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Characterization of image spaces of Riemann-Liouville fractional integral operators on Sobolev spaces W^(m,p)(Ω)

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Science China Mathematics 2021年第12期64卷 2611-2636页

作者： lijing Zhao Weihua Deng Jan S.Hesthaven School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710129China School of Mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou 730000China EPFL-SB-MATHICSE-MCSS Ecole Polytechnique Federale de LausanneLausanne CH-1015Switzerland

Fractional operators are widely used in mathematical models describing abnormal and nonlocal *** there are extensive numerical methods for solving the corresponding model problems,theoretical analysis such as the regularity result,or the relationship between the left-side and right-side fractional operators is seldom *** of considering the fractional derivative spaces,this paper starts from discussing the image spaces of Riemann-Liouville fractional integrals of L_(p)(Ω) functions,since the fractional derivative operators that are often used are all *** the high regularity situation-the image spaces of Riemann-Liouville fractional integral operators on the W^(m,p)(Ω) space is *** characterizations of the defined spaces,as well as those of the intersection of the left-side and right-side spaces are *** behavior of the functions in the defined spaces at both the nearby boundary point/points and the points in the domain is demonstrated in a clear ***,tempered fractional operators are shown to be reciprocal to the corresponding Riemann-Liouville fractional operators,which is expected to contribute some theoretical support for relevant numerical ***,we also provide some instructions on how to take advantage of the introduced spaces when numerically solving fractional equations.

关键词： image space Riemann-Liouville integral regularity property approximation

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Construction and expression of an optimized, novel human immunodeficiency virus type-1 lentiviral vector containing green fluorescent protein

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Neural Regeneration Research 2011年第7期6卷 542-545页

作者： Xia Li Xueling Ma lijing Zhao Hang Gao Hongjuan Wang Li du1 Juan Wang Nan Li Kangding Liu Department of Neurology First Bethune Hospital of Jilin University Changchun 130021 Jilin Province China Third Department of Neurology Handan central Hospital. Handan 05600-1 Hebei Province China Department of Neurology Fourth Hospital of Harbin Medical University Harbin 150001 Heilongjiang Province China Department of Pathology Jilin University Changchun 130021 Jilin Province China Neonatal Division of Pediatric Department First'Bethune Hospital of Jilin University Changchun 130021 Jilin Province China

The human immunodeficiency virus （HIV） lentiviral vector is an ideal vector for gene therapy. In the present study, the wild-type HIV-1 genome was segregated into four plasmids, and an optimized novel HIV-1 lentiviral vector containing green fluorescent protein and vesicular stomatitis virus G pseudo-capsule was constructed. The plasmids were pHR-CMV-EGFP, pCMVΔ8.9, pRSV-Rev, pCMV-VSV-G. The four plasmid system was co-transfected into 293T cells, and green fluorescent protein expression was observed. The present study obtained lentiviral particles by high-speed centrifugation, and the lentiviral particle titer was 4 × 108 TU/mL after centrifugation. Thus, an optimized novel HIV-1 lentiviral vector was successfully constructed.

关键词： gene expression gene therapy human immunodeficiency virus 1 green fluorescent protein lentivirus neural regeneration

Microstructural evolution of a PM TiAl alloy during heat treatment in α+γ phase field

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Rare Metals 2012年第5期31卷 424-429页

作者： SU Meike ZHENG lijing LANG Zebao YAN Jie ZHANG Hu School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

In this study, the effect of temperatures and cooling rates of heat treatment on the microstructure of a powder metallurgy (PM) Ti-46Al-2Cr-2Nb-(B,W) (at.%) alloy was studied. Depending on the cooling rate and temperature, the different structures were obtained from the initial near-γ (NG) microstructures by heat treatment in the α+γ field. The results show that the microstructures of samples after furnace cooling (FC) consist primarily of equiaxed γ and α 2 grains, with a few grains containing lamellae. duplex microstructures consist mainly of γ grains and lamellar colonies were obtained in the quenching into another furnace at 900°C (QFC) samples. However, further increasing of the cooling rate to air cooling (AC) induces the transformation of α→α_2 and results in a microstructure with equiaxed γ and α_2 grains, and no lamellar colonies are found.

关键词： γ-TiAl-based alloys powder metallurgy heat treatment duplex structure phase volume fractions

Antiviral strategies:What can we learn from natural reservoirs?

