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Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2576-2585页

作者： Shuai Xia Qiaoshuai Lan Yun Zhu Chao wang Wei Xu Yutang Li lijue wang Fanke Jiao Jie Zhou Chen Hua Qian wang Xia Cai Yang Wu Jie Gao Huan Liu Ge Sun Jan Munch Frank Kirchhoff Zhenghong Yuan Youhua Xie Fei Sun Shibo Jiang Lu Lu Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and Biosafety Level 3 LaboratoryShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina National Key Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina China Institute for Radiation Protection TaiyuanShanxiChina lnstitute of Molecular Virology Ulm University Medical CenterUlmGermany Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdongChina

The COVID-19 pandemic poses a global threat to public health and economy.The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines.In this study,we identified that EK1 and cholesterol-coupled derivative of EK1,EK1C4,as pan-CoV fusion inhibitors,exhibit potent antiviral activity against SARS-CoV-2 infection in both lung-and intestine-derived cell lines(Calu-3 and Caco2,respectively).They are also effective against infection of pseudotyped SARS-CoV-2 variants B.1.1.7(Alpha)and B.l.1.248(Gamma)as well as those with mutations in S protein,including N417T,E484K,N501Y,and D614G,which are common in South African and Brazilian variants.Crystal structure revealed that EK1 targets the HR1 domain in the SARS-CoV-2 S protein to block virus-cell fusion and provide mechanistic insights into its broad and effective antiviral activity.Nasal administration of EK1 peptides to hACE2 transgenic mice significantly reduced viral titers in lung and intestinal tissues.EK1 showed good safety profiles in various animal models,supporting further clinical development of EK1-based pan-CoV fusion inhibitors against SARS-CoV-2 and its variants.

关键词： clinical lung intestine

Constructing oxygen-deficient V_(2)O_(3)@C nanospheres for high performance potassium ion batteries

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Chinese Chemical Letters 2023年第3期34卷 507-511页

作者： Qiang Deng Luolan wang Jing Li Qian Cheng Xiaozhao Liu Changdong Chen Qimeng Zhang Wentao Zhong Hua wang lijue Wu Chenghao Yang Guangzhou Key Laboratory for Surface Chemistry of Energy Materials New Energy Research InstituteSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Guangdong Jiana Energy Technology Co. Ltd.Qingtang TownYingde 513056China

Potassium ion batteries(PIBs) have been regarded as promising alternatives to lithium ion batteries(LIBs)on account of their abundant resource and low cost in large scale energy storage applications. However,it still remains great challenges to explore suitable electrode materials that can reversibly accommodate large size of potassium ions. Here, we construct oxygen-deficient V_(2)O_(3)nanoparticles encapsulated in amorphous carbon shell(Od-V_(2)O_(3)@C) as anode materials for PIBs by subtly combining the strategies of morphology and deficiency engineering. The MOF derived nanostructure along with uniform carbon coating layer can not only enables fast K+migration and charge transfer kinetics, but also accommodate volume change and maintain structural stability. Besides, the introduction of oxygen deficiency intrinsically tunes the electronic structure of materials according to DFT calculation, and thus lead to improved electrochemical performance. When utilized as anode for PIBs, Od-V_(2)O_(3)@C electrode exhibits superior rate capability(reversible capacities of 262.8, 227.8, 201.5, 179.8, 156.9 mAh/g at 100, 200, 500, 1000 and2000 mA/g, respectively), and ultralong cycle life(127.4 mAh/g after 1000 cycles at 2 A/g). This study demonstrates a feasible way to realize high performance PIBs through morphology and deficiency engineering.

关键词： V_(2)O_(3)@C Nanospheres Oxygen deficiency Potassium ion batteries Anode

碳纤维复合材料天线框架竖直状态加工工艺研究

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粘接 2024年第3期51卷 65-68页

作者：胡宗文邵劲力李宗周周丽珏张菊萍上海复合材料科技有限公司上海201112 上海航天树脂基复合材料工程技术研究中心上海201112

天线阵面的平面度是与天线性能相关的最重要的技术指标,为了达到安装要求,介绍了碳纤维复合材料天线框架的结构特点、使用要求和制造技术难点,研究并分析了重力对框架平面度及其稳定性的影响,提出了竖直状态补偿、平放状态加工的机加工... 详细信息

