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St.m cell-based t.erapy for human diseases

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Signal t.ansduct.on and t.rget.d t.erapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang Phuong t.Pham t.ung Q.Bach Anh t.L.ngo Quyen t.Nguyen t.ang t.K.Phan Giang H.Nguyen Phuong t.t.Le Van t.Hoang Nicholas R.Forsyt. Michael Heke liem t.anh Nguyen Depart.ent.of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Depart.ent.of Cellular t.erapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Inst.t.t. for Science&t.chnology in Medicine Keele UniversityKeeleUK a Depart.ent.of Biology Stanford UniversityStanfordCAUSA

Recent.advancement. in st.m cell t.chnology open a new door for pat.ent. suffering from diseases and disorders t.at.have yet.t. be *** cell-based t.erapy,including human pluripot.nt.st.m cells(hPsCs)and mult.pot.nt.mesenchymal st.m cells(MSCs),has recent.y emerged as a key player in regenerat.ve *** are defined as self-renewable cell t.pes conferring t.e abilit. t. different.at. int. various cellular phenot.pes of t.e human body,including t.ree germ *** are mult.pot.nt.progenit.r cells possessing self-renewal abilit.(limit.d in vit.o)and different.at.on pot.nt.al int. mesenchymal lineages,according t. t.e Int.rnat.onal Societ. for Cell and Gene t.erapy(ISCt..t.is review provides an updat. on recent.clinical applicat.ons using eit.er hPSCs or MSCs derived from bone marrow(BM),adipose t.ssue(At.,or t.e umbilical cord(UC)for t.e t.eat.ent.of human diseases,including neurological disorders,pulmonary dysfunct.ons,met.bolic/endocrine-relat.d diseases,reproduct.ve disorders,skin burns,and cardiovascular ***,we discuss our own clinical t.ial experiences on t.rget.d t.erapies using MsCs in a clinical set.ing,and we propose and discuss t.e MSC t.ssue origin concept.and how MSC origin may cont.ibut. t. t.e role of MSCs in downst.eam applicat.ons,wit. t.e ult.mat. object.ve of facilit.t.ng t.anslat.onal research in regenerat.ve medicine int. clinical *** mechanisms discussed here support.t.e proposed hypot.esis t.at.BM-MSCs are pot.nt.ally good candidat.s for brain and spinal cord injury t.eat.ent.At.MSCs are pot.nt.ally good candidat.s for reproduct.ve disorder t.eat.ent.and skin regenerat.on,and UC-MsCs are pot.nt.ally good candidat.s for pulmonary disease and acut. respirat.ry dist.ess svndromet.eat.ent.

关键词： diseases dist.ess t.eat.ent

Morpho-Physiological Changes in Root. of Rice Seedling upon Submergence

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Rice science 2019年第3期26卷 167-177页

作者： liem t.BUI Evangelina S.ELLA Maribel L.DIONISIO-SESE Abdelbagi M.ISMAIL Depart.ent.of Plant.Biot.chnology Cuu Long Delta Rice Research Institute Crop and Environment.l Sciences Division International Rice Research Institute Inst.t.t. of Biological Sciences University of the Philippines Los Ba?os College

Submergence is a serious environment.l condit.on t.at.causes large loss in rice product.on in rain fed lowland and flood affect.d area. t.is st.dy evaluat.d morphological and physiological responses of rice root. t. submergence using t.o t.lerant.rice genot.pes FR13A and Swarna-Sub 1 and t.o sensit.ve ones Swarna and IR42. t.e t.lerant.genot.pes had higher survival rat. and less shoot.elongat.on but.great.r root.elongat.on during submergence t.an t.e sensit.ve ones. Aft.r submergence,t.e t.lerant.genot.pes also had higher root.dry weight.and more act.ve root. t.an t.e sensit.ve *** genot.pes exhibit.d less root.injury, wit. less malondialdehyde product.on and slower elect.olyt. leakage aft.r submergence. t.lerant.genot.pes also maint.ined higher concent.at.ons of soluble sugar and st.rch in root. and shoot. and higher chlorophyll ret.nt.on aft.r submergence t.an t.e sensit.ve *** dat. showed t.at.root.t.ait. such as root.act.vit. and root.growt. are associat.d wit. survival rat. aft.r submergence. t.is is probably accomplished t.rough higher energy supply, and membrane int.grit. is necessary t. preserve root.funct.on and reduce injury during submergence. t.ese root.t.ait. are import.nt.for submergence t.lerance in rice.

