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Cellulose-based Polymeric Liquid Crystals as a Biomimetic Modifier for Suppressing Protein Adsorption

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Journal of Wuhan University of Technology(Materials Science) 2015年第2期30卷 416-422页

作者：司徒方民 TAN Ruizhe GONG Lei ZHA zhengang 屠美 ZENG Rong WU Hao ZHANG Jiaqing zheng liheng College of Chinese and Culture Jinan University Department of Materials Science and Engineering College of Science and Engineering Jinan University The First Affiliated Hospital Jinan University School of medicine Jinan University Macao Medical Science & Technology Research Association

A novel biomimetic protein-resistant modifier based on cellulose-based polymeric liquid crystals was described（PLCs）. Two types of PLCs of propyl hydroxypropyl cellulose ester（PPC） and octyl hydroxypropyl cellulose ester（OPC） were prepared by esterification from hydroxypropyl cellulose, and then were mixed with polyvinyl chloride and polyurethane to obtain composite films by solution casting, respectively. The surface morphology of PLCs and their composite films were characterized by polarized optical microscopy（POM） and scanning electron microscopy（SEM）, suggesting the existence of microdomain separation with fingerprint texture in PLC composite films. Water contact angle measurement results indicated that hydrophilicity of PLC/polymer composite films was dependent on the type and content of PLC as well as the type of matrix due to their interaction. Using bovine serum albumin（BSA） as a model protein, protein adsorption results revealed that PLCs with protein-resistant property can obviously suppress protein adsorption on their composite films, probably due to their flexible LC state. Moreover, all PLCs and their composites exhibited non-toxicity by MTT assay, suggesting their safety for biomedical applications.

关键词： polymeric liquid crystals cellulose biomimetic protein adsorption biocompatibility

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皮疽诺卡菌导致中枢神经系统感染一例

脑与神经疾病杂志 2024年第7期32卷 444-448页

作者：张亚楠张永亮赵萌郑立恒陈颜强河北省胸科医院石家庄050000 河北医科大学第二医院

目的分析河北省胸科医院神经内科收治的1例皮疽诺卡菌导致中枢神经系统感染患者的临床资料,为临床医师提供参考。方法本文报道1例由皮疽诺卡菌引起的脑脓肿病历,该患者早期主要表现为发热伴头痛,后期表现为意识障碍伴抽搐。患者先后曾住... 详细信息

目的分析河北省胸科医院神经内科收治的1例皮疽诺卡菌导致中枢神经系统感染患者的临床资料,为临床医师提供参考。方法本文报道1例由皮疽诺卡菌引起的脑脓肿病历,该患者早期主要表现为发热伴头痛,后期表现为意识障碍伴抽搐。患者先后曾住院3次,于2019年7月6日就诊于河北省胸科医院,通过脑脊液二代基因测序中发现病原体为皮疽诺卡菌,肺泡灌洗液培养发现诺卡菌,实施靶向复方磺胺甲噁唑治疗,症状未见缓解,后期合并了肺部念珠菌感染,并死于急性呼吸窘迫综合征。结果患者通过二代基因测序检测为诺卡菌,同时肺泡灌洗液发现该菌,并给予靶向抗生素治疗,后因急性呼吸窘迫症死亡。结论诺卡菌病临床表现无特异性,易被误诊。二代基因测序是一种无需培养的快速检测方法,可用于直接鉴定临床标本中的微生物;皮疽诺卡菌感染中枢神经系统的诊断以及鉴别诊断有更重要的意义。

关键词：皮疽诺卡菌中枢神经系统感染结核菌二代基因测序

Field distribution of the Z_(2)topological edge state revealed by cathodoluminescence nanoscopy

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Opto-Electronic Advances 2022年第4期5卷 76-84页

作者： Xiao He Donglin Liu Hongfei Wang liheng zheng Bo Xu Biye Xie Meiling Jiang Zhixin Liu Jin Zhang Minghui Lu Zheyu Fang School of Physics State Key Lab for Mesoscopic PhysicsAcademy for Advanced Interdisciplinary StudiesCollaborative Innovation Center of Quantum Matterand Nano-optoelectronics Frontier Center of Ministry of EducationPeking University Yangtze Delta Institute of OptoelectronicsPeking UniversityBeijing 100871China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringNanjing UniversityNanjing 210093China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Department of Physics and HKU-UCAS Joint Institute for Theoretical and Computational Physics at Hong Kong the University of Hong KongPokfulam RoadHong KongChina

Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode ***,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge ***,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical *** investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices.

