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Bushen Kangshuai tablet inhibits progression of atherosclerosis by intervening in macrophage autophagy and polarization

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Journal of Traditional Chinese Medicine 2020年第1期40卷 28-37页

作者： Xie Yingyu tian lijun Fang Zihan Zhong Aiqin Ao Zhang Xu Shixin Wang Yanan Zhang Junping Department of Cardiology Medicine First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 300193China Geriatrics First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China tianjin Key Laboratory of Traditional Research of Traditional Chinese Medicine Prescription and Syndrome First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Epidemiology College of global public healthNew York University726 BroadwayNew York 10003USA

OBJECTIVE:To investigate the efficacy of Bushen Kangshuai(BS-KS)tablet on autophagy and polarization in mouse macrophage RAW ***:Macrophage autophagy was induced by oxidized low-density lipoprotein(100μg/m L).To detect the levels of autophagy,macrophage were transfected with double fluorescence LC3 autophagy adenovirus,then the numbers of autophagosomes and autophagic lysosomes were asessed by confocal *** autophagy related proteins expression of PI3 K,Akt,phospho-m Akt(p-Akt)and m TOR,phospho-m TOR(p-TOR),p62,microtubule-associated protein 1(LC3-Ⅱ)were determined by western *** macrophage polarization model was induced by lipopolysaccharide(1μg/m L).The m RNA levels of i NOS,CD86(M1 macrophages marker molecules),and CD206,Arg-1(M2 macrophages marker molecules)were detected by real-time quantitative *** concentration of cytokines TNF-αand IL-10 was determined by enzyme-linked immunosorbent *** protein expression of nuclear proteins PPAR-γ,NF-κB,and cytoplasmic protein IKBαwas determined by western ***:The expression of the autophagy-related protein LC3-Ⅱwas increased and the expression of p62 was decreased in the BS-KS intervention *** protein expression of PI3 K,p-Akt,and p-m TOR was also ***-KS also inhibited the m RNA expression of i NOS and CD86 on M2 macrophage,but promoted the expression of CD206 and Arg-1 on M2 *** respect to the regulation of inflammatory factors,BS-KS could inhibit the secretion of pro-inflammatory TNF-αand promote the secretion of anti-inflammatory *** also inhibited the protein expression of IKB-αand NF-κB,and promoted the expression of nuclear protein PPAR-γ.CONCLUSION:We believe that BS-KS promotes macrophage autophagy by increasing the level of autophagy protein and inhibiting the PI3 K/Akt/m TOR signaling ***,BS-KS seems to inhibit macrophage M1 polarization and promote M2 polarization via the PPAR gamma/NF-κB signaling pathway,thus play

关键词： Atherosclerosis Macrophages Autophagy Lipoproteins,LDL Lipopolysaccharides Signal transduction Bushen Kangshuai tablets

BASF Demonstrates Innovations for High-performance Wind Power in Asia

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China Chemical Reporter 2009年第20期20卷 8-8页

作者： tian lijun

BASF demonstrated how the latest innovations from the chemical industry canprovide better performance for wind turbines,at Wind Power Asia in Beijing onJuly 8-10,*** offers state-of-the-art epoxy *** BASF’s Baxxodur two-component systems,based on epoxy resins and curing agents,the productionoutput of large rotor blades can be significantly *** assure that theforms for blades are filled completely and rapidly,the BASF systems

关键词： BASF resins epoxy curing react assure manufacture

BASF Presents Its First Carbon Balance

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China Chemical Reporter 2008年第7期19卷 15-15页

作者： tian lijun

BASF is the world’s first company to present a comprehensive carbon balance for its *** results show that BASF products can save three times more greenhouse gas emissions than the entire amount caused by the producti... 详细信息

关键词： BASF faced greenhouse emissions disposal challenge

BASF Launches New Concrete Admixture Plant in Shandong

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China Chemical Reporter 2008年第1期19卷 19-19页

作者： tian lijun

On December 14th,2007 BASF’s Construction Chemicals Busi-ness opened its new concrete admixture plant in Zibo,Shandong *** facility has been launched to enhance

关键词： Shandong BASF facility admixture struction opened

Scalable and fast fabrication of graphene integrated micro-supercapacitors with remarkable volumetric capacitance and flexibility through continuous centrifugal coating

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Journal of Energy Chemistry 2021年第1期30卷 284-290,I0009页

作者： Xiaoyu Shi lijun tian Sen Wang Pengchao Wen Ming Su Han Xiao Pratteek Das Feng Zhou Zhaoping Liu Chenglin Sun Zhong-Shuai Wu Xinhe Bao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026AnhuiChina Great Scientific Research Institute Datong Coal Mine Group Co.LtdDatong 037003ShanxiChina Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Ningbo Graphene Innovation Center Co. LtdNingbo 315200ZhejiangChina Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina

Microscale electrochemical energy storage devices,e.g., micro-supercapacitors(MSCs),possessing tailored performance and diversified form factors of lightweight,miniaturization,flexibility and exceptional integration are highly necessary for the smart power sources-unitized *** the great progress,the fabrication of MSCs combining high integration with high volumetric performance remains largely ***,we develop a simple,fast and scalable strategy to fabricate graphene based highly integrated MSCs by a new effective continuous centrifugal coating ***,the resulting highly conductive graphene films can act as not only patterned microelectrodes but also metal-free current collectors and interconnects,endowing modular MSCs with high integrity,remarkable flexibility,tailored voltage and capacitance output,and outstanding performance *** importantly,the strong centrifugal force and shear force generated in continuous centrifugal coating process lead to graphene films with high alignment,compactness and packing density,contributing to excellent volumetric capacitance of ~31.8 F cm^(-3) and volumetric energy density of ~2.8 mWh cm^(-3),exceeding most reported integrated ***,our work paves a novel way for simple and scalable fabrication of integrated MSCs and offers promising opportunities as standalone microscale power sources for new-generation electronics.

