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Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts

分子细胞生物学报:英文版 2016年第1期8卷 73-87页

作者： Domiziana Costamagna Mattia Quattrocelli Florence van Tienen lieve umans Irineus FMde Coo An Zwijsen Danny Huylebroeck Maurilio Sampaolesi Translational Cardiomyology Laboratory Stem Cell Biology and EmbryologyDepartment of Development and RegenerationKU LeuvenLeuvenBelgium Laboratory of Experimental Medicine and Clinical Pathology Department of Clinical and Biological SciencesUniversity of TurinTurinItaly Department of Clinical Genetics Maastricht University Medical CenterMaastrichtThe Netherlands Laboratory for Developmental Signalling VIB Center for the Biology of DiseaseDepartment of Human GeneticsKU LeuvenLeuvenBelgium Laboratory of Molecular Biology(Celgen) Department of Development and RegenerationKU LeuvenLeuvenBelgium Department of Neurology Erasmus MC-Sophia Children’s HospitalRotterdamThe Netherlands Department of Cell Biology Erasmus MCRotterdamThe Netherlands Division of Human Anatomy Department of Public HealthExperimental and Forensic MedicineUniversity of PaviaPaviaItaly

Mesoangioblasts(MABs)are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle *** circuits that regulate the myogenic commitment of MABs are still poorly *** critical role of bone morphogenetic protein(BMP)signalling during proliferation and differentiation of adult myogenic precursors,such as satellite cells,has recently been *** whether BMP signalling impacts on the myogenic potential of embryonic and adult MABs both in vitro and in *** of BMP inhibited MAB myogenic differentiation,whereas interference with the interactions between BMPs and receptor complexes induced ***,siRNA-mediated knockdown of Smad8 in Smad1/5-null MABs or inhibition of SMAD1/5/8 phosphorylation with Dorsomorphin(DM)also improved myogenic differentiation,demonstrating a novel role of ***,using a transgenic mouse model of Smad8 deletion,we demonstrated that the absence of SMAD8 protein improved MAB myogenic ***,once injected into a-Sarcoglycan(Sgca)-null muscles,DM-treated MABs were more efficacious to restore a-sarcoglycan(aSG)protein levels and re-establish functional muscle ***,in acute muscle damage,DM-treated MABs displayed a better myogenic potential compared with BMP-treated and untreated ***,SMADs also control the myogenic commitment of human MABs(hMABs).BMP signalling antagonists are therefore novel candidates to improve the therapeutic effects of hMABs.

关键词： BMP signalling mesoangioblast pericytes skeletal muscle regeneration SMAD

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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

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Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration?

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Neural Regeneration Research 2019年第8期14卷 1313-1316页

作者： An Beckers lieve Moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven

Dendrites form an essential component of the neuronal circuit have been largely overlooked in regenerative research. Nevertheless, subtle changes in the dendritic arbors of neurons are one of the first stages of various neurodegenerative diseases, leading to dysfunctional neuronal networks and ultimately cellular death. Maintaining dendrites is therefore considered an essential neuroprotective strategy. This mini-review aims to discuss an intriguing hypothesis, which postulates that dendritic shrinkage is an important stimulant to boost axonal regeneration, and thus that preserving dendrites might not be the ideal therapeutic method to regain a full functional network upon central nervous system damage. Indeed, our study in zebrafish, a versatile animal model with robust regenerative capacity recently unraveled that dendritic retraction is evoked prior to axonal regrowth after optic nerve injury. Strikingly, inhibiting dendritic pruning upon damage perturbed axonal regeneration. This constraining effect of dendrites on axonal regrowth has sporadically been proposed in literature, as summarized in this short narrative. In addition, the review discusses a plausible underlying mechanism for the observed antagonistic axon-dendrite interplay, which is based on energy restriction inside neurons. Axonal injury indeed leads to a high local energy demand in which efficient axonal energy supply is fundamental to ensure regrowth. At the same time, axonal lesion is known to induce m让ochondrial depolarization, causing energy depletion in the axonal compartment of damaged neurons. Mitochondria, however, become mostly stationary after development, which has been proposed as a potential underlying reason for the low regenerative capacity of adult mammals. Per contra, upon reduced neuronal activity, mitochondrial mobility enhances. In this view, dendritic shrinkage after axonal injury in zebrafish could result in less synaptic input and hence, a release of mitochondria within the so

关键词： axonal regeneration dendritic remodeling retina central nervous system zebrafish mitochondrial transport mitochondrial dynamics energy supply

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Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration

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Neural Regeneration Research 2016年第5期11卷 740-742页

作者： Kim Lemmens Inge Van Hove lieve Moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven

Matrix metalloproteinases（MMPs）are members of the metzincin superfamily named after the zinc ion and the conserved methionine residue at the active *** addition to their role in extracellular matrix（ECM）remodeling... 详细信息

关键词： MMP Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration MMPs

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Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics

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Neural Regeneration Research 2023年第1期18卷 219-225页

作者： An Beckers Luca Masin Annelies Van Dyck Steven Bergmans Sophie Vanhunsel Anyi Zhang Tine Verreet Fabienne EPoulain Karl Farrow lieve Moons Neural Circuit Development and Regeneration Research Group Animal Physiology and Neurobiology SectionDepartment of BiologyKatholieke Universiteit LeuvenLeuvenBelgium Poulain Lab Department of Biological SciencesUniversity of South CarolinaColumbiaSCUSA Neuro-Electronics Research Flanders Vlaams Instituut voor Biotechnologie(VIB)LeuvenBelgium Leuven Brain Institute LeuvenBelgium Imec LeuvenBelgium

Axonal regeneration in the central nervous system is an energy-intensive *** contrast to mammals,adult zebrafish can functionally recover from neuronal *** raises the question of how zebrafish can cope with this high energy *** previously showed that in adult zebrafish,subjected to an optic nerve crush,an antagonistic axon-dendrite interplay exists wherein the retraction of retinal ganglion cell dendrites is a prerequisite for effective axonal *** postulate a‘dendrites for regeneration’paradigm that might be linked to intraneuronal mitochondrial reshuffling,as ganglion cells likely have insufficient resources to maintain dendrites and restore axons ***,we characterized both mitochondrial distribution and mitochondrial dynamics within the different ganglion cell compartments(dendrites,somas,and axons)during the regenerative *** nerve crush resulted in a reduction of mitochondria in the dendrites during dendritic retraction,whereafter enlarged mitochondria appeared in the optic nerve/tract during axonal *** dendritic regrowth in the retina,mitochondrial density inside the retinal dendrites returned to baseline ***,a transient increase in mitochondrial fission and biogenesis was observed in retinal ganglion cell somas after optic nerve *** together,these findings suggest that during optic nerve injury-induced regeneration,mitochondria shift from the dendrites to the axons and back again and that temporary changes in mitochondrial dynamics support axonal and dendritic regrowth after optic nerve crush.

关键词： axonal regeneration central nervous system dendrite remodeling energy metabolism fission mitochondria mitochondrial trafficking optic nerve crush retina zebrafish

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ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies

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Neural Regeneration Research 2015年第12期10卷 1949-1950页

作者： Inge Van Hove Evy Lefevere lieve Moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven Laboratory of Ophthalmology Department of NeurosciencesKU Leuven

Optic neuropathies or optic nerve diseases are a frequent cause of permanent vision loss that can occur after inflammation,ischemia,infection,tumors,trauma and/or an elevated pressure inside the eye（also called intra... 详细信息

关键词： ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies RGCs

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Reaching for the brain：stimulating neural activity as the big leap in optic nerve regeneration

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Eye Science 2016年第4期31卷 221-224页

作者： Emiel Geeraerts lieve Moons Lies De Groef Research Group Neural Circuit Development and Regeneration Animal Physiology and Neurobiology Section Department of Biology KU LeuvenLeuven Belgium

In the August issue of Nature Neuroscience,Lim and coworkers reported on their study of axonal regeneration in the adult optic nerve,revealing that combined activation of mammalian target of rapamycin(mTOR)signaling a... 详细信息

关键词：神经再生大脑动作中枢神经系统神经科学视觉中心神经活动 mTOR

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Synthesis and Biological Investigation of Thiazolylthioacetamides Derivatives as A Novel Class of Potential Antiviral Agents

Synthesis and Biological Investigation of Thiazolylthioaceta...

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2011年全国药物化学学术会议——药物的源头创新

作者： Christophe Pannecouque lieve Naesens Erik De Clercq Rega Institute for Medical Research K.U.LeuvenMinderbroedersstraat 10B-3000 LeuvenBelgium

＜正＞In continuation of our endeavor to develop new,potent,selective and less toxic antiviral agents,a novel series of 2-（2-amino/chloro-4-（2,4-dibromophenyl） thiazol-5-ylthio）acetamide derivatives was synthesized via an expeditious route and evaluated for their anti-HIV activities against wild-type virus and clinically relevant mutant strains,and for their anti-influenza virus activities against influenza A

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Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promi...

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2011年全国药物化学学术会议——药物的源头创新

作者： lieve Naesens Evelien Vanderlinden Erik De Clercq Rega Institute for Medical Research Katholieke Universiteit LeuvenB-3000 LeuvenBelgium

＜正＞Human influenza viruses are highly contagious pathogens that affect the airway epithelia, resulting in acute respiratory symptoms with potentially severe or life-threatening complications in specific risk *** viruses are classified in three main types:A,B,and *** subdivision in subtypes（e.g.A/H1N1 and A/H3N2） is based on the structure of the hemagglutinin and neuraminidase antigens.

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蜀素帖

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七彩语文（初中） 2020年第12期 18-22页

作者：寒酌 lieve(画) 不详

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