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Journal of Integrative Plant Biology 2022年第10期64卷 1849-1855页

作者： Wenbo Pan Weiwei Li lijing Liu Huawei Zhang Peking University Institute of Advanced Agricultural Sciences Weifang 261325China The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China

Viruses cause many severe diseases in both plants and animals,urging us to explore new antiviral *** their natural reservoirs,viruses live and replicate while causing mild or no *** animals,such as bats,are the predicted natural reservoir of multiple viruses,indicating that they possess broad-spectrum antiviral *** of host defenses against viruses are generally studied independently in plants and *** this article,we speculate that some antiviral strategies of natural reservoirs are conserved between *** verify this hypothesis,we created null mutants of 10-formyltetrahydrofolate synthetase(AtTHFS),an Arabidopsis thaliana homologue of methylenetetrahydrofolate dehydrogenase,cyclohydrolase and formyltetrahydrofolate synthetase 1(MTHFD1),which encodes a positive regulator of viral replication in *** found that disruption of AtTHFS enhanced plant resistance to three different types of plant viruses,including the tomato spotted wilt virus(TSWV),the cucumber mosaic virus(CMV)and the beet severe curly top virus(BSCTV).These results demonstrate a novel antiviral strategy for plant *** further discuss the approaches used to identify and study natural reservoirs of plant viruses,especially those hosting many viruses,and highlight the possibility of discovering new antiviral strategies from them for plant molecular breeding and antiviral therapy.

关键词： antiviral strategy antiviral therapy cropmolecular breeding natural reservoir virus

Multiphase synergistic immobilization of complex trialkyl phosphine oxide end-waste into an iron-containing aluminosilicate glass-ceramic

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Journal of Materials Science & Technology 2024年第18期185卷 83-97页

作者： Pan Tan Xiaoyan Shu lijing Huang Sihong Luo Jing Chen Yuexiang Lu Mingfen Wen Faqin Dong du Liu Xiaoan Li Xirui Lu State Key Laboratory of Environmental-friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety Southwest University of Science and TechnologyMianyang 621010China Tianfu Institute of Research and Innovation Southwest University of Science and TechnologyChengdu 610299China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China NHC Key Laboratory of Nuclear Technology Medical Transformation Mianyang Central HospitalMianyang 621010China

The objective of this study was to address the challenges associated with complex TRPO waste,by utiliz-ing a natural aluminosilicate material to produce glass-ceramic waste *** the simulated waste content was below 30 wt.%,glassy waste forms were successfully *** and Fe played crucial roles in the formation of Si-O-Ce bonds and[FeO_(4)]-tetrahedra in the glass network,which effectively immo-bilized other waste ***,when the waste content exceeded 30 wt.%,the waste was incor-porated into feldspar,iron-manganese crystals,fluorite ceramic,and *** combination of ceramic and glass matrices synergistically immobilized the waste,resulting in excellent mechanical performance and chemical *** leaching rates of LR_(Ce)and LR_(Nd)were remarkably low around-10^(−6)to 10^(−7)g m^(−2)d^(−1),after 42 ***,the study also investigated the role of multi-valence elements,such as Ce,Fe,and Mn,in the formation of iron-containing aluminosilicate *** findings offer a novel approach to effectively immobilize complex nuclear waste.

关键词： Environmental protection Complex nuclear waste Aluminosilicate Fluorite Performance

STUDY ON INDEX SYSTEM OF ASSESSMENT OF PUBLIC DISASTER PERCEPTION IN THE WESTERN CHINA

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Chinese Geographical Science 2003年第3期13卷 284-288页

作者： ZHOUOi lijing-yi ZHAOJing-bo DepartmentofGeography ShcamxiNormalUniversityXi‘an710062P.R.China KeyLaboratoryofDisasterMonitoringandMechanismSimulatingofShcumxiProvince BaojiCollegeofArtsandSciencesBaoji721007P.R.China

The study on humanity response to global environment change is a new direction in the research of global change science, of which an important aspect is to study the adaptation strategies of human being to environmental changes in different regions. One reasonable and scientific adaptation strategy is based on not only scientific assessment of the impact of environmental change on society, but also correct estimation of the public perception of environmental change, whereas the research on the latter is terribly weak. This paper intends to understand the personality difference in public perception of environment in the western China primarily by establishing the assessment index system of nation environmental perception and analyzing the results of questionnaire survey in some regions of Shaanxi Province. The conclusions are as follows: 1) The state of public perception of disaster is one of the foundations of constituting and enforcing reasonable adaptation strategy to environmental change. 2) The personality differences of public perception of disaster appear as follows: female disaster perception is stronger than male;the order of disaster perception from strong to weak from the point of age characteristics is 20-30, 0-20, 40-50, 30-40, 50-60, 60 year old or over in turns; the order of disaster perception from strong to weak from the point of educational characteristics is senior high school, college, illiterate, junior high school, primary school, in turns; the order of disaster perception from strong to weak from the point of occupation characteristics is student, farmer, teacher, worker and functionary, in turns; the order of disaster perception from strong to weak from the point of habitat characteristics is city, countryside, towns, and metropolis in turns.

