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Effect of Cuzhi liquid on learning and memory dysfunction in a mouse model of Alzheimer's disease

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Journal of Traditional Chinese Medicine 2018年第6期38卷 890-895页

作者： liu lijuan Yu Chen liu Junbao Pharmacy Department People's Hospital of Henan Province People's Hospital of Zhengzhou University Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Traditional Chinese Medicine Department People's Hospital of Henan Province People's Hospital of Zhengzhou University

OBJECTIVE: To examine the effects of Cuzhi liquid on learning and memory abilities in a mouse model of Alzheimer's disease(AD).METHODS: One hundred mice were divided into the normal, AD model, piracetam group, Cuzhi liquid low dose and Cuzhi liquid high dose, each group 20 mice. The AD mouse model was induced by daily intraperitoneal injection of D-galactose and sodium nitrite. AD mice then received intragastric administration of piracetam or Cuzhi liquid for60 d, and changes in learning and memory abilities were assessed using the water maze test. The activity of acetylcholinsterase(AchE) and monamine oxidase(MAO), and the levels of nitrogen monoxidum(NO) and malonaldehyde(MDA), were measured in brain tissues. Amyloid protein deposition was assessed by methyl violet staining, and B-cell lymphoma-2(Bcl-2) expression in the hippocampal cornus ammonis 1 region was detected by ***: In the water maze test, the escape latency of the model group was longer than that of the normal group(P < 0.01). The escape latency of the three using drug treatment groups was significantly less than that of the normal group(P < 0.05). The activity of AchE and MAO, and the levels of NO and MDA, in the brain of the model group were significantly higher than that of the normal group(P <0.01), but significantly reduced in the three drug treatment groups compared with the model group(P < 0.05). AchE activity showed a greater reduction in the two Cuzhi liquid groups compared with the piracetam group(P < 0.01), to levels similar to the normal group. There were no differences in MAO activity or NO levels between the three drug treatment groups, while MDA levels were reduced more in the high-dose Cuzhi liquid group compared with the other treatment groups(P < 0.01). Hippocampal Bcl-2 expression was significantly reduced in the model group compared with the normal group(P < 0.01), but significantly improved in the three drug treatment groups(P < 0.05). The high-dose Cuzhi l

关键词： Alzheimer disease Learning Memory Acetylcholinesterase Oxidoreductases Nitric oxide Malondialdehyde Amyloidogenic proteins Lymphoma,B-cell Cuzhi liquid

Valuations on Concave Functions and Log-Concave Functions

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Wuhan University Journal of Natural Sciences 2019年第6期24卷 479-484页

作者： liu lijuan School of Mathematics and Computational Science Hunan University of Science and Technology

Recently, the theory of valuations on function spaces has been rapidly growing. It is more general than the classical theory of valuations on convex bodies. In this paper, all continuous, SL(n) and translation invaria... 详细信息

关键词： valuations concave functions log-concave functions characterization theorem

Lie bialgebra structures on derivation Lie algebra over quantum tori

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Frontiers of Mathematics in China 2017年第4期12卷 949-965页

作者： Xiaomin TANG lijuan liu Jinli XU Department of Mathematics Heilongjiang University Harbin 150080 China Harbin Institute of Technology Press Harbin 150001 China Department of Mathematics Northeast Forestry University Harbin 150040 China

We investigate Lie bialgebra structures on the derivation Lie algebra over the quantum torus. It is proved that, for the derivation Lie algebra W over a rank 2 quantum torus, all Lie bialgebra structures on W are the coboundary triangular Lie bialgebras. As a by-product, it is also proved that the first eohomology group H1 （W, W × W） is trivial,

关键词： Lie bialgebra Yang-Baxter equation derivation Lie algebra over quantum tori

Synthesis, Post-modification and Catalytic Properties of Metal-organic Framework NH2-MIL-53（Al）

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Chemical Research in Chinese Universities 2017年第2期33卷 231-238页

作者： liu Lili TAI Xishi ZHOU Xiaojing liu lijuan School of Chemistry & Chemical Engineering and Environmental Engineering Weifang University Weifang 261061 P. R. China

