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Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma

Cancer Biology & Medicine 2019年第1期16卷 139-146页

作者： lijuan li Nan Wu Fangxuan li lingmei li lijuan Wei Juntian liu Department of Cancer Prevention Center Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical UniversityMinistry of Education Department of Pathology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical UniversityMinistry of Education

Objective: Secretory breast carcinoma(SBC) is a rare type of breast malignancy, accounting for less than 0.02% of all infiltrating breast malignancies. The pure SBC, a type of SBC without another type of breast malignant neoplasm, is particularly rare. This study aimed to investigate the clinicopathologic and molecular features of pure ***: The main pathological parameters such as estrogen receptor(ER), progesterone receptor(PR), and human epithelial growth factor receptor 2(C-erbB-2) were detected by immunohistochemistry(IHC), and the clinicopathologic and prognostic difference were compared with invasive ductal carcinoma(IDC). Fluorescent in situ hybridization(FISH) and reverse transcription polymerase chain reaction(RT-PCR) was performed to identify the ETV6-NTRK3 rearrangement of ***: We found that the positivity rates of ER, PR, C-erbB-2, p53, and S-100 were 47.7%(21/44), 52.3%(23/44), 36.4%(16/44), 27.3%(12/44), and 95.5%(42/44), respectively, which were higher than those reported in previous studies. Special periodic acid-Schiff analysis was performed in 36 patients, and the value of the Ki-67 index ranged from 1% to 50%(mean value:10%). Interestingly, most patients with pure SBC harbored an ETV6-NTRK3 rearrangement with an 88.6%(39/44) expression rate. Compared with IDC, the tumor size of most patients with SBC was larger than 2 cm(P = 0.024). Ultrasound showed benign lesions, and the total misdiagnosis rate was higher(P = 0.020). Although the pathological classification was mostly triple-negative breast cancers(P = 0.036), there was less metastasis(P = 0.029), and the overall prognosis was better than that of the IDC ***: Although axillary lymph node metastasis, local recurrence, or distant metastasis may occur, SBC is also considered an indolent neoplasm with a good prognosis. Once diagnosed, surgical treatment should be performed as soon as possible,followed by appropriate adjuvant chemotherapy, irradiation, and endocrine the

关键词： Breast cancer pure secretory breast carcinoma clinicopathologic feature therapeutics and prognosis

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Selective recovery of lithium from simulated brine using different organic synergist

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Chinese Journal of Chemical Engineering 2019年第2期27卷 335-340页

作者： Huifang li lijuan li Xiaowu Peng lianmin Ji Wu li Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt Lakes Chinese Academy of Sciences Key Laboratory of Salt Lake Resources Chemistry of Qinghai Province University of Chinese Academy of Sciences Qinghai University

The organic synergists, including Octanol, ethyl acetate(EA), butyl acetate(BA), methyl isobutyl ketone(MIBK),diisobutyl ketone(DIBK), N,N-bis(2-ethylhexyl) acetamide(N523) and 8-hydroxylquiolate, were added to the TBP–FeCl_3 extraction system to extract lithium from brine. The effects of concentration of organic synergist and total organic extractant, molar ratio of Fe/li, phase ratio, counter-current extraction and the acidity of stripping agent on lithium extraction were investigated to optimize the extraction conditions. Under the optimize conditions, the results of counter-current extraction showed the mixed extraction system was the preponderance on the lithium extraction. Especially the separation of lithium in organic phase and aqueous phase and the separation mass ratio of Mg/li increased greatly. An extraction mechanism was proposed based on the analysis of FT-IR spectra and Raman spectra.

关键词： Organic synergist lithium extraction Mixed extraction system Mechanism

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Seismic behavior of large-scale FRP–recycled aggregate concrete–steel columns with shear connectors

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 823-844页

作者： Zeng Lan li lijuan Yang Xianqian liu Feng School of Civil and Transportation Engineering Guangdong University of Technology Guangzhou 510006 China MOE Key Laboratory of Disaster Forecast and Control in Engineering School of Mechanics and Construction Engineering Jinan University Guangzhou 510632 China Architectural Design and Research Institute of Guangdong Province Guangzhou 510000 China