关键词： photonic topological insulator edge state cathodoluminescence TMDC

Programmable Self-Assembly of Gold Nanoarrows via Regioselective Adsorption

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Research 2021年第1期2021卷 727-736页

作者： Cheng Chen liheng zheng Fucheng Guo Zheyu Fang Limin Qi Beijing National Laboratory for Molecular Sciences(BNLMS) College of ChemistryPeking UniversityBeijing 100871China State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum MatterSchool of PhysicsPeking UniversityBeijing 100871China

Programing the self-assembly of colloidal nanoparticles into predetermined superstructures represents an attractive strategy to realize functional assemblies and novel nanodevices,but it remains a ***,gold nanoarrows(GNAs)showing a distinct convex-concave structure were employed as unique building blocks for programmable self-assembly involving multiple assembly *** adsorption of 1,10-decanedithiol on the vertexes,edges,and facets of GNAs allowed for programmable self-assembly of GNAs with five distinct assembly modes,and regioselective blocking with 1-dodecanethiol followed by adsorption of 1,10-decanedithiol gave rise to programmable self-assembly with six assembly modes including three novel wing-engaged *** assembly mode was essentially determined by regioselective adsorption of the dithiol linker dictated by the local curvature together with the shape complementarity of *** approach reveals how the geometric morphology of nanoparticles affects their regioselective functionalization and drives their self-assembly.

关键词： adsorption Adsorption curvature

血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6在结核性胸膜炎胸膜纤维化患者中的变化及临床意义

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国际检验医学杂志 2024年第15期45卷 1828-1833,1838页

作者：张晓光吕培高江彦石良静王永军郑立恒刘会河北省胸科医院医务处河北石家庄050041 河北省胸科医院肾内科河北石家庄050041 河北省胸科医院检验科河北石家庄050041 河北省胸科医院感染性疾病科河北石家庄050041

目的探讨血清和胸腔积液纤溶酶原激活剂抑制物-1(PAI-1)、转化生长因子-β(TGF-β)、血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)在结核性胸膜炎胸膜纤维化患者中的变化及临床意义。方法选取2020年7月至2023年7月该院收治的103例结核... 详细信息

目的探讨血清和胸腔积液纤溶酶原激活剂抑制物-1(PAI-1)、转化生长因子-β(TGF-β)、血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)在结核性胸膜炎胸膜纤维化患者中的变化及临床意义。方法选取2020年7月至2023年7月该院收治的103例结核性胸膜炎胸膜纤维化患者作为研究对象,治疗2周后,根据糖皮质激素治疗疗效将其分为显效组、非显效组。比较两组治疗前及治疗1、2周后血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平。采用Spearman相关分析血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平与疗效的相关性。治疗2周后血清PAI-1、TGF-β、VEGF、IL-6水平与胸腔积液中该指标水平之间进行Pearson相关分析。绘制受试者工作特征曲线分析治疗1、2周后血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平对结核性胸膜炎胸膜纤维化患者疗效的预测价值。结果两组治疗1、2周后血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平低于治疗前,显效组治疗1、2周后血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平低于非显效组,差异有统计学意义(P<0.05)。治疗1、2周后血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平与疗效呈负相关(P<0.05)。治疗2周后血清PAI-1、TGF-β、VEGF、IL-6水平和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平呈正相关(r=0.761、0.783、0.812、0.741,均P<0.05)。治疗1、2周后血清和胸腔积液各指标联合检测的曲线下面积(AUC)大于其单独指标的AUC(P<0.05)。结论结核性胸膜炎胸膜纤维化患者血清和胸腔积液PAI-1、TGF-β、VEGF、IL-6水平与疗效有关,血清及胸腔积液PAI-1、TGF-β、VEGF、IL-6联合检测的预测价值较好,能够为临床干预提供参考依据。

关键词：胸膜纤维化纤溶酶原激活剂抑制物-1 转化生长因子-β 血管内皮生长因子白细胞介素-6

Phonon scattering and exciton localization: molding exciton flux in two dimensional disorder energy landscape

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eLight 2021年第1期1卷 57-68页

作者： Pengfei Qi Yang Luo Beibei Shi Wei Li Donglin Liu liheng zheng Zhixin Liu Yanglong Hou Zheyu Fang School of Physics State Key Laboratory for Mesoscopic PhysicsAcademy for Advanced Interdisciplinary StudiesCollaborative Innovation Center of Quantum MatterNano-Optoelectronics Frontier Center of Ministry of EducationPeking UniversityBeijing 100871China. Institute of Modern Optics Tianjin Key Laboratory of Micro-Scale Optical Information Science and TechnologyNankai UniversityTianjin 300350China. Beijing Key Laboratory for Magnetoelectric Materials and Devices Beijing Innovation Centre for Engineering Science and Advanced TechnologyDepartment of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China.

Two dimensional excitonic devices are of great potential to overcome the dilemma of response time and integration in current generation of electron or/and photon based *** ultrashort diffusion length of exciton arising from ultrafast relaxation and low carrier mobility greatly discounts the performance of excitonic *** scattering and exciton localization are crucial to understand the modulation of exciton flux in two dimensional disorder energy landscape,which still remain ***,we report an optimized scheme for exciton diffusion and relaxation dominated by phonon scattering and disorder potentials in WSe2 *** effective diffusion coefficient is enhanced by>200%at 280 *** excitons tend to be localized by disorder potentials accompanied by the steadily weakening of phonon scattering when temperature drops to 260 K,and the onset of exciton localization brings forward as decreasing *** findings identify that phonon scattering and disorder potentials are of great importance for long-range exciton diffusion and thermal management in exciton based systems,and lay a firm foundation for the development of functional excitonic devices.

