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Deciphering In-vivo Cross-linking Mass Spectrometry Data for Dynamic Protein Structure Analysis

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Chemical Research in Chinese Universities 2022年第3期38卷 758-762页

作者： ZHAO Lili gong Zhou ZHAO Qun ZHANG lihua ZHANG Yukui CAS Key Laboratory of Separation Science for Analytical Chemistry National Chromatographic R.&A.CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023P.R.China University of Chinese Academy of Sciences Beijing100039P.R.China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430071P.R.China

Protein structure and protein-protein interactions(PPIs)are crucial for regulating cellular activities required for cell viability and homeostasis.Chemical cross-linking coupled with mass spectrometry(CXMS)has become a versatile tool providing insights into both protein structure with distance restraints and protein-protein interactions with interface sites.Cross-links as the most information-rich data in a CXMS experiment are responsible for the structural model validation and integrative modeling with high throughput and sensitivity.In this work,ensemble refinement of the existing protein structure against the in-vivo cross-linking distance restraints was performed for dynamic protein structure modeling and protein interaction binding interface building in the intracellular environment.These results indicate great potential of in-vivo CXMS data for providing a molecular basis of protein structural dynamics exploration and function performance.

关键词： In-vivo chemical cross-linking Cross-linking distance restraint Ensemble refinement Structural dynamics Disorder region

Power Synchronization Compensation Strategy Based on Second-order Compensation Links for Voltage-controlled Inverters in Microgrids

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1935-1947页

作者： Jiawei Dong Chunyang gong Jun Bao lihua Zhu Hui Chen Zhixin Wang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghaiChina Shanghai University of Electrical Power ShanghaiChina Shanghai Xilong Solar Energy Technology Co. Ltd.ShanghaiChina Shanghai Chint Power Systems Co. Ltd.ShanghaiChina College of Automation Engineering Shanghai University of Electric PowerShanghaiChina

A second-order compensation link is adopted to control voltage-controlled inverters(VCIs) in microgrid systems to enhance the performance of the power synchronization process of the inverter. The second-order compensation link is classified as both a real pole compensator(RPC) and a complex pole compensator(CPC) according to the pole position. Given a model for the VCI power output, the design process for the second-order compensation link, which is equipped with an RPC and a CPC, is detailed. Moreover, the frequency-domain compensation effects of the RPC and CPC are analyzed using the root locus and Bode diagrams of the system before and after compensation. Finally, the compensation effects of the two types of second-order compensators are compared with the commonly used high-pass filter using MATLAB/Simulink, which verifies the RPC and CPC strategies. Simulation results show that the two types of compensators designed in this study can effectively increase the system cutting frequency and improve the phase margin in the frequency domain while accelerating the power synchronization process, simultaneously making it smoother and reducing overshoot in the time domain. The RPC has better gain robustness, whereas the CPC has better time constant robustness. By implementing an RPC or a CPC, the dynamic time of the power synchronization compensation strategy is reduced within 0.5 s, and the overshoot is reduced within 10% in the experiments with two inverters.

关键词： Frequency-domain analysis power synchronization second-order compensation link stability voltage-controlled inverter(VCI) microgrid

Joint Optimization Scheme for the Reconfigurable Intelligent Surface-Assisted Untrusted Relay Networks

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China Communications 2023年第12期20卷 19-29页

作者： Lihua Gong Wei Xu Xiaoxiu Ding Nanrun Zhou Qibiao Zhu Department of Electronic Information Engineering Nanchang UniversityNanchang 330031China Shanghai Key Laboratory of Integrate Administration Technologies for Information Security School of Information Security EngineeringShanghai Jiao Tong UniversityShanghai 200240China

To further improve the secrecy rate,a joint optimization scheme for the reconfigurable intelligent surface(RIS)phase shift and the power allocation is proposed in the untrusted relay(UR)networks assisted by the RIS.The eavesdropping on the UR is interfered by a source-based jamming strategy.Under the constraints of unit modulus and total power,the RIS phase shift,the power allocation between the confidential signal and the jamming signal,and the power allocation between the source node and the UR are jointly optimized to maximize the secrecy rate.The complex multivariable coupling problem is decomposed into three sub-problems,and the non-convexity of the objective function and the constraints is solved with semi-definite relaxation.Simulation results indicate that the secrecy rate is remarkably enhanced with the proposed scheme compared with the equal power allocation scheme,the random phase shift scheme,and the no-RIS scheme.

