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长余辉基适配体传感器在食品安全检测中的应用进展

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分析科学学报 2024年第2期40卷 231-238页

作者：顾天悦高雪梅陈柯霖严诸颖陈丽建赵旭江南大学食品科学与资源挖掘全国重点实验室江苏无锡214122 江南大学国际食品安全联合实验室江苏无锡214122 江南大学食品学院分析食品安全学研究所江苏无锡214122 江南大学化学与材料工程学院合成和生物胶体重点实验室江苏无锡214122

食品工业的迅速发展离不开安全体系的构建。食品安全检测关系经济民生,是分析领域的研究热点。长余辉纳米粒子具有免原位激发和磷光可再生性,在激发光停止后持续发光,从而消除背景荧光干扰,是理想的光学传感元件。适配体是具有识别性能... 详细信息

食品工业的迅速发展离不开安全体系的构建。食品安全检测关系经济民生,是分析领域的研究热点。长余辉纳米粒子具有免原位激发和磷光可再生性,在激发光停止后持续发光,从而消除背景荧光干扰,是理想的光学传感元件。适配体是具有识别性能的寡核苷酸序列,兼具快速响应性、高特异性和灵敏度。二者通过基团键合可构建性能独特的探针,产生靶标刺激的信号变化,在食品安全检测领域享有壮阔前景。本文阐述了近年来长余辉基适配体传感器在食品安全检测中的研究进展。重点聚焦于实现传感器光学激活的设计策略,简要介绍了相应原理的研究应用,最后对于该技术面临的挑战和机遇进行讨论和展望,以推进食品安全检测的发展。

关键词：食品安全长余辉纳米粒子适配体生物传感器磷光猝灭

老年胃肠道全麻手术患者颈动脉超声指标与每搏量变异度变化的相关性

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中华全科医学 2024年第1期22卷 42-45,49页

作者：张雪寅骆宏陈立建合肥市第一人民医院麻醉科安徽合肥230061 安徽医科大学第一附属医院麻醉科安徽合肥230022

目的评估颈动脉校正血流时间(FTc)和颈动脉峰流速变异度(ΔVpeak)对老年胃肠道手术患者全麻诱导机械通气时每搏量变异度(SVV)≥13%的预测能力。方法选取合肥市第一人民医院于2021年7月—2022年12月行腹腔镜胃肠道手术的患者60例。于... 详细信息

目的评估颈动脉校正血流时间(FTc)和颈动脉峰流速变异度(ΔVpeak)对老年胃肠道手术患者全麻诱导机械通气时每搏量变异度(SVV)≥13%的预测能力。方法选取合肥市第一人民医院于2021年7月—2022年12月行腹腔镜胃肠道手术的患者60例。于气管插管后5 min(T1)测定超声参数和血流动力学参数。SVV≥13%为容量有反应组(R组);SVV<13%为容量无反应组(N组),各纳入30例患者。完成容量负荷试验后5 min(T2),再次测量相同的血流动力学参数。采用Pearson相关性分析研究超声参数与SVV的相关性,采用ROC曲线评估FTc和ΔVpeak预测SVV≥13%的能力。结果 R组患者麻醉诱导前(T0)至T2时点FTc明显低于N组患者,而ΔVpeak明显高于N组患者,差异均有统计学意义(P<0.05)。2组患者T2时点FTc明显高于同组T0时点,而T2时点ΔVpeak明显低于同组T0时点,差异均有统计学意义(P<0.05)。FTc预测SVV≥13%的灵敏度为83.3%,特异度为76.7%;ΔVpeak预测SVV≥13%的灵敏度为80.0%,特异度为63.3%。FTc与SVV的相关性系数为-0.674,表明FTc和SVV呈负相关关系;ΔVpeak与SVV的相关性系数为0.765,表明ΔVpeak和SVV呈正相关关系。结论 FTc、ΔVpeak与SVV具有良好的相关性。FTc和ΔVpeak均能预测老年患者全麻期间的容量反应性。