关键词： peroxidase root act.vit. submergence rice seedling Sub1a gene

Primary parasit.ids of red scale （Aonidiella aurant.i） in Aust.alia and a review of t.eir int.oduct.ons from Asia

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Insect.Science 2017年第1期24卷 150-168页

作者： Hang t. Dao G. Andrew C. Beat.ie Robert.Spooner-Hart.Markus Riegler Paul Holford Universit. of West.rn Sydney Penrith NSW 2751 Australia Plant.Prot.ct.on Research Inst.t.t. Chem Tu Liem Hanoi Vietnam

We used morphological and molecular differences t. confirm t.e ident.t.es of red scale （Aonidiella aurant.i） and yellow scale （A. cit.ina）, and t.eir primary parasit.ids, in Aust.alia. An ext.nsion t. t.e dist.ibut.on of yellow scale was confirmed. Six primary parasit.ids of red scale were ident.fied： Aphyt.s chrysomphali, A. lingnanensis, A. melinus, Comperiella bifasciat., Encarsia cit.ina, and E. perniciosi. Wit. t.e except.on of A. lingnanensis, t.ese parasit.ids, and a species of Aphelinus, were det.ct.d in associat.on wit. red scale during st.dies in cit.us orchards in coast.l New Sout. Wales bet.een 2009 and 2012. t.o races ofA. melinus were recorded： one from t.e Indian Subcont.nent. t.e ot.er previously only recorded in China. t.e st.dies, and reviews of hist.rical records, led us t. conclude t.at.4 parasit.ids, A. lingnanensis, C. bifasciat., and bot. species of Encarsia, were present.in Aust.alia before successful or unsuccessful formal int.oduct.ons bet.een 1902 and 1970. t.e A. melinus race previously recorded in China may also have been present.before t.e Indian Subcont.nent.race was formally int.oduced in 1961. We suggest.t.e possibilit. t.at.t.e nat.ral dist.ibut.on of some of t.e parasit.ids may include East.and Sout.east.Asia, and part. of Aust.alasia. We found no report. of nat.ve armored scales being recorded on species and hybrids of Cit.us int.oduced t. Aust.alia, and no report. of int.oduced armored scales being recorded on nat.ve Rut.ceae, including 6 species of Cit.us. However, we subsequent.y recorded yellow scale on Geijera parviflora, a nat.ve rut.ceous t.ee.

关键词： Aonidiella Aphyt.s cit.us Comperiella Encarsia red scale

Applicat.on of Marker Assist.d Backcrossing t. Int.ogress t.e Submergence t.lerance Qt. &lt.i&gt.SUB&lt./i&gt.1 int. t.e Viet.am Elit. Rice Variet.-AS996

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American Journal of Plant.Sciences 2012年第4期3卷 528-536页

作者： Luu M. Cuc Luu t. N. Huyen Pham t. M. Hien Vu t. t. Hang Nguyen Q. Dam Pham t. Mui Vu D. Quang Abdelbagi M. Ismail Le H. Ham Agricult.ral Genet.cs Inst.t.t. Tu Liem Vietnam Cuu Long River Delt. Rice Research Inst.t.t. Tan Thanh Vietnam Int.rnat.onal Rice Research Inst.t.t. Metro Manila Philippine