天线阵面的平面度是与天线性能相关的最重要的技术指标,为了达到安装要求,介绍了碳纤维复合材料天线框架的结构特点、使用要求和制造技术难点,研究并分析了重力对框架平面度及其稳定性的影响,提出了竖直状态补偿、平放状态加工的机加工方案,进行了天线框架消除重力影响状态下加工的验证试验。试验结果表明,按此方案加工的天线框架在竖直悬挂状态下的有源安装面和波导安装面平面度均达标,满足天线框架地面展开试验及在轨失重状态下的使用要求。

关键词：碳纤维复合材料天线框架竖直状态消除重力影响平面度

Incorporating multifunctional LiAlSiO_(4) into polyethylene oxide for high-performance solid-state lithium batteries

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Journal of Energy Chemistry 2021年第2期30卷 116-123,I0005页

作者： Yuqi Wu Xinhai Li Guochun Yan Zhixing wang Huajun Guo Yong Ke lijue Wu Haikuo Fu Jiexi wang School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina Guangdong Jiana Energy Technology Co. Ltd.Qingyuan 513056GuangdongChina

High ionic conductivity,good electrochemical stability,and satisfactory mechanical property are the crucial factors for polymer solid state electrolytes.Herein,fast ion conductor LiAlSiO_4(LASO) is incorporated into polyethylene oxide(PEO)-based solid-state electrolytes(SSEs).The SSEs containing LASO exhibit enhanced mechanical properties performance compared to pristine PEO-LiTFSI electrolyte.A reduced melting transition temperature of 40.57℃ is enabled by introducing LASO in to PEO-based SSE,which is beneficial to the motion of PEO chain and makes it possible for working at a moderate environment.Coupling with the enhanced motion of PEO,dissociation of the lithium salt,and conducting channel of LASO,the optimized composite polymer SSE exhibits a high ionic conductivity of 4.68×10^(-4),3.16×10^(-4) and 1.62×10^(-4) S cm^(-1) at 60,50 and 40℃,respectively.The corresponding LiFePO_4//Li solid-state battery exhibits high specific capacities of 166,160 and 139 mAh g^(-1) at 0.2 C under 60,40 and 25℃.In addition,it remains 130 mAh g^(-1) at 4.0 C,and maintains 91.74% after 500 cycles at 1.0 C under 60℃.This study provides a simple approach for developing ionic conductor-filled polymer electrolytes in solid-state lithium battery application.

关键词： LiAlSiO_(4) Polyethylene oxide Solid state battery Composite polymer electrolyte Ionic conductivity

Towards single-molecule optoelectronic devices

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Science China Chemistry 2018年第11期61卷 1368-1384页

作者： lijue Chen Anni Feng Maoning wang Junyang Liu Wenjing Hong Xuefeng Guo Dong Xiang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Collaborative Innovation Center of Chemistry for Energy Materials Xiamen University Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Institute of Modern Optics College of Electronic Information and Optical Engineering Nankai University Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesCollege of Chemistry and Molecular Engineering Peking University

Benefiting from the development of molecular electronics and molecular plasmonics, the interplay of light and electronic transport in molecular junctions has attracted growing interest among researchers in both fields, leading to a new research direction of "single-molecule optoelectronics". Here, we review the latest developments of photo-modulated charge transport,electroluminescence and Raman spectroscopy from single-molecule junctions, and suggest future directions for single-molecule optoelectronics.

关键词：单个分子设备拉曼光谱学研究人员电子学光电子连接运输

NUMERICAL SIMULATIONS OF HIGHLY NONLINEAR STEADY AND UNSTEADY FREE SURFACE FLOWS

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Journal of Hydrodynamics 2011年第6期23卷 683-696页

作者： YANG Chi HUANG Fuxin wang lijue WAN De-cheng Center for Computational Fluid Dynamics George Mason University Fairfax Virginia USA State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

A numerical simulation model based on an open source Computational Fluid Dynamics （CFD） package-Open Field Operation and Manipulation （OpenFOAM） has been developed to study highly nonlinear steady and unsteady free surface flows. A two-fluid formulation is used in this model and the free surface is captured using the classical Volume Of Fluid （VOF） method. The incompressible Euler/Navier-Stokes equations are solved using a finite volume method on unstructured polyhedral cells. Both steady and unsteady free surface flows are simulated, which include：（1） a submerged NACA0012 2-D hydrofoil moving at a constant speed, （2） the Wigley hull moving at a constant speed, （3） numerical wave tank, （4） green water overtopping a fixed 2-D deck, （5） green water impact on a fixed 3-D body without or with a vertical wall on the deck. The numerical results obtained have been compared with the experimental measurements and other CFD results, and the agreements are satisfactory. The present numerical model can thus be used to simulate highly nonlinear steady and unsteady free surface flows.

