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卖空管制放松能够抑制企业商誉泡沫吗?

财贸研究 2021年第9期32卷 96-110页

作者：田园高利芳安徽财经大学会计学院安徽蚌埠233030

选取2007—2018年我国A股上市公司为研究样本,采用双重差分法,考察卖空管制放松对企业商誉泡沫的影响。研究发现,卖空管制放松可以有效抑制商誉泡沫,且这一抑制效应在非国有企业中更为显著。作用机制检验表明,卖空机制主要通过降低企业... 详细信息

选取2007—2018年我国A股上市公司为研究样本,采用双重差分法,考察卖空管制放松对企业商誉泡沫的影响。研究发现,卖空管制放松可以有效抑制商誉泡沫,且这一抑制效应在非国有企业中更为显著。作用机制检验表明,卖空机制主要通过降低企业代理成本与提高企业信息透明对商誉泡沫产生抑制作用。异质性检验结果显示,在高管权力低、内控质量高的企业中,卖空管制放松对商誉泡沫的抑制效应更为明显。

关键词：卖空机制融资融券商誉泡沫代理成本信息透明度

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指数型随机共振微弱振动信号检测方法

振动与冲击 2019年第9期38卷 53-61页

作者：张刚曹莉贺利芳易甜重庆邮电大学通信学院重庆400065 信号与信息处理重庆市重点实验室重庆400065

在实际工程故障诊断中特征频率信号经常淹没在噪声中,信息提取非常困难。为了提取强噪声背景中的微弱信号,将简谐势阱与Gaussian Potential模型相结合,提出一种作用在Duffing方程下的新型指数型双稳随机共振系统。首先,推导逃逸率并研... 详细信息

在实际工程故障诊断中特征频率信号经常淹没在噪声中,信息提取非常困难。为了提取强噪声背景中的微弱信号,将简谐势阱与Gaussian Potential模型相结合,提出一种作用在Duffing方程下的新型指数型双稳随机共振系统。首先,推导逃逸率并研究系统参数对输出信噪比影响;其次,基于指数型双稳随机共振系统对冲击衰减信号以及谐波振动信号进行检测;最后为检测大噪声下多频信号提出指数型双稳随机共振和经验模态分解的微弱信号联合检测方法并应用于轴承故障信号检测中。实验分析及仿真结果表明,指数型双稳随机共振模型在信号检测中是可行的,并且对于多频谐波信号通过随机共振后进行经验模态分解可使检测更加准确,联合检测不仅能识别故障信号,还能识别故障倍频信号。

关键词：指数型双稳随机共振经验模态分解故障信号检测

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

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Cancer Communications 2022年第4期42卷 287-313页

作者： Xiao Zhang Yunhua Xu lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang Department of Laboratory Medicine Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Institute of Thoracic Oncology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Department of Bio-bank Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030P.R.China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200071P.R.China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric disorderShanghai Jiao Tong UniversityShanghai 200030P.R.China Department of Clinical Laboratory Medicine Shanghai Tenth People’s Hospital of Tongji UniversityShanghai 200072P.R.China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against *** purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ***:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this *** and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA *** viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to *** were observed using transmission electron *** localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal *** between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation *** analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze *** xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular ***:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma ***,cir93 interac

关键词： exosome circRNA_101093 ferroptosis desensitization lung adenocarcinoma lipid peroxidation poly-unsaturated fatty acid taurine N-arachidonoyl taurine RNA-protein interaction

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同轴磁场调制式磁齿轮电磁优化设计

兵工学报 2021年第10期42卷 2206-2214页

作者：陈泳丹田真沈宏继刘丽芳中国北方车辆研究所车辆传动重点实验室北京100072 63963部队北京100072

随着未来特种车辆对传动效率和可靠性需求的不断提高,电传动将成为未来传动的重要发展方向,磁齿轮电磁优化设计是未来新型电传动研发中的关键技术之一。对同轴磁场调制式磁齿轮传动原理进行分析,建立磁齿轮磁力传动的解析方程,形成基于T... 详细信息

随着未来特种车辆对传动效率和可靠性需求的不断提高,电传动将成为未来传动的重要发展方向,磁齿轮电磁优化设计是未来新型电传动研发中的关键技术之一。对同轴磁场调制式磁齿轮传动原理进行分析,建立磁齿轮磁力传动的解析方程,形成基于Taguchi法与多目标鲁棒性优化算法相结合的磁齿轮电磁优化设计方法,对典型工况下磁齿轮样机的速度与转矩特性进行台架试验。结果表明:磁齿轮样机额定工况下传动比稳定在6.67,输出转矩为359.7 N·m,输出功率为56.49 kW,效率达到98.1%,转矩性能与效率达到优化设计目标,验证了电磁优化设计方法的有效性。

关键词：磁齿轮磁场调制电磁优化 Taguchi法多目标鲁棒性优化

Clinical phenotype features and genetic etiologies of 38 children with progressive myoclonic epilepsy

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Acta Epileptologica 2020年第1期2卷 111-125页

作者： Jing Zhang Ying Yang Xueyang Niu Jiaoyang Chen Wei Sun Changhong Ding lifang Dai Liping Zhang Qi Zeng Yi Chen Xiaojuan tian Xiaoling Yang Taoyun Ji Zhixian Yang Yanling Yang Yuwu Jiang Yuehua Zhang Department of Pediatrics Peking University First HospitalNo.1 of Xian Men StreetXicheng DistrictBeijing 100034China. Department of Neurology Xuanwu HospitalCapital Medical UniversityNo.45 of Changchun StreetXicheng DistrictBeijing 100034China. Department of Neurology Beijing Children’s HospitalCapital Medical UniversityNo.56 of South Lishi RoadXicheng DistrictBeijing 100045China. Department of Pediatrics Xuanwu HospitalCapital Medical UniversityNo.45 of Changchun StreetXicheng DistrictBeijing 100034China.

Background:Progressive myoclonic epilepsy(PME)is a group of neurodegenerative diseases with genetic heterogeneity and phenotypic similarities,and many cases remain unknown of the genetic *** study is aim to summarize the clinical features and study the genetic causes of PME ***:Sanger sequencing of the target gene,Next Generation Sequencing(NGS)panels of epilepsy,trio-based Whole Exome Sequencing(WES)and detection of cytosine-adenine-guanine(CAG)repeat number were used to investigate the genetic causes of PME ***:Thirty-eight children with PME whose seizure onset age ranged from 3 months to 12 years were collected from February 2012 to November 2019 in three hospitals in Beijing,*** seizure types included myoclonic seizures(n=38),focal seizures(n=19),generalized tonic-clonie seizure(GTCS)(n=13),absence seizures(n=4),atonic seizures(n=3),epileptic spasms(n=2)and tonic seizures(n=1).Twenty-seven cases were sporadic and 11 had family members *** PME-related genes were identified in 30 out of 38(78.9%)patients who had either recessively inherited or de novo heterozygous *** these 30 cases,there were 12 cases(31.6%)of neuronal ceroid lipofuscinoses(the causing gene contains TPP1,PPT1,CLN5,CLN6 and MFSD8),two cases of sialidosis(the causing gene is NEU1),two cases of neuronopathic Gaucher disease(the causing gene is GBA),one case of spinal muscular atrophy-progressive myoclonic epilepsy(the causing gene is ASAH1),four cases of KCNC1 mutation-related PME,four cases of KCTD7 mutation-related PME,two cases of TBC1D24 mutation-related PME,one case of GOSR2 related PME,and two of dentatorubral-pallidoluysian atrophy(the causing gene is ATN1).In total,13 PME genes were identified in our *** etiology was not clear in eight ***:PME is a group of clinically and genetically heterogeneous *** diagnosis was clear in 78.9%of PME *** of genetic testing methods could inc

关键词： Progressive myoclonic epilepsy Genotype Phenotype

类固醇激素对21-羟化酶缺乏症患者随访价值的研究

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中华检验医学杂志 2022年第3期45卷 289-295页

作者：兰天姚辉丰利芳罗杰阮雯华中科技大学同济医学院附属武汉儿童医院遗传代谢内分泌科武汉430016

目的观察液相色谱-串联质谱(LC-MS/MS)与免疫法检测多种类固醇激素的一致性。寻找多种类固醇激素在21-羟化酶缺乏症(21-OHD)中的诊断价值、筛选随访指标。方法2019年5月至2020年5月,武汉儿童医院收集实验组为109例接受规范治疗的经典型2... 详细信息

目的观察液相色谱-串联质谱(LC-MS/MS)与免疫法检测多种类固醇激素的一致性。寻找多种类固醇激素在21-羟化酶缺乏症(21-OHD)中的诊断价值、筛选随访指标。方法2019年5月至2020年5月,武汉儿童医院收集实验组为109例接受规范治疗的经典型21-OHD患者,对照组为94名正常儿童。同时用免疫法和LC-MS/MS法检测17-羟孕酮(17-OHP)、雄烯二酮(Δ4-A)、睾酮和皮质醇。采用LC-MS/MS法检测另外16种肾上腺类固醇激素。实验组分为过度治疗组(17-OHP<4 ng/ml)、控制良好组(4 ng/ml≤17-OHP<12 ng/ml)和控制欠佳组(17-OHP≥12 ng/ml)。分析免疫法与LC-MS/MS检测结果的一致性,比较21-OHD患者与对照组LC-MS/MS血清多种类固醇浓度差异,发掘多种类固醇激素检测的诊断价值,比较不同疗效21-OHD患者20种类固醇浓度差异,筛选更有价值的随访指标。结果(1)LC-MS/MS与免疫法同时检测的4项指标中,T、17-OHP的一致性高。免疫法测定的皮质醇和Δ4-A浓度高于LC-MS/MS。(2)LC-MS/MS检测的肾上腺分泌的20种类固醇激素中21-OHD患者较对照组有6种激素明显偏高,6种激素明显偏低,8种没有统计学差异。(3)抑制过度组17-OHP降低、11-脱氧皮质醇升高;控制欠佳组17-OHP、孕烯醇酮、孕酮、17-羟孕烯醇酮、21-脱氧皮质醇、Δ4-A、雌酮升高。结论LC-MS/MS可一次性检测多种类固醇激素,评价维度更多面。随访中20种激素中仅8种与患者控制状态密切相关,可减少不必要的消耗。

关键词： 21-羟化酶缺乏症液相色谱-串联质谱类固醇激素随访

Status of aquatic organisms resources and their environments in Yangtze River system(2017-2021)⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile Yang Li Shen Yongfeng He Huiwu tian Lei Gao Jinming Wu Zhigang Mei Nian Wei Lin Wang Tingbing Zhu Feifei Hu Jinling Gong Hongchun Du Xinbin Duan Huatang Deng Daoqun Wang Fengyue Zhu Yunfeng Li Fan Wu Huijun Ru Yan Zhang Junyi Li Junlin Yang Yuntao Zhou Dongdong Fang Yinping Wang Danqing Lin Yanping Yang Peijie Li Silei Liu Jian Yang Ping Zhuang Sikai Wang Tao Zhang Gang Yang Wenbo Yang Lilai Yuan Kun Cao Shuo Xu Huiyuan Liu Zhiqiang Liang Chongrui Wang Hong Li Xiping Yuan Xin Yang Yilong Fu Yanping Zhang Haixin Zhang Zhiying Tao Sheng Wang Xiaoping Gao Binsong Jin Kemao Li Guojie Wang Shenglong Jian Yingqin Li Chenjiang Xue Chunyun Lei Shaowei Xue Yi Sun Bin Zhu Ke Shao Xingkun Hu Meihua Xiong Jun Du Bin He Tao Yan Yingying Huang Yuanchao Zou Biwen Xie Yongming Wang Bin Li Fei Liu Yaoyao Zhang Fei Fan Zhijian Wang Jing Huang Haoran Gu Hailong Ge Yan Dan Yan Li Shuqiao Wang Chuang Zhang Lu Zhou Xue Wang Sheng Zeng Yan Xiang Xugang He Jianhui Qin Chengxing Xia Jie Hou Yifu Shi lifang Gao Zhiqiang Zhu Hongbao Shen Yun Du Xuejun Duan Jiawu Xiong Deguo Yang Shaoping Liu Zhaohui Ni Hui Zhang Kai Liu Feng Zhao Yingren Li Jianwei Wang Qiwei Wei Yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science Institute Changsha410153China Jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery Sciences Jiujiang332000China School of Life Sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery Technology Extension Center Xining810012China Yunnan Academy of Fishery Sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China School of Life Sciences Neijiang Normal UniversityNeijiang641100China School of Life Sciences Southwest UniversityChongqing400715China Chongqing Fishery Sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of State Forestry and Grassland Administration Changsha410014China

The Yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of Yangtze Fisheries Resources and Environment Investigation(2017-2021)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 24 institutes and universities that located in the Yangtze River basin surveys the status of(1)fish species composition and spatial distribution,(2)current fish abundance,(3)endangered fishes,(4)Yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the Yangtze River mainstream and 10 of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 163 genus,37 families,and 18 orders)before 2017,but only 323 fish species(including 15 new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole Yangtze River *** is estimated that there were 886 million individuals weighing 124.8 million kg,merely equivalent to 27.3%of the resources in 1950s,30.9%of the resources in 1960s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the Yangtze River system,only 15 of 29 were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes Yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation Yangtze river system

Mechanoresponsive MiR-138-5p Targets MACF1 to Inhibit Bone Formation

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医用生物力学 2019年第A1期34卷 72-73页

作者： Zhihao Chen Zhao Fan Liang Chao lifang Hu Chen Lei Zhang Yan Yin Chong Dijie Li tian Ye Wuxia Qiu Kewen Zhang Chaofei Yang Xiaona Li Li Yu Weiyi Chen Zhang Ge Qian Airong Lab for Bone Metabolism Key Lab for Space Biosciences and BiotechnologyResearch Center for Special Medicine and Health Systems EngineeringNPU-UAB Joint Laboratory for Bone MetabolismSchool of Life SciencesNorthwestern Polytechnical UniversityXi’an710072China Northwestern Polytechnical University-Hong Kong Baptist UniversityJoint Rese arch Centre for Translational Medicine on Musculoskeletal Health in Space Xi’an710072China Institute forAdvancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China