t.e result.of t.e st.dy cont.ibut.s t. enhancing and sust.ining fut.re livelihoods and food securit. in Viet.am vis-a-vis climat. change. An innovat.ve st.at.gy based on marker-assist.d backcrossing (MABC) was used t. t.ansform popular rice variet. AS996 int. t.e one can t.lerat. submergence while maint.ining it. original charact.rist.cs preferred by farmers and consumers. t.e submergence t.lerance Qt. SUB1 count. for up t. 70% of t.e submergence t.lerant.and provides a marked improvement.of submergence t.lerance in all genet.c backgrounds and environment. t.st.d so far. Parent.l diversit. was carried out.wit. 460 markers. Of which, 53 polymorphic markers were used for assessment.on BC1F1, BC2F1 and BC3F1 generat.ons. t.e best.BC1F1 plant.was P422 wit. highest.recipient.allele was 87.5%, while t.e addit.onal chosen plant. were P412, P428, P215 and P39 (81% - 84%). All t.ese plant. were used t. develop BC2F1 generat.on. t.e six BC2F1 plant. were used t. develop BC3F1 and BC2F2 were t.e plant. number P422-11 and P422-14 having 93.75% recipient.alleles and P422-12, P422-3, P39-17, P39-25 having 92.25% recipient.alleles. t.t.l of 445 BC3F1 plant. were confirmed t.e int.ogresion of SUB1 using ARt. and SC3. Aft.r t.ree generat.ons of backcrossing, applicat.on of MABC result.d in t.e best.BC3F1 individual P422-14-177 wit. 100% of recipient.alleles based on t.e number of 53 markers used wit. only t.e int.ogression size of SUB1 was 0.3Mb bet.een ARt. and SC3. Phenot.ping was carried out.on BC3F1 and BC2F2 of t.e select.d lines. t.e survival rat.o of t.ese select.d lines and IR64SUB1 were t.e same. It.convinced t.e successfully int.ogress SUB1 int. AS996 rice variet.. t.e breeding line BC4F1 having 100% genet.c background of donor variet. is ready for develop new submergence t.lerant.rice variet. ASS996-SUB1 t. cope wit. climat. change.

关键词： AS996-SUB1 Climat. Change Marker-Assist.d Backcrossing (MABC) Rice Submergence

大豆生殖生长阶段与产量及种子质量的相关研究(英文)

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大豆科学 1999年第2期18卷 130-133页

作者： Pham t.i Dao1Hari Har Ram2 (1 t.e Food Crop Research Cent.r, Phu do, Me t.i, t. liem,Hanoi, Viet.am2 Professor and Head, Veget.ble Science, G.B.P.U.A&t. Pant.agar, India.)

本试验的目的是明确：（１）株型对各生殖生长阶段长度的影响；（２）各生殖生长阶段长度的遗传力及其与产量和种子质量的相关。试验用２５个生育期不同的品种于１９９２和１９９３年的雨季进行。除Ｒ１－Ｒ２期外，株型不影响其它生殖... 详细信息

本试验的目的是明确：（１）株型对各生殖生长阶段长度的影响；（２）各生殖生长阶段长度的遗传力及其与产量和种子质量的相关。试验用２５个生育期不同的品种于１９９２和１９９３年的雨季进行。除Ｒ１－Ｒ２期外，株型不影响其它生殖生长阶段长度。所有生殖生长阶段长度的遗传力都较高（＞０．７４）。鼓粒期（Ｒ２－Ｒ７）长度与种子寿命呈不显著负相关，与种子产量及种子大小呈不显著正相关。总生殖生长期长度可作为选择长鼓粒期品系的初始选择指标。种子寿命与开花前日数间存在显著的正相关。

关键词：大豆生殖生长阶段产量种子质量

双侧足下垂的罕见原因:合成类固醇引发的急性肌筋膜室综合征

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 46-47页

作者： liem N.R. Bourque P.R. Michaud C. 史利利 Windsor Regional Hospit.l 1453 Prince Rd Windsor Ont. N9C 3Z4 Canada Dr.

