检索结果-南通市图书馆

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef lieve moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration?

引用

Neural Regeneration Research 2019年第8期14卷 1313-1316页

作者： An Beckers lieve moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven

Dendrites form an essential component of the neuronal circuit have been largely overlooked in regenerative research. Nevertheless, subtle changes in the dendritic arbors of neurons are one of the first stages of various neurodegenerative diseases, leading to dysfunctional neuronal networks and ultimately cellular death. Maintaining dendrites is therefore considered an essential neuroprotective strategy. This mini-review aims to discuss an intriguing hypothesis, which postulates that dendritic shrinkage is an important stimulant to boost axonal regeneration, and thus that preserving dendrites might not be the ideal therapeutic method to regain a full functional network upon central nervous system damage. Indeed, our study in zebrafish, a versatile animal model with robust regenerative capacity recently unraveled that dendritic retraction is evoked prior to axonal regrowth after optic nerve injury. Strikingly, inhibiting dendritic pruning upon damage perturbed axonal regeneration. This constraining effect of dendrites on axonal regrowth has sporadically been proposed in literature, as summarized in this short narrative. In addition, the review discusses a plausible underlying mechanism for the observed antagonistic axon-dendrite interplay, which is based on energy restriction inside neurons. Axonal injury indeed leads to a high local energy demand in which efficient axonal energy supply is fundamental to ensure regrowth. At the same time, axonal lesion is known to induce m让ochondrial depolarization, causing energy depletion in the axonal compartment of damaged neurons. Mitochondria, however, become mostly stationary after development, which has been proposed as a potential underlying reason for the low regenerative capacity of adult mammals. Per contra, upon reduced neuronal activity, mitochondrial mobility enhances. In this view, dendritic shrinkage after axonal injury in zebrafish could result in less synaptic input and hence, a release of mitochondria within the so

关键词： axonal regeneration dendritic remodeling retina central nervous system zebrafish mitochondrial transport mitochondrial dynamics energy supply

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics

引用

Neural Regeneration Research 2023年第1期18卷 219-225页

作者： An Beckers Luca Masin Annelies Van Dyck Steven Bergmans Sophie Vanhunsel Anyi Zhang Tine Verreet Fabienne EPoulain Karl Farrow lieve moons Neural Circuit Development and Regeneration Research Group Animal Physiology and Neurobiology SectionDepartment of BiologyKatholieke Universiteit LeuvenLeuvenBelgium Poulain Lab Department of Biological SciencesUniversity of South CarolinaColumbiaSCUSA Neuro-Electronics Research Flanders Vlaams Instituut voor Biotechnologie(VIB)LeuvenBelgium Leuven Brain Institute LeuvenBelgium Imec LeuvenBelgium

Axonal regeneration in the central nervous system is an energy-intensive *** contrast to mammals,adult zebrafish can functionally recover from neuronal *** raises the question of how zebrafish can cope with this high energy *** previously showed that in adult zebrafish,subjected to an optic nerve crush,an antagonistic axon-dendrite interplay exists wherein the retraction of retinal ganglion cell dendrites is a prerequisite for effective axonal *** postulate a‘dendrites for regeneration’paradigm that might be linked to intraneuronal mitochondrial reshuffling,as ganglion cells likely have insufficient resources to maintain dendrites and restore axons ***,we characterized both mitochondrial distribution and mitochondrial dynamics within the different ganglion cell compartments(dendrites,somas,and axons)during the regenerative *** nerve crush resulted in a reduction of mitochondria in the dendrites during dendritic retraction,whereafter enlarged mitochondria appeared in the optic nerve/tract during axonal *** dendritic regrowth in the retina,mitochondrial density inside the retinal dendrites returned to baseline ***,a transient increase in mitochondrial fission and biogenesis was observed in retinal ganglion cell somas after optic nerve *** together,these findings suggest that during optic nerve injury-induced regeneration,mitochondria shift from the dendrites to the axons and back again and that temporary changes in mitochondrial dynamics support axonal and dendritic regrowth after optic nerve crush.