关键词： iterative optimization physical layer security reconfigurable intelligent surface untrusted relay secrecy rate

Clinical and imaging features of phosphaturic mesenchymal tumors

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Chinese Medical Journal 2023年第3期136卷 351-353页

作者： Cheng Chang Aihong Yu Yuhua You Xiaoxin Peng Xiaoguang Cheng Xintong Li Wei Liang Lihua Gong Wei Deng Department of Radiology Beijing Jishuitan Hospitalthe 4th Medical College of Peking UniversityBeijing 100035China Department of Radiology Beijing Anding HospitalCapital Medical UniversityBeijing 100088China The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders Beijing 100088China Department of Pathology Beijing Jishuitan Hospitalthe 4th Medical College of Peking UniversityBeijing 100035China Department of Endocrinology Beijing Jishuitan Hospitalthe 4th Medical College of Peking UniversityBeijing 100035China

To the Editor:Phosphaturic mesenchymal tumor(PMT)is a rare,slowly progressive,histomorphologically distinct entity of tumors that can emerge anywhere in the body.[1]According to World Health Organization,PMT has two pathological types:benign and malignant.[2]PMT was discovered due to tumor-induced osteomalacia(TIO)and is increasingly accepted in recent years as the leading cause of TIO.[1]However,most published reports have focused on the clinicopathological,immunohistochemical,and molecular genetic studies on PMT rather than the radiological work-ups.[3,4]Hence,the aim of this study was to find the common imaging characteristics of PMT to assist clinical diagnosis.

关键词： tumors mesenchymal tumor

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紫外光对铝合金焊接接头腐蚀行为的影响

焊接学报 2022年第4期43卷 106-112,I0010页

作者：龚利华郭为民江苏科技大学镇江212003 中国船舶重工集团公司第七二五研究所海洋腐蚀与防护重点实验室青岛266237

通过光学显微镜分析研究了6061铝合金熔化极惰性气体保护焊(metal inter gas welding,MIG焊)和搅拌摩擦焊(friction stir welding,FSW)对接头组织的影响.结合极化曲线测试,比较了紫外光照射与暗态对预沉积NaCl的基材及焊接接头腐蚀行为... 详细信息

通过光学显微镜分析研究了6061铝合金熔化极惰性气体保护焊(metal inter gas welding,MIG焊)和搅拌摩擦焊(friction stir welding,FSW)对接头组织的影响.结合极化曲线测试,比较了紫外光照射与暗态对预沉积NaCl的基材及焊接接头腐蚀行为影响的差异.结果表明,MIG焊接头组织均匀性较差,焊缝Mg含量远高于母材,使得表现出较差的热力学稳定性.紫外光照射加速了铝合金焊接接头的腐蚀,尤其是明显加速了MIG焊接头的腐蚀.30天的紫外光照射对FSW接头的影响与母材相近.这些影响与材料本身的耐腐蚀性能及铝合金表面形成的半导体性质腐蚀产物密切有关.

关键词：紫外光铝合金焊接接头腐蚀行为

Occurrence and distribution of micro-and mesoplastics in the high-latitude nature reserve,northern China

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Frontiers of Environmental Science & Engineering 2022年第9期16卷 15-24页

作者： Wenwen gong Yu Xing lihua Han Anxiang Lu Han Qu Li Xu Beijing Research Center for Agricultural Standards and Testing Beijing Academy of Agriculture and Forestry ScienceBeijing 100097China Beijing Municipal Key Laboratory of Agriculture Environment Monitoring Beijing 100097China Department of Pharmacology College of MedicineThe University of ArizonaTucsonAZ85721USA

Microplastics pollution has received growing attention worldwide in recent years.However,data on microplastics in the freshwater environment are still limited,especially in high-latitude nature reserves in Northern China.The first study on microplastic pollution in the Liaohe River Reserve in Northern China is reported here,and mesoplastics were also incorporated.Surface water and sediment samples were collected from 32 sites along the nature reserve.The abundance,type,shape,color,and size of micro-and mesoplastics were measured using density extraction,optical microscopy,and FTIR spectroscopy.The data showed that diverse micro-and mesoplastics were found widespread in the 32 sites,and the average abundance of these plastics was 0.11±0.0410^(–2) items/L in surface water and 62.29±54.30 items/kg in sediment.Moreover,70%and 66%were smaller than 2000μm in surface water and sediment,respectively.Fiber accounted for 91.86%in surface water and 43.48%in sediment,indicating that the major source of micro-and mesoplastics in the Liaohe River Reserve may be domestic sewage and aquaculture.A total of 16 and 27 polymers were identified in surface water and sediment,respectively,and mostly consisted of rayon,polyester,polystyrene,and poly(ethylene terephthalate).Moreover,both the risk index and the pollution load index demonstrated a low risk of micro-and mesoplastics in surface water and sediment in the Liaohe River Reserve.

