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Optimization of Gas-Flooding Fracturing Development in Ultra-Low Permeability Reservoirs

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Fluid Dynamics & Materials Processing 2024年第3期20卷 595-607页

作者： lifeng liu Menghe Shi Jianhui Wang Wendong Wang Yuliang Su Xinyu Zhuang Tight Oil Research Institute PetroChina Research Institute of Petroleum Exploration&DevelopmentBeijing100083China Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Qingdao266580China Oil&Gas Technology Research Institute Changqing Oilfield CompanyXi’an710018China

Ultra-low permeability reservoirs are characterized by small pore throats and poor physical properties, which areat the root of well-known problems related to injection and production. In this study, a gas injection floodingapproach is analyzed in the framework of numerical simulations. In particular, the sequence and timing of fracturechanneling and the related impact on production are considered for horizontal wells with different fracturemorphologies. Useful data and information are provided about the regulation of gas channeling and possible strategiesto delay gas channeling and optimize the gas injection volume and fracture parameters. It is shown that inorder to mitigate gas channeling and ensure high production, fracture length on the sides can be controlled andlonger fractures can be created in the middle by which full gas flooding is obtained at the fracture location in themiddle of the horizontal well. A Differential Evolution (DE) algorithm is provided by which the gas injectionvolume and the fracture parameters of gas injection flooding can be optimized. It is shown that an improvedoil recovery factor as high as 6% can be obtained.

关键词： Ultra-low permeability reservoir gas injection flooding component simulation fracture parameters intelligent optimization differential evolution

Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo Rita Marques Adélio Mendes lifeng liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA

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Chinese Medical Journal 2024年第6期137卷 729-736页

作者： Lin Yuan Zhiying liu Xin Zhang Feili Wei Shan Guo Na Guo lifeng liu Zhenglai Ma Yunxia Ji Rui Wang Xiaofan Lu Zhen Li Wei Xia Hao Wu Tong Zhang Bin Su Beijing Key Laboratory for HIV/AIDS Research Clinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Background:Total human immunodeficiency virus(HIV)DNA and integrated HIV DNA are widely used markers of HIV *** digital polymerase chain reaction(ddPCR)can be used for absolute quantification without needing a standard ***,we developed duplex ddPCR assays to detect and quantify total HIV DNA and integrated HIV ***:The limit of detection,dynamic ranges,sensitivity,and reproducibility were evaluated by plasmid constructs containing both the HIV long terminal repeat(LTR)and human CD3 gene(for total HIV DNA)and ACH-2 cells(for integrated HIV DNA).Forty-two cases on stable suppressive antiretroviral therapy(ART)were assayed in total HIV DNA and integrated HIV *** coefficient analysis was performed on the data related to DNA copies and cluster of differentiation 4 positive(CD4^(+))T-cell counts,CD8^(+)T-cell counts and CD4/CD8 T-cell ratio,*** assay linear dynamic range and lower limit of detection(LLOD)were also ***:The assay could detect the presence of HIV-1 copies 100%at concentrations of 6.3 copies/reaction,and the estimated LLOD of the ddPCR assay was 4.4 HIV DNA copies/reaction(95%confidence intervals[CI]:3.6-6.5 copies/reaction)with linearity over a 5-log_(10)-unit range in total HIV DNA *** the integrated HIV DNA assay,the LLOD was 8.0 copies/reaction(95%CI:5.8-16.6 copies/reaction)with linearity over a 3-log 10-unit *** HIV DNA in CD4^(+)T cells was positively associated with integrated HIV DNA(r=0.76,P<0.0001).Meanwhile,both total HIV DNA and integrated HIV DNA in CD4^(+)T cells were inversely correlated with the ratio of CD4/CD8 but positively correlated with the CD8^(+)T-cell ***:This ddPCR assay can quantify total HIV DNA and integrated HIV DNA efficiently with robustness and *** can be readily adapted for measuring HIV DNA with non-B clades,and it could be beneficial for testing in clinical trials.

