检索结果-南通市图书馆

Chaiqinchengqi decoction regulates necrosis-apoptosis via regulating the release of mitochondrial cytochrome c and caspase-3 in rats with acute necrotizing pancreatitis

引用

Journal of Traditional Chinese Medicine 2014年第2期34卷 178-183页

作者： Ziqi Lin Jia Guo Ping Xue Lei Huang lihui deng Xiaonan Yang Qing Xia Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan University

OBJECTIVE: To explore the effect and the mechanism of Chaiqinchengqi decoction(CQCQD) on the apoptosis-necrosis switch of pancreatic acinar cells in acute necrotizing pancreatitis(ANP) in ***: Sixty Sprague-Dawley rats were randomized into the control group, the ANP group and the CQCQD group. The acute pancreatitis(AP)model was induced by intraperitoneal injections of4 g/kg 8% L-Arginine(PH 7.0) twice with a 1 h interval. Rats in the CQCQD group were intragastrically administered CQCQD(20 mL/kg every 2 h, 3 times,then 20 mL/kg every 6 h, 3 times). Rats were killed at the 6 and 24 h after the induction of *** pancreatic tissues were collected for pathology and to isolate pancreatic acinar cells and ***: CQCQD significantly ameliorated the severity of ANP by reducing the pancreatic histopathology score, indicated by lactate dehydrogenase levels at the 6 and 24 h. The CQCQD group promoted the apoptosis of pancreatic acinar cells by raising the apoptosis index compared with the ANP group and the control group. Mitochondrial cytochrome c at the 6 and 24 h in the ANP group were lower than that in the control group or the CQCQD group(0.67±0.13 vs 1.54±0.03 vs 0.81±0.09; 0.71±0.08 vs 1.55±0.09 vs 0.89±0.16, P0.05;0.97±0.09, P<0.05). CQCQD increased caspase-3 activity over the ANP group at the 6 ***: CQCQD can induce apoptosis and relieve the necrosis of pancreatic acinar cells via promoting the release of mitochondrial cytochrome c and increasing pancreatic caspase-3 activity in ANP rats.

关键词： Pancreatitis, acute necrotizing AcinarCells Mitochondria Apoptosis Necrosis Chaiqin-chengqi decoction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Water flooding flowing area identification for oil reservoirs based on the method of streamline clustering artificial intelligence

引用

Petroleum Exploration and Development 2018年第2期45卷 328-335页

作者： JIA Hu deng lihui State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation in Southwest Petroleum University Chengdu 610500China

For the case of carbonate reservoir water flooding development, the flow field identification method based on streamline modeling result was proposed. The Ocean for Petrel platform was used to build the plug-in that exported the streamline data, and the subsequent data was processed and clustered through Python programming, to display the flow field with different water flooding efficiencies at different time in the reservoir. We used density peak clustering as primary streamline cluster algorithm, and Silhouette algorithm as the cluster validation algorithm to select reasonable cluster number, and the results of different clustering algorithms were compared. The results showed that the density peak clustering algorithm could provide better identified capacity and higher Silhouette coefficient than K-means, hierachical clustering and spectral clustering algorithms when clustering coefficients are the same. Based on the results of streamline clustering method, the reservoir engineers can easily identify the flow area with quantification treatment, the inefficient water injection channels and area with developing potential in reservoirs can be identified. Meanwhile, streamlines between the same injector and producer can be subdivided to describe driving capacity distribution in water phase, providing useful information for the decision making of water flooding optimization, well pattern adjustment and deep profile modification.

