciences 2009年第6期52卷 774-783页

作者： CHANG lijun WANG ChunYong ding ZhiFeng Institute of Geophysics China Earthquake AdministrationBeijing 100081China

Based on the polarization analysis of teleseismic SKS waveform data recorded at 65 seismic stations which respectively involved in the permanent and temporary broadband seismograph networks deployed in eastern China, the SKS fast-wave direction and the delay time between the fast and slow shear waves at each station were determined by use of SC method and the stacking analysis method, and then the image of upper mantle anisotropy in eastern China was acquired. In the study region, from south to north, the fast-wave polarization directions are basically EW in South China, gradually clockwise rotate to NWW-SEE in North China, then to NW-SE in Northeast China. The delay time falls into the interval [0.41 s, 1.52 s]. Anisotropic characteristics in eastern China indicate that the upper mantle anisotropy is possibly caused by both the collision between the Indian and Eurasian Plates and the subduction from the Pacific and Philippine Sea Plates to the Eurasian Plate. The collision between two plates made the crust of western China thickening and uplifting and the material eastwards extruding, and then caused the upper mantle flow eastwards and southeastwards. The subduction of Pacific Plate and Philippine Sea Plate has resulted in the lithosphere and the asthenosphere deformation in eastern China, and made the alignment of upper mantle peridotite lattice parallel to the deformation direction. The fast-wave polarization direction is consistent with the direction of lithosphere extension and the GPS velocity direction, implying that the crust-upper mantle deformation is possibly a vertically coherent deformation.

关键词： eastern China upper mantle anisotropy SKS wave fast-wave direction lithosphere deformation

心理援助热线求助者自杀企图的特征及相关因素分析

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中华行为医学与脑科学杂志 2018年第3期27卷 207-211页

作者：廖震华刘发荣丁丽君吴素英董学体季建林厦门市仙岳医院心理科厦门361012 复旦大学附属中山医院心理科上海200032

目的探讨心理援助热线求助者自杀企图的特征及相关因素，为国内心理援助热线自杀预防和干预提供参考依据。方法厦门心理援助热线2010年9月至2015年8月接听来电中，将1299例有自杀企图相关资料的求助者纳入研究。来电过程中评估求助者抑... 详细信息

目的探讨心理援助热线求助者自杀企图的特征及相关因素，为国内心理援助热线自杀预防和干预提供参考依据。方法厦门心理援助热线2010年9月至2015年8月接听来电中，将1299例有自杀企图相关资料的求助者纳入研究。来电过程中评估求助者抑郁情绪和其他精神症状，并询问其物质滥用、躯体问题、生活事件、亲友自杀史、无望感、被虐待史、害怕被攻击等自杀相关因素情况。结果1299例求助者中，有自杀企图求助者361例（27．8％），既往有自杀未遂史223例（17．2％）。不同性别、年龄段、职业的求助者自杀企图发生率均差异无统计学意义（均P〉0．05）。1024例（78．8％）评估有精神症状，其中794例（61．1％）评估有焦虑症状，708例（54．5％）评估有抑郁症状，864例（66．5％）求助者合并存在2项及以上症状；比较抑郁伴发其他精神症状的求助者自杀企图发生率，发现抑郁伴发焦虑症状、伴发强迫症状、伴发惊恐症状及伴发恐惧症状自杀企图发生率均有统计学差异（均P〈0．05）。多因素Logistic回归分析显示，高抑郁情绪（β=0．389，OR=1．48，95％CI=1．08—2．02，P=0．015）、既往自杀未遂史（β=0．487，OR=1．63，95％CI=1．19～2．22，P=0．002）、高无望感（β=0．618，OR=1．86，95％CI=1．32～2．60，P〈0．01）与求助者自杀企图有关联。结论对于有自杀企图的求助者，注意评估他们精神症状的伴发情况，高抑郁情绪、既往自杀未遂史、高无望感等特征，以便有针对性进行自杀干预和预防。

关键词：热线心理援助自杀企图相关因素