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Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells

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Cellular & Molecular Immunology 2011年第1期8卷 31-40页

作者： Li Liu lihua Duan Min gong Hong Dai Quan gong Fang Zheng Zheng Tan Congyi Wang Feili gong Min Fang Laboratory of Transplantation Department of ImmunologyTongji Medical College of Huazhong University of Science and TechnologyWuhanChina The Center for Biomedical Research Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

It has been reported that splenic stromal cells(SSCs)are capable of directly supporting the development of CD11c ^(lo)CD45RB^(+) IL-10-producing dendritic cells(DCs)from lineage-negative c-kit^(+) progenitor cells in the absence of exogenous cytokines.In vitro,DCs that differentiate on stromal cells suppress mixed leukocyte reaction responses and induce primary alloreactive CD4^(+) T cells to differentiate into IL-10-producing Tr1 cells.However,the precise mechanisms by which these SSCs exert their regulatory functions in vivo remain undefined.Furthermore,their possible contribution to the development of allograft transplantation tolerance has yet to be examined.Here,we have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived SSCs and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection.We show that intravenous SSC infusion prolonged murine skin allograft survival.The prolonged graft survival is associated with augmentation of the generation of regulatory DC subsets and CD4^(+) CD25^(+) Foxp3^(+) regulatory T cells(Tregs),as well as upregulation of the production of suppressive cytokines IL-10 and transforming growth factor(TGF)-b.Moreover,we found that indoleamine 2,3-dioxygenase and SSC-derived regulatory DCs contribute to allograft protection by infusion of donor-specific SSCs.Our data suggest that donor-derived SSCs could be used as a therapeutic target to promote transplantation tolerance.

关键词： dendritic cell indoleamine 2,3-dioxygenase splenic stromal cell transplantation

Research Progress of Jianpi Qushi Powder Combined with Standard Anti Hp Quadruple Therapy in the Treatment of Hp Infectious Gastritis with Spleen Deficiency and Dampness Stagnation

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Chinese Medicine 2022年第1期13卷 15-21页

作者： Qiangcai Mai Shoulan gong Guosheng Su lihua Qin Guigang Orthopedic Hospital of Integrated Traditional Chinese and Western Medicine Guigang China Guigang Skin Disease Prevention and Treatment Hospital Guigang China People’s Hospital of Guangxi ASEAN Economic and Technological Development Zone/Nanning Tenth People’s Hospital Nanning China

Stomach Helicobacter pylori infection is one of the common gastric diseases. Helicobacter pylori infectious gastritis of spleen deficiency and dampness stagnation is a relatively intractable chronic disease. In recent years, traditional Chinese medicine methods have emerged one after another in the treatment of gastric Helicobacter pylori infection. By collecting references, the author reviewed the clinical characteristics of gastric Helicobacter pylori infection and the new progress of traditional Chinese medicine treatment.

关键词： Traditional Chinese Medicine Jianpi Qushi Powder Quadruple Therapy Spleen Deficiency Dampness Stagnation Type Helicobacter Pylori Infection Gastritis

Occurrence and distribution of micro-and mesoplastics in the high-latitude nature reserve,northern China

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Frontiers of Environmental Science & Engineering 2022年第9期16卷 15-24页

作者： Wenwen gong Yu Xing lihua Han Anxiang Lu Han Qu Li Xu Beijing Research Center for Agricultural Standards and Testing Beijing Academy of Agriculture and Forestry ScienceBeijing 100097China Beijing Municipal Key Laboratory of Agriculture Environment Monitoring Beijing 100097China Department of Pharmacology College of MedicineThe University of ArizonaTucsonAZ85721USA

Microplastics pollution has received growing attention worldwide in recent years.However,data on microplastics in the freshwater environment are still limited,especially in high-latitude nature reserves in Northern China.The first study on microplastic pollution in the Liaohe River Reserve in Northern China is reported here,and mesoplastics were also incorporated.Surface water and sediment samples were collected from 32 sites along the nature reserve.The abundance,type,shape,color,and size of micro-and mesoplastics were measured using density extraction,optical microscopy,and FTIR spectroscopy.The data showed that diverse micro-and mesoplastics were found widespread in the 32 sites,and the average abundance of these plastics was 0.11±0.0410^(–2) items/L in surface water and 62.29±54.30 items/kg in sediment.Moreover,70%and 66%were smaller than 2000μm in surface water and sediment,respectively.Fiber accounted for 91.86%in surface water and 43.48%in sediment,indicating that the major source of micro-and mesoplastics in the Liaohe River Reserve may be domestic sewage and aquaculture.A total of 16 and 27 polymers were identified in surface water and sediment,respectively,and mostly consisted of rayon,polyester,polystyrene,and poly(ethylene terephthalate).Moreover,both the risk index and the pollution load index demonstrated a low risk of micro-and mesoplastics in surface water and sediment in the Liaohe River Reserve.