关键词：颈动脉校正血流时间颈动脉峰流速变异度每搏变异度全身麻醉老年

2014—2022年重庆市大足区入托入学查验补种趋势分析

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预防医学情报杂志 2024年第5期40卷 521-527,534页

作者：王倩李正强李德俊陈丽剑廖洁重庆市大足区疾病预防控制中心免疫规划科重庆402360

目的了解重庆市大足区2014—2022年入托入学儿童查验补种趋势变化,为提高儿童疫苗接种率,建立免疫屏障提供科学依据。方法对2014—2022年重庆市大足区儿童接种门诊上报的入托入学查验和补种数据,采用Excel 2007和SPSS 19.0软件对数据进... 详细信息

目的了解重庆市大足区2014—2022年入托入学儿童查验补种趋势变化,为提高儿童疫苗接种率,建立免疫屏障提供科学依据。方法对2014—2022年重庆市大足区儿童接种门诊上报的入托入学查验和补种数据,采用Excel 2007和SPSS 19.0软件对数据进行描述性流行病学分析,对查验率、漏种率和补种率进行χ^(2)检验,趋势分析的结果用年度变化百分比(annual percent of change,APC)表示。检验水准为α=0.05。结果2014—2022年重庆市大足区入托入学机构查验率均为100.00%,新生查验率与持证率由2014年的95.61%、90.78%增长到100.00%、99.98%,APC分别为0.50%(t=5.58,P=0.001)、0.80%(t=2.74,P0.05);小学机构中,流脑A+C疫苗的补种完成率以年均4.81%增长(t=8.15,P<0.05)。结论重庆市大足区的入托入学查验补种工作取得一定成绩。但仍有不足之处,今后还需多举措加大私立幼儿园的查验和小学生的补种工作。

关键词：入托入学查验补种

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智能化矿用喷浆机器人研究及应用

中国煤炭 2024年第7期50卷 91-96页

作者：贾建龙王志鹏赵耀斌刘飞贾明超高子龙呼雨陈利剑国能榆林能源有限责任公司青龙寺煤矿分公司陕西省榆林市719400 中煤科工机器人科技有限公司广东省深圳市518057

针对现有井下传统人工喷浆存在的作业效率低、劳动强度大等问题,研究出一种智能化矿用喷浆机器人,结合巷道喷浆工艺,提出了一体化自主喷浆作业工艺完成上料、搅拌、远距离泵送及喷浆的全自动流程化作业;介绍了智能化矿用喷浆机器人的系... 详细信息

针对现有井下传统人工喷浆存在的作业效率低、劳动强度大等问题,研究出一种智能化矿用喷浆机器人,结合巷道喷浆工艺,提出了一体化自主喷浆作业工艺完成上料、搅拌、远距离泵送及喷浆的全自动流程化作业;介绍了智能化矿用喷浆机器人的系统组成,采用模块化设计方法,基于拖缆式供电、全液压驱动、多传感器布局等实现机器人样机研制;重点阐述了喷浆机械臂壁面感知与路径规划技术,实现对喷浆机械臂更加高效、稳定的喷浆作业;现场应用表明,采用智能化矿用喷浆机器人一次喷浆作业需1~2人参与,作业效率为18 min/m,对比人工作业,喷浆效率提升2倍,且喷浆作业质量得到显著改善,实现了井下巷道高效、高质量的智能化喷浆作业。

关键词：喷浆机器人喷浆作业工艺喷浆机械臂壁面感知路径规划

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Application and progress of the detection technologies in hepatocellular carcinoma

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Genes & Diseases 2023年第5期10卷 1857-1869页

作者： Qi Yan Yuan-song Sun Ran An Fang Liu Qi Fang Zhen Wang Tao Xu lijian chen Jian Du School of Basic Medical Sciences Anhui Medical UniversityHefeiAnhui 230032China Department of Emergency Surgery The Second Hospital of Anhui Medical UniversityHefeiAnhui 230032China Department of Anesthesiology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsSchool of PharmacyHefeiAnhui 230032China Institute for Liver Diseases of Anhui Medical University Anhui Medical UniversityHefeiAnhui 230032China

