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Hybrid ZnO@Au Nanorod Array for Fast and Repeatable Bacteria Inactivation

Chinese Journal of Chemistry 2023年第17期41卷 2132-2142页

作者： Yu Liu Xiaoyu Zhao Xiaosa Zhang Xiaodan Jia lie wu Xiue Jiang College of Science Shenyang University of Chemical TechnologyShenyangLiaoning 110142China Shenyang National Laboratoryfor Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangLiaoning 110016China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of Scienc ChangchunJilin 130022China

Comprehensive Summary,The worldwide abuse of antibiotics and resultant antimicrobial resistance made the development of new antibacterial materials an urgent and significant issue.Herein,a hybrid ZnO@Au nanorod array with fast bacterial inactivation and excellent recyclability was reported.93%bacteria could be inactivated within 5 min ultra-sonication under indoor daylight,and the killing rate maintains above 90%after seven repeated using cycles.Antibacterial mechanism involves extracellular reactive oxygen species(ROS)generated from photocatalysis and piezoelectricity of nanorod array,intracellular ROS generation and decrease of adenosine-triphosphate(ATP)originated from electron transfer(ET)from bacteria to nanorod array,as well as mechanical effect from the nanorod,among which ET mechanism plays a major role.Large Schottky barrier from the hybrid interface not only enhances the ROS generation by promoting the charge transfer and carrier separation as well as light utilization,but also enables one-direction electron transfer from bacteria to nanorod array.The resultant continuous electron loss breaks the energy metabolism and disturbs the redox equilibrium,leading to bacterial death.This study demonstrates the great potential of hybrid structure in antibacterial applications and indicates ET as a novel effective antibacterial mechanism for semiconductor materials,which provides insights into the design of next-generation antibacterial materials.

关键词： Antibacterial Hybrid structure Zinc oxide nanorod Electron transfer Reactive oxygen species Microarrays Nanocomposites Semiconductors

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Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis

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Fundamental Research 2022年第1期2卷 66-73页

作者： Xiaofei Zhang lie wu Wenyao Zhen Shanshan Li Xiue Jiang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of ScienceChangchunJilin 130022China Graduate School of University of Science and Technology of China Anhui 230026China Changchun University ChangchunJilin 130022China

Ferroptosis is a cell death pathway mediated by iron-dependent accumulation of lipid peroxide.However,the specific downstream molecular events of iron-dependent lipid peroxidation are yet to be elucidated.In this study,based on various spectral analyses,we have found evidence that singlet oxygen is produced through the Russell mechanism during the self-reaction of lipid peroxyl radicals generated via iron-dependent lipid peroxidation regardless of the presence of cholesterol.Significantly reduced generation of singlet oxygen was observed in the absence of iron.The generated singlet oxygen accelerated the oxidative damage of lipid membranes by propagating lipid peroxidation and facilitated ferroptotic cancer cell death initiated by erastin.In this work,singlet oxygen has been revealed to be a new reactive species that participates in ferroptosis,thus improving the understanding on iron-dependent lipid peroxidation and the mechanism of ferroptosis.

关键词： Ferroptosis Lipid peroxidation Singlet oxygen Russell mechanism

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Switch of substrate specificity of hyperthermophilic acylaminoacyl peptidase by combination of protein and solvent engineering

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Protein & Cell 2011年第6期2卷 497-506页

作者： Chang Liu Guangyu Yang lie wu Guohe Tian Zuoming Zhang Yan Feng State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin UniversityChangchun 130023China Changchun Institute of Biological Products China National Biotec GroupChangchun 130061China

The inherent evolvability of promiscuous enzymes endows them with great potential to be artificially evolved for novel functions.Previously,we succeeded in transforming a promiscuous acylaminoacyl peptidase(apAAP)from the hyperthermophilic archaeon Aeropyrum pernix K1 into a specific carboxylesterase by making a single mutation.In order to fulfill the urgent requirement of thermostable lipolytic enzymes,in this paper we describe how the substrate preference of apAAP can be further changed from p-nitrophenyl caprylate(pNP-C8)to p-nitrophenyl laurate(pNP-C12)by protein and solvent engineering.After one round of directed evolution and subsequent saturation mutagenesis at selected residues in the active site,three variants with enhanced activity towards pNP-C12 were identified.Additionally,a combined mutant W474V/F488G/R526V/T560W was generated,which had the highest catalytic efficiency(kcat/Km)for pNP-C12,about 71-fold higher than the wild type.Its activity was further increased by solvent engineering,resulting in an activity enhancement of 280-fold compared with the wild type in the presence of 30%DMSO.The structural basis for the improved activity was studied by substrate docking and molecular dynamics simulation.It was revealed that W474V and F488G mutations caused a significant change in the geometry of the active center,which may facilitate binding and subsequent hydrolysis of bulky substrates.In conclusion,the combination of protein and solvent engineering may be an effective approach to improve the activities of promiscuous enzymes and could be used to create naturally rare hyperthermophilic enzymes.

