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高考改革:困境、反思与展望

国家教育行政学院学报 2009年第8期140卷 49-53页

作者：李立峰华东师范大学教育学系上海200235

面对高等教育大众化的挑战,高考改革存在着许多两难困境,如统一考试与多元评价、扩大自主与公平选才等矛盾。对此,未来高考改革的思路是:逐步落实高校的招生自主权,明晰政府、高校和考试机构等的责权关系;按照"解放两端、稳住中端"的指... 详细信息

面对高等教育大众化的挑战,高考改革存在着许多两难困境,如统一考试与多元评价、扩大自主与公平选才等矛盾。对此,未来高考改革的思路是:逐步落实高校的招生自主权,明晰政府、高校和考试机构等的责权关系;按照"解放两端、稳住中端"的指导思想,探索自主招生的多元模式;有步骤地适时推行适应高等教育大众化要求的分类考试改革。

关键词：高考改革自主招生困境展望

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

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Acta Pharmaceutica Sinica B 2024年第1期14卷 319-334页

作者： Ying Qin Dekang li Chunting Qi Huaijiang Xiang Huyan Meng Jingli liu Shaoqing Zhou Xinyu Gong Ying li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen lifeng Pan Ying li li Tan Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Institute of Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112China Department of Burn and Plastic Surgery Shenzhen Institute of Translational MedicineShenzhen University Medical SchoolShenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China

Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical ***,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to ***,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical *** also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory ***,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development.

关键词： RIPK1 Necroptosis Type-II kinase inhibitors Rational design Lead optimization Structure‒activity relationship Anti-inflammation Preclinical drug discovery

Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： lina Deng Weiye Zhang Hanxuan lin lifen Xiang Ying Xu Yadi Wang Qiang li Yinyan Zhu Xiaodong Zhou Wenbin Wang lifeng Yin Hangwen Guo Chuanshan Tian Jian Shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum *** view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly *** far,the polarization state of light has rarely been reported as a control parameter for this ***,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static ***,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization *** transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic *** results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

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科举学的文化地理视角

东南学术 2005年第4期 65-70页

作者：李立峰厦门大学教育研究院

从文化地理的角度研究科举学具有整体综合的优势,可以丰富和拓宽科举学的研究内容和研究视域;科举人才与地域经济、政治、文化和教育等因素有着互为因果、彼此影响的复杂关系,而科举考试的配额制度作为调节科举人才与政治、经济、文化... 详细信息

从文化地理的角度研究科举学具有整体综合的优势,可以丰富和拓宽科举学的研究内容和研究视域;科举人才与地域经济、政治、文化和教育等因素有着互为因果、彼此影响的复杂关系,而科举考试的配额制度作为调节科举人才与政治、经济、文化和教育发展的中介机制,起到了非常重要的作用;研究科举考试的区域配额制度对于现代高考“倾斜的录取分数线”问题也具有极为强烈的借鉴意义;这便是从文化地理视角研究科举学的旨趣所在。

关键词：科举制科举学文化地理

Infection,pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile,adult and aged Syrian hamsters

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Cellular & Molecular Immunology 2022年第12期19卷 1392-1399页

作者： Lunzhi Yuan Huachen Zhu Peiwen Chen Ming Zhou Jian Ma Xuan liu Kun Wu Rirong Chen Qiwei liu Huan Yu lifeng li Jia Wang Yali Zhang Shengxiang Ge Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamenFujianChina State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology(STU/HKU)Shantou UniversityShantouGuangdongChina EKIH Pathogen Research Institute Futian DistrictShenzhenGuangdongChina Department of Microbiology Howard University College of MedicineWashingtonDCUSA

The new predominant circulating SARS-CoV-2 variant,Omicron,can robustly escape current vaccines and neutralizing *** Omicron has been reported to have milder replication and disease manifestations than some earlier variants,its pathogenicity in different age groups has not been well ***,we report that the SARS-CoV-2 Omicron BA.1 sublineage causes elevated infection and lung pathogenesis in juvenile and aged hamsters,with more body weight loss,respiratory tract viral burden,and lung injury in these hamsters than in adult *** hamsters show a reduced interferon response against Omicron BA.1 infection,whereas aged hamsters show excessive proinflammatory cytokine expression,delayed viral clearance,and aggravated lung *** inhaled IFN-α2b treatment suppresses Omicron BA.1 infection and lung pathogenesis in juvenile and adult ***,the data suggest that the diverse patterns of the innate immune response affect the disease outcomes of Omicron BA.1 infection in different age groups.

