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Acta Pharmaceutica Sinica B 2023年第11期13卷 4341-4372页

作者： Yanyu jiang Shuaishuai Ni Biying Xiao lijun jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Ubiquitin(Ub)and ubiquitin-like(Ubl)pathways are critical post-translational modifications that determine whether functional proteins are degraded or activated/*** date,>600 associated enzymes have been reported that comprise a hierarchical task network(e.g.,E1–E2–E3 cascade enzymatic reaction and deubiquitination)to modulate substrates,including enormous oncoproteins and tumor-suppressive *** strategies,such as classical biochemical approaches,multiomics,and clinical sample analysis,were combined to elucidate the functional relations between these enzymes and *** this regard,the fundamental advances and follow-on drug discoveries have been crucial in providing vital information concerning contemporary translational efforts to tailor individualized treatment by targeting Ub and Ubl ***,emphasizing the current progress of Ub-related pathways as therapeutic targets in cancer is deemed *** the present review,we summarize and discuss the functions,clinical significance,and regulatory mechanisms of Ub and Ubl pathways in tumorigenesis as well as the current progress of small-molecular drug *** particular,multiomics analyses were integrated to delineate the complexity of Ub and Ubl modifications for cancer *** present review will provide a focused and up-to-date overview for the researchers to pursue further studies regarding the Ub and Ubl pathways targeted anticancer strategies.

关键词： Ub and Ubl modifications Ub-activating enzyme Ub-conjugating enzyme Ub ligase Multiomics analyses Drug discovery Small molecule inhibitor Molecular glue

Deployment Dynamic Modeling and Driving Schemes for a Ring-Truss Deployable Antenna

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 163-182页

作者： Baiyan He lijun jia Kangkang Li Rui Nie Yesen Fan Guobiao Wang Key Laboratory of Mechanism Theory and Equipment Design Ministry of EducationTianjin UniversityTianjin 300350China Xi’an Institute of Space Radio Technology Xi’an 710000China International Institute for Innovative Design and Intelligent Manufacturing of Tianjin University in Zhejiang Shaoxing 312077China

Mesh reflector antennas are widely used in space tasks owing to their light weight,high surface accuracy,and large folding *** are stowed during launch and then fully deployed in orbit to form a mesh reflector that transmits *** deployment is essential for duty services;therefore,accurate and efficient dynamic modeling and analysis of the deployment process are *** major challenge is depicting time-varying resistance of the cable network and capturing the cable-truss coupling behavior during the deployment *** paper proposes a general dynamic analysis methodology for cable-truss *** the topological diversity and geometric nonlinearity,the cable network's equilibrium equation is derived,and an explicit expression of the time-varying tension of the boundary cables,which provides the main resistance in truss deployment,is *** deployment dynamic model is established,which considers the coupling effect between the soft cables and deployable *** effects of the antenna's driving modes and parameters on the dynamic deployment performance were investigated.A scaled prototype was manufactured,and the deployment experiment was conducted to verify the accuracy of the proposed modeling *** proposed methodology is suitable for general cable antennas with arbitrary topologies and parameters,providing theoretical guidance for the dynamic performance evaluation of antenna driving schemes.

关键词： Cable antenna Deployment dynamics Performance evaluation Driving scheme Deployable structure

Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2331-2333页

作者： Lili Cai Lihui Li Xihui Chen lijun jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Dear Editor,S phase kinase-associated protein 2(SKP2),a substrate recognition component of the SCFSKP2 ubiquitin ligase complex,plays an oncogenic role in tumorigenesis by targeting a variety of tumor suppressors(e.g.,p21,p27,and p130)for ubiquitina-tion and subsequent degradation.1 As a well-characterized oncoprotein,the aberrant expression and dysregulation of SKP2 are frequently observed in different human *** its critical role in governing tumorigenesis and progression,SKP2 has emerged as a potential pharmacological target for anticancer therapy.

关键词： SKP2 suppressor shock

New Life of the Lhobas

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China's Tibet 2004年第6期15卷 9-11页

作者： jia lijun

People of the Lhoba ethnic group groaned under slavery some 50 years ago, living in dense forests. Today, however, people of the Lhoba ethnic group, with the smallest population compared to others, enjoy a life enjoye... 详细信息

关键词：生活水平西藏居住环境房屋民族习俗

Magnetic Properties of Nanometer-Scale NiZnCu Ferrite Thin Films Fabricated by Spray-Spin-Heating-Coating Method

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Journal of Materials Science & Technology 2004年第1期20卷 35-37页

作者： Yulan JING, Huaiwu ZHANG, lijun jia, Yu SHI and Yingli LIUInstitute of Information and Materials, University of Electronic Science and Technology of China, Chengdu 610054, China Inst. of Info. and Mat. Univ. of Electron. Sci. and Technol. Chengdu 610054 China

A new nanometer-scale ferrite thin film with excellent high-frequency characteristics has been developed by the spray-spin-heating-coating method. The effects of the ion synthesis mechanism, chemical stoichiometry, fabrication method, and doping content on the magnetic properties and microstructure of the thin films have been analyzed. The films formed between 75℃ and 90℃ by spray-spin-heating-coating methods was discovered with fine grain size of about 21 nm, high saturation magnetization (4πMs) of about 6.5 kGs, coercivity of about 9.8 Oe, as well as initial permeability of about 14.0. These films can be widely used in radio-frequency integrated circuit devices.