The application of fi ber-reinforced polymer (FRP) composites for the development of high-performance composite structural systems has received signifi cant recent research attention. A composite of FRP–recycled aggregate concrete (RAC)–steel column (FRSC), consisting of an outer FRP tube, an inner steel tube and annular RAC fi lled between two tubes, is proposed herein to facilitate green disposal of demolished concrete and to improve the ductility of concrete columns for earthquake resistance. To better understand the seismic behavior of FRSCs, quasi-static tests of large-scale basalt FRSCs with shear connectors were conducted. The infl uence of the recycled coarse aggregate (RCA) replacement percentage, shear connectors and axial loading method on the lateral load and deformation capacity, energy dissipation and cumulative damage were analyzed to evaluate the seismic behavior of FRSCs. The test results show that FRSCs have good seismic behavior, which was evidenced by high lateral loads, excellent ductility and energy dissipation capacity, indicating RAC is applicable in FRSCs. Shear connectors can signifi cantly postpone the steel buckling and increase the lateral loads of FRSCs, but weaken the deformation capacity and energy dissipation performance.

关键词： recycled aggregate concrete (RAC) fi ber-reinforced polymer (FRP) FRP–RAC–steel column (FRSC) shear connector seismic behavior

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Sensitivity of Penman-Monteith Reference Crop Evapotranspiration in Tao'er River Basin of Northeastern China

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Chinese Geographical Science 2008年第4期18卷 340-347页

作者： liANG liqiao li lijuan ZHANG li li Jiuyi li Bin Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

A non-dimensional relative sensitivity coefficient was employed to predict the responses of reference crop evapotranspiration (ET0) to perturbation of four climate variables in Tao'er River Basin of the northeastern China. Mean monthly ET0 and yearly ET0 from 1961 to 2005 were estimated with the FAO-56 Penman-Monteith Equation. A 45-year historical dataset of average monthly maximum/minimum air temperature, mean air temperature, wind speed, sunshine hours and relative humidity from 15 meteorological stations was used in the analysis. Results show that: 1) Sensitivity coefficients of wind speed, air temperature and sunshine hours were positive except for those of air tem- perature of Arxan Meteorological Station, while those of relative humidity were all negative. Relative humidity was the most sensitive variable in general for the Tao'er River Basin, followed by sunshine hours, wind speed and air tem- perature. 2) Similar to climate variable, monthly sensitivity coefficients exhibit large annual fluctuations. 3) Sensitivity coefficients for four climate variables all showed significant trends in seasonal/yearly series. Also, sensitivity coefficients of air temperature, sunshine hours and wind speed all showed significant trends in spring. 4) Among all sensitiv- ity coefficients, the average yearly sensitivity coefficient of relative humidity was highest throughout the basin and showed largest spatial variability. Longitudinal distribution of sensitivity coefficients for air temperature, relative hu- midity and sunshine hours was also found, which was similar to the distribution of the three climate variables.

关键词： reference crop evapotranspiration Penman-Monteith Equation sensitivity coefficient Tao'er River Basin

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Impacts of external forcing on the 20th century global warming

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Chinese Science Bulletin 2007年第22期52卷 3148-3154页

作者： li lijuan WANG Bin ZHOU TianJun LASG Institute of Atmospheric Physics (IAP) Chinese Academy of Sciences Beijing 100029 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

The impacts of external forcing,including natural and anthropogenic,on the 20th century global warming were assessed with the use of the Grid Atmospheric Model of IAP/LASG Version 1.1.0,fol-lowing the standard coordinated experiment design of the Climate Variability and Predictability(CliVAR) International Climate of the Twentieth Century Project(C20C) ,Phase II. The results indicate that external forcing plays an important role in the evolution of the land surface air temperature on in-terannual,decadal,and interdecadal time scales,and contributes greatly to the global warming in the following two periods:the early twentieth century between the 1910s and the 1940s and the late twen-tieth century after the 1970s. External forcing also has strong impact on the regional temperature change during the two warming periods except for parts of the Eurasia and the North America conti-nents. In the cooling period,however,the impact of internal variability is dominant.