关键词： global change disaster perception disaster reduction strategy western China

Applications of CRISPR/Cas genome editing in economically important fruit crops:recent advances and future directions

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Molecular Horticulture 2023年第1期3卷 391-419页

作者： Zhimin Ma lijing Ma Junhui Zhou Peking University Institute of Advanced Agricultural Sciences Weifang 261000ShandongChina

Fruit crops,consist of climacteric and non-climacteric fruits,are the major sources of nutrients and fiber for human *** 2013,CRISPR/Cas(Clustered Regularly Interspersed Short Palindromic Repeats and CRISPR-Associated Protein)genome editing system has been widely employed in different plants,leading to unprecedented progress in the genetic improvement of many agronomically important fruit ***,we summarize latest advancements in CRISPR/Cas genome editing of fruit crops,including efforts to decipher the mechanisms behind plant development and plant immunity,We also highlight the potential challenges and improvements in the application of genome editing tools to fruit crops,including optimizing the expression of CRISPR/Cas cassette,improving the delivery efficiency of CRISPR/Cas reagents,increasing the specificity of genome editing,and optimizing the transformation and regeneration *** addition,we propose the perspectives on the application of genome editing in crop breeding especially in fruit crops and highlight the potential *** is worth noting that efforts to manipulate fruit crops with genome editing systems are urgently needed for fruit crops breeding and demonstration.

关键词： CRISPR/Cas Plant development Plant immunity Genome editing Fruit crops

Network pharmacology and molecular docking study on the effect of Kaempferol in treatment of metabolic associated fatty liver disease

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Journal of Traditional Chinese Medicine 2022年第5期42卷 788-794页

作者： ZHOU Kaixuan ZHANG Dong BAO Huiwei LI lijing College of Pharmacy Changchun University of Chinese MedicineChangchun 130117China

OBJECTIVE: To study therapeutic effect of kaempferol on metabolic associated fatty liver disease(MAFLD) by network pharmacology and molecular docking combined with cell experiments. METHODS: First, use the Swiss Target Prediction database to predict the targets of kaempferol, and collect the targets of MAFLD through the Disgenet database and the Gene Cards database. Then, the common target of kaempferol and MAFLD was enriched and analyzed by the Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes, and the protein-protein interaction(PPI) network was constructed through the string database to obtain the key targets, and carry out molecular docking of key targets with kaempferol;In cell experiment, oleic acid induced steatosis in Hep G2 cells, which was intervened by kaempferol, the level of triglyceride(TG) was detected, the lipid deposition was observed by oil red O staining, and the protein expression was detected by Western blot. RESULTS: The results showed that there are 33 common targets for kaempferol and MAFLD. The biological process of GO is related to the regulation of protein kinase B, cell apoptosis, inflammatory factors, lipoxygenase, etc. Its action pathway is related to the phosphatidylinositol-3-kinase and protein kinase B(PI3K-AKT) signaling pathway, hypoxia-inducible factor 1 signaling pathway, forkhead box protein O signaling pathway, AMP-activated protein kinase signaling pathway, tumor necrosis factor signaling pathway, etc., the key targets are protein kinase B(AKT1), prostaglandin G/H synthase 2, matrix metalloproteinase-9, epidermal growth factor receptor, and the molecular docking of kaempferol with the four key targets shows good binding properties. Cell experiments show that kaempferol can reduce cell TG levels, reduce lipid deposition, increase the expression of PI3K, AKT, and beclin-1, and reduce the expression of caspase-3 and nuclear factor-kappa B. Kaempferol can treat MAFLD by regulating the PI3K-AKT signaling pathway to regu

关键词： Metabolic associated fatty liver disease kaempferol network pharmacology molecular docking simulation protein kinase B protoonco-gene proteins c-akt signaling transduction

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Mechanism of NO decomposition on perovskite (-like) catalysts

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Chinese Science Bulletin 2005年第7期50卷 707-710页

作者： ZHUJunjiang XlAODehai lijing YANGXiangguang WUYue ChangchunInstituteofAppliedChemistry ChineseAcademyofSciencesChangchun130022China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China ChangchunInstituteofAppliedChemistry ChineseAcademyofSciencesChangchun130022China

NOx emitting from industrial and mobile exhaust are serious pollutant in air atmosphere, and the removal of them is an urgent task of today in environment-protection field[1,2]. Although the present three-way-catalyst (TWC)can remove NOx from the mobile exhaust effectively, it will be out of work as lean-burn strategies are used to increase energy efficiency (for example, the diesel engine operated in the lean-burn condition), hence, the technology that can remove NOx in the presence of excess oxygen is desired[3]. In addition, because the capability of noblemetal catalyst for NOx removal is weak at high temperatures (＞873 K)[4], it is thus necessary to comprehend the process of NOx decomposition, which would help to solve the problem of NOx removal.

关键词：一氧化氮钙钛矿催化剂分解反应大气污染环境保护