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Advance in the Research of Wetland Tourism in China

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湿地科学 2008年第4期6卷 536-542页

作者： ZHANG Yichuan QIAO lifang ZHENG Shujing College of Landscape Architecture Henan Institute of Science and Technology Xinxiang 453003 Henan P. R. China

The wetland tourism in China has been one of the most popular tourisms as its fast growth in China in recent years. The significance of the wetland tourism research for the local sustainable development was noticed and have summarized this review in 3 aspects: resources, including assessment, resources and products development; planning, including the orientation of wetland tourism, the landscape planning and application of science and technology; and management, including tourism capacity, environmental evaluation, the ecological compensation and the public participation. The wetland tourism research in China is insufficient in the following fields: the depth of extensive studies, the application of mathematics, the objective planning and the evaluation of ecological influence. What should be more noticed in the future research is that it is considered as landscape ecology, landscape planning and the relevant wetland-structure controlling, the environment and landscape pattern change caused by tourism, tourism risk evaluation, the economics and sociology research in wetland tourism.

关键词：中国湿地旅游自然环境旅游资源旅游开发发展战略

Advance in Research of Ecology and Landscape Reconstruction of the River Floodplain In China

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湿地科学 2008年第1期6卷 80-86页

作者： QIAO lifang QI Anguo ZHANG Yichuan College of Landscape Architecture Henan Institute of Science and Technology Xinxiang 453003 Henan P. R. China

The research of ecology and landscape reestablishment of river floodplain is considered favorable to its conservation and *** similarity and difference among river floodplain,wetland,riverside and shore have been reviewed,as well as the progress in the research of floodplain ecology reestablishment in quantitative evaluation,vegetation restoration,the influence on animal habitat and the application of eco-engineering;and of the landscape reestablishment in resource development and utilization,landscape feature and changes,landscape function,structure and *** potentially important fields are expected to be the change of landscape pattern in different scales,the reasonable protection and utilization in the floodplain tourism,the simulating and monitoring of landscape dynamics,the planning and designing methods of floodplain landscape and the management of floodplain ecosystems.

关键词：生态再造景观改造中国洪水

Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis

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Signal Transduction and Targeted Therapy 2019年第1期4卷 445-453页

作者： Yaqi Lyu Qingqing Xiao lifang Yin Lei Yang Wei He School of Pharmacy China Pharmaceutical University210009 NanjingChina Shanghai Dermatology Hospital 200443 ShanghaiChina

Metastasis is a major cause of chemotherapeutic failure and *** of a specific component of the extracellular matrix(ECM)by matrix metalloproteinases(MMPs)affects the physical barrier of the tumor microenvironment(TME)and induces ***,lysolipid-containing thermosensitive liposomes(LTSLs)were prepared to deliver an MMP inhibitor,marimastat(MATT),to the TME to inhibit MMP activity and *** rapidly released their payloads at 42°*** with the saline control,MATT-LTSLs exhibited enhanced accumulation in the tumor and a 20-fold decrease in tumor growth in 4T1 tumor-bearing mice;moreover,MATT-LTSLs reduced MMP-2 and MMP-9 activity by 50%and 43%,respectively,and downregulated MMP-2 and MMP-9 expression in vivo by 30%and 43%,*** importantly,MATT-LTSL treatment caused a 7-fold decrease in metastatic lung nodules and a 6-fold reduction in microvessels inside the *** believe this study provides an effective approach for the suppression of metastasis,and the use of a cytotoxic agent in combination with MATT is a potential strategy for metastatic cancer treatment.

关键词： metastasis expression. lung

Natural continuous influent nitrifier immigration effects on nitrification and the microbial community of activated sludge systems

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Journal of Environmental Sciences 2018年第12期30卷 159-167页

作者： lifang Yu Ren Li Robert Delatolla Ru Zhang Xiuling Yang Dangcong Peng School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology Department of Civil Engineering University of Ottawa

Two sequencing batch reactors（SBRs） were operated for 100 days under aerobic conditions,with one being fed with unsterilized municipal wastewater（USBR）, and the other fed with sterilized municipal wastewater（SSBR）. Respirometric assays and fluorescence in situ hybridization（FISH） results show that active nitrifiers were present in the unsterilized influent municipal wastewater. The maximum ammonia utilization rate（AUR） and nitrite utilization rate（NUR） of the unsterilized influent were 0.32 ± 0.12 mg NH4＋-N/（L·hr） and0.71 ± 0.18 mg NO2--N/（L·hr）. Based on the maximum utilization rates, the estimated seeding intensity for the ammonia oxidizing bacteria（AOB） and nitrite oxidizing bacteria（NOB） of the USBR was 0.08 g AOB/（g AOB·day） and 0.20 g NOB/（g NOB·day） respectively. The fraction of nitrifiers/total bacteria in the influent was 5.35% ± 2.1%, the dominant AOB was Nitrosomonas spp., Nitrosococcus mobilis hybridizated with Nsm156, and the dominant NOB was Nitrospira hybridizated with Ntspa662. The influent nitrifiers potentially seeded the activated sludge of the bioreactor and hence demonstrated a mitigation of the acclimatization times and instability during start-up and early operation. The AUR and NUR in the USBR was 15% and 13% higher than the SSBR respectively during the stable stage, FISH results showed that nitrifiers population especially the Nitrospira in the USBR was higher than that in the SSBR. These results indicate that the natural continuous immigration of nitrifiers from municipal influent streams may have some repercussions on the modeling and design of bioreactors.

关键词： Nitrifier immigration Influent wastewater Seeding effect Nitrification Nitrospira

Attacking contrast enhancement forensics in digital images

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Science China(Information Sciences) 2014年第5期57卷 170-182页

作者： CAO Gang ZHAO Yao NI RongRong TIAN HuaWei YU lifang School of Computer Science Communication University of China Institute of Information Science Beijing Jiaotong University People's Public Security University of China

Currently,plenty of digital image forensic techniques have been proposed and used as diagnostic *** is urgent and significant to assess the reliability of such techniques applied in practical *** this paper,we investigate the security of existing digital image contrast enhancement(CE)forensic *** the standpoint of attackers,we propose two types of attacks,CE trace hiding attack and CE trace forging attack,which could invalidate the forensic detector and fabricate two types of forensic errors,*** CE trace hiding attack is implemented by integrating local random dithering into the design of pixel value *** CE trace forging attack is proposed by modifying the gray level histogram of a target pixel region to counterfeit peak/gap *** trace forging attack is typically applied to create sophisticated composite images which could deceive the prior CE-based composition *** experimental results demonstrate the efficacy of our proposed CE anti-forensic schemes.

关键词： digital forensics anti-forensics attack contrast enhancement composite image histogram

Drug Nanorod-Mediated Intracellular Delivery of microRNA-101 for Self-sensitization via Autophagy Inhibition

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Nano-Micro Letters 2019年第4期11卷 453-468页

作者： Xiaofei Xin Xiaoqing Du Qingqing Xiao Helena SAzevedo Wei He lifang Yin Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 210009People’s Republic of China School of Engineering and Materials Science Institute of BioengineeringQueen MaryUniversity of LondonLondon E14NSUK

Autophagy is closely related to the drug resistance and metastasis in cancer *** co-delivery of combinatorial therapy with small-molecular drugs and nucleic acids is promising to address drug ***,a drug-delivering-drug(DDD)platform consisting of anti-tumor-drug nanorods as a vehicle for cytosol delivery of nucleic acid(miR-101)with potent autophagic-inhibition activity is reported for combinatorial *** developed 180-nm nanoplatform,with total drug loading of up to 66%,delivers miR-101 to cancer cells,with threefold increase in intracellular level compared to conventional gene carriers and inhibits the autophagy significantly,along with above twofold reduction in LC3II mRNA and approximately fivefold increase in p62 mRNA over the control demonstrated in the results in *** in turn,the delivery of miR-101 potentiates the drug’s ability to kill cancer cells,with a threefold increase in apoptosis over that of chemotherapy *** anti-tumor study in vivo indicates the combined therapy that enables a reduction of 80%in tumor volume and>twofold increase in apoptosis than of the single-drug *** summary,via the carrier-free strategy of DDD,this work provides a delivery platform that can be easily customized to overcome drug resistance and facilitates the delivery of combined therapy of small-molecular drugs and nucleic acids.

关键词： Nanocrystals MicroRNA delivery Autophagy inhibition Cytotoxicity Combinatorial therapy

Synthesis of Layered Hydroxide Zinc m-Aminobenzoate Compounds and Their Exfoliation Reactions

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Chinese Journal of Chemistry 2011年第9期29卷 1837-1845页

作者： Zhao, lifang Wang, Hongshe Wang, Yan Miao, Jianyin Feng,Qi Department of Chemistry and Chemical Engineering Baoji University of Arts and Science Baoji Shaanxi 721013 China Department of Advanced Materials Science Faculty of Engineering Kagawa University 2217-20 Hayashi Takamatsu 761-0396 Japan

Two types of layered hydroxide zinc m-aminobenzoate compounds with structures of layered basic metal salt （LBMS） were prepared by the reaction of zinc hydroxide with m-aminobenzoic acid solution in the temperature range of 40----120℃. The formation reactions, structures, chemical compositions, and exfoliation reactions of the layered compounds in alcohol solvents were investigated by XRD, TG-DTA, SEM, and TEM. One layered phase with a basal spacing of 1.08 nm has a a-Ni（OH）2-1ike structure, and its chemical formula can be written as Zn（OH）0.67（m-NH2C6HaCOO）l.33. This phase has strip-like particle morphology and cannot be exfoliated into its nanosheets in alcohol solvents. The other layered phase with a basal spacing of 2.66 nm has a zinc hydrox- ide-nitrate-like structure, and can be exfoliated in alcohol solvents.

关键词： layered compound layered basic metal salt hydrothermal synthesis exfoliation reaction nanosheet

The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation

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Protein & Cell 2012年第6期3卷 450-459页

作者： lifang Niu Falong Lu Taolan Zhao Chunyan Liu Xiaofeng Cao State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Institute for Agricultural Biosciences Oklahoma State UniversityArdmoreOK 73401USA Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599USA Graduate School of the Chinese Academy of Sciences Beijing 100039China

Arabidopsis AtPRMT10 is a plant-specific type I protein arginine methyltransferase that can asymmetrically dimethylate arginine 3 of histone H4 with auto-methylation *** of AtPRMT10 derepress FLOWERING LOCUS C(FLC)expression resulting in a late-flowering ***,to further investigate the biochemical characteristics of AtPRMT10,we analyzed a series of mutated forms of the AtPRMT10 *** demon-strate that the conserved“VLD”residues and“double-E loop”are essential for enzymatic activity of *** addition,we show that Arg54 and Cys259 of AtPRMT10,two residues unreported in animals,are also important for its enzymatic *** find that Arg13 of AtPRMT10 is the auto-methylation ***,substitution of Arg13 to Lys13 does not affect its enzymatic *** vivo complementation assays reveal that plants expressing AtPRMT10 with VLD-AAA,E143Q or E152Q mutations retain high levels of FLC expression and fail to rescue the late-flowering phenotype of atprmt10 *** together,we conclude that the methyltransferase activity of AtPRMT10 is essential for repressing FLC expression and promoting flowering in Arabidopsis.

关键词： protein arginine methyltransferases(PRMTs) flowering methyltransferase activity

Reactive extraction for intensifying 2-ethylhexyl acrylate synthesis using deep eutectic solvent [Im:2PTSA]

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Green Energy & Environment 2021年第3期6卷 405-412页

作者： Ruizhuan Wang Hao Qin Jingwen Wang Hongye Cheng lifang Chen Zhiwen Qi State Key Laboratory of Chemical Engineering and School of Chemical Engineering East China University of Science and Technology130 Meilong RoadShanghai200237China

2-Ethylhexyl acrylate(2-EHA)is one of the most widely used acrylates in the polymer industry,which is synthesized via Fisher esterification that is limited by chemical *** intensify the esterification process,in this work,reactive extraction concept is proposed,with halogen-free deep eutectic solvent(DES[Im:2PTSA])as dual solvent-catalyst that consists of imidazole(Im)and p-toluenesulfonamide(PTSA).The bifunctional effects of the DES[Im:2PTSA]are evaluated by thermodynamic analysis and experimental *** phase splitting is verified byσ-potential analysis predicted by COSMO-RS theory,combined with experiments,and the optimal acid-to-alcohol molar ratio is set to *** esterification kinetics is then experimentally determined and fitted using the molar-based and activity-based pseudo-homogeneous(PH)models,*** activity-based PH model,that considers the bifunctional roles of the DES,proves to be more accurate with small RMSD of *** stability of DES after recycling is validated to further confirm the industrial prospects of DES[Im:2PTSA]in 2-EHA production.

关键词： 2-Ethylhexyl acrylate Deep eutectic solvent Reactive extraction Esterification kinetics COSMO-RS