关键词：全球变暖气候环境气候

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Sparse representation based on projection method in online least squares support vector machines

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控制理论与应用（英文版） 2009年第2期7卷 163-168页

作者： lijuan li Hongye SU Jian CHU State Key Laboratory of Industrial Control Technology Institute of Advanced Process Control Zhejiang University Hangzhou Zhejiang 310027 China College of Automation Nanjing University of Technology Nanjing Jiangsu 210009 China

A sparse approximation algorithm based on projection is presented in this paper in order to overcome the limitation of the non-sparsity of least squares support vector machines （LS-SVM）. The new inputs are projected into the subspace spanned by previous basis vectors （BV） and those inputs whose squared distance from the subspace is higher than a threshold are added in the BV set, while others are rejected. This consequently results in the sparse approximation. In addition, a recursive approach to deleting an exiting vector in the BV set is proposed. Then the online LS-SVM, sparse approximation and BV removal are combined to produce the sparse online LS-SVM algorithm that can control the size of memory irrespective of the processed data size. The suggested algorithm is applied in the online modeling of a pH neutralizing process and the isomerization plant of a refinery, respectively. The detailed comparison of computing time and precision is also given between the suggested algorithm and the nonsparse one. The results show that the proposed algorithm greatly improves the sparsity just with little cost of precision.

关键词： Least squares support vector machines Projection Sparsity pH neutralizing process Isomerization

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Recovery of li_(2)CO_(3)and FePO_(4)from spent liFePO_(4)by coupling technics of isomorphic substitution leaching and solvent extraction

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Chinese Journal of Chemical Engineering 2023年第2期54卷 306-315页

作者： Yong Niu Xiaowu Peng Jinfeng li Yuze Zhang Fugen Song Dong Shi lijuan li Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Engineering Laboratory for Green Applications of Salt Lakes and Salt DepositsQinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China Qinghai Technology Research and Development Center of Comprehensive Utilization of Salt Lakes Resources Xining 810008China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

Efficient and low-cost recycling of spent lithium iron phosphate(liFePO_(4),LFP)batteries has become an inevitable *** this study,an integrated closed-loop recycling strategy including isomorphic substitution leaching and solvent extraction process for spent LFP was *** inexpensive FeCl_(3)was used as leaching agent to directly substitute Fe^(2+)from LFP.99%of li can be rapidly leached in just 30 min,accompanied by 98%of FePO_(4)precipitated in *** tri-n-butyl phosphate(TBP)-sulfonated kerosene(SK)system was applied to extract li from lixivium through a twelve-stage countercurrent process containing synchronous extraction and stepwise stripping of li^(+)and Fe^(3+).80.81%of li can be selectively enriched in stripping liquor containing 3.059 mol·L^(-1)of li^(+)under optimal *** the Fe stripping liquor was recovered for LFP re-leaching,of which,Fe^(2+)was oxidized to Fe^(3+)by appropriate H_(2)O_(2).Raffinate and lixivium were concentrated and entered into extraction process to accomplished closeloop recycling ***,the results suggest that more than 99%of li was ***_(3)holding in solution was directly regenerated without any pollutant *** sustainable mothed would be an alternative candidate for total element recycling of spent LFP batteries with industrial potential.

关键词： Spent liFePO_(4) Leaching lithium Extraction Stripping Recovery

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Shape optimization of aluminium alloy spherical reticulated shells considering nonlinearities

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1565-1580页

作者： Wei liU lishu XU Shaojun ZHU lijuan li Feng liU Zhe XIONG School of Civil and Transportation Engineering Guangdong University of TechnologyGuangzhou 510006China School of Advanced Manufacturing Guangdong University of TechnologyJieyang 515231China College of Civil Engineering Tongji UniversityShanghai 200092China Tongji Lvjian Co. LtdShanghai 200092China

This study proposes a shape optimization method for K6 aluminum alloy spherical reticulated shells with gusset joints,considering geometric,material,and joint stiffness *** optimization procedure adopts a genetic algorithm in which the elastoplastic non-linear buckling load is selected as the objective function to be *** confinement of the adjustment range of the controlling points,optimization results have enabled a path toward achieving a larger elastoplastic non-linear buckling load without changing the macroscopic shape of the structure.A numerical example is provided to demonstrate the effectiveness of the proposed *** addition,the variation in structural performance during optimization is *** parametric analysis,practical design tables containing the parameters of the optimized shape are obtained for aluminum alloy spherical shells with common geometric *** explore the effect of material nonlinearity,the optimal shapes obtained based on considering and not considering material non-linear objective functions,the elastoplastic and elastic non-linear buckling loads,are compared.