关键词： Integrated micro-supercapacitors Continuous centrifugal coating Graphene Flexibility Volumetric capacitance

BASF and SINOPEC Submit FS for Expansion of Nanjing Site

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China Chemical Reporter 2008年第9期19卷 10-10页

作者： tian lijun BASF Sang Jinghua Sinopec

BASF and China Petroleum & Chemical Cor-poration(Sinopec Corp.)have submitted the technical and commercial feasibility study(FS)for the approval of the planned

关键词： Nanjing BASF Petroleum planned approval submitted

具有异质行为特征的网约车司机劳动供给建模与激励

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系统工程理论与实践 2024年第11期44卷 3612-3625页

作者：江晓岚田丽君福州大学经济与管理学院福州350108

如何调动合适数量的司机在合适的时间为乘客提供服务是网约车运营的核心.考虑司机行为特征的异质性,本文以时间拓展网络为基础,假设司机效用由消费效用和参考效用组成,构建可兼容两大行为理论的统一框架来刻画司机的上下班劳动供给行为... 详细信息

如何调动合适数量的司机在合适的时间为乘客提供服务是网约车运营的核心.考虑司机行为特征的异质性,本文以时间拓展网络为基础,假设司机效用由消费效用和参考效用组成,构建可兼容两大行为理论的统一框架来刻画司机的上下班劳动供给行为,并提出相应的均衡求解算法,分析不同行为理论驱使和偏好不同工作时长的司机在均衡市场中的上下班时间选择.在此基础上提出抽成式和任务式两类激励方式,建立相应模型,研究具有不同行为特征的司机对不同激励方式的反应,并探索平台的最优激励策略.研究结果表明,受新古典主义行为驱动的司机对激励的反应高于目标收入行为驱动的司机,任务式激励对偏好工作时间长的全职司机激励效应较高,兼职司机偏好抽成式与任务阈值低的激励方式.本文为平台理解司机劳动供给行为,进一步管理和激励运力提供理论参考和现实依据.

关键词：网约车司机时间拓展网络行为特征劳动供给激励

基于粒子群优化算法的电压暂降监测点优化配置

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电工技术学报 2014年第4期29卷 181-187页

作者：周超田立军山东大学电气工程学院济南250061

为实现全网电压暂降故障点的可监测性,提出一种应用粒子群优化(PSO)算法对全网电压暂降监测点进行优化配置的方法。首先利用解析式法原理,通过线路临界故障点确定可观测区域,构建出各种短路故障情况下系统的电压暂降可观测矩阵,然后以... 详细信息

为实现全网电压暂降故障点的可监测性,提出一种应用粒子群优化(PSO)算法对全网电压暂降监测点进行优化配置的方法。首先利用解析式法原理,通过线路临界故障点确定可观测区域,构建出各种短路故障情况下系统的电压暂降可观测矩阵,然后以监测点数目最少为目标函数,以全网各节点电压满足完全可观测为约束条件,建立电压暂降监测点优化配置的0-1线性规划模型。结合罚函数思想应用PSO算法进行优化求解,并综合考虑配置节点的优先级最终确定最优配置方案。通过对IEEE 39节点标准测试系统的仿真计算证明了该方法的有效性。

关键词：电压暂降监测点解析式法可观测矩阵优化配置粒子群优化罚函数

One-pot topotactic synthesis of Ti^(3+) self-doped 3D TiO_2 hollow nanoboxes with enhanced visible light response

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Chinese Journal of Catalysis 2018年第8期39卷 1373-1383页

作者： Chengjiang Zhang lijun tian Lianqin Chen Xiaofang Li Kangle Lv Kejian Deng Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission ＆ Ministry of Education South-Central University for NationalitiesWuhan430074HubeiChina College of Chemistry and Chemical Engineering Wuhan University of Science and TechnologyWuhan430081HubeiChina

Ti^（3＋） self-doped anatase three-dimensional（3D） TiO_2 hollow nanoboxes were synthesized via a topological transformation process involving template participation by a facile one-pot hydrothermal treatment with an ethanol solution of zinc powder and TiOF_2. It is worth noting that the 3D TiO_2 hollow nanoboxes are assembled from six single-crystal nanosheets and have dominant exposure of the {001} facets. It is found from EPR spectra that adding zinc powder is an environment-friendly and effective strategy to introduce Ti^（3＋） and oxygen vacancy（Ov） into the bulk of 3D hollow nanoboxes rather than the surface, which is responsible for their enhanced visible photocatalytic *** photocatalytic activity was evaluated by measuring the formation rate of hydroxide free radicals using 7-hydroxycoumarin as a probe. The sample prepared with zinc/TiOF_2 mass ratio of0.25 exhibited the highest RhB photodegradation activity under visible-light irradiation with a degradation rate of 96%, which is 4.0-times higher than that of pure TiO_2. The results suggest a novel approach to construct in-situ 3D hierarchical TiO_2 hollow nanoboxes doped with Ti^（3＋） and Ov without introducing any impurity elements for superior visible-light photocatalytic activity.

关键词： Ti3+self‐doped Topological transformation Three‐dimensional hollow nanoboxes Visible light response Photocataly ticactivity