关键词： Exciton diffusion Exciton relaxation 2D semiconductors Phonon scattering Disorder potentials

Large Rabi splitting obtained in Ag‐WS2 strong‐coupling heterostructure with optical microcavity at room temperature

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Opto-Electronic Advances 2019年第5期2卷 1-9页

作者： Bowen Li Shuai Zu Zhepeng Zhang liheng zheng Qiao Jiang Bowen Du Yang Luo Yongji Gong Yanfeng Zhang Feng Lin Bo Shen Xing Zhu Pulickel M. Ajayan Zheyu Fang School of Physics State Key Laboratory for Mesoscopic Physics Academy for Advanced Interdisciplinary Studies and Nano-optoelectronics Frontier Center of Ministry of Education Peking University Beijing 100871 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Department of Materials Science and NanoEngineering Rice University 6100 Main Street Houston TX 77005 USA Collaborative Innovation Center of Quantum Matter Beijing 100871 China

Manipulation of light-matter interaction is critical in modern physics, especially in the strong coupling regime, where the generated half-light, half-matter bosonic quasiparticles as polaritons are important for fundamental quantum science and applications of optoelectronics and nonlinear optics. Two-dimensional transition metal dichalcogenides (TMDs) are ideal platforms to investigate the strong coupling because of their huge exciton binding energy and large absorption coefficients. Further studies on strong exciton-plasmon coupling by combining TMDs with metallic nanostructures have generated broad interests in recent years. However, because of the huge plasmon radiative damping, the observation of strong coupling is significantly limited at room temperature. Here, we demonstrate that a large Rabi splitting (~300 meV) can be achieved at ambient conditions in the strong coupling regime by embedding Ag-WS2 heterostructure in an optical microcavity. The generated quasiparticle with part-plasmon, part-exciton and part-light is analyzed with Hopfield coefficients that are calculated by using three-coupled oscillator model. The resulted plasmon-exciton polaritonic hybrid states can efficiently enlarge the obtained Rabi splitting, which paves the way for the practical applications of polaritonic devices based on ultrathin materials.

关键词： Rabi splitting strong coupling transition metal dichalcogenides optical microcavity surface plasmons

Helically Grooved Gold Nanoarrows: Controlled Fabrication, Superhelix, and Transcribed Chiroptical Switching

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CCS Chemistry 2021年第9期3卷 2473-2484页

作者： Song Wang liheng zheng Wenjie Chen Lukang Ji Li Zhang Wensheng Lu Zheyu Fang Fucheng Guo Limin Qi Minghua Liu Beijing National Laboratory for Molecular Science(BNLMS) CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing 100871 Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesCollege of ChemistryPeking UniversityBeijing 100871

Plasmonic chiroptical materials,coupled by chirality and surface plasmons,have been attracting great interest due to their potential applications,such as photonics,chiral recognition,asymmetric catalysis and ***,we constructed a new chiral plasmonic nanostructure—helically grooved gold nanoarrows(HeliGNAs)by introducing L-/Dcysteine(L-/D-Cys)during the growth of the gold nanoarrows(GNAs).The variation of the concentration of L-/D-Cys leads to the HeliGNAs with a tunable plasmonic circular dichroism(PCD).

关键词： helically grooved gold nanoarrows superhelix plasmonic circular dichroism L-/D-cysteine chiroptical switch

Giant excitonic upconverted emission from two-dimensional semiconductor in doubly resonant plasmonic nanocavity

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Light(Science & Applications) 2022年第7期11卷 1523-1534页

作者： Pengfei Qi Yuchen Dai Yang Luo Guangyi Tao liheng zheng Donglin Liu Tianhao Zhang Jiadong Zhou Bo Shen Feng Lin zheng Liu Zheyu Fang School of Physics State Key Laboratory for Mesoscopic PhysicsAcademy for Advanced Interdisciplinary StudiesCollaborative Innovation Center of Quantum MatterNano-optoelectronics Frontier Center of Ministry of EducationPeking UniversityBeijing 100871China Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China Photonics Research Center School of PhysicsMOE Key Lab of Weak-Light Nonlinear Photonicsand Tianjin Key Lab of Photonics Materials and Technology for Information ScienceNankai UniversityTianjin 300071China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

Phonon-assisted upconverted emission is the heart of energy harvesting,bioimaging,optical cryptography,and optical *** has been demonstrated that emerging two-dimensional(2D)semiconductors can provide an excellent platform for efficient phonon-assisted upconversion due to the enhanced optical transition strength and phonon-exciton interaction of 2D ***,there is little research on the further enhancement of excitonic upconverted emission in 2D ***,we report the enhanced multiphoton upconverted emission of 2D excitons in doubly resonant plasmonic *** to the enhanced light collection,enhanced excitation rate,and quantum efficiency enhancement arising from the Purcell effect,an upconverted emission amplification of>1000-fold and a decrease of 2~3 orders of magnitude in the saturated excitation power are *** findings pave the way for the development of excitonic upconversion lasing,nanoscopic thermometry,and sensing,revealing the possibility of optical refrigeration in future 2D electronic or excitonic devices.

关键词： converted resonant doubly