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Advanced 4D-bioprinting technologies for brain tissue modeling and study

International Journal of Smart and Nano Materials 2019年第3期10卷 177-204页

作者： Timothy J.Esworthy Shida Miao Se-Jun Lee Xuan Zhou Haitao Cui Yi Y.Zuo lijie grace zhang Department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDCUSA Department of Mechanical Engineering University of Hawaii at ManoaHonoluluHIUSA Department of Medicine The George Washington UniversityWashingtonDCUSA Department of Biomedical Engineering The George Washington UniversityWashingtonDCUSA Department of Electrical and Computer Engineering The George Washington UniversityWashingtonDCUSA

Although the process by which the cortical tissues of the brain fold has been the subject of considerable study and debate over the past few decades,a single mechanistic description of the phenomenon has yet to be fully ***,two competing explanations of cortical folding have arisen in recent years;known as the axonal tension and the differential tangential expansion *** the present review,these two models are introduced by analyzing the computational,theoretical,materials-based,and cell studies which have yielded *** Four-dimensional bioprinting is presented as a powerful technology which can not only be used to test both models of cortical folding de novo,but can also be used to explore the reciprocal effects that folding associated mechanical stresses may have on neural ***,the fabrication of‘smart’tissue models which can accurately simulate the in vivo folding process and recapitulate physiologically relevant stresses are *** also provide a general description of both cortical neurobiology as well as the cellular basis of cortical *** discussion also entails an overview of both 3D and 4D bioprinting technologies,as well as a brief commentary on recent advancements in printed central nervous system tissue engineering.

关键词： 4D bioprinting smart materials brain cortical folding gyrification

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A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation

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Nano Research 2019年第6期12卷 1381-1388页

作者： Haitao Cui Shida Miao Timothy Esworthy Se-jun Lee Xuan Zhou Sung Yun Hann Thomas J.Webster Brent T.Harris lijie grace zhang Department of Mechanical and Aerospace Engineering The George Washington UniversityWashingtonDC 20052USA Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Neurology and Pathology Georgetown UniversityWashingtonDC 20007USA Departments of Electrical and Computer Engineering The George Washington UniversityWashingtonDC 20052USA Department of Biomedical Engineering The George Washington UniversityWashingtonDC 20052USA Department of Medicine The George Washington UniversityWashingtonDC 20052USA

Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over ***,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation ***,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell *** novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications.

关键词： near-infrared light responsive four-dimensional (4D) printing dynamically and remotely controllable graphene brain neural stem cell

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Sequence-controlled dynamic covalent units enable decoupling of mechanical and self-healing performance of polymers

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Science China Chemistry 2025年第2期68卷 745-753页

作者： Luzhi zhang Hongfei Huang lijie Sun Xiaopeng Ma Hui Tan Zhengwei You Respiratory Department Shenzhen Children’s Hospital Affiliated to Shantou University Medical CollegeShenzhen 518038China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua UniversityShanghai 201620China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China

Sequence regulation provides an effective approach to controlling the properties of polymer ***,this approach remains an open question in the field of dynamic polymers,which emerge as more and more important new generation ***,we systematically investigate the effect of sequence control of dynamic covalent units in tuning the properties of *** sequence-controlled poly(oxime-urethanes)are *** dynamic oxime-urethane groups are relatively dispersed(SCP-1)or concentrated(SCP-2)distributed in their molecular *** sequence control strategy provides an efficient way to decouple the mechanical and self-healing performance of polymers,which is one of the most pressing challenges in the *** relatively dispersed oxime-urethane groups in SCP-1 not only facilitate the reorganization of the dynamic covalent bonds but also increase the probability of the reformation of hydrogen *** reversible dissociation/reassociation of dynamic bonds is conducive to dissipating energy to enhance mechanical performance and promote self-healing *** a result,SCP-1 exhibits much faster self-healing than SCP-2,and its tensile strength is nearly twice that of *** addition,energy dissipation capacity and degradation behavior also show significant sequence ***,this work reveals a new molecular structure-property relationship and provides a powerful strategy to construct high-performance polymers.

关键词： sequence control dynamic polymer poly(oxime-urethane) strength polyurethane

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu lijie Yang Wanrong Jiang Xinyuan zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai zhang Boxin Liu Yu Shi Haoxue Wang lijie Huang Su zhang Ruixin zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang lijie Mao Zhimin zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei zhang Wei Zhou Yuming Huang Liang Xie Tonghui Li Huimin Kang lijie Wang Yang Yu Yani Ding Junfeng Li Jiaxiang Chen Miaoting Sun Shuo Cheng Xiaoxiao Meng Jihui Gao Guangbo Zhao School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina China Datang Technology Innovation Co. LtdXiong’an 071799HebeiChina

