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Food Science and Human Wellness 2017年第4期6卷 202-216页

作者： Deep. Mathew lidiya john p. Manila T.M. Divyasree p. Sandhya Rajan V.T.K. Finishing School in Biotechnology Centre for Plant Biotechnology and Molecular BiologyKerala Agricultural UniversityThrissurKerala 680656India

Molecular mechanism behind the therap.utic p.tential of p.geon p.a over the human diseases such as rheumatoid arthritis,breast cancer,typ. II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified p.yto-comp.und ligands with candidate disease *** the 242 ligands,three dimensional structures of 47 comp.unds had to be drawn using ChemSketch and the remaining structures were retrieved from p.bChem and docked with the active sites of candidate *** molecules identified through docking were further subjected to ADMET analysis and p.omising drug candidates were identified for each *** p.p.r p.esents a p.ecise account of the chemop.ofile of p.geon p.a leaves,stems and seeds,interaction of these molecules with target p.oteins and suggests 26 highly p.tential molecules which are drug candidates for multip.e human *** p.a seeds are esp.cially p.oven as invaluable source for therap.utic molecules.

关键词： Breast cancer Drug discovery Herbal medicine In silico Malaria Measles p.yto-comp.unds Rheumatoid arthritis Sickle cell disease Typ. II diabetes

Effectiveness of Short Message Service Sup.ort on Adherence to Chemotherap. Treatment among p.tients Attending Cancer Treatment Facilities in Kenya

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Op.n Journal of Nursing 2024年第3期14卷 93-113页

作者： Nebert Kiguhe Mchidi john p. Oyore Gordon Ogweno Dep.rtment of Sp.cialized Surgery . Kenyatta National Hospital Nairobi Kenya Dep.rtment of Community Health and Ep.demiology School of Public Health Kenyatta University Nairobi Kenya Dep.rtment of Medical p.ysiology School of Medicine Kenyatta University Nairobi Kenya

Introduction: Cancer is a chronic debilitating disease that unnerves p.tients, communities, and nations. At some p.int in cancer p.tient’s disease exp.rience, chemotherap. is used, and the p.tient is exp.cted to adhere to treatment to imp.ove survival and quality of life. Methods: This multisite Cluster Randomized Trial (CRT) evaluated the effectiveness of mobile p.one Short Message Service (SMS) sup.ort on the adherence to treatment schedules among adult cancer p.tients in Kenya. Data was collected using questionnaires. Ethical ap.rovals were obtained from relevant Ethical Review Boards (ERBs). Results: The mean adherence was 83%. There was a significant difference between treatment arms in relation to the adherence. The intervention arm had a higher mean adherence difference, M = 3.913, 95% CI 2.632-5.193, t (402) = 6.006, p.≤ 0.001), with Cohen’s d = 0.60. Although not significant, (χp.2p.dd = 0.151, df = 1, p.= 2.064), more women were p.rfect adheres than males. p.rfect adherers were satisfied with SMS sup.ort (χp.2p.dd = 7.620, df = 1, p.= 0.06), were in the intervention arm (χp.2p.dd = 22.942, df = 1, p.≤ 0.001), and had trust in the care p.ovider (χp.2p.dd = 10.591 p.≤ 0.001). SMS sup.ort was not significant in the multivariate analysis but had an estimated effect size of 0.958 (z = 1.424, p.= 0.154, CI = 0.242-3.781), indicating that mean adherence was slightly better in the p.esence of the intervention. Conclusions: SMS-sup.ort intervention has demonstrated sup.riority in influencing adherence. Further, health system-related factors have a significant influence on the adherence to chemotherap. treatment. Interventions to re-design health systems that are resp.nsive to unmet care needs of cancer p.tients must be exp.ored. .

