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Induction of Autologous Bone-Marrow Stem Cells by Low-Level Laser Therapy Has Beneficial Effects on the Kidneys Post-Ischemia-Reperfusion Injury in the Rat

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Journal of Biomedical Science and Engineering 2014年第8期7卷 453-463页

作者： Hana Tuby lidya maltz Uri Oron Department of Zoology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel

Acute renal failure has a 50% - 80% mortality rate. Currently, treatment options for this life-threatening disease are limited. Low-level laser therapy (LLLT) has been found to modulate biological activity. The aim of the present study was to investigate the possible beneficial effects of laser application to stem cells in the bone marrow, on the kidneys of rats that had undergone ischemia-reperfusion injury (IRI). IRI was induced by occlusion of the renal artery to 3- and 7-month-old rats for 15 or 30 minutes. In an additional experiment IRI was applied to both kidneys for 20 min each in 2-3-month-old rats. Rats were then divided randomly into two groups of control and laser-treated. Laser therapy (Ga-Al-As 810 nm, 200 mW output for 2 min) was applied to the bone marrow 1 and 7 days post-IRI to the kidneys, and rats were sacrificed 2 weeks later. Histomorphometry and immunohistochemistry were performed on kidney sections and blood markers for kidney function. Quantitative histomorphometric analysis revealed a reduction in dilatation of the renal tubules, restored structural integrity of the renal tubules, and reduced necrosis in the laser-treated rats as compared to the control, non-laser-irradiated group. C-kit positive cell density in kidneys post-IRI and laser-treatment was significantly (p = 0.015) 3.2-fold higher compared to the control group. Creatinine and blood urea nitrogen content were significantly lower in the laser-treated rats as compared to control. It is concluded that LLLT application to the bone marrow (BM) causes a significant increase in the density of mesenchymal stem cells in the kidneys post-IRI, probably by induction of stem cells in the BM, which subsequently migrate to the IRI kidney, significantly reducing the pathological features of the kidney and increasing kidney function post IRI.

关键词： Kidney Mesenchymal Stem Cells (MSCs) Low-Level Laser Therapy (LLLT) Ischemia-Reperfusion Injury (IRI)

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Effect of autologous mesenchymal stem cells induced by low level laser therapy on cardiogenesis in the infarcted area following myocardial infarction in rats

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Journal of Biomedical Science and Engineering 2013年第8期6卷 24-31页

作者： Hana Tuby Tali Yaakobi lidya maltz Yaakov Delarea Orit Sagi-Assif Uri Oron Department of Cell Biology and Immunology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel Department of Zoology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel

In this study, we investigated the hypothesis that photobiostimulation by low-energy laser therapy (LLLT) applied to the bone marrow (BM) of myocardial infarcted rats may attenuate the scarring processes that follow myocardial infarction (MI). Wistar rats underwent experimental MI. LLLT (Ga-Al-As diode laser) was applied to the BM of the exposed tibia at different time intervals post-MI (4 hrs, 48 hrs and 5 days). Sham-operated infarcted rats served as control. Infarct size was significantly reduced (55%) in the laser-treated rats as compared to the control non-treated rats, at 2 weeks post-MI. A significant 3-fold increase was observed in the density of desmin immunopositive stained cells 14 days post-MI in the infarcted area of the laser-treated rats as compared to the non-laser-treated controls. The electron microscopy from the control infarcted rat hearts revealed a typical interphase area between the intact myocardium and the infarcted area, with conspicuous fibroblasts with collagen deposition dispersed among them. In rats that were laser treated (to BM), the interphase zone demonstrated cells with different intracellular structures. There was also a significant increase in the percentage of c-kit positive cells and macrophages in the circulating blood of the laser treated rats as compared to control non treated ones. In the majority of the cells clusters of myofibrils anchored to well-developed Z-lines and structures resembling the morphological characteristics of mature intact cardiomyocytes were evident. In conclusion, LLLT to the BM of rats post-MI induces cardiogenesis mainly at the borders of the infarcted area in the heart.

