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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang lijuan wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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Large-Time Behavior of Periodic Solutions to Fractal Burgers Equation with Large Initial Data

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Chinese Annals of Mathematics,Series B 2012年第3期33卷 405-418页

作者： lijuan wang Weike wang Department of Mathematics Shanghai Jiao Tong UniversityShanghai 200240China

The asymptotic behavior of periodic solutions to fractal nonlinear Burgers equation is considered and the initial data are allowed to be arbitrarily *** exponential decay estimates of the solutions are obtained for th... 详细信息

关键词： Fractal Burgers equation Large-time behavior Large initial data Periodic solution Exponential decay

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An Experimental Study on Constraint Cooling Process of Hot-rolled CoilS

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Journal of Materials Science & Technology 2003年第Z1期19卷 220-222页

作者： lijuan wang Chunli ZHANG State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 China Shanghai Baosteel Group Corporation Shanghai 201900 China

In order to master mechanical property, surface quality and microstructure of constraint cooling (CC) coils undervarious water cooling parameters, more than 100 coils cooling experiments were done with real production process,of which is designed a cooling experimental instrument in the end. The experiments show that high initial coolingtemperature, discontinuous cooling style, and long cooling time can improve mechanical property of cooling coilsand shorten cooling time. The CC coils experiments cover the different steel grades, so that CC process effects onhot-rolled coils may be predicted and controlled actively.

关键词： Constraint cooling, Hot-rolled coils, Experiment

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Exact synchronization and asymptotic synchronization for linear ODEs

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Science China Mathematics 2022年第6期65卷 1163-1178页

作者： lijuan wang Qishu Yan School of Mathematics and Statistics Computational Science Hubei Key LaboratoryWuhan UniversityWuhan 430072China School of Science Hebei University of TechnologyTianjin 300401China

This paper studies exact synchronization and asymptotic synchronization problems for a controlled linear system of ordinary differential equations. In this paper, we build up necessary and sufficient conditions for exact synchronization and asymptotic synchronization problems. When a system is not controllable but exactly synchronizable, it can be asymptotically synchronized in any given rate and the state of exact synchronization is given. However, when a system is not controllable and can be asymptotically synchronized in any given rate,it may not be exactly synchronizable.

关键词： exact synchronization asymptotic synchronization ordinary differential system

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Facile synthesis of Ag/La2O2CO3 hierarchical micro/nanostructures for antibacterial activity and phosphate removal

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Journal of Rare Earths 2020年第12期38卷 1372-1378页

作者： Xindang Bo lijuan wang Yanbao Zhao Engineering Research Center for Nanomaterials Henan UniversityKaifeng 475004China Department of Chemical Engineering Henan Vocational College of Applied TechnologyZhengzhou 450042China

In this study,hierarchical Ag/La2 O2 CO3 micro/nanostructures(MNSs)were synthesized by in situ loading Ag nanoparticles(NPs)on the surface of the La2 O2 CO3 *** prepared La2 O2 CO3 MNSs present flower-like shape and can be tuned by the molar ratio of La(NO3)3 and CO(NH2)*** the molar ratio of 1:2 to 1:55,the La2 O2 CO3 MNSs mainly consist of polyhedral rods,irregular rods and irregular spindles and their size is about 10,8 and 7μm,*** loading Ag NPs,the spindle-like Ag/La2 O2 CO3 MNSs were used for phosphate removal and antibacterial *** the initial phosphate concentration of20 mg/L,the removal rate is 59.6%.The Ag/La2 O2 CO3 MNSs have significant antibacterial activity and their MIC values for *** and *** are 31.3 and 15.6μg/mL,*** results indicate that Ag/La2 O2 CO3 MNSs may have good application prospects in open water to inhibit bacterial growth.

关键词： Ag/La2O2CO3 Micro/nanostructures Antibacterial activity Phosphate removal activity Rare earths

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A Range-Based Node Localization Scheme for UWASNs Considering Noises and Aided With Neurodynamics Model

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IEEE/CAA Journal of Automatica Sinica 2023年第11期10卷 2168-2170页

作者： lijuan wang Xiujuan Du Chong Li School of Computer Qinghai Normal UniversityQinghai Provincial Key Laboratory of IoTXining 810008 the State Key Laboratory of Tibetan Intelligent Information Processing and Application Xining 810008 Academy of Plateau Science and Sustainability Xining 810008China

Dear Editor,This letter focuses on the node localization problem in underwater acoustic sensor networks(UWASNs) with the time-dependent property and various noise disturbances. A range-based localization scheme aided with an integral-feedback-based neurodynamics(IND)model is proposed and referred to as IND-RS, which has the stability against the internal perturbations encountered during the solving process.

关键词： dynamics underwater networks

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Coordinating ecosystem service trade-offs to achieve win–win outcomes: A review of the approaches

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Journal of Environmental Sciences 2019年第8期31卷 103-112页

作者： Hua Zheng lijuan wang Tong Wu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences

Ecosystem service(ES) trade-offs have been broadly recognized and studied over the past decade. However, how to coordinate the relationships among ES trade-offs to achieve win–win outcomes remains a considerable challenge for decision makers. Here, we summarize the current approaches applied to minimize ES trade-offs for win–wins and analyze the trade-offs among different ESs and their drivers. Based on a systematic review of the literature from 2005 to 2018, we identified 170 potentially relevant articles, 47 of which were selected for the review,recording 70 actual or potential trade-offs. Analysis of these case studies showed that trade-off pairs between provisioning services and regulating services/biodiversity accounted for 80% of total pairs. Furthermore, more than half of the ES trade-offs were driven by land use/land cover changes. Harvest and resource demand, natural resource management, and policy instruments were also among the main drivers. Four approaches to coordinate ES trade-offs were identified, including ecosystem, landscape-scale, multi-objective optimization, and policy intervention(and other) approaches. Based on the above, we recommend a rigorous understanding of the roles of different stakeholders, spatial scales of management, trade-off dynamics, and integrated implementation of diverse approaches to coordinate ES trade-offs in order to better achieve win–win outcomes.