关键词： water flooding water flooding efficiency flow field identification streamline simulation cluster algorithm artificial intelligence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, ameliorates hepatic fibrosis in rats with type 2 diabetes

引用

Chinese Medical Journal 2014年第2期127卷 225-231页

作者： Zhou Hong Fang Caixia Zhang lihui deng Yonggui Wang Mian Meng Fengling Department of Endocrinology Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background Hyperglycemia may accelerate liver ***,there is no effective treatment for liver fibrosis induced by type 2 *** study aim was to investigate whether RhoA/Rho kinase （ROCK） pathway is involved in liver fibrosis in the rats with type 2 diabetes and define the protective effects of fasudil on *** A rat model of type 2 diabetes was established by high fat diet combined with streptozotocin （30 mg/kg,intraperitoneal injection）.Animals were randomly assigned to 3 groups：control rats,untreated diabetic rats that received vehicle and fasudil-treated diabetic rats that received ROCK inhibitor fasudil hydrochloride hydrate （10 mg/kg per day,intraperitoneal injection,for 14 weeks）.The morphological features of liver were observed by HE *** of collagen in livers was determined by Masson staining and the measurement of *** mRNA expression of transforming growth factor-β1 （TGFβ1）,connective tissue growth factor （CTGF）,type-Ⅰ,and type-Ⅲ procollagen was assessed with real-time polymerase chain *** phosphorylation of myosin phosphatase target subunit-1 （MYPT1）and the protein levels of TGFβ1 and α-smooth muscle actin （α-SMA） were evaluated by Western *** Compared with control rats,untreated diabetic rats showed higher values of collagen and hydroxyproline in livers （P ＜0.01）,the phosphorylation of MYPT1 and the protein levels of TGFβ1 and α-SMA were increased （P ＜0.01）,and the mRNA expression of TGFβ1,CTGF,type-Ⅰ,and type-Ⅲ procollagen was upregulated （P ＜0.01）; compared with untreated diabetic rats,treatment with fasudil signifcantly reduced values of collagen and hydroxyproline （P ＜0.01）,and decreased the phosphorylation of MYPT1 and the levels of TGFβ1 and α-SMA （P ＜0.01）,concomitant with the downregulation of TGFβ1/CTGF,type-Ⅰ,and type-Ⅲ procollagen mRNA expression （P ＜0.01）.Conclusions Fasudil ameliorates liver fibrosis in rats with type 2 diabetes at least partly by inhibiting TG

关键词： diabetes liver fibrosis Rho kinase transforming growth factor-β1 fasudil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于流线聚类人工智能方法的水驱油藏流场识别

引用

石油勘探与开发 2018年第2期45卷 312-319页

作者：贾虎邓力珲油气藏地质与开发工程国家重点实验室西南石油大学成都610500

以某碳酸盐岩油藏注水开发为例,提出针对流线模拟结果的流场识别方法。在流线模拟计算完成后,利用基于Ocean平台自行编写的插件将流线数据导出,并通过Python编程语言进行后续数据处理及聚类分析,直观反映不同开发阶段水驱油藏流场分布... 详细信息

以某碳酸盐岩油藏注水开发为例,提出针对流线模拟结果的流场识别方法。在流线模拟计算完成后,利用基于Ocean平台自行编写的插件将流线数据导出,并通过Python编程语言进行后续数据处理及聚类分析,直观反映不同开发阶段水驱油藏流场分布。采用密度峰值聚类算法作为流线聚类主要算法,以轮廓系数算法作为聚类评价算法,选取合理的聚类数,并对不同聚类算法结果进行对比。当聚类数相同时,密度峰值聚类算法比K-means、层次聚类、谱聚类算法对不同类型流线区分能力更强且轮廓系数较高,说明了算法的有效性。依据流线聚类结果可对流场进行量化处理,有效识别油藏中无效注水循环通道以及具有开发潜力的区域,同时可对同一注采井间流线进行细分,描述注采井间水相驱动能力大小分布,为注水优化、井网层系调整、深部调剖等方案决策提供依据。

关键词：水驱开发水驱效率流场识别流线模拟聚类算法人工智能中图

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis

引用

Acta Pharmaceutica Sinica B 2024年第8期14卷 3591-3604页

作者： Juan Rong Chenxia Han Yan Huang Yiqin Wang Qi Qiu Manjiangcuo Wang Shisheng Wang Rui Wang Juqin Yang Xia Li Chenggong Hu Zhiyao Chen lihui deng Wei Huang Qing Xi Dan Du West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest China Hospital/West China Medical SchoolSichuan UniversityChengdu 610041China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Advanced Mass Spectrometry Center Research Core FacilityFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Proteomics-Metabolomics Platform Research Core FacilityInstitutes for Systems GeneticsWest China HospitalSichuan UniversityChengdu 610093China Biobank West China HospitalSichuan UniversityChengdu 610093China West China School of Nursing Sichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