关键词： acylaminoacyl peptidase esterase substrate specificity protein engineering solvent engineering

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H_(2)O_(2)‑Responsive MB–BSA–Fe(III)Nanoparticles as Oxygen Generators for MRI‑Guided Photodynamic Therapy

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Journal of Analysis and Testing 2018年第1期2卷 69-76页

作者： Wen‑Yao Zhen Jing Bai Xiao‑Dan Jia lie wu Xiu‑E Jiang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina University of Science and Technology of China Hefei 230026AnhuiChina

The local tumor hypoxia has become one of the main obstacles for photodynamic therapy(PDT).To break through this barrier,the fabrication of O_(2)-evolving nanoplatform has been more significant.Herein,the uniform methylene blue(MB)–bovine serum albumin(BSA)–Fe(III)nanoparticles(MB–BSA–Fe(III)NPs)were successfully synthesized by biomineralization approach.MB–BSA–Fe(III)NPs show high loading capacity of MB,and Fe(ΙΙΙ)has excellent catalytic performance towards abundant H_(2)O_(2) in cancer cells to generate O_(2),overcoming tumor hypoxia.All these combination effects remarkably increase the therapeutic efficiency of PDT,resulting in almost complete destruction of cancer cells.Most importantly,MB–BSA–Fe(III)NPs exhibit T2-magnetic resonance imaging,which have the potential for precise visualization of the tumor location.Our results demonstrate that MB–BSA–Fe(III)is a novel H_(2)O_(2)-responsive and O_(2)-evolving nanoplatform and it has great potential for clinical applications such as cancer diagnosis,treatment or drug delivery.

关键词： Photodynamic therapy Biomineralization H_(2)O_(2)-responsive O_(2)generator Photosensitizer Magnetic resonance imaging

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核桃灸防控青少年低、中度近视的短期疗效观察

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中国中医眼科杂志 2024年第7期34卷 637-640页

作者：唐雨蕊马菊梅吴烈中国中医科学院广安门医院南区北京102627

目的观察核桃灸疗法防控青少年低、中度近视的临床疗效。方法纳入2020年4月—2021年4月中国中医科学院广安门医院及首都医科大学附属北京中医医院诊治的青少年低、中度近视患儿84例(168只眼)。随机分为治疗组和对照组,每组42例(84只眼)... 详细信息

目的观察核桃灸疗法防控青少年低、中度近视的临床疗效。方法纳入2020年4月—2021年4月中国中医科学院广安门医院及首都医科大学附属北京中医医院诊治的青少年低、中度近视患儿84例(168只眼)。随机分为治疗组和对照组,每组42例(84只眼)。对照组予健康用眼教育+框架眼镜治疗,治疗组在对照组基础上联合核桃灸治疗。2组均治疗3个月。分别在治疗前后检测裸眼视力、睫状肌麻痹前后的屈光度、眼轴长度和角膜曲率。结果2组治疗前裸眼视力、睫状肌麻痹前后的屈光度、眼轴长度和角膜曲率比较,差异均无统计学意义(P>0.05)。(1)裸眼视力:2组治疗前后裸眼视力比较和治疗后2组间比较,差异均无统计学意义(P>0.05)。(2)屈光度:对照组治疗后麻痹前、后屈光度均较治疗前升高,差异均有统计学意义(t_(麻痹前)=2.638,P=0.009;t_(麻痹后)=2.800,P=0.006),观察组治疗后麻痹前、后屈光度与治疗前比较,差异均无统计学意义(P>0.05)。治疗后2组间比较,观察组麻痹前屈光度低于对照组,差异有统计学意义(t=2.619,P=0.010)。而2组麻痹后屈光度比较,差异无统计学意义(P>0.05)。(3)眼轴、角膜曲率:2组治疗前后眼轴、角膜曲率比较和治疗后2组间比较,差异均无统计学意义(P>0.05)。结论核桃灸疗法可以缓解甚至消除青少年低、中度近视的调节张力,能在一定程度上稳定裸眼视力。

关键词：近视核桃灸视力屈光度

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Black Phosphorus: An Effective Feedstock for the Synthesis of Phosphorus-Based Chemicals

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CCS Chemistry 2019年第2期1卷 166-172页