关键词： Ecosystem services Synergy Trade-offs Ecosystem management Win–wins

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A Hybrid Unsupervised Clustering-Based Anomaly Detection Method

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Tsinghua Science and Technology 2021年第2期26卷 146-153页

作者： Guo Pu lijuan wang Jun Shen Fang Dong School of Cyber Engineering Xidian UniversityXi'an 710126China School of Computing and Information Technology University of WollongongNSW 2522Australia School of Computer Science and Engineering Southeast UniversityNanjing 211189China

In recent years,machine learning-based cyber intrusion detection methods have gained increasing *** number and complexity of new attacks continue to rise;therefore,effective and intelligent solutions are *** machine learning techniques are particularly appealing to intrusion detection systems since they can detect known and unknown types of attacks as well as zero-day *** the current paper,we present an unsupervised anomaly detection method,which combines Sub-Space Clustering(SSC)and One Class Support Vector Machine(OCSVM)to detect attacks without any prior *** proposed approach is evaluated using the well-known NSL-KDD *** experimental results demonstrate that our method performs better than some of the existing techniques.

关键词： unsupervised learning clustering intrusion detection feature selection

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A Lagrangian Trajectory Analysis of Azimuthally Asymmetric Equivalent Potential Temperature in the Outer Core of Sheared Tropical Cyclones

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Advances in Atmospheric Sciences 2023年第9期40卷 1689-1706页

作者： Yufan DAI Qingqing LI Xinhang LIU lijuan wang Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Pacific Typhoon Research Center and Key Laboratory of Meteorological Disaster of the Ministry of Education Nanjing University of Information Science and TechnologyNanjing 210044China

In this study,the characteristics of azimuthally asymmetric equivalent potential temperature(θ_(e))distributions in the outer core of tropical cyclones(TCs)encountering weak and strong vertical wind shear are examined using a Lagrangian trajectory *** forced downdrafts in the outer rainbands can transport low-entropy air downward,resulting in the lowestθ_(e)in the downshear-left boundary *** estimations ofθ_(e)recovery indicate that air parcels,especially those originating from the downshear-left outer core,can gradually revive from a low entropy state through surface enthalpy fluxes as the parcels move *** a result,the maximumθ_(e)is observed in the downshear-right quadrant of a highly sheared *** trajectory analyses also indicate that parcels that move upward in the outer rainbands and those that travel through the inner core due to shear make a dominant contribution to the midlevel enhancement ofθ_(e)in the downshear-left outer *** particular,the former plays a leading role in suchθ_(e)enhancements,while the latter plays a secondary *** a result,moist potential stability occurs in the middle-to-lower troposphere in the downshear-left outer core.

关键词： tropical cyclone vertical wind shear outer core asymmetric equivalent potential temperature trajectory analysis

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Fluid mineralization of the Dajing Sn-polymetal deposit: Evidence from LA-ICP-MS analysis of individual fluid inclusions

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Chinese Science Bulletin 2006年第22期51卷 2781-2788页

作者： wang lijuan wang Yuwang wang Jingbin D Gunther Beijing Institute of Geology for Mineral Resources Beijing 100012 China Key Laboratory of Mineral Resources Institute of Geology andGeophysics Chinese Academy of Sciences Beijing 100029 China ETH Swiss Federal Institute of Technology Zurich Switzerland

从 Dajing 存款的 Sn-Cu 矿石身体并且从 Huanggangliang 存款的 Sn 矿石身体在荧石和石英套住的单个液体包括上的 LA-ICP-MS 分析被进行用液体的 Rb/Sr 和 Sn/Cu 比率在 Dajing 存款跟踪 Cu 富有、 Sn 富有的液体的来源和进化。在 theD... 详细信息

从 Dajing 存款的 Sn-Cu 矿石身体并且从 Huanggangliang 存款的 Sn 矿石身体在荧石和石英套住的单个液体包括上的 LA-ICP-MS 分析被进行用液体的 Rb/Sr 和 Sn/Cu 比率在 Dajing 存款跟踪 Cu 富有、 Sn 富有的液体的来源和进化。在 theDajing 的Cu富有的液体扔的结果表演，相对，在 Na 并且可能的富人源于深层的基本岩浆，包含 Cuseveral 到几多于 Sn ，和 Sr 的十时间几到几多于 Rb 的十时间，当时Sn富有的液体，相对，在 K 并且可能的富人源于高级花岗石的岩浆，包含 Sn 几到几多于 Cu ，和 Rb 的十时间几到几多于 Sr 的十时间。这被建议 Sn 富有并且 Cu 富有的液体在阶段被混合对低温度和低咸度中等，在 Dajing 存款的中央部分导致 Cu-Sn 矿石身体的形成。

关键词：单一包含物 LA-ICP-MS分析矿石成型流体矿物学

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