检索结果-南通市图书馆

H2S protects against diabetes-accelerated atherosclerosis by preventing the activation of NLRP3 inflammasome

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第2期34卷 94-102页

作者： Qiao Zheng lihong pan Yong Ji Key Laboratory of Cardiovascular and Cerebrovascular Medicine Key Laboratory of Targeted Intervention of Cardiovascular DiseaseCollaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Hydrogen sulfide(H2S) is an important messenger for its strong anti-inflammatory effects, which may be involved in multiple cardiovascular diseases. In our previous study, we revealed that H2S attenuated diabetesaccelerated atherosclerosis through suppressing oxidative stress. Here we report that GYY4137, a H2S donor,reduced the plaque formation of aortic roots and the levels of both intercellular cell adhesion molecule 1(ICAM1)and vascular cell adhesion molecule 1(VCAM1) in diabetes-accelerated atherosclerotic cells and mouse models.The inflammatory factors of TNF-α, IL-1β, IL-6, and MCP1 were also significantly reduced by GYY4137.Mechanically, GYY4137 suppressed the activation of pyrin domain containing protein 3(NLRP3) inflammasome in diabetes-accelerated atherosclerosis conditions. Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and ox LDL could be reversed, indicating that H2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome. In conclusion, our study indicates that GYY4137 effectively protects against the development of diabetes-accelerated atherosclerosis by inhibiting inflammasome activation.

关键词： H2S NLRP3 inflammation diabetes-accelerated atherosclerosis

Expert consensus on difficulty assessment of endodontic therapy

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang pan Jian Yang Jiayuan Wu Yihuai pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

个体化营养干预联合运动指导对妊娠期糖尿病孕产妇血糖及体重的影响

在线全文

学校读者我要写书评

暂无评论

中国医药指南 2024年第16期22卷 120-122页

作者：潘丽红三明市将乐县白莲镇卫生院产科三明353300

目的探究个体化营养干预联合有氧-抗阻运动对妊娠期糖尿病(GDM)孕产妇血糖及体重控制的影响。方法选择2022年1月至2023年10月将乐县白莲镇卫生院收治的GDM患者78例,按随机数字表法分为对照组和观察组,两组各39例。对照组予以常规护理... 详细信息

目的探究个体化营养干预联合有氧-抗阻运动对妊娠期糖尿病(GDM)孕产妇血糖及体重控制的影响。方法选择2022年1月至2023年10月将乐县白莲镇卫生院收治的GDM患者78例,按随机数字表法分为对照组和观察组,两组各39例。对照组予以常规护理干预,观察组予以个体化营养干预联合有氧-抗阻运动,两组干预均持续至分娩结束。对比两组干预前后的血糖水平、体重控制、血脂水平及不良妊娠结局。结果干预后,观察组餐后2 h血糖、空腹血糖、糖化血红蛋白较对照组低(P<0.05);观察组孕期总增重低于对照组(P<0.05);观察组甘油三酯、总胆固醇低于对照组(P<0.05);观察组不良妊娠结局发生率低于对照组(P<0.05)。结论个体化营养干预与有氧-抗阻运动能够促进GDM患者的血糖水平及血脂水平恢复平稳,帮助患者更好地控制孕期增重,且有利于降低不良妊娠结局发生率。

关键词：妊娠期糖尿病个体化营养干预有氧-抗阻运动血糖体重控制不良妊娠结局

基于BiLSTM模型的BDS-3短期钟差预报精度研究

在线全文

学校读者我要写书评

暂无评论

测绘学报 2024年第1期53卷 65-78页

作者：潘雄黄伟凯赵万卓张思莹张龙杰金丽宏武汉纺织大学计算机与人工智能学院湖北武汉430200 武汉纺织大学数理科学学院湖北武汉430200

提出了一种改进的北斗钟差预测模型,将传统的单向长短期记忆神经网络(LSTM)扩展为双向长短期记忆网络(BiLSTM),引入了3种自适应匹配超参数的算法提高钟差数据短期预报的精度。首先,对LSTM进行优化,建立BiLSTM模型,介绍了超参数的3种选... 详细信息

提出了一种改进的北斗钟差预测模型,将传统的单向长短期记忆神经网络(LSTM)扩展为双向长短期记忆网络(BiLSTM),引入了3种自适应匹配超参数的算法提高钟差数据短期预报的精度。首先,对LSTM进行优化,建立BiLSTM模型,介绍了超参数的3种选择方案(粒子群搜索(PSO)、麻雀搜索(SSA)和贝叶斯搜索(BOA)),并给出了相应的适用范围。然后,详细介绍基于超参数优化BiLSTM模型的钟差预报的步骤。最后,利用GFZ卫星钟差数据,从不同轨道类型、5 min采样间隔、15 min采样间隔等方面进行了1、6和12 h的单天和多天预报对比试验,并进行了相应模型的时间复杂度分析。试验结果表明,采用超参数方案优化后的BiLSTM模型在进行1、6和12 h预报时,相较于二次多项式模型、灰色模型、长短期记忆神经网络的模型和BiLSTM模型,平均精度可分别提升86.21%、83.32%、69.99%和55.17%。在3种优化方案中,使用PSO算法对IGSO类型卫星的优化效果较好;使用BOA算法对MEO类型卫星的钟差优化效果较好;使用SSA算法在整体上优化效果最好。虽然经过超参数优化后的BiLSTM模型训练时间相对常用模型较长,但预报速度较快,总体上能够满足实时预报时间要求。