关键词： Low-Level Laser Therapy Myocardial Infarction Macrophage Desmin Ultrastructure c-Kit Positive Cells

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Intrahepatic CD8^+ lymphocyte trapping during tolerance induction using mushroom derived formulations:A possible role for liver in tolerance induction

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World Journal of Gastroenterology 2008年第24期14卷 3872-3878页

作者： Mony Shuvy Tiberiu Hershcovici lidya Zolotarov Yaron Ilan Cristina LulI-Noguera Harry Wichers Ofer Danay Dan Levanon Liver Unit Department of Medicine Hadassah HebrewUniversity Medical Center Jerusalem IL-91120 Israel WageningenUniversity and Research Center Wageningen 6706 KN TheNetherlands Migal Kiryat Shmone 11016Israel

AIM: To determine the immunomodulatory effect of Shiitake (a mushroom extract),we tested its effect on liver-mediated immune regulation in a model of immune-mediated colitis. METHODS: Four groups of mice were studied. Colitis was induced by intracolonic instillation of TNBS in groups A and B. Groups A and C were treated daily with Shiitake extract,while groups B and D received bovine serum albumin. Mice were evaluated for development of macroscopic and microscopic. The immune effects of Shiitake were determined by FACS analysis of intra-hepatic and intrasplenic lymphocytes and IFN-γ ELISPOT assay. RESULTS: Administration of Shiitake resulted in marked alleviation of colitis,manifested by signifi cant improvement in the macroscopic and microscopic scores,and by reduction in IFN-γ-producing colonies in group A,compared to group B mice (1.5 pfu/mL vs 3.7 pfu/mL,respectively). This beneficial effect was associated with a significant increase in the intra-hepatic CD8+ lymphocyte trapping,demonstratedby an increased intrasplenic/intrahepatic CD4/CD8 lymphocyte ratio. These effects were accompanied by a 17% increase in the number of intrahepatic natural killer T (NKT) cells. A similar effect was observed when Shiitake was administered to animals without disease induction. CONCLUSION: Shiitake extract affected liver-mediated immune regulation by altering the NKT lymphocyte distribution and increasing intrahepatic CD8+ T lymphocyte trapping,thereby leading to alleviation of immune-mediated colitis.

关键词： Mushrooms Colitis Immune modulation Shiitake Natural killer T cell

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Oral Co-administration of Soy-derived Extracts with Alcohol or with Sugar-sweetened Beverages Exerts Liver and Sugar Protective Effects

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Journal of Clinical and Translational Hepatology 2017年第3期5卷 208-215页

作者： Tawfik Khoury Devorah Rotnemer-Golinkin Yehudit Shabat lidya Zolotarovya Yaron Ilan Gastroenterology and Liver Units Department of Medicine Hadassah-Hebrew University Medical CenterJerusalem Israel

Background and Aims:Both alcoholic drinks and high sugar-containing soft drinks cause major health problems *** administration of OS and M1 soy-derived extracts has been shown to alleviate liver injury in animal *** aim of the present study was to determine the liver-and sugar-protective effect of OS and M1 soy-derived extracts when added to alcohol and sugar-enriched ***:Mice were treated with alcohol or high sugarcontaining drinks,with and without administration of a combination of OS and M1 soy *** were observed for the effects on liver injury,glucose metabolism,and the immune ***:Co-administration of the soy extracts OS and M1 significantly alleviated the liver injury induced by acute alcohol,as evidenced by decreased liver *** beneficial effects were associated with promotion of subsets of regulatory T lymphocytes and with a trend towards a pro-inflammatory to an anti-inflammatory cytokine ***-administration of OS M1 soy extracts with sugar-sweetened beverages significantly alleviated the increases in serum sugar ***:OS and M1 extracts exert a synergistic hepato-and glucose-protective effect in models of alcohol-induced liver damage and soft drinks-associated increases in serum *** extracts may provide a solution to the two pressing health problems.

关键词： Soy Soda drinks Alcoholic liver disease T regulatory cells

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Respiration Rates of Organic Soil Depending on Changes of Moisture and Aeration

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Open Journal of Soil Science 2017年第6期7卷 101-110页

作者： Zofia Fischer Pavel Blazka lidya Dubis Faculty of Mathematics Informatics and Landscape ArchitectureJohn Paul ⅡCatholic University of LublinLublinPoland Department of Science University of South BohemiaCeske BudejoviceCzech