Acute pancreatitis(AP)is a potentially fatal condition with no targeted treatment *** inhibiting xanthine oxidase(XO)in the treatment of AP has been studied in several experimental models and clinical trials,whether XO is a target of AP and what its the main mechanism of action is remains ***,we aimed to re-evaluate whether XO is a target aggravating AP other than merely generating reactive oxygen species that trigger *** first revealed that XO expression and enzyme activity were significantly elevated in the serum and pancreas of necrotizing AP *** also found that allopurinol and febuxostat,as purine-like and non-purine XO inhibitors,respectively,exhibited protective effects against pancreatic acinar cell death in vitro and pancreatic damage in vivo at different doses and treatment time ***,we observed that conditional Xdh overexpression aggravated pancreatic necrosis and *** mechanism analysis showed that XO inhibition restored the hypoxia-inducible factor 1-alpha(HIF-1α)-regulated lactate dehydrogenase A(LDHA)and NOD-like receptor family pyrin domain containing 3(NLRP3)signaling pathways and reduced the enrichment of^(13)C_(6)-glucose to^(13)C_(3)-***,we observed that clinical circulatory XO activity was significantly elevated in severe cases and correlated with C-reactive protein levels,while pancreatic XO and urate were also increased in severe AP *** results together indicated that proper inhibition of XO might be a promising therapeutic strategy for alleviating pancreatic necrosis and preventing progression of severe AP by downregulating HIF-1α-mediated LDHA and NLRP3 signaling pathways.

关键词： Xanthine oxidase inhibitor Multi-omics HIF-1a Necrotizing acute pancreatitis Lactate Therapeutic target NLRP3 Metabolic flux

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

超高分子量聚乙烯架桥纤维与裂缝的交互微观力学

引用

复合材料学报 2017年第7期34卷 1505-1510页

作者：邓李慧冉敏吴琪琳东华大学纤维材料改性国家重点实验室上海201620 东华大学材料科学与工程学院上海201620

使用拉曼光谱研究了架桥纤维与裂缝微观力学,以超高分子量聚乙烯(UHMWPE)纤维为例,将纤维搭桥试样进行微拉伸试验,着重分析架桥纤维的止裂作用和架桥纤维/环氧树脂界面的应力分布,并对不同位置架桥试样的裂缝扩展速度和应力分布进行分析... 详细信息

使用拉曼光谱研究了架桥纤维与裂缝微观力学,以超高分子量聚乙烯(UHMWPE)纤维为例,将纤维搭桥试样进行微拉伸试验,着重分析架桥纤维的止裂作用和架桥纤维/环氧树脂界面的应力分布,并对不同位置架桥试样的裂缝扩展速度和应力分布进行分析,并进一步运用剪切滞后模型,对架桥纤维在不同拉伸载荷下的应力分布进行了拟合分析,结果表明:架桥纤维能够分散部分外载应力,对于裂纹扩展具有显著的止裂作用。在低于UHMWPE纤维最大应变拉伸时,发现在裂缝中心位置处架桥纤维所承受的应力最大,其应力不超过2GPa,而基体树脂的应力可达到12GPa,架桥纤维/基体界面的应力传递达不到100%。以UHMWPE为架桥的应力传递模型呈"正抛物线"型,应力分布存在于粘结区、脱粘区和架桥区。

关键词：拉曼光谱架桥纤维裂缝界面微观力学应力传递

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

激光陀螺机抖控制的DDS锁相频率合成方法及其国产化设计

引用

中国惯性技术学报 2024年第9期32卷 932-937页

作者：王磊许浩邓力珲崔颖吴一西安航天精密机电研究所西安710100

激光陀螺通常采用数模转换器(DAC)配合模拟乘法器产生正弦自激振荡的机抖控制方式,乘法器模块现阶段没有国产化替代方案,存在自激振荡在高低温条件下偶发不起振问题。因此,选用国产化微处理器MCU配合DAC替换乘法器模块,采用捕获抖动过... 详细信息