关键词：钟差预报 BiLSTM 超参数优化神经网络

基于深度学习的太赫兹编码频率选择表面优化设计

在线全文

学校读者我要写书评

暂无评论

激光与光电子学进展 2024年第4期61卷 341-348页

作者：周攀巩蕾阳志强王利国杨利红李瑶王海斌于洁西安工业大学光电工程学院陕西西安710021

针对太赫兹频率选择表面(FSS)单元结构复杂、参数繁多、优化耗时等问题,基于卷积神经网络(CNN)并结合遗传算法,提出一种FSS智能化融合设计方法,并将其应用于典型滤波FSS的性能优化设计。将FSS周期单元拓扑编码为16×16的“0/1”旋转对... 详细信息

针对太赫兹频率选择表面(FSS)单元结构复杂、参数繁多、优化耗时等问题,基于卷积神经网络(CNN)并结合遗传算法,提出一种FSS智能化融合设计方法,并将其应用于典型滤波FSS的性能优化设计。将FSS周期单元拓扑编码为16×16的“0/1”旋转对称序列,收集26000组0.5~3 THz的透反射光谱作为数据集,利用19层CNN实现光谱预测,对测试集的平均绝对误差低至0.06。利用预测光谱与目标光谱的差值,给出各类典型FSS设计的通用目标函数,结合遗传算法,设计实现了带宽为0.1 THz的单频带通和带阻FSS、带宽为0.5 THz的单频带通和带阻FSS、带宽为0.2 THz的双频带通FSS,且均具有良好极化稳定性。计算结果表明,通过优化设计FSS的拓扑编码,可以简洁高效地实现各类典型带通带阻FSS。

关键词：频率选择表面拓扑编码卷积神经网络遗传算法

1种罕见SERPINC1基因复合杂合突变及其机制研究

在线全文

学校读者我要写书评

暂无评论

中华检验医学杂志 2024年第3期47卷 301-307页

作者：张柯林双女谢海啸叶龙颖秦朗译潘景业杨丽红王明山温州医科大学附属第一医院医学检验中心浙江省检验诊断及转化研究重点实验室温州325015

目的对1个遗传性抗凝血酶(AT)缺陷症患者所携带的复合杂合突变进行分子机制研究。方法先证者因"突发晕厥并四肢抽搐一天"于2018年11月就诊于温州医科大学附属第一医院。采集先证者及其家系成员(共3代9人)外周静脉血并进行家系调查。采... 详细信息

目的对1个遗传性抗凝血酶(AT)缺陷症患者所携带的复合杂合突变进行分子机制研究。方法先证者因"突发晕厥并四肢抽搐一天"于2018年11月就诊于温州医科大学附属第一医院。采集先证者及其家系成员(共3代9人)外周静脉血并进行家系调查。采用发色底物法检测AT活性(AT:A),免疫比浊法检测AT抗原(AT:Ag)。对SERPINC1基因进行直接测序以确定突变位点。利用多种计算机工具预测突变的保守性和疏水性变化。构建重组质粒表达载体并瞬时转染HEK293T细胞以进行体外过表达研究。采用Western Blotting、ELISA和细胞免疫荧光实验对重组AT蛋白进行体外表征。结果先证者为一例21岁男性。AT:A为33%,AT:Ag同步下降,属于Ⅰ型AT缺陷症。基因分析显示先证者在第2和第5外显子分别携带c.318319insT(p.Asn107*)杂合插入突变和c.922G>T(p.Gly308Cys)杂合错义突变。该两个突变位点在同源物种中均完全保守;疏水性分析表明,p.Gly308Cys突变可能降低氨基酸残基307-313的亲水性。体外表达显示,重组蛋白AT-G308C在转染细胞裂解液和培养上清中的含量分别降低至46.98%±2.94%和41.35%±1.48%;经蛋白酶体抑制剂(MG132)处理后,Western Blotting分析显示在细胞质中的AT-G308C蛋白量恢复到与野生型相似的水平;在细胞裂解液和培养上清中均未检测到重组蛋白AT-N107*。结论p.Asn107*杂合插入突变和p.Gly308Cys杂合错义突变与该家系先证者AT水平降低有关。p.Asn107*杂合插入突变可能触发无义突变介导的mRNA降解,从而消除异常转录本;p.Gly308Cys杂合错义突变可能通过改变局部残基的疏水性导致AT蛋白在细胞质中发生蛋白酶体依赖性降解。