关键词： Microplastics Mesoplastics Water Sediment Characteristic Risk Assessment

Comparative mitochondrial genome analysis of Varunidae and its phylogenetic implications

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Acta Oceanologica Sinica 2022年第6期41卷 119-131页

作者： Ying Zhang Li gong Xinting Lu Zengliang Miao lihua Jiang Bingjian Liu Liqin Liu Pengfei Li Xu Zhang Zhenming Lü National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization Zhejiang Ocean UniversityZhoushan 316022China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry Guangxi Beibu Gulf Marine Research CenterGuangxi Academy of SciencesNanning 530007China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Complete mitochondrial genomes(mitogenomes)can indicate phylogenetic relationships,as well as useful information for gene rearrangement mechanisms and molecular evolution.Currently,the phylogenetic location of the genus Varuna(Brachyura:Varunidae)has not been well resolved mainly because of limited representatives(only two extant species).Here,we determined a new mitogenome of this genus(Varuna litterata)and added the published mitogenomes to reconstruct the phylogeny of Varunidae.The 16368-bp mitogenome contains the entire set of 37 genes and a putative control region.The characteristics of this newly sequenced mitogenome were described and compared with the other 15 Varunidae mitogenomes.All 16 analyzed mitogenomes have identical gene order and similar molecular features.The sliding window and genetic distance analyses demonstrate highly variable nucleotide diversity,with comparatively low variability of COI and COII,and high variability of ND6.The nonsynonymous/synonymous substitution rates(dN/dS ratio)analysis shows that all 13 PCGs are under purifying selection and ATP8 gene evolves under the least selective pressure.Twelve tRNA genes,two rRNAs,one PCG,and the putative control region are found to be rearranged with respect to the pancrustacean ground pattern gene order.Tandem duplication/random loss model is adopted to explain the large-scale gene rearrangement events occurring in Varunidae mitogenomes.Phylogenetic analyses show that all Varunidae species are placed into one group,and form a sister clade with Macrophthalmidae.Nevertheless,the phylogenetic relationships within Varunidae are not completely consistent based on the two different datasets used in this study.These findings will contribute to a better understanding of gene rearrangement and molecular evolution in Varunidae mitogenomes,as well as provide insights into the phylogenetic studies of Brachyura.

关键词： varunid crab Varuna litterata mitogenome gene rearrangement tandem duplication/random loss phylogeny

表面涂层和镀层受损后涂装电镀钢板的耐海洋大气腐蚀性能

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机械工程材料 2022年第8期46卷 117-121,126页

作者：龚利华潘峰江苏科技大学材料科学与工程学院镇江212003

采用划痕破坏表面涂层和镀层后,将涂装电镀锌钢板和电镀锌镍合金钢板在海洋大气环境中暴露2 a,研究了划痕附近的腐蚀产物微观形貌和元素分布,探讨了涂装电镀钢板表面涂层和镀层受损后的耐海洋大气腐蚀性能,并与原始电镀锌钢板和电镀锌... 详细信息

采用划痕破坏表面涂层和镀层后,将涂装电镀锌钢板和电镀锌镍合金钢板在海洋大气环境中暴露2 a,研究了划痕附近的腐蚀产物微观形貌和元素分布,探讨了涂装电镀钢板表面涂层和镀层受损后的耐海洋大气腐蚀性能,并与原始电镀锌钢板和电镀锌镍合金钢板进行对比。结果表明:原始电镀锌镍合金钢板的耐海洋大气腐蚀性能比电镀锌钢板差,这与电镀时电镀锌镍合金钢板镀层中产生的裂纹有关;涂装后,虽然锌镍合金镀层中仍然存在裂纹,但划痕附近的腐蚀宽度小于电镀锌钢板,说明划痕破坏后的涂装电镀锌镍合金钢板的耐海洋大气腐蚀性能优于电镀锌钢板,这与涂装前磷化处理所形成的磷酸盐堵塞裂纹,同时涂层的存在使腐蚀介质只能通过划痕侧面和涂层缺陷处到达镀层,而使镀层中的镍发挥出提高热力学稳定性的优势有关。

关键词：电镀锌钢板电镀锌镍合金钢板涂装划痕耐海洋大气腐蚀性能

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物料视觉分拣系统的研究与开发

南方农机 2023年第19期54卷 140-143,190页

作者：宫丽华承德应用技术职业学院河北承德067000

【目的】物料分拣是工农业生产不可或缺的环节,机械化分拣不仅能够节约成本、提高工作效率,而且能够提高分拣的准确率。【方法】笔者设计了一套简单、高效且低成本的自动分拣系统,分析了系统的硬件结构和软件结构。笔者选用西门子S7-120... 详细信息

【目的】物料分拣是工农业生产不可或缺的环节,机械化分拣不仅能够节约成本、提高工作效率,而且能够提高分拣的准确率。【方法】笔者设计了一套简单、高效且低成本的自动分拣系统,分析了系统的硬件结构和软件结构。笔者选用西门子S7-1200PLC作为该物料视觉分拣系统的控制核心,综合运用视觉控制器、变频器、编码器、电磁阀组、传感器、高速计数器、三相异步电机、气缸等设备,以亚龙YL-36A自动化装置为控制对象,进行系统调试。【结果】该系统能够对物料颜色及形状进行识别,实现对不同颜色物料的自动分拣,并且可以通过人机界面进行实时参数监测、手动调试或自动运行。【结论】该物料视觉分拣系统运行稳定,有利于改变传统的生产模式,提高生产效率,节约生产成本,经济效益显著。因此,大规模的现代化自动化物料传送与分拣,符合时代的发展趋势,值得广泛推广。

关键词：分拣 PLC 变频器高速计数器