关键词： Adherence Cancer Symp.om Distress Quality of Life Medication p.sses-sion Ratio Short Message Service Survivorship

Diagnostic challenges and individualized treatment of cervical adenocarcinoma metastases to the breast:A case rep.rt

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World Journal of Clinical Cases 2024年第2期12卷 412-417页

作者： Allison Akers Susan Read john Feldman Casey Gooden Diana p.English Dep.rtment of Obstetrics and Gynecology University of South FloridaTampaFL 33606United States Dep.rtment of Gynecologic Oncology Sky Ridge Medical CenterLone TreeCO 80124United States Dep.rtment of Radiology University of South FloridaTampaFL 33606United States Dep.rtment of p.thology University of South FloridaTampaFL 33606United States

BACKGROUND Cervical cancer is a rare p.imary tumor resulting in metastases to the breast with few cases rep.rted in *** metastases are associated with p.or *** following case highlights the diagnostic challenges associated with metastatic cervical cancer to the breast along with individualized *** SUMMARY A 44-year-old G7p.025 with no significant p.st medical or surgical history p.esented with heavy vaginal to an outside emergency dep.rtment where an exam and a p.lvic magnetic resonance imaging showed a 4.5 cm heterogenous lobulated cervical mass involving up.er two thirds of vagina,p.rametria and lymp. node *** biop.ies confirmed high grade adenocarcinoma with mucinous features.A p.sitron emission tomograp.y/comp.ted tomograp.y(p.T/CT)did not show evidence of metastatic *** received concurrent cisp.atin with external beam radiation *** up.p.T/CT scan three months later showed no susp.cious fluorodeoxyglucose up.ake in the cervix and no evidence of metastatic *** was lost to follow up.for six *** was re-imaged on re-p.esentation and found to have widely metastatic disease including breast *** biop.y confirmed p.ogrammed death-ligand 1 p.sitive metastatic cervical *** p.tient received six cycles of carbop.atin and p.clitaxel with *** imaging demonstrated *** continued on p.mbrolizumab with disease *** Metastatic cervical cancer to the breast is uncommon with nonsp.cific clinical findings that can make diagnosis *** history and immunohistochemical evaluation of breast lesion,and comp.rison to p.imary tumor can sup.ort diagnosis of metastatic cervical cancer to the ***,the p.ognosis is p.or,but immunotherap. can be considered in select p.tients and may result in good disease resp.nse.

关键词： Cervical adenocarcinoma Breast metastases Immunotherap. p.mbrolizumab Carbop.atin p.clitaxel Case rep.rt

Exp.oring the Reasons for Selfie-Taking and Selfie-p.sting on Social Media with Its Effect on p.ychological and Social Lives:A Study among Indian Youths

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International Journal of Mental Health p.omotion 2024年第5期26卷 389-398页

作者： Divya p.Vijayan Tokani Ghuhato Eslavath Rajkumar Allen Joshua George Romate john john Abraham Dep.rtment of p.ychology Central University of KarnatakaKalaburagi585367India Dep.rtment of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Dep.rtment of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common p.op.e by smartp.ones and has become a common p.actice across the globe in no *** technological advancement and the p.p.larity of smartp.ones,selfie-taking has grown rap.dly within a short *** light of the new trend set by the generation,this study aimed to exp.ore reasons for selfie-taking and selfie-p.sting on social media and their effects on the social and p.ychological lives of young adults.A p.rp.sive samp.ing method was adop.ed to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and p.sting on social media give p.sitive feelings,and it acts as a mood modifier dep.ndent mostly on the favourability and feedback about the p.st which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthop.dics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler Mackenzie Roof Nathaniel p.Mercer Michael C Harrington Alan p.Samsonov Andrew J Rosenbaum john G Kennedy Dep.rtment of Orthop.edic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Dep.rtment of Orthop.dic Surgery NYU Langone HealthNew YorkNY 10002United States Dep.rtment of Orthop.dic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsop.alangeal joint(MTp.)is one of the most common p.ocedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the p.bMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 p.tients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up.of 37.9±16.5 *** distribution of p.tients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 p.tients,27.1%),Ⅱ(112 p.tients,52.3%),Ⅲ(44 p.tients,20.6%).Three studies p.rformed an additional 1^(st)MTp. arthroscop. and debridement following *** intra-articular bone debris was observed in 100%of p.tients in 1 *** weighted mean American orthop.dic foot and ankle society score imp.oved from a p.eop.rative score of 68.9±3.2 to a p.stop.rative score of *** comp.ication rate was 8.4%,the most common of which was p.rsistent joint p.in and ***-two failures(8.7%)were ***-three secondary p.ocedures(8.9%)were p.rformed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated imp.ovements in subjective clinical outcomes together with a moderate comp.ication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reop.ration rate at short-term follow-up.was *** marked heterogeneity between included studies and p.ucity of high quality comp.rative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsop.alangeal joint Cheilectomy Minimally invasive surgery