关键词： finite volume Volume Of Fluid （VOF） method nonlinear free surface flows wave body interaction

Structure Identification for Force-Induced Reaction Using Single-Molecule Conductance Measurement

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CCS Chemistry 2023年第8期5卷 1888-1895页

作者： Jueting Zheng Wenli Gao Taige Lu lijue Chen Luchun Lin Ruiyun Huang Yongxiang Tang Gang Dong Junyang Liu Yifei Pan Wengui Weng Wenjing Hong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering and Institute of Artificial Intelligence and Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM)Xiamen UniversityXiamen 361005 Department of Chemistry College of Chemistry and EngineeringXiamen UniversityXiamen 361005

Spiropyran derivatives are prototype mechanophores with a promising application as molecular sensors because of their changeable structure under external force stimuli.However,the chemical structure evolution under external stimuli remains unclear due to the uncertainty and difficulty in distinguishing the structures of different ring-opened merocyanine isomers generated in the force-induced reaction.Here we identify the structure of isomers produced by the force-induced reaction of spiropyran derivatives using a single-molecule conductance measurement and an unsupervised clustering algorithm.We found that the original data from the single-molecule conductance measurement can be divided into four clusters through unsupervised clustering.By introducing a photoinduced reaction and theoretical calculation,we identified and attributed the four clusters of data to the multiple states of the molecular junctions.Our work demonstrates that a single-molecule break junction measurement can distinguish the isomers in the force-induced reaction,suggesting the great potential of single-molecule conductance measurement and unsupervised clustering approaches for structural analysis.

关键词： single-molecule conductance measurements force-induced reaction unsupervised clustering structure identification

Direct Manufacturing of Net-Shape Functional Components by Laser Consolidation Process (Invited Paper)

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中国激光 2009年第12期36卷 3179-3191页

作者： lijue Xue Industrial Materials Institute National Research Council of Canada 800 Collip Circle London Ontario N6G 4X8 Canada

Laser consolidation(LC) is a novel computer-aided manufacturing process developed by the Industrial Materials Institute of National Research Council of Canada(NRC-IMI).This rapid manufacturing process produces net-shape functional metallic parts layer-by-layer directly from a computer aided design(CAD) model by using a laser beam to melt the injected powder and re-solidifying it on the substrate or previous layer.As an alternative to the conventional machining process,this novel manufacturing process builds net-shape functional parts or features on an existing part by adding instead of removing material.In this review paper,LC of CPM-9V tool steel,Ni-based IN-625 and IN-718 superalloys,and Ti-6Al-4V alloy will be discussed.The microstructures and functional properties of these laser consolidated materials will be examined along with several potential industrial applications.

关键词：算机辅助制造工艺激光技术加工过程激光束

以服务国家观为导向的外语教育的发展历史与瞻望

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当代外语研究 2022年第2期 76-82页

作者：宋丽珏华东政法大学外语学院上海201620

外语教育的内涵是在外国语言、文化、思维下的本我观照,其发展始终以服务国家观为导向。文章在回溯我国外语教育发展历程的基础上,瞻望其未来的发展目标。在历史上,伴随着近代国家观的萌芽与确立,外语教育也经历了清末的格局初成和民国... 详细信息

外语教育的内涵是在外国语言、文化、思维下的本我观照,其发展始终以服务国家观为导向。文章在回溯我国外语教育发展历程的基础上,瞻望其未来的发展目标。在历史上,伴随着近代国家观的萌芽与确立,外语教育也经历了清末的格局初成和民国时期的留学热潮。之后,外语教育又经历了新中国成立初期的曲折发展,以及改革开放后的勃兴。世界正处于百年未有之大变局,新冠肺炎疫情全球大流行加速了国际格局演变,当前重构外语教育的目标是培养具有全球视野和格局、通晓国际规则并能参与各领域全球事务的外语专业人才。展望未来,基于阐释国际视野、国际规则与国际法话语之间的关系,在外语教学中设置国际法话语的相关元素具备合理性和必要性。

关键词：国家观外语教育史大变局国际法话语