A postsynthetic modification method was used to prepare salicylaldehyde functionalized metal-organicframeworks through the nucleophilic addition of salicylaldehyde with the amine group present in the frameworks ofNH2-MIL-53（A1）. Hydroxyl groups were successfully grafted onto NI-I2-MIL-53（A1）, and imine groups were ***, these hydroxyl and imine groups of the resulting NH2-MIL-53（A1）-SA can be used as the anchoringgroup to stabilise Au^3＋ ions and Au^0 nanoparticles（NPs）. By doing this, Au^3＋ ions and Au^0 NPs were successfully en-capsulated in the cages of NH2-MIL-53（A1） by a simple impregnation method. The resulting gold functionalizedNH2-MIL-53（AI） showed good catalytic activities in the one-pot synthesis of structurally divergent propargylaminesby three-component coupling reactions of aldehydes, amines and alkynes. Various aromatic/aliphatic aldehydes, aro-matic alkynes, and piperidine were able to undergo three-component coupling on NH2-MIL-53（A1）-Au. In addition,the catalyst NH2-M/L-53（A/）-Au was recovered easily by centrifugation and reused up to four times. Thus, it can beused for the environmentally friendly synthesis ofpropargylamines.

关键词： Metal-organic framework Postmodification NH2-MIL-53(AI) Three-component coupling Propargyl-amine

Orlicz-Brunn-Minkowski Inequalities for Complex Projection Bodies

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Wuhan University Journal of Natural Sciences 2021年第1期26卷 8-14页

作者： WANG Wei liu lijuan School of Mathematics and Computational Science Hunan University of Science and TechnologyXiangtan 411201HunanChina

Abardia and Bernig introduced the complex projection body and established the Brunn-Minkowski inequality for complex projection *** this paper,we generalize their result and establish the Orlicz-Brunn-Minkowski inequality for complex projection *** the Orlicz-Brunn-Minkowski inequality for polars of complex projection bodies is also obtained.

关键词： convex body Orlicz addition complex projection body

Atmospheric pollution of agriculture-oriented cities in Northeast China: A case in Suihua

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Journal of Environmental Sciences 2020年第11期32卷 85-95页

作者： Lili Li Kun Wang Weiwei Chen Qingliang Zhao lijuan liu Wei liu Yang liu Junqiu Jiang Jiumeng liu Mengduo Zhang State Key Laboratory of Urban Water Resources and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Suihua Ecological Environment Monitoring Center Suihua152000China Heilongjiang Provincial Environmental Science Research Institute Harbin150090China

Agriculture-oriented cities in Northeastern China have experienced frequent atmospheric pollution *** understandings of the pollution characteristics,haze causes and effects of management on local air quality are crucial for conducting integrated management approaches for the sustainable development of agriculture-oriented *** a typical agriculture-dominant city(i.e.,Suihua)in Northeast China,we analyzed in detail the characteristics and causes of atmospheric pollution and evaluated the straw-burning prohibition using multisource *** results showed a clear temporal pattern of air quality index(AQI)on an annual scale(i.e.,2015-April 2019),with two typical pollution periods occurring in late autumn and early *** large areas of concentrated straw burning at local and regional scales accounted for the first period(i.e.,October and November),while dust emissions and farming disturbances comprised the second *** interannual variation in pollution periods among these years was large,showing similar trends from 2015 to 2017 and the postponed late-autumn pollution period in *** evaluation has shown that the prohibition effect of straw burning significantly improved air quality in 2018,with a reduction of 59%±88%in the PM2.5 concentrations in October and November compared to 2015–***,From October to April of the following year,the improvement effect was not significant due to postponement of straw burning to February or *** analysis also highlighted the roles of meteorological conditions,Therefore,combined with the promotion of straw utilization,scientifically prescribed burning considering the burning amount and location,meteorological conditions and regional transportation should be implemented.

关键词： Pollution characteristics Haze causes Straw burning prohibition Agriculture-oriented Northeast China

Triggering in-plane defect cluster on MoS_(2) for accelerated dinitrogen electroreduction to ammonia

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Journal of Energy Chemistry 2021年第11期30卷 359-366,I0008页

作者： Wanru Liao Ke Xie lijuan liu Xiuyun Wang Yu Luo Shijing Liang Fujian liu Lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhou 350002FujianChina Qingyuan Innovation Laboratory Quanzhou 362801FujianChina College of Chemistry Fuzhou UniversityFuzhou 350108FujianChina

Electrochemical nitrogen reduction reaction (eNRR) is an alternative promising manner for sustainable N2 fixation with low-emission. The major challenge for developing an efficient electrocatalyst is the cleaving of the stable Ntriple bondN triple bonds. Herein, we design a new MoS_(2) with in-plane defect cluster through a bottom-up approach for the first time, where the defect cluster is composed of three adjacent S vacancies. The well-defined in-plane defect clusters could contribute to the strong chemical adsorption and activation towards inert nitrogen, achieving an excellent eNRR performance with an ammonia yield rate of 43.4 ± 3 μg h^(−1) mgcat.^(−1) and a Faradaic efficiency of 16.8 ± 2% at −0.3 V (vs. RHE). The performance is much higher than that of MoS_(2) with the edge defect. Isotopic labeling confirms that N atoms of produced NH4+ originate from N2. Furthermore, the in-plane defect clusters realized the alternate hydrogenation of nitrogen in a side-on way to synthesize ammonia. This work provides a prospecting strategy for fine-tuning in-plane defects in a catalyst, and also promotes the progress of eNRR.