关键词： Microplastics Mesoplastics Water Sediment Characteristic Risk Assessment

Electro-acupuncture at Zusanli(ST 36) to improve lower extremity motor function in sensory disturbance patients with cerebral stroke A randomized controlled study of 240 cases

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Neural Regeneration Research 2009年第11期4卷 935-940页

作者： Weijun gong Tong Zhang lihua Cui YuqiYang Xinting Sun Department of Neurological Rehabilitation Beijing Boai Hospital China Rehabilitation Research Centre School of Rehabilitation MedicineCapital Medical University Beijing 100068 China

BACKGROUND： Studies have shown that sensory transduction is a way to introduce needle sensation. OBJECTIVE： To observe the influence of electro-acupuncture at the ＂Zusanll＂（ST 36） point on lower extremity motor function in various sensory disturbance patients with cerebral stroke. DESIGN, TIME AND SETTING： A randomized, controlled, clinical study was performed at the Department of Neurological Rehabilitation, China Rehabilitation Research Centre from September 2006 to June 2008. PARTICIPANTS： Patients with first-time cerebral infarction or hemorrhage, or with a stroke history, but no neurodysfunction （single damage）, were selected for this study. The subjects were right-handed and disease state was stable. A total of 240 inpatients were randomly assigned to the following groups： electro-acupuncture （n = 124） and control （n = 116）. The two groups were further assigned into sub-groups： no sensory disturbance, superficial sensory disturbance, deep sensory disturbance, and deep and superficial sensory disturbance. METHODS： On the basis of routine limb function training, the acupoint Zusanliwas utilized in all patients from the electro-acupuncture group. Perpendicular acupuncture was 3.0-4.0 cm deep. An electric acupuncture instrument was connected when patients developed the needle sensation, deqi. A stimulation pattern consisting of distant and dense waves of 50 Hz was used to elicit slight dorsal foot extension. Acupuncture was administered 5 times per week, 30 minutes per session, for 6 weeks in total. MAIN OUTCOME MEASURES： FugI-Meyer assessment （FMA） was used to evaluate lower extremity motor function; Ver.1.0 gait analysis to estimate gait （step frequency, step speed, and step scope）; lower extremity Composite Spasticity Scale （CSS） to estimate muscle spastic degree. RESULTS： Following treatment, motor function improved in both groups. Compared with the control group, FMA score, step speed, step frequency, and step scope were increased in the electro-acupuncture group, but there was no difference in lower extr

关键词： electro-acupuncture Zusanli （ST 36） sensory disturbance motor function sensory input

Extracellular viscosity:a potential therapeutic target to combat cancer metastasis

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Clinical Cancer Bulletin 2022年第3期1卷 157-159页

作者： lihua HE Yue gong Yi-Zhou Jiang Department of Breast Surgery Fudan University Shanghai Cancer Center/Fudan University Breast Cancer InstituteShanghai 200032

Aberrant migration plays a key role in cancer development and is particularly significant during invasion,which is the initial step of metastasis.Research over the past decade has shown that cancer cell migration is affected by several physical stimuli within the tumor microenvironment.For example,tumor metastasis is driven by interstitial flow caused by high intertumoral interstitial fluid pressure1.Shellard et al.showed that cells follow gradients in the stiffness of the substrates to prompt collective cell migration in vitro2.However,the effect of extracellular viscosities on cell function remains unclear.

关键词： extracellular viscosity cell migration cancer metastasis

荸荠皮棕色素在食品加工与贮藏中的稳定性及抗氧化性研究

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中国食品添加剂 2024年第5期35卷 93-100页

作者：朱香澔龚钰雯方美甜赖金连李丽华伍淑婕罗杨合贺州学院食品与生物学院贺州542899 广西经贸职业技术学院南宁530000 广西科技大学柳州545000 广西康养食品科学与技术重点实验室贺州542899

探讨荸荠皮棕色素在马蹄糕、油炸薯条加工与米醋贮藏中的稳定性及相同条件模拟处理下的抗氧化活性变化。将自制的荸荠皮棕色素提取物应用于马蹄糕(蒸煮)、薯条(油炸)、米醋(低pH贮藏)等典型食品加工或贮藏中,以色价及其变化率、总色差... 详细信息

探讨荸荠皮棕色素在马蹄糕、油炸薯条加工与米醋贮藏中的稳定性及相同条件模拟处理下的抗氧化活性变化。将自制的荸荠皮棕色素提取物应用于马蹄糕(蒸煮)、薯条(油炸)、米醋(低pH贮藏)等典型食品加工或贮藏中,以色价及其变化率、总色差及其变化率为指标探讨其稳定性,并通过模拟加工条件处理后,研究荸荠皮棕色素的抗氧化活性变化。研究表明,荸荠皮棕色素适用于马蹄糕蒸煮加工,蒸煮时间20 min为宜;荸荠皮棕色素可用于油炸薯条加工,以190℃下油炸60 s最佳;荸荠皮棕色素不适用于35℃下紫外光照及低pH (2.45)的米醋贮藏。经模拟条件处理后的荸荠皮棕色素ASTS、DPPH清除能力均下降,抗氧化活性降低。