关键词：抗凝血酶类抗凝血酶缺陷症血栓形成复合杂合突变体外表达

Influence of Vertical Load on Lateral-Loaded Monopiles by Numerical Simulation

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第4期135卷 465-481页

作者： Qiang Li pan Chen lihong Gao Dan Meng Jinjie Zou Huadong Engineering(Shenzhen)Corporation Limited Shenzhen518100China Faculty of Civil Engineering and Geosciences Delft University of TechnologyDelft2628 CNThe Netherlands

Monopiles are the most common foundation form of offshore wind turbines,which bear the vertical load,lateral load and bending moment.It remains uncertain whether the applied vertical load increases the lateral deflection of the pile.This paper investigated the influence of vertical load on the behaviour of monopiles installed in the sand under combined load using three-dimensional numerical methods.The commercial software PLAXIS was used for simulations in this paper.Monopiles were modelled as a structure incorporating linear elastic material behaviour and soil was modelled using the Hardening-Soil(HS)constitutive model.The monopiles under vertical load,lateral load and combined vertical and lateral loads were respectively studied taking into account the sequence of load application and pile slenderness ratio(L/D;L and D are the length and diameter of the pile).Results suggest that the sequence of load application plays a major role in how vertical load affects the deflection behaviour of the pile.Specifically,when L/D ratios obtained by lengthening the pile while keeping its diameter constant are 3,5 and 8,the relationships between lateral load and the deflection behaviour of the pile under the effect of vertical load demonstrate a similar trend.Furthermore,the cause of increased lateral capacity of the pile under the action of applied vertical load in the common practical application case and in the VPL case was analyzed by studying the variation law of soil stress along the pile embedment.Results confirm that the confining effect of vertical load increases means effective stress of the soil around the pile,thus increasing soil stiffness and pile capacity.

关键词： Pile lateral capacity combined load sequence of load application L/D ratio

Investigation on the Folding Mode and Deployment Process of an Inflatable Boarding Platform for the Marine Emergency Evacuation System

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第4期135卷 483-510页

关键词： Pile lateral capacity combined load sequence of load application L/D ratio

草地贪夜蛾卵寄生蜂——夜蛾黑卵蜂的种内识别及过寄生

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国生物防治学报 2024年第1期40卷 1-11页

作者：薛陶然潘静刘丽红徐腾黄建何玉仙王竹红福建农林大学植物保护学院/闽台作物有害生物生态防控国家重点实验室福州350002 福建省农业科学院植物保护研究所福州350013

夜蛾黑卵蜂是重大入侵害虫草地贪夜蛾的重要卵期寄生蜂。为明确夜蛾黑卵蜂的种内识别及过寄生现象,测定了夜蛾黑卵蜂对被同种自体(同一个体)或异体(不同个体)雌蜂寄生不同时间间隔后的寄主卵的识别能力,并研究了单头和多头雌蜂在不同寄... 详细信息

夜蛾黑卵蜂是重大入侵害虫草地贪夜蛾的重要卵期寄生蜂。为明确夜蛾黑卵蜂的种内识别及过寄生现象,测定了夜蛾黑卵蜂对被同种自体(同一个体)或异体(不同个体)雌蜂寄生不同时间间隔后的寄主卵的识别能力,并研究了单头和多头雌蜂在不同寄主密度下的过寄生率。结果发现,无论自体或异体寄生识别,夜蛾黑卵蜂的过寄生率均为0。单头雌蜂在不同蜂卵比下寄生24 h后,寄主卵内寄生蜂1龄幼虫的百分比均小于100%,且每粒寄主卵内只有1头1龄幼虫。多头雌蜂在寄主数量充足条件下,当蜂卵比为1:100、2:200、4:400、6:600、8:800时,未被寄生的寄主卵的百分比分别为52.8%、67.2%、63.2%、53.6%和51.2%,含1头寄生蜂1龄幼虫的寄主卵的百分比分别为47.2%、32.8%、36.8%、46.4%和48.8%;多头雌蜂在寄主数量不足条件下,当蜂卵比为2:20、3:21、4:20、7:21、20:20时,夜蛾黑卵蜂的寄生率分别为60.0%、83.0%、95.0%、94.0%和96.0%,过寄生率分别为11.0%、38.0%、64.0%、73.0%和92.0%;单粒寄主卵内寄生蜂1龄幼虫的平均数量分别为0.4、0.6、1.1、1.3和2.1头,最大数量分别为3.0、4.0、5.0、6.0和12.0头。结果表明,夜蛾黑卵蜂具有自体和异体寄生识别能力;单头雌蜂的过寄生率与寄主数量无关;多头雌蜂在寄主数量充足的条件下,不会产生过寄生;但在寄主数量不足的条件下,随着蜂卵比升高,寄生率、过寄生率、单粒草地贪夜蛾卵内寄生蜂1龄幼虫的平均数和最大数均随之增加。蜂卵比为4:20时寄生率高,过寄生率低,内部竞争低,是较为合适的接蜂比例。

关键词：夜蛾黑卵蜂草地贪夜蛾种内识别过寄生