关键词： shape optimization aluminum alloy spherical reticulated shell non-linear buckling material nonlinearity genetic algorithm

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The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families

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Cancer Biology & Medicine 2022年第6期19卷 850-870页

作者： li Dong Hailian Zhang Huan Zhang Yingnan Ye Yanan Cheng lijuan li lijuan Wei Lei Han Yandong Cao Shixia li Xishan Hao Juntian liu Jinpu Yu Cancer Molecular Diagnostics Core The Second Department of Breast Cancer Cancer Prevention Center Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China Department of Oncology Tianjin Third Central HospitalTianjin Institute of Hepatobiliary DiseaseTianjin Key Laboratory of Artificial CellArtificial Cell Engineering Technology Research Center of Public Health MinistryTianjin 300170China Analyses Technology Co.Ltd. Beijing 102600China

Objective:Approximately 5%–10%of breast cancer(BC)patients display familial traits that are genetically inherited among the members of a *** purpose of this study was to profile the germline mutations in 43 genes with different penetration rates and their correlations with phenotypic traits in Chinese familial BC ***:Ion Torrent S5™-based next generation sequencing was conducted on 116 subjects from 27 Chinese familial BC ***:Eighty-one germline mutations in 27 BC predisposition genes were identified in 82.8%(96/116)of the *** these,80.8%of the mutated genes were related to DNA damage *** possible disease-causing variants were identified in 13 of 27 BC *** 25.9%(7/27)of the BC families exhibited hereditary deficiency in BRCA1/2 genes,while 22.2%of the BC families exhibited defects in non-BRCA *** all,41.7%(40/96)of the mutation carriers had BRCA mutations,88.5%(85/96)had non-BRCA mutations,and 30.2%(29/96)had both BRCA and non-BRCA *** BC patients with BRCA mutations had a higher risk of axillary lymph node metastases than those without mutations(Plial/hereditary ***,profiling of multiple BC predisposition genes should be more valuable for screening potential pathogenic germline mutations in Chinese familial/hereditary BC.

关键词： Familial breast cancer predisposition genes DNA damage repair genes clinical features

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A Novel Hollow Carbon@MnO_(2) Electrospun Nanofiber Adsorbent for Efficient Removal of Pb^(2+) in Wastewater

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Chemical Research in Chinese Universities 2021年第3期37卷 496-504页

作者： li Wenyan li Yanzi liU Jiadi CHAO Shen YANG Tianyi li lijuan WANG Ce li Xiang Alan G.MacDiarmid Institute Jilin UniversityChangchun130012China Teaching Experimental Center Hebei Normal University for NationalitiesChengde067000China College of Plant Science Jilin UniversityChangchun130062China Department of Chemistry and Biochemistry California State UniversityLong Beach1250 Bellflower Blvd.Long BeachCA90840USA

Lead ion(Pb^(2+))is one of the most hazardous heavy metal ions in aquatic *** materials and manganese dioxide(MnO_(2))have been shown to be prospective adsorbents to cope with the lead *** this study,a novel hollow carbon@MnO_(2) composite nanofiber adsorbent was prepared by the combination of electrospinning and *** PAN nanofiber membrane is subjected to a pre-oxidation and carbonization process,and then the obtained carbon nanofibers react with KMnO4 solution during the hydrothermal process to develop the hollow carbon@MnO_(2) *** hollow carbon@MnO_(2) nanofibers displayed a higher adsorption capacity of Pb^(2+)than carbon and MnO_(2)/PDA/PAN *** maximum adsorption capacity toward Pb^(2+)by hollow carbon@MnO_(2) nanofibers was 460.83 mg/*** 5 adsorption-desorption cycles,the carbon@MnO_(2) nanofibers had a good recyclability and the removal efficiency remained 81.47%.Moreover,the removal efficiency of the hollow composite nanofibers for Pb^(2+)from real wastewater could reach 94.37%.This work shows a strategy for synthetics of the hollow carbon@MnO_(2) nanofibers,which exhibits a promising potential in actual wastewater treatment.

关键词： Carbon@MnO_(2)composite Hollow nanofiber Electrospinning Lead adsorption

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