作者： lie wu Shi Bian Hao Huang Jiahong Wang Danni Liu Paul K.Chu Xue-Feng Yu Center for Biomedical Materials and Interfaces Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Physics and Materials Science City University of Hong KongKowloon 999077Hong KongChina

We propose and demonstrate the novel concept of synthesizing organophosphorus compounds directly from black phosphorus(BP)nanoparticles as the feedstock.Compounds such as alkyl phosphines,alkyl phosphine oxides,phosphine sulfide,and hexafluorophosphate anion are prepared with good isolation yields under mild conditions.Selective synthesis of primary,secondary,and tertiary organophosphorus compounds is also demonstrated utilizing this one-pot approach.Reaction mechanisms are proposed and discussed.Compared with traditional white phosphorus(P 4)-based methods,the new synthetic concept and process utilizing elemental phosphorus are more efficient and environmentally friendly.

关键词： black phosphorus nanomaterials organophosphorus compounds phosphorus chemistry P-C coupling

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The Identification and Countermeasure Analysis of Vehicle Idle Vibration

The Identification and Countermeasure Analysis of Vehicle Id...

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FISITA 2012 World Automotive Congress--Volume 13: Noise,Vibration and Harshness(NVH)

作者： Ye Zhang Hui Wang Qingjun Zhu Yanghui Xu lie wu Beijing Automotive Technology Center

The Automotive industry of China is at big rapid development stage,each independence domestic OEM have paid more attention to independent brand vehicle,especially passenger vehicle development.As increasing of vehicle comfortableness requirement from the customer and technology input from domestic OEM,the vehicle Noise,Vibration,Harshness（NVH） performance has be regarded as one important symbol which reflects internal performance quality and outside characters,and taken more and more attention.The idle vibration is one common problem in independent brand vehicle development,because this issue is related to the powertrain system,powertrain mounts system,trimmed body system,steering wheelsteering column—Cross car beam（CCB） system etc.,the control is very difficult.

关键词： Idle vibration Control mechanism Frequency distribution Powertrain mounts Trimmed body

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通络明目胶囊治疗糖尿病视网膜病变血瘀络阻、气阴两虚证随机、双盲、多中心Ⅲ期临床试验

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中国实验方剂学杂志 2024年第7期30卷 170-178页

作者：任君霞王永争刘晓飞孙利杨立波吴烈连凤梅韦企平魏丽娟喻京生韩建科石家庄以岭药业股份有限公司络病理论创新转化全国重点实验室石家庄050035 河北以岭医院国家中医药管理局中医络病学高水平中医药重点学科石家庄050091 中国中医科学院广安门医院北京100053 北京中医药大学东方医院北京100078 长春中医药大学附属医院长春130021 湖南中医药大学第一附属医院长沙410007

目的:评价通络明目胶囊治疗糖尿病视网膜病变血瘀络阻、气阴两虚证的临床有效性和安全性。方法:采用区组随机、双盲、阳性对照、多中心临床试验设计方法。共纳入4家试验中心416例糖尿病视网膜病变血瘀络阻、气阴两虚证患者(观察组-对照... 详细信息

目的:评价通络明目胶囊治疗糖尿病视网膜病变血瘀络阻、气阴两虚证的临床有效性和安全性。方法:采用区组随机、双盲、阳性对照、多中心临床试验设计方法。共纳入4家试验中心416例糖尿病视网膜病变血瘀络阻、气阴两虚证患者(观察组-对照组数量比为3∶1)。在规范降糖治疗基础上,观察组服用通络明目胶囊(4粒/次,3次/d)+羟苯磺酸钙胶囊模拟剂(2粒/次,3次/d),对照组服用羟苯磺酸钙胶囊(2粒/次,3次/d)+通络明目胶囊模拟剂(4粒/次,3次/d)。疗程为12周。通过比较两组患者治疗前后糖尿病视网膜病变综合疗效、中医证候积分、矫正视力、眼底改变、眼底荧光血管造影等疗效指标评价通络明目胶囊疗效。同时进行一般检查、实验室检查和不良事件评价药物的安全性。结果:观察组和对照组患者基线人口学资料和疾病特征差异无统计学意义,均衡可比。治疗12周后,观察组糖尿病视网膜病变综合疗效总有效率(61.0%,189/310)优于对照组(44.1%,45/102),差异具有统计学意义(χ^(2)=8.880,P<0.01)。观察组中医证候总有效率(88.4%,259/293)优于对照组(69.9%,65/93),差异具有统计学意义(χ^(2)=17.927,P<0.01)。与对照组治疗后比较,观察组患者中医证候单项症状“目睛干涩(χ^(2)=8.305)、面色晦暗(χ^(2)=4.053)、倦怠乏力(χ^(2)=10.267)、气短懒言(χ^(2)=8.494)、大便干结(χ^(2)=8.657)”消失率均明显增高,组间比较差异均有统计学意义(P<0.05,P<0.01)。在改善矫正视力(χ^(2)=8.382)、眼底改变(χ^(2)=6.026)方面,观察组显效+有效率均优于对照组(P<0.05)。试验期间观察组与对照组的不良事件发生率分别为1.3%和2.9%,两组间比较差异无统计学意义,两组均无严重不良事件及导致退出的不良事件发生。结论:通络明目胶囊可以提高糖尿病视网膜病变综合疗效,改善中医证候疗效、视力、眼底改变和眼底荧光血管造影,且安全性良好,可以为糖尿病视网膜病变患者提供一种新的替代治疗药物。

