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Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress

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Chinese Chemical Letters 2020年第7期31卷 1801-1806页

作者： Yahui Yang Yifan Wang ligeng xu Tianfeng Chen Department of Chemistry Jinan UniversityGuangzhou 510632China

Tumor cell resistance is one of the big hurdles limiting the therapeutic efficacy of tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)-based cancer ***,the development of a sa fe and effective sensitizer agent is greatly desired for optimizing TRAIL ***,we successfully developed a Se/Fe complex with low toxicity to highly effectively inhibit tumor cells proliferation and migration capabilities through down-regulating ER stress related ***,it could more efficiently damage tumor spheroids with good penetration *** importantly,it could synergize with TRAIL treatment to induce the robust generation of reactive oxygen species(ROS),downregulating ER stress related selenoproteins for triggering tumor cells apoptosis in extrinsic and intrinsic signaling *** together,this study provides a potential chemo-drug and sensitizer agent to improve the therapeutic efficacy of TRAIL-based cancer treatment.

关键词： Se/Fe complex TRAIL ER stress ROS Cancer treatment

Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells

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Nano Research 2014年第9期7卷 1327-1336页

作者： Shuai Fang Chao Wang Jian Xiang Liang Cheng xuejiao Song ligeng xu Rui Peng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Suzhou Jiangsu 215123 China

Detection of circulating tumor cells （CTCs） plays an important role in cancer diagnosis and prognosis. In this study, aptamer-conjugated upconversion nano- particles （UCNPs） are used for the first time as nanoprobes to recognize tumor cells, which are then enriched by attaching with magnetic nanoparticles （MNPs） and placing in the presence of a magnetic field. Owing to the autofluorescence- free nature of upconversion luminescence imaging, as well as the use of magnetic separation to further reduce background signals, our technique allows for highly sensitive detection and collection of small numbers of tumor cells spiked into healthy blood samples, and shows promise for CTC detection in medical diagnostics.

关键词： circulating tumar cell (CTC)detection upconversion nanoparticles magnetic nanoparticles aptamer

Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine

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Signal Transduction and Targeted Therapy 2023年第3期8卷 921-923页

作者： Haoqiang Lai ligeng xu Chang Liu Sujiang Shi Yalin Jiang Yangyang Yu Bo Deng Tianfeng Chen Department of Oncology The First Affiliated HospitalDepartment of ChemistryJinan UniversityGuangzhou 510632China

Dear Editor,The COVID-19 pandemic still greatly threatens the public health worldwide and novel vaccines to highly effectively combat SARS-CoV-2 remains an unmet clinical ***,redox imbalance in immune cells under extra stimulation by vaccine or pathogens greatly dampens the quality of the induced immunity.1 In addition,people infected with COVID-19 that characterized by immune system malfunction were also approved to be attributed by the robust oxidative stress.

关键词： immunity vaccine stimulation

Se/Fe complex restrains selenoprotein to upregulate ROS generation trigger endoplasmic reticulum stress,a mechanism involved in TRAIL sensitization

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Se/Fe complex restrains selenoprotein to upregulate ROS gene...

厦门市北溪引水主干渠改造工程基坑及围护设计

第十一届全国化学生物学学术会议

作者： Yahui Yang Yifang Wang ligeng xu Tianfeng Chen Department of Chemistry Jinan University

Tumor cell resistance is one of the big hurdle limiting the therapeutic efficacy of tumor necrosis factor-related apoptosis-inducing ligand（TRAIL）-based cancer ***,the development of a safe and effective sensitizer agent is greatly desired for optimizing TRAIL ***,we successfully developed a Se/Fe complex with low toxicity to effectively inhibit tumor cells proliferation and migration capabilities through down-regulating ER stress related ***,it could more efficiently damage tumor spheroids with good penetration *** importantly,it could synergize with TRAIL treatment to induce robust ROS generation,down-regulating ER stress related selenoproteins for triggering tumor cells apoptosis in extrinsic and intrinsic signaling *** together,this study provides a potential chemo-drug and sensitizer agent to improve the therapeutic efficacy of TRAIL-based cancer treatment.

关键词： Se/Fe complex TRAIL selenoproteins ROS generation apoptosis

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城市道桥与防洪 2023年第2期 188-192,201页

作者：许励耕厦门市市政建设开发有限公司福建厦门361008

以北溪引水主干渠改造工程为背景,基于不同工程段提出不同基坑支护方案进行比选,得到基坑分段设计方案:具备放坡开挖界面时采用放坡开挖方式进行施工;不具备开挖界面时采用板式支护体系+内支撑的方式进行施工;过河段采用钻孔灌注桩+三... 详细信息

以北溪引水主干渠改造工程为背景,基于不同工程段提出不同基坑支护方案进行比选,得到基坑分段设计方案:具备放坡开挖界面时采用放坡开挖方式进行施工;不具备开挖界面时采用板式支护体系+内支撑的方式进行施工;过河段采用钻孔灌注桩+三轴搅拌桩止水进行基坑支护,同时兼有未来保护倒虹吸功能。

关键词：基坑围护设计分段方案比选

浅谈共玉公路工地试验室标准化建设与规范化管理

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青海交通科技 2014年第3期26卷 15-18页

作者：徐利更谢金青海省共玉公路第二项目办中心试验室西宁810008 青海省海南天和路桥工程有限公司共玉B4标西宁810008

文章介绍了共玉高速公路工地试验室的建设与管理工作的一些经验和做法。

关键词：道路工程工地试验室标准化建设规范化管理

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北溪引水主干渠改造平面方案比选及水力计算

城市道桥与防洪 2022年第10期 111-114,M0012页

作者：许励耕王璐璐厦门市市政建设开发有限公司福建厦门361008 上海市政工程设计研究总院(集团)有限公司上海市200092

基于北溪引水主干渠改造中灌新路节点形式提出3种平面布置方案,通过渠线选择、水力计算、造价等方面的比选可知,利用现状箱涵过灌新路隧道使得水头损失较小、不占用地块、对4号线影响较小。同时,结合其他因素确定改造工程选线平面方案,... 详细信息

基于北溪引水主干渠改造中灌新路节点形式提出3种平面布置方案,通过渠线选择、水力计算、造价等方面的比选可知,利用现状箱涵过灌新路隧道使得水头损失较小、不占用地块、对4号线影响较小。同时,结合其他因素确定改造工程选线平面方案,进行新旧箱涵水力复核计算,为类似工程提供参考。

关键词：北溪引水主干渠方案比选水力计算

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襟翼舵吊装及安装工艺研究

广东造船 2024年第3期43卷 89-92页

作者：蔡益晏波徐利耿张英侨中船黄埔文冲船舶有限公司广州510715

襟翼舵是船舵中的一种,是保障船舶操纵性的关键系统设备,其结构尺寸较大,对中精度要求高,因安装位置等原因,吊装难度大。本文设计制作了一种襟翼舵的吊装工装,研究了襟翼舵的吊装安装方法,通过设置吊梁的方式解决吊装位置受限的问题,蜗... 详细信息

襟翼舵是船舵中的一种,是保障船舶操纵性的关键系统设备,其结构尺寸较大,对中精度要求高,因安装位置等原因,吊装难度大。本文设计制作了一种襟翼舵的吊装工装,研究了襟翼舵的吊装安装方法,通过设置吊梁的方式解决吊装位置受限的问题,蜗轮蜗杆箱实现襟翼舵位置及姿态的调整,安全便捷地实现了襟翼舵的吊装安装,降低了劳动强度,提高了工作效率。

关键词：襟翼舵吊装对中工装吊梁蜗轮蜗杆箱关节轴承

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis