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A study on the clinical prediction model of the yin deficiency type of perimenopausal syndrome

Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 6-14页

作者： Xiang Li Jiawen Ma Chaofan Zhu lifang xie Zaiyang Zhang Keying Wang Shuaiqi An Shiyan Ren Xingchu Cai Yizhou Zhang School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina Zhejiang Famous Chinese Medicine Clinic The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053ZhejiangChina

Background:The yin deficiency type of perimenopausal syndrome(PMS)as a common category of PMS based on the theory of traditional Chinese medicine(TCM)has a high prevalence with severe symptoms and long course of ***,it is necessary to construct a prediction model to assist in ***:This study aimed to investigate the independent predictors of the yin deficiency type of PMS and to develop a clinical prediction model of this ***:PMS patients who attended the Third Affiliated Hospital of Zhejiang Chinese Medical University between February 2020 and August 2023 were selected and divided chronologically into training and validation *** regression analysis was applied in the training group to clarify the independent predictors of the yin deficiency type of PMS,and a nomogram was *** and external validations were performed in the training and validation groups to evaluate the model’s accuracy,goodness of fit,and clinical ***:Hot flashes and sweating(≥10 episodes/day),palpitations,emotional fluctuations,and abnormal sexual activity were independent predictors of the yin deficiency type of PMS(P>0.05).Based on the clinical prediction model constructed,the area under the receiver operating characteristic curve(AUR OC)in the training group was 0.989(95%CI 0.980–0.998),and the AUR OC in the validation group was 0.971(95%CI 0.940–0.999).This demonstrates that the model has superior prediction *** Hosmer-Lemeshow test was used to evaluate the model’s goodness of fit with P=0.596 for the training group and P=0.883 for the validation group,indicating a good *** decision curve analysis(DCA)curve and clinical impact curve(CIC)indicated good clinical ***:The model can accurately predict the occurrence of the yin deficiency type of PMS,which may help clinicians identify such patients at an early stage.

关键词： Yin deficiency type Perimenopausal syndrome Predictors Nomogram Clinical prediction model

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Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue

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Genes & Diseases 2023年第3期10卷 1101-1113页

作者： Lu Deng Ping Yang Caixia Li lifang xie Wanling Lu Yanhan Zhang Ming Liu Gang Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengduSichuan 610064China Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China Department of Abdominal Oncology West China HospitalSichuan UniversityChengduSichuan 610044China

Daily insulin injection is necessary for the treatment of the insulin-dependent diabetes. However, the process is painful and inconvenient. Accordingly, we have made exploratory efforts to establish an alternative method for continuous insulin supply via intramuscular injection of a designed plasmid encoding the single-strand insulin analogue (SIA), which provides safe, effective and prolonged control of insulin-dependent diabetes. To generate a SIA, a short flexible peptide was alternatively introduced into the natural proinsulin to replace its original long and rigid C-peptide. Then, the synthetic promoter SP301 was used to drive potent and specific expression of SIA in skeletal muscle cells. By combining the Pluronic L64 and low-voltage electropulse (L/E), the specialized gene delivery technique was applied to efficiently transfer the constructed plasmid into skeletal muscle cells via intramuscular injection. Through these efforts, a plasmid-based intramuscular gene expression system was established and improved, making it applicable for gene therapy. The plasmid-expressed SIA showed biological functions that were similar to that of natural insulin. A single L/E-pSP301-SIA administration provided sustained SIA expression in vivo for about 1.5 months. In addition, the diabetic mice treated with L/E-pSP301-SIA were much healthier than those with other treatments. This plasmid-based system was safe for the treatment of diabetes and did not cause immune responses or pathological damage. The results confirmed that, in a mouse model, long-term positive effects were achieved by a single intramuscular L/E-pSP301-SIA injection, which consequently provided reliable experimental basis for its clinical application for the treatment of diabetes mellitus with promising prospects.

关键词： Diabetes Gene therapy Intramuscular injection Plasmid Single-strand insulin analogue(SIA) Synthetic promoter

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The World of the Little Painters

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Women of China 1998年第7期 25-26页

作者： xie lifang A RONG

Agroup of little painters, aged three to twelve, paint actively in the study office for children’s paintings of the Children’s and Women’s Activity Center of Hunan Province. They come from ordinary families, and all of them have gone through a period of scrawling, but they have become extraordinary artists. Children here never imitate other people’s paintings; nor would I want them to. As their teacher, I encourage them to observe the world

关键词： The World of the Little Painters World

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赣南野生山金柑种质资源收集与鉴定

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植物遗传资源学报 2024年第2期25卷 237-248页

