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MiR-520f-3p inhibits epithelial-mesenchymal transition of colorectal cancer cells by targeting Yes-associated protein 1

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BIOCELL 2023年第8期47卷 1803-1810页

作者： lijun jiang WENMIN JI YAJIE GONG JIAJUN LI JINCHUN LIU Department of Gastroenterology The First Clinical Medical College of Shanxi Medical UniversityTaiyuan030001China The First Clinical Medical School Shanxi Medical UniversityTaiyuan030001China

Background:Colorectal cancer(CRC)is one of the most common malignancies.Early diagnosis is the key to effective treatment of CRC.Since microRNAs(miRNAs)can be used as biomarkers of CRC,the objective of this work was to examine the effect of miR-520f-3p,which targets YAP1(Yes-associated protein 1),on the ability of CRC cells to proliferate,invade,migrate,and undergo epithelial-mesenchymal transition(EMT).Methods:A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells.To establish the tumor-bearing mouse model,transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice,and YAP1 and miR-520f-3p levels were determined using qRT‒PCR.The viability,invasion ability,and migration ability of cells were evaluated by CCK-8,Transwell,and wound healing assays.Apoptosis was detected by flow cytometry and TUNEL assays.The regulatory link between miR-520f-3p and the YAP1 gene was examined by dual-luciferase reporter assay.Tumor tissues with positive Ki-67 expression were identified by immunohistochemistry.Vimentin,E-cadherin,and YAP1 expression were evaluated by western blotting.Results:MiR-520f-3p overexpression could inhibit proliferation,invasion,migration,and EMT and induce apoptosis in HT29 cells.YAP1 was found as a target of miR-520f-3p.The inhibitory effects of miR-520f-3p on proliferation,invasion,migration,and EMT may be reversed by overexpressing YAP1.In tumor-bearing mice,miR-520f-3p overexpression reduced the Ki-67 level,increased apoptosis,and prevented tumor development and spread.Conclusion:By targeting YAP1,miR-520f-3p may be capable of suppressing CRC cell proliferation,invasion,migration,and EMT,providing a novel therapeutic target for the disease.

关键词： Colorectal cancer Epithelial interstitial transformation MiR-520f-3p YAP1

Effect of carbon coating on electrochemical properties of AB_(3.5)-type La-Y-Ni-based hydrogen storage alloys

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Journal of Rare Earths 2022年第8期40卷 1264-1271页

作者： Ran Wu Huiping Yuan Yuru Liu Zhenyu Hou Zhinian Li Shumao Wang lijun jiang Lei Hao National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China Institute for Advanced Materials and Technology University of Science&Technology BeijingBeijing 100083China

The superlattice La-Y-Ni-based hydrogen storage alloys have high discharge capacity and are easy to prepare.However,there is still a gap in commercial applications because of the severe corrosion of the alloys in electrolyte and poor high-rate dischargeability(HRD).Therefore,(LaSmY)(NiMnAl)_(3.5) alloy was prepared by magnetic levitation induction melting,and then the alloy was coated with different contents(0.1 wt%-1.0 wt%) of nano-carbons by low-temperature sintering with sucrose as the carbon source in this work.The results show that the cyclic stability and HRD of the alloy first increase and then decrease with the increase of carbon contents.The kinetic results show that the electrocatalytic activity and conductivity of the alloy electrodes can be enhanced by carbon coating.The electrochemical properties of the alloy are the best when the carbon coating content is 0.3 wt%.Compared with the uncoated alloy,the maximum discharge capacity(C_(max)) improves from 354.5 to 359.0 mAh/g,the capacity retention rate after 300 cycles(S_(300)) enhances from 73.15% to 80.01%,and the HRD_(1200) of the alloy enhances from 74.39% to 74.39%.

关键词： La-Y-Ni-based alloy Sucrose Carbon coating Electrochemical properties Ni/MH batteries Rare earths

Expediting the Innovation and Application of Solid Hydrogen Storage Technology

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Engineering 2021年第6期7卷 731-733页

作者： lijun jiang National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

1.Introduction Hydrogen energy can be stored and transported,which is not only one of its advantages,but also the main bottleneck in its application.Solid hydrogen storage provides an important means of storing hydrogen energy with high density and safety.First,this method can greatly improve the hydrogen storage density.Among the three existing hydrogen storage methods,namely,high-pressure compression,liquefaction,and solidification,solid-state hydrogen storage has the highest volumetric hydrogen storage density.For example,the volumetric hydrogen storage density of MgH2 can reach 106 kg H2 per cubic meter.