关键词： axonal regeneration central nervous system dendrite remodeling energy metabolism fission mitochondria mitochondrial trafficking optic nerve crush retina zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies

引用

Neural Regeneration Research 2015年第12期10卷 1949-1950页

作者： Inge Van Hove Evy Lefevere lieve moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven Laboratory of Ophthalmology Department of NeurosciencesKU Leuven

Optic neuropathies or optic nerve diseases are a frequent cause of permanent vision loss that can occur after inflammation,ischemia,infection,tumors,trauma and/or an elevated pressure inside the eye（also called intra... 详细信息

关键词： ROCK inhibition as a novel potential strategy for axonal regeneration in optic neuropathies RGCs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration

引用

Neural Regeneration Research 2016年第5期11卷 740-742页

作者： Kim Lemmens Inge Van Hove lieve moons Neural Circuit Development and Regeneration Research Group Department of BiologyKU Leuven

Matrix metalloproteinases（MMPs）are members of the metzincin superfamily named after the zinc ion and the conserved methionine residue at the active *** addition to their role in extracellular matrix（ECM）remodeling... 详细信息

关键词： MMP Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration MMPs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reaching for the brain：stimulating neural activity as the big leap in optic nerve regeneration

引用

Eye Science 2016年第4期31卷 221-224页

作者： Emiel Geeraerts lieve moons Lies De Groef Research Group Neural Circuit Development and Regeneration Animal Physiology and Neurobiology Section Department of Biology KU LeuvenLeuven Belgium

In the August issue of Nature Neuroscience,Lim and coworkers reported on their study of axonal regeneration in the adult optic nerve,revealing that combined activation of mammalian target of rapamycin(mTOR)signaling a... 详细信息

关键词：神经再生大脑动作中枢神经系统神经科学视觉中心神经活动 mTOR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights from an academic endeavor into central nervous system drug discovery

引用

Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： lieve van Veggel An M.Voets Tim Vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts

引用

Journal of Molecular Cell Biology 2016年第1期8卷 73-87页

作者： Domiziana Costamagna Mattia Quattrocelli Florence van Tienen lieve Umans Irineus FMde Coo An Zwijsen Danny Huylebroeck Maurilio Sampaolesi Translational Cardiomyology Laboratory Stem Cell Biology and EmbryologyDepartment of Development and RegenerationKU LeuvenLeuvenBelgium Laboratory of Experimental Medicine and Clinical Pathology Department of Clinical and Biological SciencesUniversity of TurinTurinItaly Department of Clinical Genetics Maastricht University Medical CenterMaastrichtThe Netherlands Laboratory for Developmental Signalling VIB Center for the Biology of DiseaseDepartment of Human GeneticsKU LeuvenLeuvenBelgium Laboratory of Molecular Biology(Celgen) Department of Development and RegenerationKU LeuvenLeuvenBelgium Department of Neurology Erasmus MC-Sophia Children’s HospitalRotterdamThe Netherlands Department of Cell Biology Erasmus MCRotterdamThe Netherlands Division of Human Anatomy Department of Public HealthExperimental and Forensic MedicineUniversity of PaviaPaviaItaly

Mesoangioblasts(MABs)are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle *** circuits that regulate the myogenic commitment of MABs are still poorly *** critical role of bone morphogenetic protein(BMP)signalling during proliferation and differentiation of adult myogenic precursors,such as satellite cells,has recently been *** whether BMP signalling impacts on the myogenic potential of embryonic and adult MABs both in vitro and in *** of BMP inhibited MAB myogenic differentiation,whereas interference with the interactions between BMPs and receptor complexes induced ***,siRNA-mediated knockdown of Smad8 in Smad1/5-null MABs or inhibition of SMAD1/5/8 phosphorylation with Dorsomorphin(DM)also improved myogenic differentiation,demonstrating a novel role of ***,using a transgenic mouse model of Smad8 deletion,we demonstrated that the absence of SMAD8 protein improved MAB myogenic ***,once injected into a-Sarcoglycan(Sgca)-null muscles,DM-treated MABs were more efficacious to restore a-sarcoglycan(aSG)protein levels and re-establish functional muscle ***,in acute muscle damage,DM-treated MABs displayed a better myogenic potential compared with BMP-treated and untreated ***,SMADs also control the myogenic commitment of human MABs(hMABs).BMP signalling antagonists are therefore novel candidates to improve the therapeutic effects of hMABs.

