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Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 40-46页

作者： Wei-kun HOU lie-su meng Fang ZHENG Yu-rong WEN Wen-hua ZHU Cong-shan JIANG Xiao-jing HE Yan ZHOU She-min LU Department of Genetics and Molecular Biology School of Medicine Xi "an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi 'an Jiaotong University Xi 'an 710061 China Department of Dermatology and Venereology the First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Epidemiology and Health Statistics School of Public Health Xi 'an Jiaotong University Xi 'an 710061 China

Objective: This study was carried out to test the effects of methotrexate (MTX) and black seed oil (BSO) on pristane-induced arthritis (PIA) in ***: Inbred dark agouti (DA) rats were induced by a single subcutaneous injection of pristane,and then treated with MTX or *** severity was evaluated macroscopically and *** nitric oxide (NO) concentration was determined by the Griess method and cytokine mRNA expression in the spleen was detected by the real-time reverse transcription-polymerase chain reaction (RT-PCR).Results: The clinical arthritis severity was decreased after MTX treatment,while the BSO groups did not show significant changes compared with the disease *** plasma NO level of the MTX group was significantly decreased compared with the disease group,but the BSO groups showed no difference from the disease group in plasma NO *** interferon-γ (IFN-γ) and interleukin-17A (IL-17A) mRNA expressions in the spleens were significantly decreased in the MTX group,but only showed a declining trend in the BSO groups compared with the disease *** MTX nor BSO had an effect on the mRNA expressions of IL-4,transforming growth factor β (TGF-β),and tumor necrosis factor-α (TNF-α) in the ***: MTX,but not BSO,can reduce the arthritis severity and decrease the mRNA expressions of IFN-γ and IL-17A in pristane-induced arthritis of rats.

关键词： Methotrexate (MTX) Black seed oil (BSO) Pristane-induced arthritis (PIA) Interferon-γ (IFN-γ) Interleukin-17A (IL-17A)

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Compromised immune status of patients with post-liver transplant biliary complications

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Chinese Medical Journal 2020年第21期133卷 2622-2624页

作者： Hong Lei Min Tian Xiao-Gang Zhang lie-su meng Wen-Hua Zhu Xue-Min Liu meng-Zhou Wang Tao Wang Peng-Kang Chang Huan Chen Bo Wang Rong-Qian Wu Yi Lyu National Local Joint Engineering Research Center for Precision surgery and Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of Hepatobiliary surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi 710061China

Immunosuppression(IS)is indispensable for liver trans-plant(LTx)patients to control the unwanted alloimmune responses,which are mainly mediated by T ***,antigen-independent homeostasis of T cells is vital for sustaining long-lived T cell-mediated immunity,and excessive IS may increase the risk of opportunistic infections and ***,IS therapy for LTx patients should be tailored to the immune status of the individual patient.[1]Biliary complications(BC),including biliary strictures with cholangitis,are the most common complications after ***,the immunological characteristics especially T cell-mediated immunity of these patients are unknown yet.

关键词： patients immunity complications

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Hollow Multi-shelled Structure Photoelectric Materials: Multiple Shells Bring Novel Properties

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Chemical Research in Chinese Universities 2024年第3期40卷 413-427页

作者： su Fengmei WAN Jiawei WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese AcademyofSciencesBeijing 100049P.R.China

Hollow multi-shelled structures(HoMSs)have made significant strides across a wide spectrum of scientific investigations since the inception of the sequential templating approach(STA)in 2009,revealing distinctive temporal-spatial ordering *** recent establishment of a mathematical model for STA has not only demystified the formation of concentration waves within the STA process but also extended its relevance to gentler solutionbased systems,thereby broadening the HoMs ***,focusing on photoelectric applications,this review first summarizes the unique temporal-spatial ordering features of ***,the greatly enhanced properties of light capture and absorption,exciton separation,and transfer are deeply ***,we conclude with a perspective on the potential challenges and burgeoning opportunities that lie ahead in the advancement of HoMs development.