Mechanical stimuli play an essential role in maintaining bone remodeling and skeletal ***,bone can respond to the changes of mechanical condition to adjust its mass and *** studies discover that bedridden patients showed osteoporotic T-scores and low bone mineral density,and long-term immobilized patients presented reduced markers of bone ***,as bone formation mediated by osteoblast differentiation is a complex process,the underlying molecular mechanism of mechanical stimuli regulating bone formation is still *** evidences show that microRNAs(miRNAs)are involved in mechanical stimuli regulating bone formation or osteoblast ***,no direct evidence identifies mechanoresponsive miRNA in both human and animal bones,and clarifies its mechanoresponsive role under different mechanical conditions(*** unloading,reloading,loading).In the current study,we screened for differentially expressed miRNAs in bone specimens of bedridden patients with fractures,then identified that the expression of miR-138-5p,but not the other miRNAs,altered withbedridden time and was negatively correlated with the expression of the bone formation marker genes Alp(alkaline phosphatase).Moreover,miR-138-5p was up-regulated with reduced bone formation during unloading and down-regulated with increased bone formation during reloading in hind4imb unloaded *** addition,miR-138-5p was verified to be responsive to different mechanical unloading condition and cyclic mechanical stretch condition in primary osteogenic cells,*** in vitro data suggested that mechanoresponsive miR-138-5p directly targeted microtubule actin crosslinking factor 1(MACF1)to inhibit osteoblast *** vivo,we constructed an osteoblastic miR-138-5p transgenic mice model(TG138)with the Runx2promoter,and found that overexpression miR-138-5p supressed bone ***,osteoblast-targeted inhibition of miR-13

关键词： Mechanoresponse miR-138-5p MACF1 bone formation

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钙调蛋白磷酸酶B亚基靶向肝癌的研究

现代肿瘤医学 2023年第18期31卷 3342-3346页

作者：韩丽芳田树红海南医学院海南省药物安全性评价研究中心海南海口571199

目的:基于小动物活体成像检测技术,探讨重组人钙调蛋白磷酸酶B亚基(rhCNB)的肝癌靶向性。方法:采用肿瘤组织块法建立BALB/c裸小鼠荷人肝癌细胞SMMC-7721原位肝癌模型。原位肝癌模型建立第14天时,按荷瘤动物体重大小随机分为FITC标记的rh... 详细信息

目的:基于小动物活体成像检测技术,探讨重组人钙调蛋白磷酸酶B亚基(rhCNB)的肝癌靶向性。方法:采用肿瘤组织块法建立BALB/c裸小鼠荷人肝癌细胞SMMC-7721原位肝癌模型。原位肝癌模型建立第14天时,按荷瘤动物体重大小随机分为FITC标记的rhCNB(rhCNB-FITC)给药组和FITC对照组,每组12只,各取6只分别用于给药后2 h、24 h剖解取出心脏、肺、肝、胃、双侧肾脏和脾脏用小动物活体成像系统进行荧光检测。另取未接种肿瘤的正常BALB/c裸小鼠随机分为rhCNB-FITC给药组和空白对照组,rhCNB-FITC给药组12只,各取6只分别用于给药后2 h、24 h剖解取相同的脏器进行荧光检测。空白对照组6只,剖解取出相同的脏器进行荧光检测。结果:rhCNB-FITC给予未接种肿瘤的正常动物2 h时,主要分布于动物的肾脏、肝、胃、心和肺,脾脏未见明显分布;24 h时,主要分布于动物的肾脏,肝、胃、心、肺和脾脏未见明显分布。在原位肝癌模型试验中,rhCNB-FITC给药2 h时,主要分布于肝肿瘤、肾脏、肺、胃和心脏等组织器官,脾脏内未检测到明显荧光;FITC给药组只有在肝和胃组织中能检测到荧光,而且荧光强度明显弱于rhCNB-FITC给药组;rhCNB-FITC给药组与FITC对照组肝部(包括正常组织和肝肿瘤组织)的荧光强度比较,P<0.01,具有显著统计学意义。rhCNB-FITC给药24 h时,主要聚集在肝肿瘤、胃、肾脏和肺等组织器官,其中rhCNB在肝肿瘤部位的浓度最高;rhCNB-FITC给药组与FITC对照组肝肿瘤部的荧光强度比较,P<0.05,具有统计学意义。结论:重组人钙调蛋白磷酸酶B亚基具有良好的肝癌靶向性。

关键词：原位肝癌钙调蛋白磷酸酶B亚基肿瘤靶向性活体成像系统