关键词： BMP signalling mesoangioblast pericytes skeletal muscle regeneration SMAD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Coactivator-independent vitamin D receptor signaling causes severe rickets in mice,that is not prevented by a diet high in calcium,phosphate,and lactose

引用

Bone Research 2024年第3期12卷 648-660页

作者： Stefanie Doms lieve Verlinden Iris Janssens Justine Vanhevel Roy Eerlings RenéHoutman Shigeaki Kato Chantal Mathieu Brigitte Decallonne Geert Carmeliet Annemieke Verstuyf Department of Chronic diseases and metabolism Laboratory of Clinical and Experimental EndocrinologyKU LeuvenLeuvenBelgium Department of Cellular and Molecular Medicine Laboratory of Molecular EndocrinologyKU LeuvenLeuvenBelgium Institute of Applied Microbiology RWTH Aachen UniversityAachenGermany Precision Medicine Lab OssThe Netherlands Health Sciences Research Center Iryo Sosei UniversityIwakiFukuchimaJapan Research Institute of Innovative Medicine Tokiwa FoundationIwakiFukuchimaJapan

The vitamin D receptor(VDR)plays a critical role in the regulation of mineral and bone *** binding of 1α,25-dihydroxyvitamin D_(3) to the VDR,the activation function 2(AF2)domain repositions and recruits coactivators... 详细信息

关键词： vitamin homeostasis positions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Short-term effects of vacuum massage on epidermal and dermal thickness and density in burn scars: an experimental study

引用

Burns & Trauma 2016年第3期4卷 216-224页

作者： Jill Meirte Peter Moortgat Mieke Anthonissen Koen Maertens Cynthia Lafaire lieve De Cuyper Guy Hubens Ulrike Van Daele OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium KU Leuven Faculty of Kinesiology and Rehabilitation SciencesLeuvenBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium Department of Clinical and Lifespan Psychology Vrije Universiteit BrusselBrusselsBelgium OSCARE Organisation for BurnsScar After-care and ResearchVan Roiestraat 182170 AntwerpBelgium ZNA Stuivenberg Burn CenterAntwerpBelgium Department of Antwerp Surgical Training Anatomy and Research Centre University of AntwerpAntwerpBelgium Rehabilitation Sciences and Physiotherapy University of AntwerpUniversiteitsplein 12610 AntwerpBelgium

Background:Vacuum massage is a non-invasive mechanical massage technique invented to treat burns and *** date,no effects of vacuum massage on thickness and density of human scar tissue have been *** process in which external stimuli are converted into biochemical responses in the cell is known as *** the skin endothelial cells,fibroblasts and myofibroblasts embedded in the extracellular matrix(ECM)sense mechanical stimuli(created by vacuum massage)and may promote intracellular processes leading to matrix *** mechanotransduction could be a plausible working mechanism for vacuum massage as an anti-scarring therapy,this study aims to investigate the short-term effects of vacuum massage on thickness and density of epidermis and dermis in burn scars in order to find proof of ECM ***:A one group experimental study was *** with burn scars on upper extremities,lower extremities,and trunk were recruited for participation in this *** DUB?cutis 22 MHz ultrasound scanner was used to assess thickness and density of the epidermal and dermal skin *** baseline measurements,vacuum massage was performed according to a pre-defined *** were carried out at 5 min,30 min,1 h,and 2 h ***:Thirteen scar sites from 9 different patients were *** 8 out of the 13 scar sites,a disruption of the epidermis was noticed after the vacuum *** minutes after the intervention,epidermal density decreased statistically significantly(p=.022)and dermal thickness increased(p=.018).Both changes lasted for more than 1 h,but after 2 h,the changes were no longer statistically *** density decreased significantly(p=.048)immediately after the intervention,and this decrease was still present after 2 h(p=.011).Conclusions:Preliminary results show that the disruption of the epidermis may indicate that vacuum massage could be able to actually breach the s

关键词： Burn Scars Vacuum massage Dermal thickness Dermal density

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：