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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong Xiujie Li Yanbin wu Jinzhong wu Jianguo wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative *** SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

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Synthesis of Ti3SiC2 Bulk Materials with B2O3 Additive

Synthesis of Ti3SiC2 Bulk Materials with B2O3 Additive

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The 3～〔rd〕International Conference on High-Performance Ceramics(CICC-3)（2）

作者： lifeng wu, Chang-An Wang and Yong Huang The State Key Lab of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, P. R. China

TiSiC bulk materials by hot-pressing sintering were presented through adding a little amount of B2O3 as a low-temperature additive in different raw-material systems. In one system, elemental titanium, silicon and active carbon were used as reactants with a molar ratio of 3: 1: 2. In another one, titanium carbide, titanium and silicon reacted together with a molar ratio of 2:1:1. At different temperatures, samples were synthesized by hot-pressing with a heating rate of 30℃min-1 before 1200℃and then 10℃min-1 to peak temperatures, holding for 2h. The effect of sintering temperature on the purity of Ti3SiC2 was investigated at the range of 1200℃to 1500℃. The products mainly contained Ti3SiC2 with TiC as the second phase. In some cases, Ti5Si3 appeared as well. When sintered at 1300℃, above 98vol% Ti3SiC2 was obtained in the elemental system. The roles of B2O3 additive were considered as weakening the thermal explosion reaction in the elemental mixture and affecting the diffusion procedure at low temperature in both systems.

关键词： Ti3SiC2 bulk material B2O3 additive Hot-pressing

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高灰熔点煤的加压催化气化:K_2CO_3催化活性及钾回收特性

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化工学报 2017年第5期68卷 2155-2161页

作者：陈兆辉刘雷金亚丹吴丽锋武恒湛月平李克忠毕继诚新奥科技发展有限公司煤基低碳能源国家重点实验室河北廊坊065001 清华大学化学工程系北京100084 中国科学院山西煤炭化学研究所煤转化国家重点实验室山西太原030001

以高灰熔点煤和含钾催化剂的灰渣为研究对象,分别考察了加压固定床反应器中K_2CO_3催化半焦水蒸气气化的反应性和灰渣中钾催化剂的回收特性。实验结果表明煤中添加K_2CO_3能够促进碳的转化,随着K_2CO_3负载量和气化温度的增加,碳转化率... 详细信息

以高灰熔点煤和含钾催化剂的灰渣为研究对象,分别考察了加压固定床反应器中K_2CO_3催化半焦水蒸气气化的反应性和灰渣中钾催化剂的回收特性。实验结果表明煤中添加K_2CO_3能够促进碳的转化,随着K_2CO_3负载量和气化温度的增加,碳转化率增大,CH4收率增加。在3.5 MPa和800℃下,K_2CO_3负载量为15%时,碳转化率达到96.1%,CH4收率达到0.24 m3·(kg C)-1。灰渣中钾催化剂的回收率随碳转化率的增加先升高后减小,这与催化剂在灰渣中的存在方式有关。通过优化水洗和消解条件,高碳转化率下灰渣中的钾催化剂的总回收率高达96.5%。

关键词：煤催化气化碳酸钾甲烷回收消解

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Photonic analog signal processing and neuromorphic computing[Invited]

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Chinese Optics Letters 2024年第3期22卷 123-136页

作者： James Garofolo Ben wu Department of Electrical and Computer Engineering Rowan UniversityGlassboroNJ 08028USA

In this review paper,we discuss the properties and applications of photonic computing and analog signal *** computational circuits have large operation bandwidth,low power consumption,and fine frequency control,enabling a wide range of application-specific computational techniques that are impossible to implement using traditional electrical and digital hardware *** advantages are illustrated in the elegant implementation of optical steganography,the real-time blind separation of signals in the same bandwidth,and the efficient acceleration of artificial neural network *** working principles and use of photonic circuits for analog signal processing and neuromorphic computing are reviewed and notable demonstrated applications are highlighted.

关键词： blind-source separation optical steganography neuromorphic photonics

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The physiological role of the unfolded protein response in the nervous system

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Neural Regeneration Research 2024年第11期19卷 2411-2420页

作者： Shuangchan wu Wensheng Lin Department of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Translational Neuroscience University of MinnesotaMinneapolisMNUSA

The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfolded *** UPR aims to restore endoplasmic reticulum homeostasis by enhancing protein folding capacity,reducing protein biosynthesis,and promoting protein *** also plays a pivotal role in coordinating signaling cascades to determine cell fate and function in response to endoplasmic reticulum *** research has highlighted the significance of the UPR not only in maintaining endoplasmic reticulum homeostasis but also in influencing various physiological processes in the nervous ***,we provide an overview of recent findings that underscore the UPR’s involvement in preserving the function and viability of neuronal and myelinating cells under physiological conditions,and highlight the critical role of the UPR in brain development,memory storage,retinal cone development,myelination,and maintenance of myelin thickness.