关键词： Nanometer materials Ferrite thin film Spray-spin-heating-coating

Highways Bring Changes To Tibet

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China's Tibet 2004年第6期15卷 16-17页

作者： ZHAO ZONGZHI & jia lijun

The “roof of the world” rose some 100 million years ago. Given its poor natural conditions, this region was a world of rocks, ravines and valleys. Legs were the chief means of transport then.

关键词：公路建设西藏青藏公路经济发展交通工具

The Fire Fighters Protecting The Potala Palace

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China's Tibet 2008年第2期19卷 65-69页

作者： jia lijun Lu Yunliang

The Potala Palace is situated on the"red"mountain of Lhasa.A group of police fire fighters, unknown to most people,are actually the"guardians of the national treasures"and are living all year around inside the Potala *** they have formed a consolidated"fireproof wall"to protect this world famous cultural *** they took up residence 23 years ago, there have been no accidental fires in the palace.

关键词： The Fire Fighters Protecting The Potala Palace

Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent

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Acta Pharmaceutica Sinica B 2024年第2期14卷 729-750页

作者： Xin Chen Xianggang Mu Lele Ding Xi Wang Fei Mao Jinlian Wei Qian Liu Yixiang Xu Shuaishuai Ni lijun jia jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China College of Pharmacy Jinan UniversityGuangzhou 510632China

Chemotherapy-induced complications,particularly lethal cardiovascular diseases,pose significant challenges for cancer *** intertwined adverse effects,brought by cancer and its complication,further complicate anticancer therapy and lead to diminished clinical *** supplementation of cardioprotective agents falls short in addressing these *** bifunctional co-therapy agents provided another potential solution to consolidate the chemotherapy and reduce cardiac events *** repurposing was naturally endowed with co-therapeutic potential of two indications,implying a unique chance in the development of bi-functional ***,we further proposed a novel“trilogy of drug repurposing”strategy that comprises function-based,targetfocused,and scaffold-driven repurposing approaches,aiming to systematically elucidate the advantages of repurposed drugs in rationally developing bi-functional *** function-based repurposing,a cardioprotective agent,carvedilol(CAR),was identified as a potential neddylation inhibitor to suppress lung cancer *** target-focused SAR studies and scaffold-driven drug design,we synthesized 44 CAR derivatives to achieve a balance between anticancer and ***,optimal derivative 43 displayed promising bi-functional effects,especially in various self-established heart failure mice models with and without ***,the present study validated the practicability of the“trilogy of drug repurposing”strategy in the development of bi-functional cotherapy agents.

关键词： Anticancer Heartfailure Complication Drug repurposing Bi-functional drug

A Condition States Assessment System for Concrete Bridges Using Neural Networks

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工程科学（英文版） 2006年第3期4卷 67-76页

作者： Hu Zhijian jia lijun Xiao Rueheng Department of Bridge Engineering Tongji University Shanghai 200092 Communication College Wuhan University of Technology Wuhan 430063

Due to continuing aging and heavy utilization of many bridges and the limited available funds, the importance of proper bridge condition state assessment has risen recently, which is the crucial point for rational decision-making on MR&R activities. This paper presents a prototype of the concrete bridge condition state assessment system (CBCSAS) with the following sub-modules: inspection, parameter recognition, structural assessment, main cause identification and priority-to-action. And multi-layer neural networks, which may combine with fuzzy set theory or not, are performed to realize the structural assessment with embedding expert knowledge into the assessment system.

关键词：混凝土桥梁多层神经网络模糊集合论条件状态评价系统

The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1984-1992页

作者： Lihui Li Wenjuan Zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang Yunjing Zhang Wenlian Chen Changsheng Dong Yanmei Zhang Mingsong Wang Wenyi Wei lijun jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Laboratory Medicine Huadong HospitalAffiliated to Fudan UniversityShanghaiChina Xinhua Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell ***,the regulatory mechanism of TNFAIP1 degradation remains largely *** the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)*** importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and ***,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in *** such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this ***,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of *** together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration.

关键词： TNFAIP1 CRL complex