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Controllable construction of ionic frameworks for multi-site synergetic enhancement of CO_(2) capture

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 37-49页

作者： Yuke zhang Hongxue xu Haonan Wu lijuan Shi Jiancheng Wang Qun yi State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

CO_(2) capture is one of the key technologies for dealing with the global warming and implementing lowcarbon development *** emergence of ionic metal-organic frameworks(I-MOFs)has diversified the field of porous materials,which have been extensively applied for gas adsorption and *** this work,amino-functionalized imidazolium ionic liquid as organic monodentate ligand was used for one step synthesis microporous Cu based *** tuning of the adsorption properties was obtained by incorporating aromatic anions,such as phenoxy,benzene carboxyl,and benzene sulfonic acid group into the I-MOFs via a facile ion exchange *** new I-MOFs showed high thermal stability and high capacity of 5.4 mmol·g^(-1) under atmospheric conditions for selective adsorption of CO_(2).The active sites of microporous Cu-MOF are the ion basic center and unsaturated metal,and electrostatic attraction and hydroxyl bonding between CO_(2) and modified functional sulfonic groups are responsible for the *** work provides a feasible strategy for the design of I-MOF for functional gas capture.

关键词： carbon dioxide capture micropores ionic liquids multi-site synergism ionic metal-organic frameworks

残余胆固醇与心血管、癌症死亡率的相关性:一项全国性队列研究

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Science Bulletin 2024年第4期69卷 526-534页

作者：田原武依戚敏杰宋莉娟陈伯望王椿淇路甲鹏杨阳张小艳崔建兰许巍杨皓贺文彦张岩郑昕张海波郭远林李希 National Clinical Research Center of Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Henan Provincial Center for Disease Control and Prevention Zhengzhou 450000China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Shenzhen Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 501800China Central China Sub-Center of the National Center for Cardiovascular Diseases Zhengzhou 450000China

The health significance of triglyceride-rich lipoproteins,also known as remnant cholesterol,has been increasingly ***,evidence of their associations with cause-specific mortality in the general population was previously *** explore these associations and their heterogeneities across subgroups,a prospective cohort study was conducted including 3,403,414 community-based participants from China HEART,an ongoing government-funded public health program throughout China,from November 2014 through December *** study assessed mortality risk of all-cause mortality,cardiovascular disease(CVD)mortality(including mortality from ischemic heart diseases(IHD),ischemic stroke(IS),and hemorrhagic stroke(HS),separately),and cancer mortality(including lung cancer,stomach cancer,and liver cancer,separately).During the 4-year follow-up,23,646 individuals died from CVD(including 8807 from IHD,3067 from IS,and 5190 from HS),and 20,318 from cancer(including 6208 from lung cancer,3013 from liver cancer,and 2174 from stomach cancer).Compared with individuals with remnant cholesterol<17.9 mg/d L,multivariable-adjusted mortality hazard ratios(HRs)for individuals with remnant cholesterol≥27.7 mg/d L were 1.03(1.00–1.05)for all-cause mortality,1.17(1.12–1.21)for CVD(1.19(1.12–1.27)for IHD mortality,and 1.22(1.09–1.36)for IS mortality),and 0.90(0.87–0.94)for allcancer mortality(0.94(0.87–1.02)for lung cancer,0.59(0.53–0.66)for liver cancer,and 0.73(0.64–0.83)for stomach cancer).In summary,this study revealed a correlation between increased remnant cholesterol levels and an elevated risk of cardiovascular disease mortality,as well as a reduced risk of mortality for certain types of cancer.

关键词： Remnant cholesterol Mortality Cardiovascular disease Cancer

Solvent-dependence of KI Mediated Electrosynthesis of Imidazo[1,2-a]pyridines

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Chemical Research in Chinese Universities 2023年第2期39卷 318-324页

作者： yi yangjie xu Leitao LIU Yuyang LI Mingfang zhang lijuan YE Jiao HU Aixi College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082P.R.China

Iodized salts are widely used as mediators to promote C-H *** and additives have been described as significant roles in these ***,the further electrochemical investigations have rarely been ***,a KI mediated electrochemical annulation between acetophenones and 2-amniopyridines was *** revealed the effect of acids and solvents by cyclic voltammetry(CV),differential pulse voltammetry(DPV),and square wave voltammetry(SWV).The oxidation of 2-aminopyridine is inhibited at the potential window with the addition of strong acids,and the lowest oxidation potential difference of KI was obtained by utilizing EtOH as *** experimental studies also show that the mixture solvent of EtOH/DMSO(9/1,volume ratio)facilitates the electrochemical cyclization due to the solubility improvement of ***3SO3H has been screened as the optimal acid.A range of Imidazo[1,2-a]-pyridines have been synthesized in yields of 42%to 96%.Electrochemical investigations present that the KI mediated electrochemical reaction is probably solvent-dependence.