Hepatocellular carcinoma(HCC)has a very high incidence and fatality rate,and in most cases,it is already at an advanced stage when ***,early prevention and detection of HCC are two of the most effective ***,the methods recommended in the practice guidelines for the detection of HCC cannot guarantee high sensitivity and specificity except for the liver biopsy,which is known as the“gold standard”.In this review,we divided the detection of HCC into pre-treatment diagnosis and post-treatment monitoring,and found that in addition to the traditional imaging detection and liver biopsy,alpha fetoprotein(AFP),lens culinaris-agglutinin-reactive fraction of AFP(AFP-L3),protein induced by vitamin K absence or antagonist-II(PIVKA-II)and other biomarkers are excellent biomarkers for HCC,especially when they are combined *** notably,the emerging liquid biopsy shows great promise in detecting *** addition,lactic dehydrogenase(LDH),suppressor of cytokine signaling(SOCS)and other relevant biomarkers may become promising biomarkers for HCC post-treatment *** the detailed introduction of the diagnostic technology of HCC,we can have a detailed understanding of its development process and then obtain some enlightenment from the diagnosis,to improve the diagnostic rate of HCC and reduce its mortality.

关键词： HCC Invasive diagnosis Minimally invasive diagnosis Noninvasive diagnosis Prognostic monitoring

Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression-and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4801-4822页

作者： Kaikai Zhang lijian chen Jianzheng Yang Jiali Liu Jiahao Li Yi Liu Xiuwen Li Long chen Clare Hsu Jiahao Zeng Xiaoli Xie Qi Wang Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhou 510515China Department of Toxicology School of Public HealthSouthern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research)Guangzhou 510515China

Methamphetamine(Meth)abuse can cause serious mental disorders,including anxiety and *** gut microbiota is a crucial contributor to maintaining host mental ***,we aim to investigate if microbiota participate in Meth-induced mental disorders,and the potential mechanisms ***,15 mg/kg Meth resulted in anxiety-and depression-like behaviors of mice successfully and suppressed the Sigma-1 receptor(SIGMAR1)/BDNF/TRKB pathway in the ***-while,Meth impaired gut homeostasis by arousing the Toll-like receptor 4(TLR4)-related colonic inflammation,disturbing the gut microbiome and reducing the microbiota-derived short-chain fatty acids(SCFAs).Moreover,fecal microbiota from Meth-administrated mice mediated the colonic inflam-mation and reproduced anxiety-and depression-like behaviors in ***,SCFAs supple-mentation optimized Meth-induced microbial dysbiosis,ameliorated colonic inflammation,and repressed anxiety-and depression-like ***,Sigmarl knockout(Sigmar1^(-/-))repressed the BDNF/TRKB pathway and produced similar behavioral phenotypes with Meth exposure,and elim-inated the anti-anxiety and-depression effects of *** activation of SIGMAR1 with fluvoxamine attenuated Meth-induced anxiety-and depression-like *** findings indicated that gut microbiota-derived SCFAs could optimize gut homeostasis,and ameliorate Meth-induced mental disorders in a SIGMAR1-dependent *** study confirms the crucial role of microbiota in Methrelated mental disorders and provides a potential preemptive therapy.