This paper aims at analyzing changes in soil respiration depending on the levels of soil moisture and aeration. Organic forest soil was used in the experiments. Watering of the soil was applied starting from two initial moisture contents: 1) GWC > 0.1, desiccated soil, respiration equals to zero;2) GWC between 0.46 - 0.78, moisture of the soil approximately the same as at the time of sample collection. Watering of the soil was applied once or continuously during the experiment. The experiments were conducted under both: unrestricted air-supply and anoxic conditions. Measurements of: oxygen consumption, carbon dioxide emission, and RQ were determined with a volumetric respirometer. Soil desiccation, which occurs under good access of the air, and leads to the increase of respiration rate (the “Birch effect”), is predominantly related to aerobic respiration following the change in soil aeration. If respiration of non-desiccated soil is assumed as 100%, the oxygen consumption of desiccated soil equaled to 209.90% of such value in the non-desiccated soil at the lowest moisture level, and only to 51% at the highest. Carbon dioxide emission equaled to 191.92% and 111% at the lowest and the highest moisture levels, respectively. Desiccation did not increase the respiration rate under anoxic conditions. It either decreased or remained statistically unchanged. However, obtained values of RQ index suggest that under anoxic conditions desiccation affects fermentation processes in the soil. The value of RQ index at the moisture level lower than GWC 1 was very low attaining merely 0.3 - 0.4, which suggests active fermentation processes. At higher moisture content yet, RQ value exceeded 2.

关键词： Birch Effect Anoxia RQ Watering

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印尼非华裔汉语个体量词习得研究及教学对策

印尼非华裔汉语个体量词习得研究及教学对策

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作者： lidya Moetia Syafitri（李菲菲）福建师范大学

学位级别：硕士

个体量词是汉藏语系尤其是汉语中比较特殊的一种语法现象,然而在汉语作为第二语言教学中,个体量词并未受到应有的重视。迄今为止,前人对汉语与印尼语对比研究的成果并不多。对印尼汉语学习者而言,汉语尤其是汉语个体量词是一个难题,很... 详细信息

个体量词是汉藏语系尤其是汉语中比较特殊的一种语法现象,然而在汉语作为第二语言教学中,个体量词并未受到应有的重视。迄今为止,前人对汉语与印尼语对比研究的成果并不多。对印尼汉语学习者而言,汉语尤其是汉语个体量词是一个难题,很需要有针对性、可行性及实用性的教学实践指导。本文采用文献检索法、对比分析法、问卷调查法、统计分析法、偏误分析法,对汉语个体量词与印尼语量词进行对比研究。以印尼非华裔汉语学习者和在印尼汉语教师为研究对象,考察分析学习者对汉语个体量词的习得情况、偏误类型、偏误成因以及教师教学情况并针对初、中、高级汉语学习者提出五点教学对策和建议。本论文共分为六个部分：绪论部分主要梳理中国、外国及印尼语研究者对汉语量词和个体量词的研究成果和存在的局限。介绍研究目标、研究范围、研究方法及研究对象。第一章将汉语个体量词与印尼语量词从三个方面进行深入对比：用于有生命物、无生命物、抽象物。第二章则通过问卷调查来分析研究在印尼汉语教师和印尼非华裔汉语学习者汉语个体量词的教学和习得情况,归纳偏误的类型。第三章是借助第二语言教学的理论辨析出产生偏误的主要缘故。第四章从第二语言教学的方向出发,提出了更加有针对性、可行性及实用性的汉语个体量词教学对策以及建议。第五章是针对全文研究内容及成果的归纳总结。

关键词：汉语个体量词汉印对比印尼汉语学习者偏误汉语教学对策

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“走出去”建设人类命运共同体:中国与东盟的研究生教育合作

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苏州大学学报（教育科学版） 2021年第4期9卷 16-28页

作者：徐岚王柳 lidya P.Pranata 厦门大学教育研究院福建厦门361005

“一带一路”倡议是推进人类命运共同体建设的重要实践。东盟作为“一带一路”沿线的近邻,与中国在高等教育包括研究生教育领域的学生流动、政策互通、平台建设等方面开展了广泛合作。基于东盟各国研究生教育发展水平差异较大、结构体... 详细信息

“一带一路”倡议是推进人类命运共同体建设的重要实践。东盟作为“一带一路”沿线的近邻,与中国在高等教育包括研究生教育领域的学生流动、政策互通、平台建设等方面开展了广泛合作。基于东盟各国研究生教育发展水平差异较大、结构体系各异、国际化程度参差的现状,采取针对性措施,提高双方教育质量、打造留学中国品牌,促进教育资源共享、提高科研效率,拉动双方经济发展、实现互利共赢,实现双方文化认同、助力民心相通。以构建“一带一路”高等教育共同体为重要目标,未来中国与东盟还需进一步完善在研究生教育领域的合作机制,统一质量标准、创新合作模式,促进在高层次人才培养方面的全方位、多层次、宽领域合作。

关键词：人类命运共同体东盟研究生教育合作一带一路

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