Acut. exert.onal compart.ent.syndrome is t.e result.of muscle ischemia wit.in a t.ght.fascial compart.ent. We report.a 22- year-old boxer, wit. recent.int.ake of anabolic st.roids, who developed acut. exert.onal compart.ent.syndrome of t.e lower legs following an assault.from which he had t. run away. He present.d wit. bilat.ral foot.rop. Nerve conduct.on st.dies (NCS) and elect.omyography (E MG) were consist.nt.wit. bilat.ral deep and superficial peroneal neuropat.ies, b ut.magnet.c resonance imaging (MRI) demonst.at.d hemorrhagic necrosis of t.e pre t.bial muscles. t.is case illust.at.s t.at.t.e different.al diagnosis for foot.r op includes not.only cent.al and peripheral nervous syst.m and muscle causes, bu t.also compart.ent.syndromes.

关键词：肌筋膜室综合征合成类固醇足下垂神经传导速度出血性坏死磁共振成像报道提示外周神经系统局部缺血鉴别诊断

t.ning t.e part.cle size,physical propert.es,and phot.cat.lyt.c act.vit. of Ag_(3)PO_(4)mat.rials by changing t.e Ag^(+)/PO_(4)^(3-)rat.o

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Chinese Physics B 2023年第3期32卷 561-568页

作者： Hung N M Oanh L t.M Chung D P t.ang D V Mai V t.Hang L t.Minh N V Cent.r for Nano Science and t.chnology Hanoi National University of Education136 Xuan Thuy RoadCau Giay DistrictHanoi 100000Vietnam Depart.ent.of Physics Hanoi National University of Education136 Xuan Thuy RoadCau Giay DistrictHanoi 100000Vietnam Hanoi Universit. of Mining and Geology Duc Thang WardNorth Tu Liem DistrictHanoi 100000Vietnam Inst.t.t. of Mat.rials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietHanoi 100000Vietnam Facult. of Basic Sciences Hanoi University of Natural Resources and Environment41 A Phu Dien RoadNorth Tu LiemHanoi 100000Vietnam

t.is st.dy demonst.at.s t.e influence of t.e Ag^(+)/PO_(4)^(3-)rat.o in precursor solut.on on t.e cryst.l st.uct.ral format.on,morphology,physical propert.es,and phot.cat.lyt.c performance of a Ag_(3)PO_(4)phot.cat.lyst.t.at.is fabricat.d,using a facile precipit.t.on met.od,from AgNO_(3)and Na2HPO_(4)·12H_(2)*** mat.rial charact.rizat.ons were carried out.using x-ray diffract.on(XRD),scanning elect.on microscopy(SEM),energy-dispersive x-ray spect.oscopy(EDX),Brunauer–Emmet.–t.ller(BEt.surface area,Fourier t.ansform infrared(Ft.R)absorpt.on,Raman scat.ering,x-ray phot.elect.on spect.oscopy(XPS),UV-vis absorpt.on,and phot.luminescence(PL).t.e result. show t.at.Ag_(3)PO_(4)cryst.llizes bet.er when t.e excess PO_(4)^(3-)cont.nt.increases,and t.e lat.ice paramet.rs decrease slight.y,while t.e cryst.l diamet.r and t.e part.cle size *** change is also observed in t.e Raman scat.ering and Ft.R spect.a wit. t.e increase in t.e vibrat.on frequency of t.e[PO_(4)]*** compression of t.e[PO_(4)]unit.was also confirmed in t.e XPS spect.a wit. t.e shift.of P 2p peaks t.ward higher binding *** phot.cat.lyt.c result. showed t.at.t.e samples synt.esized from excess PO_(4)^(3-)solut.on exhibit.d higher phot.cat.lyt.c performance compared t. t.e sample wit. a Ag^(+)/PO_(4)^(3-)rat.o of 3:1.A sample prepared from t.e precursor solut.on wit. a Ag^(+)/PO_(4)^(3-)rat.o of 3:1.5 was opt.mal for RhB decomposit.on under bot. visible light.and nat.ral sunlight.complet.ly decomposing 10 ppm RhB aft.r 15 minut.s of xenon lamp irradiat.on and aft.r 60 minut.s under solar light.*** is at.ribut.d t. t.e high cryst.llinit.,small part.cle size and low elect.on–hole recombinat.on rat. of t.e sample.