关键词： density. solidification hydrogen

Large variability in ambient ozone sensitivity across 19 ethylenediurea-treated Chinese cultivars of soybean is driven by total ascorbate

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Journal of Environmental Sciences 2018年第2期30卷 10-22页

作者： lijun jiang Zhaozhong Feng Lulu Dai Bo Shang Elena Paoletti State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China National Research Council Via Madonna del Piano 10 50019 Sesto Fiorentino Italy

The sensitivity of Chinese soybean cultivars to ambient ozone（O3） in the field is unknown,although soybean is a major staple food in China. Using ethylenediurea（EDU） as an O3 protectant, we tested the gas exchange, pigments, antioxidants and biomass of 19 cultivars exposed to 28 ppm·hr AOT40（accumulated O3 over an hourly concentration threshold of40 ppb） over the growing season at a field site in China. By comparing the average biomass with and without EDU, we estimated the cultivar-specific sensitivity to O3 and ranked the cultivars from very tolerant（〈 10% change） to highly sensitive（〉 45% change）, which helps in choosing the best-suited cultivars for local cultivation. Higher lipid peroxidation and activity of the ascorbate peroxidase enzyme were major responses to O3 damage, which eventually translated into lower biomass production. The constitutional level of total ascorbate in the leaves was the most important parameter explaining O3 sensitivity among these cultivars. Surprisingly, the role of stomatal conductance was insignificant. These results will guide future breeding efforts towards more O3-tolerant cultivars in China, while strategies for implementing control measures of regional O3 pollution are being implemented. Overall, these results suggest that present ambient O3 pollution is a serious concern for soybean in China, which highlights the urgent need for policy-making actions to protect this critical staple food.

关键词： Ground-level ozone Glycine max Cultivar Ozone sensitivity Antioxidants Gas exchange Biomass Total ascorbate

Reducing the Rate of Unplanned Extubation of Venous Access in Perioperative Patients

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Journal of Clinical and Nursing Research 2022年第6期6卷 105-116页

作者： Guimei Zhang Shujie Liu Yongliang Sun lijun jiang Anesthesiology Department The Third People’s Hospital of ShenzhenShenzhen 518112Guangdong ProvinceChina Central Operating Room 2 Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

Objective:To investigate the application effect of quality control circle activities in reducing the rate of unplanned extubation of venous access in perioperative patients.Methods:The quality control circle method was used to analyze the causes,identify the actual causes of unplanned out-of-control,take corresponding measures,formulate corresponding countermeasures,implement standardized management,and carry out continuous improvement.Results:Following the implementation of quality control circle activities,the rate of unplanned extubation of venous access in perioperative patients decreased from 27.35%before improvement to 3.42%after improvement.Conclusion:The use of quality control circle activities in the safety management of venous access in perioperative patients is conducive to reducing the rate of unplanned extubation of venous access in perioperative patients.

关键词： Quality control circle Unplanned extubation

Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease:a systematic review and meta-analysis

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Translational Neurodegeneration 2021年第1期10卷 112-125页

作者： Xulong Ding Shuting Zhang lijun jiang Lu Wang Tao Li Peng Lei Department of Neurology and State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Mental Health Center and West China Brain Research Center West China HospitalSichuan UniversityChengdu 610041China Department of Rehabilitation Medicine West China HospitalSichuan UniversityChengdu 610041China

A lack of convenient and reliable biomarkers for diagnosis and prognosis is a common challenge for neurodegenerative diseases such as Alzheimer's disease(AD).Recent advancement in ultrasensitive protein assays has allowed the quantification of tau and phosphorylated tau proteins in peripheral plasma.Here we identified 66 eligible studies reporting quantification of plasma tau and phosphorylated tau 181(ptau181)using four ultrasensitive methods.Meta-analysis of these studies confirmed that the AD patients had significantly higher plasma tau and ptau181 levels compared with controls,and that the plasma tau and ptau181 could predict AD with high-accuracy area under curve of the Receiver Operating Characteristic Therefore,plasma tau and plasma ptau181 can be considered as biomarkers for AD diagnosis.

关键词： Tau Phosphorylated tau 181 Alzheimer's disease Simoa IMR EIMAF/a-EIMAF MSD Plasma biomarker

A Study on the Effect of Comprehensive Intervention Based on Transition Theory on the Readiness for Discharge of Post-Operative Breast Cancer Patients

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Advances in Breast Cancer Research 2022年第2期11卷 128-140页

作者： Na Li Wanwei Huang lijun jiang lijun Zhang Xiaohong Lin Haiting Wu Yuting Huang Yue Li Department of Nursing Sun Yat-sen University Cancer Center Guangzhou China

Purpose: To explore the effect of comprehensive intervention based on transition theory in enhancing the readiness for discharge of post-operative breast cancer patients. Method: In a non-simultaneous controlled study test, 99 post-operative breast cancer patients hospitalized between August 2019 and February 2020 were selected as the control group and 93 post-operative breast cancer patients hospitalized between March and August 2020 were selected as the test group at a Grade A tertiary tumor hospital. While the control group used the conventional care model, the test group added a comprehensive intervention based on transition theory to the routine nursing, which focused on stimulating patients’ awareness of health transitions, assisting patients to identify health critical events, strengthening social support and promoting self-management. The differences between the two groups were compared in terms of patient readiness for discharge and patient evaluation of the quality of discharge teaching. Result: The total score of readiness for discharge was higher in the test group than in the control group (171.7 ± 24.5 vs. 155.9 ± 28.9) and the scores for “Self-condition” (55.6 ± 8.2 vs. 50.8 ± 9.7), “Disease Knowledge” (64.7 ± 13.1 vs. 57.7 ± 13.8), “Coping Ability after Discharge” (24.6 ± 4.8 vs. 22.2 ± 5.6), “Expected Social Support after Discharge” (26.8 ± 4.5 vs. 25.2 ± 4.8) were higher than those of the control group, and all differences were statistically significant (p < 0.05). The total score of the test group on the quality of discharge teaching scale was higher than that of the control group (162.1 ± 19.9 vs. 152.6 ± 28.7), and the scores for “Content that Patients Self-perceived they required before discharge” (53.2 ± 9.5 vs. 49.4 ± 12.1), “Content that Patients Actually Acquired before Discharge” (51.2 ± 9.2 vs. 48.3 ± 11.3) and “Guiding Skills and Effects of Discharge for Nurses” (110.9 ± 12.6 vs. 104.3 ± 19.00) were also higher than those of the control group (p Conclusion: Comprehensive intervention b