关键词： myelin neuron oligodendrocyte Schwann cell unfolded protein response

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The photosynthetic oxygen evolution does not exclude the important role and contribution of bicarbonate photolysis

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Acta Geochimica 2024年第1期43卷 174-179页

作者： Yanyou wu Shaogang Guo State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Photosynthesis is the most important biochemical reaction on Earth. It has co-evolved and developed with the Earth, driving the biogeochemical cycle of all elements on the planet and serving as the only chemical process in nature that can convert light energy into chemical energy. Some heavy oxygen isotopic(^(18)O) labeling experiments have"conclusively" demonstrated that the oxygen released by photosynthesis comes only from water and are written into textbooks. However, it is not difficult to find that bicarbonate has never been excluded from the direct substrate of photosynthesis from beginning to end during the history of photosynthesis research. No convincing mechanism can be used to explain photosynthetic oxygen evolution solely from water photolysis. The bicarbonate effect, the Dole effect, the thermodynamic convenience of bicarbonate photolysis, the crystal structure characteristics of photosystem Ⅱ, and the reinterpretation of heavy oxygen isotopic labeling(^(18)O)experiments all indicate that the photosynthetic oxygen evolution does not exclude the important role and contribution of bicarbonate photolysis. The recently proposed view that bicarbonate photolysis is the premise of water photolysis, bicarbonate photolysis and water photolysis work together with a 1:1(mol/mol) stoichiometric relationship, and the stoichiometric relationship between oxygen and carbon dioxide released during photosynthetic oxygen evolution is also 1:1, has excellent applicability and objectivity, which can logically and reasonably explain the precise coordination between light and dark reactions during photosynthesis, the bicarbonate effect, the Dole effect, the Kok cycle and the neutrality of water and carbon in *** is of great significance for constructing the bionic artificial photosynthetic reactors and scientifically answering the question of the source of elemental stoichiometric relationships in nature.

关键词： Bicarbonate effect Dole effect Kok cycle Heavy oxygen isotope Artificial photosynthetic reactor

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Roles of Upper-Level Descending Inflow in Moat Development in Simulated Tropical Cyclones with Secondary Eyewall Formation

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Advances in Atmospheric Sciences 2024年第6期41卷 1100-1114页

作者： Nannan QIN Liguang wu Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Innovation Center of Ocean and Atmosphere System Zhuhai Fudan Innovation Research InstituteZhuhai 518057China

This study investigated the effects of upper-level descending inflow(ULDI)associated with inner-eyewall convection on the formation of the moat in tropical cyclones(TCs)with secondary eyewall formation(SEF).In our numerical experiments,a clear moat with SEF occurred in TCs with a significant ULDI,while no SEF occurred in TCs without a significant *** eyewall convection developed more vigorously in the control run.A ULDI occurred outside the inner-eyewall convection,where it was symmetrically *** ULDI was initially triggered by the diabatic warming released by the inner eyewall and later enhanced by the cooling below the anvil *** ULDI penetrated the outer edge of the inner eyewall with relatively dry air and prevented excessive solid-phase hydrometeors from being advected further *** produced extensive sublimation cooling of falling hydrometeors between the eyewall and the outer *** sublimation cooling resulted in negative buoyancy and further induced strong subsidence between the eyewall and the outer *** a result,a clear moat was *** of the moat in the ongoing SEF prevented the outer rainband from moving farther inward,helping the outer rainband to symmetrize into an outer *** the sensitivity experiment,no significant ULDI formed since the eyewall convection was weaker,and the eyewall anvil developed relatively lower,meaning the formation of a moat and thus an outer eyewall was less *** study suggests that a better-represented simulation of inner-eyewall convective structures and distribution of the solid-phase hydrometeors is important to the prediction of SEF.

关键词： tropical cyclone secondary eyewall formation upper-level descending inflow eyewall convection

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UNIFORM SUPERCONVERGENCE ANALYSIS OF A TWO-GRID MIXED FINITE ELEMENT METHOD FOR THE TIME-DEPENDENT BI-WAVE PROBLEM MODELING D-WAVE SUPERCONDUCTORS

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Journal of Computational Mathematics 2024年第2期42卷 415-431页

作者： Yanmi wu Dongyang Shi PLA Information Engineering University Zhengzhou 450001China School of Mathematics and Information Sciences Yantai UniversityYantai 264005China

In this paper,a two-grid mixed finite element method(MFEM)of implicit Backward Euler(BE)formula is presented for the fourth order time-dependent singularly perturbed Bi-wave problem for d-wave superconductors by the nonconforming EQ_(1)^(rot) *** this approach,the original nonlinear system is solved on the coarse mesh through the Newton iteration method,and then the linear system is computed on the fine mesh with Taylor’s *** on the high accuracy results of the chosen element,the uniform superclose and superconvergent estimates in the broken H^(1)-norm are derived,which are independent of the negative powers of the perturbation parameter appeared in the considered *** results illustrate that the computing cost of the proposed two-grid method is much less than that of the conventional Galerkin MFEM without loss of accuracy.