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis(PEMWE)emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis(hydrogen production rate:51.6 m L h^(-1),energy consumption:5.37 kWh Nm-^(3)H_(2)),this strategy(hydrogen production rate:66 m L h^(-1),energy consumption:3.83 kWh Nm-^(3)H_(2))increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic(PV)system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis(PDE)dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic end

关键词： Water electrolysis Hydrogen production Pulsed dynamic electrolysis Proton exchange membrane water electrolysis Mass transport

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From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes

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Nano Research 2025年第1期18卷 323-331页

作者： Jun Cheng Xuan Zhou Hongqiang zhang Zhen Zeng Yuanyuan Li Yulong Zhu Yingsheng Liao lijie Ci Deping Li State Key Laboratory of Precision Welding and Joining of Materials and Structures School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer ***,the performance of CPEs is significantly influenced by the surface characteristics of the garnet ***,the impact of garnet surface characteristics on CPEs was systematically investigated and a conversion from a typically unstable and Lewis basic surface to a more stable Lewis acidic surface was realized,which is shown to be more conductive to the improved performance of *** simultaneously removing the Li_(2)CO_(3)layer and applying a Li-Al-O coating,the influence of surface characteristics on CPEs was *** Lewis acid Li-Al-O surface coating not only promotes lithium salt dissociation,improving the ionic conductivity and ionic transfer number,but also prevents the reformation of the passive Lewis basic Li_(2)CO_(3)*** to garnet with a Lewis basic Li_(2)CO_(3)surface,the garnet modified with a Lewis acid Li-Al-O coating enhances CPEs,which exhibit an improved critical current density of 1.0 mA·cm^(-2)and highly stable lithium symmetric cell cycling for 400 h at 0.2 mA·cm^(-2).This research highlights the importance of surface chemistry in the design of high-performance solid-state batteries and presents a strategic modification approach for garnetbased CPEs.

关键词： garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries

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Sequence-controlled dynamic covalent units enable decoupling of mechanical and self-healing performance of polymers

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Science China Chemistry 2025年第2期 745-753页

作者： Luzhi zhang Hongfei Huang lijie Sun Xiaopeng Ma Hui Tan Zhengwei You Respiratory Department Shenzhen Children's Hospital Affiliated to Shantou University Medical College State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications (China Textile Engineering Society)Shanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua University Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China

Sequence regulation provides an effective approach to controlling the properties of polymer materials. However, this approach remains an open question in the field of dynamic polymers, which emerge as more and more important new generation ***, we systematically investigate the effect of sequence control of dynamic covalent units in tuning the properties of materials. Different sequence-controlled poly(oxime-urethanes) are designed. The dynamic oxime-urethane groups are relatively dispersed(SCP-1) or concentrated(SCP-2) distributed in their molecular chains. The sequence control strategy provides an efficient way to decouple the mechanical and self-healing performance of polymers, which is one of the most pressing challenges in the field. The relatively dispersed oxime-urethane groups in SCP-1 not only facilitate the reorganization of the dynamic covalent bonds but also increase the probability of the reformation of hydrogen bonds. The reversible dissociation/reassociation of dynamic bonds is conducive to dissipating energy to enhance mechanical performance and promote self-healing properties. As a result, SCP-1 exhibits much faster self-healing than SCP-2, and its tensile strength is nearly twice that of SCP-2. In addition,energy dissipation capacity and degradation behavior also show significant sequence dependence. Overall, this work reveals a new molecular structure-property relationship and provides a powerful strategy to construct high-performance polymers.

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教育、科技、人才一体改革推进体育新质生产力发展:逻辑、障碍、路径

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上海体育大学学报 2025年第1期49卷 76-87页

作者：张瑞林金礼杰王志文北京师范大学体育与运动学院北京100875

教育、科技、人才事业发展是培育体育新质生产力的先导性变量。以多维度统筹的视角,通过规律把握和障碍分析,系统提出教育、科技、人才一体改革推进体育新质生产力发展的实践路径。认为,遵循体育新质生产力在科技创新、全要素生产率提... 详细信息

教育、科技、人才事业发展是培育体育新质生产力的先导性变量。以多维度统筹的视角,通过规律把握和障碍分析,系统提出教育、科技、人才一体改革推进体育新质生产力发展的实践路径。认为,遵循体育新质生产力在科技创新、全要素生产率提升、新型生产关系构建上的要求,教育、科技、人才一体改革带来的先进技术突破、生产要素创新配置、产业转型升级,有力赋能体育新质生产力的形成与发展。但在实践中,体育高等教育体系滞后于培育新质劳动者的现实需要,体育科技创新难以实现关键核心技术突破,创新型体育人才活力激发不足。对此,围绕管理一体协同、政策一体设计、资源一体配置、载体一体贯通的战略思路,提出深化体育高等教育体系综合改革、体育科技体制改革、体育人才工作机制改革的实施策略,以提升国家体育创新体系的整体效能。

关键词：体育新质生产力教育科技人才体制机制

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