关键词： Human immunodeficiency virus HIV Integrated HIV-1 DNA Total HIV DNA Droplet digital polymerase chain reaction HIV reservoir Antiretroviral therapy

Human mpox co-infection with advanced HIV-1 and XDR-TB in a MSM patient previously vaccinated against smallpox:A case report

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Biosafety and Health 2024年第3期6卷 186-190页

作者： Yuan Fang Fuchun Wang Taiyi Jiang Junyi Duan Tao Huang Hao liu Lin Jia Han Jia Benyong Yan Mei Zhang Wen Wang Caiping Guo lifeng liu Yuening Zhang Tong Zhang Beijing Youan Hospital Capital Medical UniversityBeijing 100069China

Mpox is a zoonotic infectious disease caused by the mpox virus(MPXV).Historically,the majority of mpox cases have been documented in Central ***,since May 2022,there has been a notable rise in reported cases from regions beyond ***,over 110 countries spanning Europe,North America,South America,Asia,and other territories have reported mpox *** report details a case involving a patient who identifies as a man who has sex with men(MSM)and is concurrently infected with MPXV,human immunodeficiency virus type 1(HIV-1),Pneumocystis jiroveci,as well as extensively drug-resistant tuberculosis(XDR-TB).This patient had also received a vaccination for smallpox in the ***,we provide photographic documentation charting the progression of dermatological manifestations associated with *** case highlights the significance of sexual intercourse as a crucial mode of transmission for *** rapid and widespread dissemination of the MPXV across various regions,especially among MSM communities,underscores the importance of enhancing preventive education efforts targeted at high-risk populations.

关键词： Mpox Mpox virus(MPXV) Human immunodeficiency virus type 1 (HIV-1)Extensively drug-resistant tuberculosis(XDR-TB)

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预康复在肺癌患者中应用的研究进展

军事护理 2024年第1期41卷 40-42,60页

作者：张方圆刘丽峰天津医科大学肿瘤医院肺部肿瘤科天津300060

肺癌作为最常见的恶性肿瘤之一,其在国内的发病率和病死率均居恶性肿瘤首位[1],作为一个人口大国,我国所面临的肺癌癌症负担沉重。外科手术是中早期肺癌的主要治疗手段,也是目前临床治愈肺癌的重要方法[2]。

关键词：早期肺癌外科手术临床治愈恶性肿瘤人口大国治疗手段预康复病死率

pH响应型药物递送系统在肿瘤免疫治疗领域的研究进展

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中国药科大学学报 2024年第4期55卷 522-529页

作者：王世豪刘力凤丁杨李苏昕中国药科大学药学院药剂系南京211198

肿瘤免疫疗法是激活宿主自身免疫系统对抗肿瘤的治疗方式,已广泛应用于临床,然而存在响应率低、免疫相关不良事件等缺陷。有别于传统的化学治疗,免疫治疗的靶标表现出更为广泛的空间异质性,分布在不同细胞类型及二级细胞器中,药物分子... 详细信息

肿瘤免疫疗法是激活宿主自身免疫系统对抗肿瘤的治疗方式,已广泛应用于临床,然而存在响应率低、免疫相关不良事件等缺陷。有别于传统的化学治疗,免疫治疗的靶标表现出更为广泛的空间异质性,分布在不同细胞类型及二级细胞器中,药物分子易产生脱靶与在靶毒性,极大地影响了治疗的有效性与安全性。由于代谢水平的改变,肿瘤微环境较正常组织显微酸性,而细胞内吞途径伴随着质子的进一步泵入,因此pH可以作为理想的选择性刺激条件,以实现“门控”式的药物精准递释。近年来,pH响应型材料在肿瘤免疫治疗中被广泛研究,如高分子聚合物、生物大分子、脂质纳米粒、生物膜、无机纳米粒、金属-有机框架等。本文从不同的载体类型出发,综述了pH响应型肿瘤免疫治疗的研究策略,为新一代靶向制剂研发提供参考。