关键词： Electrochemical annulation Electrochemical behavior Solvent Strong acid KI

基于脂质代谢组学研究羟基红花黄色素A治疗高脂血症LDLR^(-/-)小鼠的作用机制

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天津中医药大学学报 2024年第1期43卷 1-7页

作者：唐华靖罗雅歌杨磊徐宝欣徐静雅苗琳柴丽娟张晗王怡毛浩萍天津中医药大学方剂学教育部重点实验室天津301617 悦康药业集团股份有限公司北京100176

[目的]基于脂质代谢组学方法考察羟基红花黄色素A(HSYA)对高脂饲料诱导的LDLR^(-/-)小鼠高脂血症脂质代谢的影响及其机制。[方法]将28只雄性LDLR^(-/-)小鼠分为对照组与高脂组。对照组喂养普通饲料,高脂组喂养高脂饲料,6周后,高脂组按... 详细信息

[目的]基于脂质代谢组学方法考察羟基红花黄色素A(HSYA)对高脂饲料诱导的LDLR^(-/-)小鼠高脂血症脂质代谢的影响及其机制。[方法]将28只雄性LDLR^(-/-)小鼠分为对照组与高脂组。对照组喂养普通饲料,高脂组喂养高脂饲料,6周后,高脂组按照血清中低密度脂蛋白胆固醇(LDL-C)含量平均分为4组:模型组、辛伐他汀组、HSYA(3.8 mg/kg)低剂量组、HSYA(7.6 mg/kg)高剂量组。给药11周,给药期间同时给予高脂饲料饲养。全自动生化仪检测小鼠血清中丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、三酰甘油(TG)、总胆固醇(TC)、LDL-C含量,苏木精-伊红(HE)染色观察肝组织病理形态,油红O染色观察小鼠肝脏组织脂肪蓄积情况,采用靶向脂质组学技术对LDLR^(-/-)小鼠血清中脂质进行测定。[结果]与对照组比较,模型组小鼠血清中LDL-C、TC、TG、AST、ALT含量升高(P1,P1,P<0.05)。[结论]研究利用脂质组学技术,发现HSYA可以通过调节高脂血症LDLR^(-/-)小鼠血清中脂质代谢水平,发挥治疗高脂血症的作用,为临床应用HSYA提供了新的参考依据。

关键词：羟基红花黄色素A 高脂血症脂质组学脂代谢

PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment

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Journal of Environmental Sciences 2019年第3期31卷 11-19页

作者： Baihuan Feng lijuan Li Hongbing xu Tong Wang Rongshan Wu Jie Chen yi zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang Department of Occupational and Environmental Health Peking University School of Public Health Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Peking University Institute of Earth and Environment Chinese Academy of Sciences

Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated.

关键词： PM2.5 PAHs Seasonal variation Sources Cancer risk assessment

Differentially expressed miRNAs in anthers may contribute to the fertility of a novel Brassica napus genic male sterile line CN12A

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Journal of Integrative Agriculture 2020年第7期19卷 1731-1742页

作者： DONG Yun WANG yi JIN Feng-wei XING lijuan FANG Yan zhang Zheng-ying ZOU Jun-jie WANG Lei xu Miao-yun Crop Research Institute Gansu Academy of Agricultural SciencesLanzhou 730070P.R.China National Key Facility for Crop Gene Resources and Genetic ImprovementBiotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Gansu Provincial Key Lab of Aridland Crop Sciences/Gansu Agricultural University Lanzhou 730070.P.R.China

In Brassica napus L.(rapeseed),complete genic male sterility(GMS)plays an important role in the utilization of *** microRNAs(miRNAs)play essential regulatory roles during bud development,knowledge of how GMS is regulated by miRNAs in rapeseed is rather *** this study,we obtained a novel recessive GMS system,*** sterile line CN12A has defects in tapetal diferentiation and *** sequencing was employed to examine the expression of miRNAs in the buds of CN12A and the fertile line *** identifed 85 known miRNAs and 120 novel miRNAs that were expressed during rapeseed anther *** comparing the expression levels of miRNAs between CN12A and CN12B,19 and 18 known miRNAs were found to be difrentially expressed in 0.5--1.0 mm buds and in 2.5--3.0 mm buds,*** these,the expression levels of 14 miRNAs were higher and the levels of 23 miRNAs were lower in CN12A compared with *** predicted target genes of these iferentially expressed miRNAS encode protein kinases,F-box domain-containing proteins,MADS-box family proteins,SBP-box gene family members,HD ZIP proteins,floral homeotic protein APETAL A 2(AP2)。and nuclear factor Y,subunit *** targets have previously been reported to be involved in pollen development and male sterility,suggesting that miRNAs might act as regulators of GMS in rapeseed ***,RT-qPCR data suggest that one of the dffrentially expressed miRNAs,bna-miR159,plays a role in tapetal differentiation by regulating the expression of transcription factor BnMYB101 and participates in tapetal degradation and infuences callose degradation by manipulating the expression of *** findings contibute to our understanding of the roles of miRNAs during anther development and the occurrence of GMS in rapeseed.