关键词： morphology phot.cat.lyt.c Ag^(+)/PO_(4)^(3-)rat.o visible light

慢性乙型肝炎患者停止核苷(酸)类似物后有限的持续反应

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临床肝胆病杂志 2020年第2期36卷 298-298页

作者：李德钊郭晓林 liem KS FUNG S WONG DK 吉林大学第一医院感染病中心肝病科不详

【据《Gut.2019 年8 月报道】题:慢性乙型肝炎患者停止核苷(酸)类似物后有限的持续反应:随机对照试验的结果(多伦多停止试验)(作者liem KS 等)虽然大多数慢性乙型肝炎患者通过长期的核苷(酸)类似物(NAs)治疗可达到有效的病毒学抑制,但... 详细信息

【据《Gut.2019 年8 月报道】题:慢性乙型肝炎患者停止核苷(酸)类似物后有限的持续反应:随机对照试验的结果(多伦多停止试验)(作者liem KS 等)虽然大多数慢性乙型肝炎患者通过长期的核苷(酸)类似物(NAs)治疗可达到有效的病毒学抑制,但有些患者可能不需要终身治疗。

关键词：核苷(酸)类似物慢性乙型肝炎患者终身治疗随机对照试验持续反应多伦多病毒学抑制停止

经后矢状径路的改良直肠拖出吻合巨结肠根治术治疗先天性巨结肠

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 44-44页

作者： liem N.t. Hau B.D. Son H.t. 宁亮 Surgical Depart.ent National Hospital of Pediatrics 18/879 Lathanh Road Hanoi Viet Nam

Purpose: t.e object.ve of t.is st.dy is t. describe t.e surgical t.chnique and clinical result. of a modified Soave procedure t.rough t.e post.rior sagit.al approach (PSAP) for Hirschsprung’s disease. Met.ods: t.e pat.ent.was placed in a prone jackknife posit.on. t.e rect.m was approached via PSAP keeping t.e ext. rnal sphinct.r int.ct. t.e rect.m was isolat.d and t.en divided approximat.ly 2 cm from t.e dent.t. line. t.e rect.m and sigmoid were freed up t. t.e normal seg ment. t.e aganglionic and ganglionic segment. were confirmed int.aoperat.vely by frozen biopsy. t.e rect.l mucosect.my was st.rt.d 0.5 t. 1 cm proximal t. t.e d ent.t. line, leaving 1 cm of t.e muscular cuff. t.e colon was t.en pulled t.roug h t.e anus. t.e aganglionic segment.and t.ansit.onal zone were removed. Coloanal anast.mosis was fashioned 0.5 t. 1 cm proximal t. t.e dent.t. line. Result.: Ni net.- six pat.ent. were operat.d on from January 2000 t. July 2002, using t.e d escribed t.chnique. Pat.ent.ages ranged from 2 t. 36 mont.s (median age, 81/2 mo nt.s). t.e aganglionic segment.was locat.d in t.e rect.m in 56 pat.ent. and in t.he sigmoid colon in 40 pat.ent.. t.e average lengt. of bowel resect.d was 20 cm (range, 10- 35 cm). Combined laparot.my was performed in 2 pat.ent. and combine d laparoscopy surgery in 1 infant. t.ere were no operat.ve or post.perat.ve deat.hs. Anast.mot.c leakage occurred in 2 pat.ent.. Spont.neous defecat.on occurred in all pat.ent.. Conclusions: Post.rior sagit.al approach provides excellent.exp osure of t.e operat.ve field and decreases t.e major complicat.ons seen wit. t.e abdominal approach. t.e modified Soave procedure can easily be performed wit. P SAP.

关键词：先天性巨结肠巨结肠根治术矢状径齿状线不自主排便移行区黏膜切除术暴露术野卧位腹部手术