作者：罗嗣芳张祖铭柳嘉程孙静贤杨月华赖圣炜谢丽芳牛王翠严翔陈兆星赣州市柑桔科学研究所江西赣州341000

通过与赣南各县(区)果业主管部门合作及走访果农,在赣南进行了野生山金柑种质资源调查与收集,共收集与鉴定评价野生山金柑种质资源716份。结果表明,赣南野生山金柑分布于安远、龙南、章贡、崇义、于都、信丰等县(区),可分为野生和人工... 详细信息

通过与赣南各县(区)果业主管部门合作及走访果农,在赣南进行了野生山金柑种质资源调查与收集,共收集与鉴定评价野生山金柑种质资源716份。结果表明,赣南野生山金柑分布于安远、龙南、章贡、崇义、于都、信丰等县(区),可分为野生和人工移植两类,主要生存环境为原始森林、山林、山谷、丘陵和盆景;性状分析发现树姿、节间长度、刺数量、刺长度、叶片长度、叶片宽度、叶柄、叶形、翼叶、叶尖缺刻、单果重量、果面主色、果面杂色、种子数量、油胞明显度、果皮厚度16个性状存在差异;进一步基于差异性状进行聚类分析,在欧氏距离等于17.5时716份种质被分为4大类,欧氏距离小于14时可进一步分成8小类;基于16个性状进行主成分分析得到6个特征值大于1且与农艺性状相关联的主成分。根据柑橘产业需求,筛选出3份无刺、34份无籽、67份大果、12份晚熟的野生山金柑种质资源。综上,赣南野生山金柑鉴定结果对山金柑新品种选育、柑橘产业发展具有较明确的利用价值。

关键词：野生山金柑种质资源调查与收集鉴定评价赣南

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赣南脐橙产业发展现状及对策

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中国果树 2024年第8期 133-139页

作者：柳嘉程梁梅青娄伟谢丽芳王小丽胡承孝牛王翠赣州市柑桔科学研究所江西341000 赣州市果业发展中心华中农业大学资源与环境学院

赣南脐橙产业是赣州市乡村振兴中经历50年形成的产业。2023年,赣州市脐橙种植面积12.93万hm^(2),品牌价值691.27亿元。在新形势下,赣南脐橙产业发展到新阶段,对其进行深入调研,发现赣南脐橙产业存在产业产品安全令人担忧、品牌效应没有... 详细信息

赣南脐橙产业是赣州市乡村振兴中经历50年形成的产业。2023年,赣州市脐橙种植面积12.93万hm^(2),品牌价值691.27亿元。在新形势下,赣南脐橙产业发展到新阶段,对其进行深入调研,发现赣南脐橙产业存在产业产品安全令人担忧、品牌效应没有充分凸显、人才梯队培养“政府缺位”、果园设施保障迫在眉睫、产业标准体系亟待推陈出新、产业社会化服务体系建设差距较大等问题。因此,提出高度重视产业安全、高度重视品种的研发和品质的提升、更加重视发挥品牌引领作用、更加重视科技人才支撑、加快建立现代产业链标准体系、加快健全产业社会化服务体系、扶持规范农村电商平台发展、支持发展果品精深加工等助推赣南脐橙产业高质量发展的建议。

关键词：赣南脐橙产业发展现状对策

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Methods for Estimating Mean Annual Rate of Earthquakes in Moderate and Low Seismicity Regions

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Earthquake Research in China 2012年第3期26卷 335-347页

作者： Peng Yanju Zhang lifang Lv Yuejun xie Zhuojuan Institute of Crustal Dynamics China Earthquake Administration Beijlng 100085 China

Two kinds of methods for determining seismic parameters are presented, that is, the potential seismic source zoning method and grid-spatially smoothing method. The Gaussian smoothing method and the modified Gaussian smoothing method are described in detail, and a comprehensive analysis of the advantages and disadvantages of these methods is made. Then, we take centrai China as the study region, and use the Gaussian smoothing method and potential seismic source zoning method to build seismic models to calculate the mean annual seismic rate. Seismic hazard is calculated using the probabilistic seismic hazard analysis method to construct the ground motion acceleration zoning maps. The differences between the maps and these models are discussed and the causes are investigated. The results show that the spatial smoothing method is suitable for estimating the seismic hazard over the moderate and low seismicity regions or the hazard caused by background seismicity; while the potential seismic source zoning method is suitable for estimating the seismic hazard in well-defined seismotectonics. Combining the spatial smoothing method and the potential seismic source zoning method with an integrated account of the seismicity and known seismotectonics is a feasible approach to estimate the seismic hazard in moderate and low seismicity regions.