关键词：荸荠皮棕色素食品加工食品贮藏稳定性抗氧化活性

不同菌剂对边坡植物高羊茅种子萌发和土壤性质的影响

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山东农业工程学院学报 2024年第4期41卷 25-29页

作者：巩春娟江丽华吴广宁李静何秋月张桂斋任慧群王聪山东农业工程学院山东济南250100 山东高速绿色生态发展有限公司山东济南250100

近年来生态护坡已经成为高速公路建设中边坡防护的重要发展方向,但边坡坡度陡、坡面自然条件差和土壤肥力低对植物生长有不利影响,而微生物菌剂对植物的生长和土壤性质的改良具有良好的提高和改善效果。本文采用高羊茅为供试植物,定制... 详细信息

近年来生态护坡已经成为高速公路建设中边坡防护的重要发展方向,但边坡坡度陡、坡面自然条件差和土壤肥力低对植物生长有不利影响,而微生物菌剂对植物的生长和土壤性质的改良具有良好的提高和改善效果。本文采用高羊茅为供试植物,定制坡度为15°的铁箱模拟边坡,分别用枯草芽孢杆菌、贝莱斯芽孢杆菌和速生短杆菌拌土处理,研究不同菌剂对不同位置高羊茅种子萌发以及土壤性质的影响。试验表明,枯草芽孢杆菌和贝莱斯芽孢杆菌的添加对边坡不同位置上的高羊茅种子萌发和土壤性质的改良具有促进作用,但后者的促进作用略低于前者。速生短杆菌处理下的高羊茅发芽率低于对照组,土壤有机质、水解氮、速效磷含量与对照组相比无显著性差异。在同一处理下,边坡不同位置对种子发芽率和土壤性质有不同程度的影响,但其无显著差异(P>0.05)。综合来看,当高速公路边坡绿化选用高羊茅时,可施加枯草芽孢杆菌促进其的生长和改善土壤养分。

关键词：不同菌剂不同位置高羊茅种子萌发土壤性质

输尿管软镜手术与加速康复外科理念相结合治疗上尿路结石的应用效果

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中国医药指南 2024年第16期22卷 6-9页

作者：林浩群韦建海黄海健苏清华龚丽华刘建蔡文达马胜武东莞市黄江医院泌尿外科东莞523750

目的探索上尿路结石患者行输尿管软镜碎石术与加速康复外科理念相结合治疗模式对患者机体康复的控制情况。方法筛选2021年10月至2023年12月东莞市黄江医院收治的上尿路结石患者100例作为研究对象,按照随机信封抽签方式将患者分为两组... 详细信息

目的探索上尿路结石患者行输尿管软镜碎石术与加速康复外科理念相结合治疗模式对患者机体康复的控制情况。方法筛选2021年10月至2023年12月东莞市黄江医院收治的上尿路结石患者100例作为研究对象,按照随机信封抽签方式将患者分为两组,对照组行经皮肾镜碎石术+加速康复外科理念,观察组行输尿管软镜碎石术+加速康复外科理念,观察患者各项指标变化。结果观察组手术时间、术中出血量、肠鸣音恢复时间、术后肛门排气时间、住院时间均低于观察组(均P 0.05);干预后,观察组疼痛评分低于对照组(P 0.05)。结论上尿路结石患者开展输尿管软镜碎石术与加速康复外科理念相结合治疗可明显改善病情,有助于清除结石,且创伤相对较小,患者术后胃肠功能可快速恢复,减少并发症发生风险,为患者营造良好的康复环境,应用优势显著。

关键词：上尿路结石输尿管软镜手术加速康复外科理念

过渡金属配合物催化烯烃配位聚合综合实验的设计——催化剂构效关系的典型案例

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化工高等教育 2024年第1期41卷 141-148页

作者：李婷罗明玲覃峰陈伟强李家兴公培伟刘鹏郭丽华冯媛媛广东西顿新材料科技有限公司广东韶关512400 曲阜师范大学化学与化工学院山东曲阜273165

文章介绍了一个涉及合成化学多领域的综合实验,要求学生利用合成的有机配体制备相应的过渡金属配合物,并作为催化剂均相催化烯烃配位聚合,同时对所得聚合物性能进行测试。该实验串联了有机配体合成、金属配合物合成、高分子催化合成和... 详细信息

文章介绍了一个涉及合成化学多领域的综合实验,要求学生利用合成的有机配体制备相应的过渡金属配合物,并作为催化剂均相催化烯烃配位聚合,同时对所得聚合物性能进行测试。该实验串联了有机配体合成、金属配合物合成、高分子催化合成和高分子材料性能测试模块的内容,能让学生观察到烯烃配位聚合中的催化剂构效关系,有利于全面提高学生的学习兴趣、实验技能和独立思考能力。

关键词：过渡金属配合物配位聚合构效关系综合实验