关键词： SARS-CoV-2 Omicron Lung pathology Innate immune response Interferon treatment

'Repair' Treg cells in Tissue Injury

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'Repair' Treg cells in Tissue Injury

第十二届全国免疫学学术大会

作者： li lifeng Zhang Chaoqi Kexin Feng Daoyang Fan Wenhua Xue Jingli Lu Biotherapy Center The First Affiliated Hospital of Zhengzhou University Department of Oncology The First Affiliated Hospital of Zhengzhou University Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Department of Orthopedics Peking University Third Hospital

Studies in mice and humans have elucidated an import role for Tregs in promoting tissue repair and restoring tissue *** is growing evidence that Tregs are present in some injured tissues with distinct phenotypical and functional diversity;these local Tregs function as a traditional modulator by limiting local immune responses,as well as act as a nontraditional role with capacity to exert self-derived pro-repair factors that contribute to parenchymal cellular *** this review,we provide an overview of the emerging knowledge about the Treg-mediated repair in damaged tissues and organs,with a particular focus on Tregs resident in local tissues;we also discuss the central role of Treg-derived prorepair factors and how they are modulated in the context of injury.

关键词： Treg cells Tissue injury repair

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美国刑法中犯意要求边缘化研究

环球法律评论 2007年第6期29卷 35-43页

作者：李立丰吉林大学法学院

作为基本概念范畴,犯意长期以来在美国刑法中扮演十分重要的角色,但随着时代的发展和法定犯罪主导地位的稳固,犯意的核心概念色彩开始在大量犯罪当中淡化,而对于这种边缘化趋势的考察,首先需要从美国刑法中自然犯罪与法定犯罪的二元区... 详细信息

作为基本概念范畴,犯意长期以来在美国刑法中扮演十分重要的角色,但随着时代的发展和法定犯罪主导地位的稳固,犯意的核心概念色彩开始在大量犯罪当中淡化,而对于这种边缘化趋势的考察,首先需要从美国刑法中自然犯罪与法定犯罪的二元区分模式入手,通过对犯意边缘化前提条件的框定,明确其不同维度的区分,从而在此基础上对美国刑法犯意边缘化加以具体刻画和分析,由此探知这样一种动态变化背后的深层次原因。

关键词：美国刑法犯意边缘化评析

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爆破振动信号反问题研究初探

金属矿山 2020年第10期49卷 124-134页

作者：李立峰武汉理工大学资源与环境工程学院湖北武汉430070

爆破振动是炸药爆炸后,其部分能量以弹性波的形式向外传播,使某处岩体产生振动的现象。当一次爆破中各个炮孔以毫秒延期的方式起爆时,所测得的爆破振动信号就可以看作是每个炮孔所产生的爆破地震波的叠加。那么其反问题之一就是从监测... 详细信息

爆破振动是炸药爆炸后,其部分能量以弹性波的形式向外传播,使某处岩体产生振动的现象。当一次爆破中各个炮孔以毫秒延期的方式起爆时,所测得的爆破振动信号就可以看作是每个炮孔所产生的爆破地震波的叠加。那么其反问题之一就是从监测所得的爆破振动信号中获取对应于单孔的爆破振动信号。针对所提出的反问题,从反卷积和波形群延迟的角度分别对单孔信号波形的获取进行详细的分析,使用维纳滤波反卷积法、频域商反卷积法以及群延迟合成法分别对不同规模(即不同炮孔数和延期时间)的爆破振动信号分析,以获得单孔振动信号。分析表明,维纳滤波反卷积法和频域商反卷积法能够获得一个标准化的特征孔波形,但是比较适合孔数较少、规模较小的爆破;而基于群延迟的算法能够适应任何孔数的爆破振动信号。爆破振动信号反问题的研究目前还不够深入,还处于初探阶段,但是爆破振动信号反问题的研究却可以为智能爆破的实现提供重要的理论支持,使爆破中的智能反馈成为可能。

关键词：爆破振动反问题单孔波形反卷积群延迟

流动与现代化:一项关于土改的历史社会学分析

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学海 2022年第2期 89-99页

作者：李灏哲李里峰南京大学政府管理学院南京210023 南京大学政府管理学院暨亚太发展研究中心南京210023

农民频繁流动及其导致的国家治理难题,是1949年后开展土地改革运动的重要背景之一。土地改革使众多农民从流动转向定居,结束了过去颠沛流离的生活,国家也得以重建与农民的政治联系,并通过各类新型组织强化了乡村社会治理。土地改革蕴含... 详细信息

农民频繁流动及其导致的国家治理难题,是1949年后开展土地改革运动的重要背景之一。土地改革使众多农民从流动转向定居,结束了过去颠沛流离的生活,国家也得以重建与农民的政治联系,并通过各类新型组织强化了乡村社会治理。土地改革蕴含了解决流民问题、管控流动人口的治理逻辑,服务于在特定条件下建设现代国家的历史任务。

关键词：农民流动国家管控现代化土地改革