激光陀螺通常采用数模转换器(DAC)配合模拟乘法器产生正弦自激振荡的机抖控制方式,乘法器模块现阶段没有国产化替代方案,存在自激振荡在高低温条件下偶发不起振问题。因此,选用国产化微处理器MCU配合DAC替换乘法器模块,采用捕获抖动过零信号快速获得控制相位,使用PI控制器进行相位-频率差运算,采取查找表方式实现频率合成,输出周期驱动信号(正弦信号或三角波信号),实现抖动偏频闭环控制。所提方案在某三轴一体小型化三自惯组产品50型陀螺控制系统中应用,实现了关键器件的国产化替代设计,且陀螺系统固定位置百秒计数均值的标准方差优于5‰。

关键词：机抖控制锁相环频率合成国产化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

从育人价值的本位出发构建西医院校中医学课程思政的探索

引用

中国中医药现代远程教育 2025年第2期23卷 4-7页

作者：金涛王华楠李宁夏庆邓力珲四川大学华西医院中西医结合科四川成都610041

此文围绕以育人为本位的价值理念,对西医院校中医课程思政的构建进行了探索。文章分析了目前西医院校中医课程以及中医课程思政的现状和背景,中医课程思政建设符合国家建设高水平大学、培养高质量人才的要求和维护人类健康的需求,其必... 详细信息

此文围绕以育人为本位的价值理念,对西医院校中医课程思政的构建进行了探索。文章分析了目前西医院校中医课程以及中医课程思政的现状和背景,中医课程思政建设符合国家建设高水平大学、培养高质量人才的要求和维护人类健康的需求,其必要性不言而喻,并具有可行性。从教学目标和计划、教学内容的挖掘与整合、教学形式的改革与创新、教师队伍培训和教学效果评价措施五个方面具体展开,探讨了课程思政构建的内容,为实现以育人为本位的医学人才培养目标提供了思路。

关键词：育人价值西医院校中医学课程思政

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

维护企业稳定、长久、顺畅的销售渠道

引用

六盘水师范高等专科学校学报 2004年第4期16卷 86-88页

作者：邓礼辉水钢销售公司贵州水城553028

企业的销售渠道一旦建成,就必须考虑如何保持销售渠道的稳定、长久、顺畅,以保证企业能够在激烈的市场竞争中得以生存和不断发展。

关键词：企业销售渠道成功营销利润链

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新型水基防蜡剂的制备以及在海上油田的应用

引用

辽宁化工 2024年第2期53卷 210-213,237页

作者：邓利惠中海石油(中国)有限公司天津分公司天津滨海新区300459

以烯丙基聚乙二醇(XPEG-700),丙烯酸(AA),马来酸酐(MAH),烯丙基磺酸钠(SAS)为原料,共聚合成一种新型水基防蜡剂。研究了引发剂添加量及单体对防蜡剂性能的影响,确定了防蜡剂的最佳合成配方,结果表明,m(XPEG-700)∶m(AA)∶m(MAH)∶m(SAS)... 详细信息

以烯丙基聚乙二醇(XPEG-700),丙烯酸(AA),马来酸酐(MAH),烯丙基磺酸钠(SAS)为原料,共聚合成一种新型水基防蜡剂。研究了引发剂添加量及单体对防蜡剂性能的影响,确定了防蜡剂的最佳合成配方,结果表明,m(XPEG-700)∶m(AA)∶m(MAH)∶m(SAS)=7.0∶15.0∶6.0∶6.0,引发剂用量占单体质量的0.8%,合成防蜡剂的防蜡率达到95%以上。海上油田现场应用结果表明,当新型清防蜡剂的加注量为80 mg/L时,原油中的蜡含量降低明显,管线的输送效率得到了很大地改善。

关键词：水基防蜡剂溶液共聚海上油田应用

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：