关键词： Hollow multi-shelled structure Photoelectric conversion Sequential templating approach Light absorption Chargetransfer

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Toll Like Receptor 3 Plays an Important Role in the Initiation and Development of Pristane Induced Arthritis Model in Rats

Toll Like Receptor 3 Plays an Important Role in the Initiati...

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2008年全国生物化学与分子生物学学术大会

作者： lie-su meng Wen-hua Zhu Cong-shan Jiang Fu-jun Zhang Yan Han Qi-lan Ning She-min Lu (Department of Genetics and Molecular Biology,Xi’an Jiaotong University School of Medicine,Xian 710061,China)

Rheumatoid arthritis (RA) is a chronic immuno-inflammation disease that afflicts the synovium of diarthrodial *** pathogenic mechanisms inciting this disease are not fully *** like receptors (TLRs) may participate in ...

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Structure and Representations for Electrical lie Algebra of Type D_(5)

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Algebra Colloquium 2024年第2期31卷 271-284页

作者： Yulu Chen Ran Shen Yucai su College of Science Donghua UniversityShanghai 201620China 不详

In this paper,we prove that the electrical lie algebra e D_(5)is isomorphic to the semidirect product of sp_(4)and a 2-step nilpotent lie ***,we classify the irreducible highest weight modules for e D_(5).

关键词： electrical lie algebra 2-step nilpotent lie algebra highest weight module

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On the Infinite-Dimensional Modular lie superalgebras of O-Type

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Algebra Colloquium 2024年第2期31卷 347-360页

作者： Xiaoning Xu Jing Zhao Yucai su School of Mathematics and Statistics Liaoning UniversityShenyang 110036China 不详

The natural filtrations of infinite-dimensional lie superalgebras of O-type over a field of positive characteristic are proved to be invariant under automorphisms by studying ad-nilpotent *** observe that two lie superalgebras of O-type are isomorphic if and only if the integers in the definition of these lie superalgebras are ***,all the lie superalgebras of O-type are classified in the sense of isomorphism.

关键词： filtration isomorphism classification

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Stability of 12 Housekeeping Genes in PIA and AIPI Rat Models

Stability of 12 Housekeeping Genes in PIA and AIPI Rat Model...

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2008年全国生物化学与分子生物学学术大会

作者： Cong-shan Jiang Wen-hua Zhu lie-su meng Xiao-jing He Fang Zheng Qi-lan Ning Yan Han She-min Lu (Department of Genetics and Molecular Biology,Xi’an Jiaotong University School of Medicine,Xian 710061,China)

Inflammation may affect the expression level of housekeeping *** is thus evident that normalizing expression of the interest gene to stably expressed reference genes is critical when performing gene expression studies...

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公共卫生事件下长三角港口拥堵与应对机制研究

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苏州大学学报（哲学社会科学版） 2024年第4期45卷 39-49页

作者：王列辉苏晨华东师范大学中国行政区划研究中心上海200241

2022年3月,长三角地区发生公共卫生事件,长三角港口出现拥堵,物流供应链体系受到冲击,这为港口应对突发事件提供了案例经验。基于对长三角港口拥堵指数、航运供应链和航运网络结构在不同时间段的分析,发现上海因疫情封控后,4月份长三角... 详细信息

2022年3月,长三角地区发生公共卫生事件,长三角港口出现拥堵,物流供应链体系受到冲击,这为港口应对突发事件提供了案例经验。基于对长三角港口拥堵指数、航运供应链和航运网络结构在不同时间段的分析,发现上海因疫情封控后,4月份长三角港口拥堵明显,但涉及民生物资的供应链得到优先保障;太仓港和南京港成为长三角地区重要的货物集散枢纽,在特殊时期承担重要的中转功能;上海港与宁波舟山港则依然保持着向外输出的门户枢纽功能。得益于长三角港口一体化协同机制,政府、企业与港口管理者利用多式联运方案,保障长三角物资运输有序和供应链通畅,这对于全球其他港口群应对突发事件有借鉴价值。

关键词：航运供应链港口拥堵应对机制港口协作长三角地区公共卫生事件

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“河北胡化”新论——一个基于中原传统社会与政治结构的阐释

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民族研究 2024年第4期 73-94,M0004,M0005页