关键词： Transition Theory Breast Cancer Readiness for Discharge

Leveraging on few-shot learning for tire pattern classification in forensics

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Journal of Automation and Intelligence

Journal of Automation and Intelligence 2023年第3期2卷 146-151页

作者： lijun jiang Syed Ariff Syed Hesham Keng Pang Lim Changyun Wen School of Engineering Republic PolytechnicSingapore Maschine Technology Pte.Ltd Singapore School of Electrical&Electronic Engineering Nanyang Technological UniversitySingapore

This paper presents a novel approach for tire-pattern classification,aimed at conducting forensic analysis on tire marks discovered at crime scenes.The classification model proposed in this study accounts for the intricate and dynamic nature of tire prints found in real-world scenarios,including accident sites.To address this complexity,the classifier model was developed to harness the meta-learning capabilities of few-shot learning algorithms(learning-to-learn).The model is meticulously designed and optimized to effectively classify both tire patterns exhibited on wheels and tire-indentation marks visible on surfaces due to friction.This is achieved by employing a semantic segmentation model to extract the tire pattern marks within the image.These marks are subsequently used as a mask channel,combined with the original image,and fed into the classifier to perform classification.Overall,The proposed model follows a three-step process:(i)the Bilateral Segmentation Network is employed to derive the semantic segmentation of the tire pattern within a given image.(ii)utilizing the semantic image in conjunction with the original image,the model learns and clusters groups to generate vectors that define the relative position of the image in the test set.(iii)the model performs predictions based on these learned features.Empirical verification demonstrates usage of semantic model to extract the tire patterns before performing classification increases the overall accuracy of classification by∼4%.

关键词： Meta-learning Few-shot classification Semantic segmentation

散光精准定位标记工具用于飞秒激光小切口角膜基质透镜取出术矫正近视散光的效果

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眼科新进展 2024年第6期44卷 475-479页

作者：胥丽萍蒋丽君姜允彬朱永唯浙江中医药大学附属嘉兴市中医医院眼科浙江省嘉兴市314000

目的探讨散光精准定位标记工具用于飞秒激光小切口角膜基质透镜取出术(SMILE)矫正近视散光的效果。方法选取2022年1月至12月在我院行SMILE且散光在-5.00~-1.25 D的患者120例120眼(均选右眼)作为研究对象,按随机数表将患者分为标记组(60... 详细信息

目的探讨散光精准定位标记工具用于飞秒激光小切口角膜基质透镜取出术(SMILE)矫正近视散光的效果。方法选取2022年1月至12月在我院行SMILE且散光在-5.00~-1.25 D的患者120例120眼(均选右眼)作为研究对象,按随机数表将患者分为标记组(60例)和不标记组(60例)。标记组患者由手术医生使用我科自主研发的散光精准定位标记工具进行标记。所有患者分别于术前及术后1 d、术后1周、术后3个月进行检查,收集术前及术后3个月的检查数据(裸眼视力、最佳矫正视力、电脑验光结果)。利用矢量分析工具计算相关散光评价指标:|平均差异矢量|(|DV|)、矫正指数(CI)、误差角度绝对值(|AofE|)。采用尼德克屈光分析仪测量患者高阶像差,包括球差、彗差、三叶草差。应用SPSS 26.0软件对两组患者相关数据进行统计学分析。结果术前两组患者最佳矫正视力、球镜度和柱镜度差异均无统计学意义(均为P>0.05)。标记组患者术后3个月裸眼视力(logMAR)优于不标记组,差异有统计学意义(P0.05)。术后3个月两组患者|DV|、CI差异均无统计学意义(均为P>0.05);术后3个月标记组患者|AofE|小于不标记组,差异有统计学意义(P0.05);术后3个月两组患者彗差、三叶草差、球差均较术前明显增加(均为P<0.05)。术后3个月标记组患者彗差小于不标记组,差异有统计学意义(P<0.05)。结论散光精准定位标记工具标记后行SMILE较不标记具有更佳的散光矫正效果,能明显优化SMILE所带来的彗差,提高患者视觉质量。

关键词：小切口角膜基质透镜取出术近视散光散光精准定位标记工具矢量分析角度偏差高阶像差视觉质量