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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 45-45页

作者： liekfeld a. Pahms N. Torun N. 刘玮 Clinic of Ophthalmology University School of Medicine Berlin CampusVirchowKlinikum Augustenburger Platz 1 13353 Berlin Germany

Purpose: To investigate the effect of different intraocular lenses (IOLs) on lens epithelial cells (LECs) and on human capsular bags in vitro and to evaluate the transferability of this model to clinical situations. Methods: Sham cataract surgery, including IOL-into-the-bag implantation, was performed on38 donor eyes after removal of the cornea. The capsular bag including the IOL was removed, pinned on a culture dish, covered with medium, and incubated. Two different IOLswere compared per pair of donor eyes. In each pair of donor eyes, the two different IOLs to be compared were implanted individually into capsular bags. The time required for complete coverage of the posterior capsule by a confluent monolayer of LECs was documented. The following IOLs were compared: three-piece acrylic IOLs of different sizes and single-piece polymethylmethacrylate (PMMA) versus acrylic IOLs. Results: A complete monolayer of LECs on the posterior capsule was observed to form at times varying from 8 days (PMMA IOLs) to more than 60 days (three-piece hydrophobic acrylic IOLs). A significant difference between PMMA IOLs and hydrophobic acrylic IOLs was found. Conclusions: The human capsular bag model employed allows short-term evaluation of secondary cataract formation for different IOLs. This model’ s correlation with clinical results is good.

关键词：继发性白内障晶体植入囊袋后囊白内障手术人工晶体后发性白内障晶状体上皮细胞可移植性于水

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疱疹性角膜炎的特异性抗体产生以眼内炎和角膜新生血管化为预测因素

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 41-41页

作者： Robert P.-Y. liekfeld a Metzner S. U. Pleyer 桑延智 Augenklinik Charit'e CampusVirchowKlinikum Augustenburger Platz 113353 Berlin Germany

Purpose: The purpose of the study is to investigate whether analysis of specific antibody synthesis can aid the diagnosis of herpes keratitis. Methods: Aqueous humor was collected from 39 patients with presumed recurrent herpes keratitis, including 23 consulting for keratitis and 16 patients scheduled for penetrating keratoplasty. Local antibody production was ascertained by analysis of paired aqueous humor/serum samples, using a modified micro-ELISA technique. Results: Local production of antibodies was found in 32 patients (82% ): anti-herpes simplex virus (HSV) antibodies in 26 (67% ) and anti-varicella zoster virus (VZV) antibodies in 11 (28% ). Twenty of 23 patients with active keratitis (87% ), and 12 of 16 undergoing keratoplasty (75% ), tested positive. Five patients had local production of both anti-HSV and anti-VZV antibodies, whereas seven patients tested negative. Local antibody production was significantly associated with intraocular inflammation (P< 0.05), corneal neovascularisation (P< 0.05), and positive response to anti-viral treatment (P< 0.05). No complications were encountered in sampling aqueous humor. Conclusions: Assessment of local anti- HSV and-VZV antibody production is a safe and reliable diagnostic procedure for recurrent herpes keratitis. It might be particularly helpful in patients presenting with intraocular inflammation and neovascularisation since it discriminates between herpes and non-herpes pathologies and may therefore be useful for preventive and therapeutic strategies.

关键词：疱疹性角膜炎角膜新生血管化眼内炎疱疹病局部抗体角膜移植术抗单纯疱疹病毒新生血管形成阳

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