关键词： Time-dependent Bi-wave problem Two-grid mixed finite element method Uniform superclose and superconvergent estimates

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调亏灌溉与氮营养对玉米根区土壤水氮有效性的影响

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农业工程学报 2010年第2期26卷 135-141页

作者：刘小刚张富仓杨启良李志军吴立峰昆明理工大学现代农业工程学院昆明650024 西北农林科技大学旱区农业水土工程教育部重点实验室杨凌712100

为探索调亏灌溉与氮营养对玉米根区土壤水氮有效性的影响,采用盆栽玉米试验,研究了水分调亏时期和不同施氮量对玉米根区土壤硝态氮迁移动态和水氮利用的影响。结果表明:施氮量决定根区土壤硝态氮含量,各生育阶段的灌水量和养分吸收影响... 详细信息

为探索调亏灌溉与氮营养对玉米根区土壤水氮有效性的影响,采用盆栽玉米试验,研究了水分调亏时期和不同施氮量对玉米根区土壤硝态氮迁移动态和水氮利用的影响。结果表明:施氮量决定根区土壤硝态氮含量,各生育阶段的灌水量和养分吸收影响硝态氮的变化动态。调亏灌溉的玉米根区中、下层土壤硝态氮含量介于常规灌溉的高水和低水处理之间。抽穗期结束时根区中、下层土壤硝态氮含量与施氮量呈正相关关系。施氮量、调亏时期对干物质和全氮累积量影响显著。拔节期水分亏缺对干物质累积量影响最大,苗期水分亏缺影响次之,抽穗期水分亏缺影响最小。苗期亏水、高氮处理的水分利用效率最高。高氮处理的植株全氮累积量最大,是无氮处理的2.54～3.23倍。低氮调亏灌溉的氮肥表观利用效率都大于30%,比高氮调亏灌溉的高约6.6%。最佳的水氮组合为抽穗期亏水低氮处理。

关键词：灌溉水氮迁移有效性水氮利用效率玉米

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Designing ultrastable P2/O3-type layered oxides for sodium ion batteries by regulating Na distribution and oxygen redox chemistry

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Journal of Energy Chemistry 2024年第7期94卷 466-476页

作者： Jieyou Huang Weiliang Li Debin Ye Lin Xu Wenwei wu Xuehang wu School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004GuangxiChina Guangxi Key Laboratory for High-value Utilization of Manganese Resources Guangxi Normal University for NationalitiesChongzuo 532200GuangxiChina

P2/O3-type Ni/Mn-based layered oxides are promising cathode materials for sodium-ion batteries(SIBs)owing to their high energy ***,exploring effective ways to enhance the synergy between the P2 and 03 phases remains a ***,we design a P2/O3-type Na_(0.76)Ni_(0.31)Zn_(0.07)Mn_(0.50)Ti_(0.12)0_(2)(NNZMT)with high chemical/electrochemical stability by enhancing the coupling between the two *** the first time,a unique Na*extraction is observed from a Na-rich O3 phase by a Na-poor P2 phase and systematically *** process is facilitated by Zn^(2+)/Ti^(4+)dual doping and calcination condition regulation,allowing a higher Na*content in the P2 phase with larger Na^(+)transport channels and enhancing Na transport *** of reduced Na^(+)in the O3 phase,which increases the difficulty of H^(+)/Na^(+) exchange,the hydrostability of the O3 phase in NNZMT is considerably ***,Zn^(2+)/Ti^(4+)presence in NNZMT synergistically regulates oxygen redox chemistry,which effectively suppresses O_(2)/CO_(2) gas release and electrolyte decomposition,and completely inhibits phase transitions above 4.0 *** a result,NNZMT achieves a high discharge capacity of 144.8 mA h g^(-1) with a median voltage of 3.42 V at 20 mA g^(-1) and exhibits excellent cycling performance with a capacity retention of 77.3% for 1000 cycles at 2000 mA g^(-1).This study provides an effective strategy and new insights into the design of high-performance layered-oxide cathode materials with enhanced structure/interface stability forSIBs.

关键词： Sodium-ion batteries P2/O3-type layered oxides Na distribution Oxygen redox chemistry Hydrostability

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