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Mind the gap:acute bilateral vocal cord palsy in CIDP after extending the IVIG treatment interval?

Neuroimmunology and Neuroinflammation 2021年第3期8卷 211-215页

作者： liesa regner Bendix Labeit Paul Muhle Tobias Ruck Rainer Dziewas Tobias Warnecke Sonja Suntrup-Krueger Department of Neurology with Institute of Translational Neurology University Hospital MünsterMünster 48149Germany

Cranial nerve involvement is rarely seen in chronic inflammatory demyelinating polyneuropathy(CIDP).We present a patient diagnosed with CIDP who was in a stable medical condition under long-term treatment with intravenous immunoglobulin(IVIG)every five weeks for more than seven *** a 12-day delay in the patient's regular IVIG therapy,he developed acute bilateral vocal cord *** patient had to be intubated and tracheostomized because of acute respiratory *** from mechanical ventilation was complicated due to *** antibiotic treatment and restarting IVIG therapy vocal cord palsy rapidly improved allowing for subsequent *** coincidence between treatment delay and symptom development does not prove definitive causality this case report may serve as a reminder how time critical IVIG therapy can be for sufficient symptom ***,it provides evidence that IVIG therapy may be effective for the treatment of cranial nerve symptoms in CIDP.

关键词： Bilateral vocal fold palsy chronic inflammatory demyelinating polyneuropathy intravenous immunoglobulin case report

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The Importance of Bringing the Family Together. Exploring the Experience and Meaning of Family Health Conversations in Dementia Care

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Open Journal of Nursing 2019年第11期9卷 1153-1172页

作者： Laila Mohrsen Busted Dorthe S. Nielsen regner Birkelund The Department of Regional Health Research Faculty of Health Sciences University of Southern Denmark Odense Denmark The Health Sciences Research Center UCL University College Odense Denmark Migrant Health Clinic Odense University Hospital Center for Global Health University of Southern Denmark Odense Denmark

Aim: The aim of this study was to investigate family members’ experience of engaging in the “Family Health Conversations” intervention. Methods: A qualitative study was conducted with 15 family members who engaged in the intervention. The study used semi-structured interviews and data were analysed using reflexive thematic analysis. Findings: Through analysis and interpretation of the data, three themes were identified: 1) Support for navigating in unknown waters;2) Bringing peace and relief to the family;3) Involving the relative with dementia in Family Health Conversations. Family Health Conversations showed were beneficial to the families of persons with dementia and of great importance to both individual family members and the family. Involving the person with dementia in the Family Health Conversations was not always beneficial for the family. Conclusion: Deciding when to involve the person with dementia in Family Health Conversations requires thorough knowledge of the family as well as the person with dementia, to avoid excluding them. The intervention supports retaining selfhood and autonomy for the person with dementia, even when the individual did not participate in the conversation.

关键词： Family Health Conversations Dementia Care Family Members

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血浆游离DNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)

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中华神经外科疾病研究杂志 2014年第3期13卷 258-258页

作者： Rodrigues Filho EM1 Simon D Ikuta N Klovan C Dannebrock F de Oliveira CO regner A 1ULBRA Laboratório de Biomarcadores do TraumaCanoasRSBrazil

Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain *** of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free DNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma DNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher DNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma DNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma DNA levels were independently associated with death( P < 0. 001). In conclusion,high cell-free DNA concentration was a predictor of short-term mortality following severe TBI.

关键词：神经外科学疾病临床研究症状

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兴奋剂依赖病人大脑灰质改变及脑-行为关系的性别差异研究

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国际医学放射学杂志 2016年第1期 78-78页

作者： M.F.regner M.Dalwani D.Yamamoto R.I.Perry J.T.Sakai J.M.Honce 倪玲 Department of Radiology University of Colorado School of Medicine

摘要目的通过特定行为学测量的方法,如依赖症状计数、行为方法和冲动,研究性别能否调节长期禁欲的兴奋剂依赖性病人的灰质体积（GMV）,并表征性别如何调节GMV。材料与方法本研究经科罗拉多机构伦理委员会批准并获得病人知情同意书。在... 详细信息

摘要目的通过特定行为学测量的方法,如依赖症状计数、行为方法和冲动,研究性别能否调节长期禁欲的兴奋剂依赖性病人的灰质体积（GMV）,并表征性别如何调节GMV。材料与方法本研究经科罗拉多机构伦理委员会批准并获得病人知情同意书。在该前瞻性、平行组的研究中,127例年龄和性别匹配的被试[68例对照（女28例,男40例）和59例兴奋剂依赖病人（女28例,男31例）]行颅脑3 T扰相梯度回波反转恢复T;W MRI。影像利用基于体素的形态测量软件

关键词：兴奋剂女性病人性别差异差异(心理学)

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