关键词： In-plane defect clusters Ammonia synthesis MoS_(2) Electrocatalysis Isotopic labeling

Nitric oxide alleviates aluminum-induced oxidative damage through regulating the ascorbateglutathione cycle in roots of wheat

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Journal of Integrative Plant Biology 2015年第6期57卷 550-561页

作者： Chengliang Sun lijuan liu Yan Yu Wenjing liu Lingli Lu Chongwei Jin Xianyong Lin MOE Key Laboratory of Environment Remediation and Ecological Health College of Natural Resource & Environmental SciencesZhejiang University Key Laboratory of Subtropical Soil Science and Plant Nutrition of Zhejiang Province College of Environmental and Resource SciencesZhejiang University

The possible association with nitric oxide （NO） and ascorbate-glutathione （AsA-GSH） cycle in regulating aluminum （Al） tolerance of wheat （Triticum aestivum L.） was investigated using two genotypes with different Al resistance. Exposure to Al inhibited root elongation, and triggered lipid peroxidation and oxidation of AsA to dehydroascorbate and GSH to glutathione disulfide in wheat roots. Exogenous NO significantly increased endogenous NO levels, and subsequently al eviated Al-induced inhibition of root elongation and oxidation of AsA and GSH to maintain the redox molecules in the reduced form in both wheat genotypes. Under Al stress, significantly increased activities and gene transcriptional levels of ascorbate peroxi-dase, glutathione reductase, and dehydroascorbate reductase, were observed in the root tips of the Al-tolerant genotype Jian-864. Nitric oxide application enhanced the activity and gene transcriptional level of these enzymes in both wheat geno-types. g-Glutamylcysteine synthetase was not significantly affected by Al or NO, but NO treatments increased the activity of glutathione peroxidase and glutathione S-transferase to a greater extent than the Al-treated wheat seedlings. Proline was significantly decreased by Al, while it was not affected by NO. These results clearly suggest that NO protects wheat root against Al-induced oxidative stress, possibly through its regulation of the AsA-GSH cycle.

关键词： Aluminum ascorbate glutathione nitric oxide reactive oxygen species wheat

Melatonin: A master regulator of plant development and stress responses

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Journal of Integrative Plant Biology 2021年第1期63卷 126-145页

作者： Chengliang Sun lijuan liu Luxuan Wang Baohai Li Chongwei Jinand Xianyong Lin MOE Key Laboratory of Environment Remediation and Ecological Health College of Environmental&Resource SciencesZhejiang UniversityHangzhou 310058China Department of Agriculture and Environment McGill UniversityMontrealQuebecH9X 3V9Canada Key Laboratory of Subtropical Soil Science and Plant Nutrition of Zhejiang Province College of Environmental&Resource SciencesZhejiang UniversityHangzhou 310058China

Melatonin is a pleiotropic molecule with multiple functions in plants. Since the discovery of melatonin in plants, numerous studies have provided insight into the biosynthesis, catabolism, and physiological and biochemical functions of this important molecule. Here, we describe the biosynthesis of melatonin from tryptophan, as well as its various degradation pathways in plants. The identification of a putative melatonin receptor in plants has led to the hypothesis that melatonin is a hormone involved in regulating plant growth,aerial organ development, root morphology, and the floral transition. The universal antioxidant activity of melatonin and its role in preserving chlorophyll might explain its anti-senescence capacity in aging leaves. An impressive amount of research has focused on the role of melatonin in modulating postharvest fruit ripening by regulating the expression of ethylene-related *** evidence also indicated that melatonin functions in the plant's response to biotic stress,cooperating with other phytohormones and wellknown molecules such as reactive oxygen species and nitric oxide. Finally, great progress has been made towards understanding how melatonin alleviates the effects of various abiotic stresses, including salt, drought, extreme temperature, and heavy metal stress. Given its diverse roles, we propose that melatonin is a master regulator in plants.

关键词： anti-senescence crosstalk fruit ripening melatonin plant growth stress conditions