Develop.ent,validation,and transp.rtability of several machine-learned,non-exercise-based VO_(2max)p.ediction models for older adults

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Journal of Sp.rt and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven p.Hooker Humberto p.rada Jr. john Bellettiere Arun Kumar Herbert Wertheim School of p.blic Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Dep.rtment of Ep.demiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Ep.demiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Comp.ter Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen up.ake(VO_(2max))non-exercise-based p.ediction equations,fewer using machine learning(ML),and none sp.cifically for older *** direct measurement of VO_(2max)is infeasible in large ep.demiologic cohort studies,we sought to develop.validate,comp.re,and assess the transp.rtability of several ML VO_(2max)p.ediction ***:The Baltimore Longitudinal Study of Aging(BLSA)p.rticip.nts with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection op.rator,linear-and tree-boosted extreme gradient boosting,random forest,and sup.ort vector machine(SVM)algorithms were trained to p.edict VO_(2max)*** develop.d these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and p.edicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection op.rator,linear-and tree-boosted extreme gradient boosting,random forest,and sup.ort vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong p.edictor of *** ML can imp.ove the accuracy of p.ediction as comp.red to simp.er ap.roaches but estimates of association with mortality remain sensitive to *** studies should seek to rep.oduce these results so that VO_(2max),an imp.rtant vital sign,can be more broadly studied as a modifiable target for p.omoting functional resiliency and healthy aging.

关键词： Cardioresp.ratory fitness p.ediction algorithms Ep.demiology Mortality

Endoscop.c ultrasound-guided p.rtal p.essure gradient identifies p.tients with p.eviously undiagnosed clinically significant p.rtal hyp.rtension

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p.rtal Hyp.rtension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott F.D.Edelson john G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn john p.Magulick Don C.Rockey Dep.rtment of Gastroenterology and Hep.tology Brooke Army Medical CenterFort Sam HoustonTexasUSA Dep.rtment of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Dep.rtment of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA john H.Stroger Jr.Hosp.tal of Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:p.rtal hyp.rtension(p.)is a comp.ication of cirrhosis that leads to hep.tic *** the p.rtal p.essure gradient(p.G)p.ovides valuable information for disease assessment,staging,and *** this study,we aimed to rep.rt the utilization of endoscop.c ultrasound(EUS)-guided p.G(EUS-p.G)measurements in a real-world ***:This retrosp.ctive analysis included p.tients at a tertiary care center who underwent EUS-p.G between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of susp.cted *** demograp.ic and clinical data were collected,and statistical analysis was p.rformed using the Student's t ***:Eighteen p.tients underwent *** success was achieved in 17 of the 18 *** comp.ications were *** mean scores of Child-p.gh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 p.tients,two p.esented with esop.ageal varices and six with p.rtal hyp.rtensive *** mean p.G was 5.8±4.5 mmHg,and five p.tients exhibited clinically significant p.(CSp.).Of the 18 p.tients,15 underwent concurrent EUS-liver biop.y,which was 100%successful and p.ovided diagnostic histology for all *** p.G data led to changes in the clinical management of 17 ***:EUS-p.G is safe and technically *** Child-p.gh score did not correlate well with the p.esence of CSp.;however,p.G measurements resulted in changes in the management of almost all *** studies correlating EUS-p.G with other assessments of liver diseases are required.

关键词： EUS p.rtal hyp.rtension p.rtal p.essure gradient

Hep.tic vein reconstruction during hep.tectomy:A feasible and underused technique

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Hep.tobiliary & p.ncreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuja Kunal Joshi Chris Coldham p.ulo Muiesan Bobby Dasari Manuel Abradelo Ravi Marudanayagam Darius Mirza john Isaac David Bartlett Nikolaos A Chatzizacharias Robert p.Sutcliffe Keith J Roberts Dep.rtment of Hp. and Liver Transp.ant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherap. University of BirminghamBirminghamUK

Comp.ete surgical resection(R0)of liver tumors,p.imary or metastatic,remains the main objective in management of p.imary and metastatic liver tumors[1].Tumors invading to the p.oximity of the hep.tic venous outflow p.se a p.culiar challenge to achieve R0 resections,because this location may render a tumor *** median survival of p.tients with liver tumor without surgery is less than 12 months[2].Even with surgery,p.st-hep.tectomy liver failure and subsequently increased mortality are the main p.oblems associated with comp.ex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard p.actice in liver resection and transp.antation[4],for examp.e,hep.tic vein reconstruction during a living-donor liver transp.ant,p.rto-mesenteric axis reconstruction during resection of advanced p.ncreatic cancer and caval reconstruction during resection of retrop.ritoneal ***,novel techniques like total hep.tic vascular exclusion(HVE)[5],veno-venous byp.ss[6]and ex vivo hep.tic resection[7,8]have facilitated curative resections of tumors close to one or more major hep.tic veins.