关键词： Brassica napus L. genic male sterility miRNAs targets molecular regulation network

Heat flow pattern,base of methane hydrates stability zones and BSRs in Shenhu Area,northern South China Sea

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Acta Oceanologica Sinica 2011年第1期30卷 59-67页

作者： zhang yi HE lijuan WANG Jiyang xu Xing SHA Zhibing GONG Yuehua WANG Hongbing LIANG Jinqiang Institute of Geology and Geophysics Chinese Academy of Science Beijing 100029 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Guangzhou Marine Geological Survey Guangzhou Guangdong 510760 China

Using the collected 433 heat flow values, we estimated the bases of methane hydrate stability zone （BHSZ）, in northern South China Sea （NSCS）. Through comparing BHSZs with the depths of bottom simulating reflectors （BSRs）, in Shenhu Area （SA）, we found that there are big differences between them. In the north of SA, where the water depth is shallow, many slumps developed and the sedimentation rate is high, it appears great negative difference （as large as -192%）. However, to the southeast of SA, where the water depth is deeper, sedimentation rate is relatively low and uplift basement topography exists, it changes to positive difference （as large as ＋45%）. The differences change so great, which haven＇t been observed in other places of the world. After considering the errors from the process of heat flow measurement, the BSR depth, the relationship of thermal conductivity with the sediments depth, and the fluid flow activities, we conclude that the difference should be not caused by these errors. Such big disagreement may be due to the misunderstanding of BSR. The deviant ＂BSRs＂ could represent the paleo-BSRs or just gas-bearing sediment layers, such as unconformities or the specific strata where have different permeability, which are not hydraterelated BSRs.

关键词： methane hydrate BSR base of methane hydrate stability zone slump heat flow

LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma

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Genes & Diseases 2022年第1期9卷 151-164页

作者： Hongbin zhang Ke xu Qin Xiang lijuan Zhao Benxu Tan Ping Ju Xiufu Lan yi Liu Jian zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu zhang Tingxiu Xiang Department of Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical ScienceJinanShandong 250117PR China Department of Oncology People's Hospital of Juxian CountyRizhaoShandong 276599PR China Chongqing Key Laboratory of Molecular Oncology and Epigenetics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Oncology The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610599PR China Department of Oncology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402177PR China Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China College of Science and Mathematics West Chester University of PennsylvaniaWest ChesterPA 19383USA Department of Orthopedics Daping HospitalArmy Medical UniversityChongqing 400042PR China Engineering Department Women&Children's Health Care Hospital of LinyiLinyiShandong 276016PR China Department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250013PR China Department of Radiology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical ScienceJinanShandong 250013PR China Medical Department Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical ScienceJinanShandong 250013PR China Department of Oncology Chongqing Traditional Chinese Medicine HospitalChongqing 400042PR China

This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible *** analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological *** analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with *** analysis and multivariate analysis were used to investigate the prognostic *** LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)*** term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential ***1 was significantly overexpressed in HCC tumor tissues compared with normal *** LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,*** analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell ***,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment ***,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis.

关键词： CDK1 HCC LPCAT1 Overall survival Prognostic marker

基于数据挖掘技术研究王付使用经方治疗胃癌用药规律

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新中医 2024年第14期56卷 138-144页

作者：牛晓骥马丽娟马铭悦王帮民王守梅胡爱艳徐怡张树辉王付(指导) 上海中医药大学附属岳阳中西医结合医院上海200437 青海省中医院青海西宁810000 郑州大学附属肿瘤医院/河南省肿瘤医院河南郑州450008 河南经方医药中心河南郑州450008

目的:研究王付使用经方治疗胃癌用药规律。方法:使用王付经方门诊大数据系统,搜集王付治疗胃癌的门诊处方,使用Excel表格建立处方数据库,通过SPSS Modeler18.0、Cytoscape及R语言软件进行关联规则和聚类分析。结果:共纳入王付治疗胃癌... 详细信息

目的:研究王付使用经方治疗胃癌用药规律。方法:使用王付经方门诊大数据系统,搜集王付治疗胃癌的门诊处方,使用Excel表格建立处方数据库,通过SPSS Modeler18.0、Cytoscape及R语言软件进行关联规则和聚类分析。结果:共纳入王付治疗胃癌的处方515张,涉及中药109味,中药累计使用频次8 197次,使用频次较高的中药依次是人参、甘草、半夏、黄芩、黄连。药物功效类别以补虚药、清热药、化痰止咳平喘药为主,温热药多于寒凉、平性药,归经以脾、胃、肺经最多。关联规则中的药物均为半夏泻心汤核心药物,聚类分析得到治疗胃癌基础方5张。结论:王付在运用经方治疗胃癌时攻补兼施、寒热并用、阴阳平调,常用基础方有半夏泻心汤等,配合使用十八反药物,如人参-藜芦,附子-半夏,海藻-甘草,为深入挖掘经方在胃癌治疗中的应用价值提供了启发和指导。

关键词：胃癌经方数据挖掘用药规律半夏泻心汤王付