关键词： Methamphetamine Gut microbiota Short-chain fatty acids Sigma-1 receptor Mental disorders Colonic inflammation Intestinal barrier Gut-brain axis

MiR-711 and miR-183-3p as potential markers for vital reaction of burned skin

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Forensic Sciences Research 2022年第3期7卷 503-509页

作者： Kaikai Zhang Ming cheng Jingtao Xu lijian chen Jiahao Li Qiangguo Li Xiaoli Xie Qi Wang Department of Forensic Pathology School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Forensic Science Centre of Guangdong Provincial Public Security Department GuangzhouChina Department of Critical Medicine Mudan District People’s HospitalHezeChina Department of Toxicology School of Public HealthSouthern Medical UniversityGuangzhouChina

In forensic practice,the identification of antemortem burns and postmortem burns is of the utmost *** from previous studies have shown that miRNAs,with lengths stretching over 18–25 nucleotides,are highly stable and resistant to ***,there has been little research into the application of miRNAs in identifying antemortem and postmortem *** study compared the expression of miR-711 and miR-183-3p levels in mouse and postmortem human burned skins using RT-qPCR ***-qPCR examination of burned mouse skins showed that increased miR-711 and miR-183-3p expression in comparison to intact skin *** increased expressions of these two miRNAs were observed until 120 h after death in burned mouse skins,whereas no significant changes were found in postmortem burned *** human burned skins,the increased levels of these two miRNAs at 48 h following autopsy occurred in 19 of 26 subjects,which appeared to be related to the severity of the *** findings suggest that miR-711 and miR-183-3p may act as biomarkers for vital reaction of skin burn.

关键词： Forensic sciences forensic pathology vital reaction skin burn miR-711 miR-183-3p

幽门螺杆菌感染相关免疫性血小板减少症的研究进展

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重庆医学 2024年第6期53卷 934-938,960页

作者：龙春月陈立坚常阳吕梅周泽平李劲瑜邰文琳徐益恒昆明医科大学第二附属医院检验科昆明650106 福清市医院检验科福建福清350300 昆明医科大学第二附属医院血液内科昆明650106

免疫性血小板减少症(ITP)是一种以血小板生成减少和破坏增多为特征的获得性自身免疫性疾病,现普遍认为其发病与体液免疫、细胞免疫、遗传易感性、基因表达异常、感染等多种因素有关。幽门螺杆菌(Hp)在人群中易感,与胃炎、消化性溃疡等... 详细信息

免疫性血小板减少症(ITP)是一种以血小板生成减少和破坏增多为特征的获得性自身免疫性疾病,现普遍认为其发病与体液免疫、细胞免疫、遗传易感性、基因表达异常、感染等多种因素有关。幽门螺杆菌(Hp)在人群中易感,与胃炎、消化性溃疡等消化道疾病密切相关,最近研究发现Hp也可能与血液系统疾病ITP的发生相关。Hp诱发ITP的机制涉及Hp毒力因子、单核细胞吞噬功能增加、诱导血小板聚集与活化、树突状细胞与辅助性T淋巴细胞平衡紊乱、地域与遗传因素等多个方面。本文主要就Hp感染诱发ITP的发病机制相关研究进展作一综述,为ITP的治疗提供新的研究思路。

关键词：幽门螺杆菌免疫性血小板减少症发病机制综述

Serum Protein Level Is Related to ADL in Patients with Parkinson’s Disease

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Open Journal of Nursing 2022年第11期12卷 738-744页

作者： Lihe Huang Xuezhen Deng Jieyi Yang Xuemei He Yanchun Zhu lijian chen Neurology Department Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China Guangzhou Medical University Guangzhou China

Objectives: To establish an ADL prediction model for Parkinson’s inpatients as an auxiliary evaluation scheme. Methods: The data of Parkinson’s patients hospitalized in the Department of Neurology of Affiliated Brain Hospital of Guangzhou Medical University from 2019 to 2022, which suited the criteria were collected, and a multiple linear regression model was established with serum total protein, serum albumin, age, BMI and education level as independent variables and BI scores as dependent variables. Results: A total of 95 PD patients were included (mean 70.05 ± 10.87 years): 53 males and 42 females. The correlation analysis showed that the serum total protein (r = 0.398, P Conclusion: The ADL multiple linear regression model can be used as an important means to evaluate the ADL ability of PD patients in hospital.

关键词： Parkinson’s Disease Nursing Serum Total Protein Serum Albumin Activities of Daily Living