关键词：通络明目胶囊糖尿病视网膜病变随机双盲多中心临床试验

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Recent progress of hybrid cathode interface layer for organic solar cells

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Journal of Energy Chemistry 2024年第4期91卷 383-406页

作者： Jianru Wang Dan Zhou Zhentian Xu Yujie Pu Senmei Lan Fang Wang Feiyan wu Bin Hu Yongfen Tong Ruizhi Lv Honglin Chu lie Chen Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources RecycleNanchang Hangkong UniversityNanchang 330063JiangxiChina College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031JiangxiChina

Organic solar cells(OSCs)have gained conspicuous progress during the past few decades due to the development of materials and upgrading of the device structure.The power conversion efficiency(PCE)of the single-junction device had surpassed 19%.The cathode interface layer(CIL),by optimizing the connection between the active layer and the cathode electrode,has become a momentous part to strengthen the performances of the OSCs.Simultaneously,CIL is also indispensable to illustrating the working mechanism of OSCs and enhancing the stability of the OSCs.In this essay,hybrid CILs in OSCs have been summarized.Firstly,the advancement and operating mechanism of OSCs,and the effects and relevant design rules of CIL are briefly concluded;secondly,the significant influence of CIL on enhancing the stability and PCE of OSCs is presented;thirdly,the characteristics of organic hybrid CIL and organic-inorganic hybrid CIL are introduced.Finally,the conclusion and outlook of CIL are summarized.

关键词： Organic solar cells Theoperation mechanism Organic hybrid cathode interface layer Organic-inorganic hybrid CIL

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AuCu和石墨烯助催化剂协同增强氮化碳的光催化性能

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化学研究与应用 2023年第12期35卷 2897-2907页

作者：吕佳武烈张峰长春医学高等专科学校吉林长春130031 中国科学院长春应用化学研究所吉林木长春130022 山东省济南生态环境监测中心山东济南250101

在热解法合成石墨相C_(3)N_(4)的基础上,先后采用溶剂热法和共沉淀法将石墨烯和AuCu双金属纳米颗粒负载到C_(3)N_(4)表面,得到AuCu/石墨烯/C_(3)N_(4)复合光催化剂。采用XRD、IR、BET、TEM、XPS、Absorption、PL、电化学等技术对AuCu/... 详细信息

在热解法合成石墨相C_(3)N_(4)的基础上,先后采用溶剂热法和共沉淀法将石墨烯和AuCu双金属纳米颗粒负载到C_(3)N_(4)表面,得到AuCu/石墨烯/C_(3)N_(4)复合光催化剂。采用XRD、IR、BET、TEM、XPS、Absorption、PL、电化学等技术对AuCu/石墨烯/C_(3)N_(4)的结构进行分析,并详细评估其在可见光下分解水制氢和还原CO_(2)的性能。石墨烯的负载可以增加材料的比表面积,促进光生电荷的迁移。AuCu双金属以合金的形式负载于石墨烯/C_(3)N_(4)表面,平均粒径3.7nm。纳米Au的表面等离共振效应能拓宽材料的光谱吸收范围,而第二金属Cu的引入能加速光生电子的分离和传输。因此,石墨烯和AuCu双助催化剂的负载能显著增强C_(3)N_(4)的光催化性能。当AuCu的原子比为3:2、AuCu和石墨烯的负载量分别为0.5和1wt%时,得到的Au_(3)Cu_(2)/GC复合光催化剂表现出最佳的光催化性能,其分解水制氢的速率达到324.8μmol/h,光催化还原CO_(2)制取CH_(4)的活性和选择性分别为36.1μmol/hg和91.3%,并表现出良好的光催化稳定性。

关键词： AuCu/石墨烯/C_(3)N_(4) 表面等离共振效应光解水 CO_(2)还原光生载流子分离

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