作者：苏航中国社会科学院民族学与人类学研究所民族历史研究室 100081

陈寅恪“河北胡化论”的理论基础是民族一文化史观,其中蕴含了文化决定民族、民族一文化决定政治两个决定关系,二者反映了文化民族主义的影响。然而前者并不成立,后者则不能前置于古代时期。“河北胡化论”的核心实不在于陈寅恪所坚持... 详细信息

陈寅恪“河北胡化论”的理论基础是民族一文化史观,其中蕴含了文化决定民族、民族一文化决定政治两个决定关系,二者反映了文化民族主义的影响。然而前者并不成立,后者则不能前置于古代时期。“河北胡化论”的核心实不在于陈寅恪所坚持的全盘胡化,其能否成立的关键在于地方化的政治模式和道德形态是否来源于非汉文化的影响。本文指出,具有差序格局的中原传统社会结构塑造了亲近疏远的行为准则,具备家国二重性的王朝国家政治结构在君臣之间构建了依附性与限制性的双重道德。二者通过人情博奔体现出来,并结合在一起,为臣民的相对主义忠诚奠定了道德基础。依据这一道德,君主必须照顾臣民亲情圈的小义小利,才能激发臣民的感报之心。这种人情之忠中双方道德义务的限度,由各方势力的政治博奔设定。河朔故事是安史乱后中央与藩镇重建统治关系过程中所达成的新的政治和道德约定,是中原社会道德模式和政治模式基于河北政治独立这一新现实的发展,而非“胡化”的结果。目河朔为“夷狄”是“尊王夷”的政治修辞,而非真实的族类区分标准。以亲情主义为主导的传统社会的组织原则为中华民族的历史凝聚提供了重要动力。

关键词：河北胡化民族文化史观差序格局家国二重性亲情主义

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Freeze–thaw effects on erosion process in loess slope under simulated rainfall

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Journal of Arid Land 2020年第6期12卷 937-949页

作者： su Yuanyi LI Peng REN Zongping XIAO lie ZHANG Hui State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi'an University of TechnologyXi'an 710048China Key Laboratory of National Forestry Administration on Ecological Hydrology and Disaster Prevention in Arid Regions Xi'an 710048China China JIKAN Research Institute of Engineering Investigations and Design Co.Ltd. Xi'an 710048China

Seasonal freeze–thaw processes have led to severe soil erosion in the middle and high *** area affected by freeze–thaw erosion in China exceeds 13%of the national *** understanding the effect of freeze–thaw on erosion process is of great significance for soil and water conservation as well as for ecological *** this study,we designed simulated rainfall experiments to investigate soil erosion processes under two soil conditions,unfrozen slope(UFS)and frozen slope(FS),and three rainfall intensities of 0.6,0.9 and 1.2 mm/*** results showed that the initial runoff time of FS occurred much earlier than that of the *** the same rainfall intensity,the runoff of FS is 1.17–1.26 times that of UFS;and the sediment yield of FS is 6.48–10.49 times that of *** increasing rainfall time,rills were produced on the *** the appearance of the rills,the sediment yield on the FS accounts for 74%–86%of the total sediment *** erosion was the main reason for the increase in soil erosion rate on FS,and the reduction in water percolation resulting from frozen layers was one of the important factors leading to the advancement of rills on slope.A linear relationship existed between the cumulative runoff and the sediment yield of UFS and FS(R2>0.97,PFS0.6(72.30μm)>UFS1.2(72.23μm)>substrate(71.23μm)>FS1.2(71.06μm)>FS0.9(70.72μm).During the early stage of the rainfall,the MWD of the FS was relatively ***,during the middle to late rainfall,the particle composition gradually approached that of the soil *** different rainfall intensities,the mean soil erodibility(MK)of the FS was 7.22 times that of the *** ratio of the mean regression coefficient C2(MC2)between FS and UFS was roughly correspondent with ***,the parameter C2 can be used to evaluate soil erodibility after the appearance of the ***

关键词： unfrozen slope(UFS) frozen slope(FS) simulated rainfall soil size selectivity soil erodibility loess hilly region

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