关键词： Moderate and low seismicity regions Annual seismic activity rate Grid-spatially smoothing method Potential seismic source zoning method

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地下室防渗漏工程中的环境影响与可持续发展措施研究

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智能城市应用 2024年第4期7卷 67-69页

作者：黎军杨光年谢丽芳广西国信集团工程有限公司广西南宁530401 广西北投紫云置业有限公司广西南宁542800 宾阳县宾州镇第五初级中学广西南宁530401

随着城市化进程的加快和建筑业的快速发展,地下室的建设越来越普遍。地下室作为一种有效利用地下空间的建筑形式,被广泛应用于商业、住宅、交通等领域。地下室作为地下工程,受到地下水、土壤、地基等多种因素的影响,容易发生渗漏问题。... 详细信息

随着城市化进程的加快和建筑业的快速发展,地下室的建设越来越普遍。地下室作为一种有效利用地下空间的建筑形式,被广泛应用于商业、住宅、交通等领域。地下室作为地下工程,受到地下水、土壤、地基等多种因素的影响,容易发生渗漏问题。地下室渗漏不仅会影响地下室内部的使用功能,还可能对地下结构的安全稳定性产生威胁,甚至导致严重的环境问题。因此,为了保障地下室结构的完整性和稳定性,保障周边环境和社会的安全与稳定,有必要开展地下室防渗漏工程的相关研究和实践。通过深入分析地下室防渗漏工程的环境影响和可持续发展措施,可以为工程实践提供科学的理论指导和技术支持,推动地下室防渗漏工程向着更加可持续的方向发展。

关键词：地下室防渗漏环境影响可持续发展有效措施

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执行力文化的工作效应与图书馆管理

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图书情报知识 2007年第3期24卷 99-102页

作者：谢丽芳湖北大学图书馆武汉430062

执行力文化就是把“执行力”作为所有行为的最高准则和终极目标的文化。它涉及的是“怎样做正确的事”,决定事情的效果。图书馆执行力文化是图书馆价值观得以体现的根本保证,也是搞好图书馆建设的关键。引入竞争机制能提高员工素质和责... 详细信息

执行力文化就是把“执行力”作为所有行为的最高准则和终极目标的文化。它涉及的是“怎样做正确的事”,决定事情的效果。图书馆执行力文化是图书馆价值观得以体现的根本保证,也是搞好图书馆建设的关键。引入竞争机制能提高员工素质和责任心,促进图书馆事业的发展。

关键词：执行力员工素质责任心竞争机制

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浇施噻虫嗪防治柑橘木虱研究

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中国果树 2024年第7期 95-99页

作者：夏长秀彭龙李梦媛张油兵张祖铭陈兆星赖圣炜谢丽芳张振宇严翔赣州市柑桔科学研究所江西341000 华中农业大学植物科学技术学院

为了寻找田间防治柑橘木虱(Diaphorina citri)的新方法,在脐橙上开展浇施噻虫嗪防控柑橘木虱试验。结果表明:4月中下旬浇施1次25%噻虫嗪水分散粒剂1 500倍液(施药量0.17 g/m^(2))可有效控制柑橘木虱1.5~3.0个月;25%噻虫嗪水分散粒剂1 50... 详细信息

为了寻找田间防治柑橘木虱(Diaphorina citri)的新方法,在脐橙上开展浇施噻虫嗪防控柑橘木虱试验。结果表明:4月中下旬浇施1次25%噻虫嗪水分散粒剂1 500倍液(施药量0.17 g/m^(2))可有效控制柑橘木虱1.5~3.0个月;25%噻虫嗪水分散粒剂1 500倍液浇施脐橙树28 d后,脐橙果实的噻虫嗪含量为0.06 mg/kg,远低于《食品安全国家标准食品中农药最大残留限量》(GB 2763—2021)规定的噻虫嗪在柑橘类水果中最大残留限量(0.5 mg/kg)的标准,在采收前1个月浇施25%噻虫嗪水分散粒剂1 500倍液防治柑橘木虱是安全的。

关键词：噻虫嗪柑橘木虱浇施农药残留

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A Novel Supervised Multi-model Modeling Method Based on k-means Clustering

A Novel Supervised Multi-model Modeling Method Based on k-me...

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2010 Chinese Control and Decision Conference

作者： Linlin Liu,lifang Zhou,Shenggang xie Department of System Engineering,Zhejiang University,Hangzhou 310027,China

A supervised multi-model modeling method is proposed for the nonlinear system in this *** the traditional k-means clustering method,the error of modeling multi-model is always ignored or even not considered in the clustering ***,this unsupervised clustering method has large modeling *** the new modeling method, the initial clusters are firstly obtained by the k-means clustering,then the data of clusters are reclassified considering the modeling errors of the multi-model,at last the new precise model parameters are *** paper has given the analysis of the rationality of the *** the end of the paper,the simulation results of the wastewater treatment process show that the supervised multi-model modeling method can improve the modeling precision and predictive performance.

关键词： K-means Clustering Supervised Multi-model Modeling Wastewater Treatment

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