关键词：肿瘤免疫治疗药物递送系统 pH响应靶向

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肺癌患者术前预康复管理的最佳证据总结

中华护理教育 2024年第7期21卷 881-887页

作者：张方圆焦杰刘丽峰天津医科大学肿瘤医院肺部肿瘤科天津市300060 天津医科大学肿瘤医院中西医结合科天津市300060

目的系统检索、评价、提取和整合肺癌患者术前预康复管理的相关证据。方法计算机检索国内外数据库和相关专业网站中肺癌患者术前预康复管理的临床实践指南、临床决策、专家共识和系统评价,文献检索时限为2018年1月—2022年12月。由2名... 详细信息

目的系统检索、评价、提取和整合肺癌患者术前预康复管理的相关证据。方法计算机检索国内外数据库和相关专业网站中肺癌患者术前预康复管理的临床实践指南、临床决策、专家共识和系统评价,文献检索时限为2018年1月—2022年12月。由2名研究人员独立进行文献筛选和质量评价,根据主题进行证据提取和汇总。结果最终共纳入14篇文献,包括4篇指南、1篇临床决策、2篇专家共识和7篇系统评价。通过证据提取和归类,从运动训练、营养支持、戒烟指导、心理支持和口腔卫生5个方面总结出26条证据。结论临床人员应结合具体的临床情况和患者的意愿,开展肺癌患者个体化预康复方案的最佳证据实践,以改善患者术前心肺功能储备,使患者术后更好、更快地恢复。

关键词：肺癌术前预康复证据总结循证护理学

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井下主通风控制系统的配置和功能分析

能源与节能 2024年第5期 168-170页

作者：刘利峰晋能控股煤业集团轩岗煤电有限责任公司山西原平034114

为进一步实现井下主通风系统的自动化控制,结合轩岗煤矿的实际情况,在原有通风系统的基础上增加了PLC(Programmable Logic Controller,可编程逻辑控制器)控制单元和变频调速功能,对井下主通风控制系统进行整体配置。从主控模块、变频系... 详细信息

为进一步实现井下主通风系统的自动化控制,结合轩岗煤矿的实际情况,在原有通风系统的基础上增加了PLC(Programmable Logic Controller,可编程逻辑控制器)控制单元和变频调速功能,对井下主通风控制系统进行整体配置。从主控模块、变频系统、传感器等多个角度着手,详细探讨了煤矿井下主通风系统各个功能模块的配置和落实,并对该系统进行了实际测试。测试结果显示,该系统能够根据瓦斯体积分数的变化,对通风机运行情况予以快速响应和智能调整,表明其整体性能良好,具有一定的应用价值。

关键词：主通风控制系统系统配置系统功能

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城市更新引入社会资本的路径及政策支持研究

中国物价 2024年第9期 92-97页

作者：刘立峰柴璐中国宏观经济研究院投资研究所中国社会科学院大学经济学院

作为助力城市更新持续发展的中坚力量,社会资本可通过政企合作、城市更新基金、多元主体协同等方式参与更新项目。但在实践过程中发现,城市更新引入社会资本仍存在诸多阻碍,一定程度上抑制了社会资本的积极性和创造性。为畅通社会资本... 详细信息

作为助力城市更新持续发展的中坚力量,社会资本可通过政企合作、城市更新基金、多元主体协同等方式参与更新项目。但在实践过程中发现,城市更新引入社会资本仍存在诸多阻碍,一定程度上抑制了社会资本的积极性和创造性。为畅通社会资本的参与路径,需要培育具有资源整合能力的实施主体,制定收益平衡机制。对此建议:创新优化土地资源、财政税收、投融资等支持社会资本参与的政策,统筹要素资源、完善综合开发,构建激励与约束并重的政策环境,进一步提振社会资本参与城市更新项目的信心。

关键词：社会资本城市更新路径研究政策支持