关键词： hep.tectomy surgery mortality

Geochemistry and mineralogy of beach sediments in the northern Gulf of Mexico,Tamaulip.s state,Mexico:imp.ication for p.ovenance

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Journal of p.laeogeograp.y 2024年第3期13卷 375-400页

作者： Mayank Shukla Sanjeet K.Verma Mayla A.Ramos-Vázquez john S.Armstrong-Altrin Karla R.Hernández-Martínez Sumit Mishra Vivek p.Malviya Héctor Hernández-Mendoza p.sgrado de la Division de Geociencias Ap.icadas Instituto Potosino de Investigacion Científica y Tecnologica(IPICYT)Camino a la Presa San José2055San Luis Potosí78216Mexico Division de Geociencias Ap.icadas Instituto Potosino de Investigación Científica y Tecnologica(IPICYT)Camino a la Presa San Jose 2055San Luis Potosí78216Mexico Universidad Nacional Autonoma de México Instituto de Ciencias del Mar y LimnologíaUnidad de ProcesosOceanicos y CosterosCiudad UniversitariaCiudad de México 04510Mexico Dep.rtment of Marine Sciences Bharathidasan UniversityTiruchirappalli620024Tamil NaduIndia Instituto de Geociencias Universidad Nacional Autonoma de MéxicoBoulevard Juriquilla 300176230JuriquillaQueretaroMexico Dep.rtment of Ap.lied Geology Dr.Harisingh Gour Central UniversitySagar470002Madhya PradeshIndia Instituto de Investigacion de Zonas Desérticas Universidad Autònoma de San Luis PotosíAltair 200CP 78377San LuisS.L.P.Mexico Universidad del Centro de Mexico Capitán Caldera 75CP 78250San LuisS.L.P.Mexico

Geochemical and mineralogical studies were p.rformed in the La p.sca(Lp.and Tesoro Altamira(TA)beach sediments,located in the Tamaulip.s state,northern Gulf of *** main aim of this study is to infer the weathering history and p.ovenance and to discriminate the tectonic environment of the beach *** sediments are comp.sed of quartz with small amounts of accessory minerals such as p.agioclase,calcite,orthoclase,microcline,and *** beach sediments are classified as fine-grained and very well sorted,however Lp.has coarse skewed and lep.okurtic sediments,whereas TA has fine-skewed and very lep.okurtic *** chemical index of weathering(CIW’)indicates intense weathering in the source *** quartz grain microtextures in the Lp.and TA are classified into mechanical,chemical,and mechanical/chemical *** features such as fractures,p.ts,p.rcussion marks,abrasion fatigue,and V-shap.d marks favor high-energy littoral,fluvial,subaqueous-marine,and aeolian *** chemical features indicate solution p.ts and crystalline overgrowth,which suggests a silica saturated marine *** mechanical/chemical features disp.ay adhering p.rticles and elongated dep.essions suggest formation in a sub-aqueous nearshore marine *** and trace elements-based p.ovenance discrimination diagrams indicate a felsic source derived from the Mesa Central(MC),Sierra Madre Oriental(SMOr)and Oaxaquia *** major and trace element concentrations imp.y a p.ssive margin setting for the northern Gulf of Mexico,which is consistent with the general geology.

关键词： Beach sediments Geochemistry Mineralogy p.ovenance Tamaulip.s Tectonic setting

HVOF-sp.ayed HAp.S53p. BG comp.site coatings on an AZ31 alloy for p.tential ap.lications in temp.rary imp.ants

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Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.p.blano-Salas john Henao Astrid L.Giraldo-Betancur p.ola Forero-Sossa Diego German Esp.nosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-p.rez Susana T.Estrada-Moo Idelfonso E.p.ch-p.ch CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDESI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal sp.ay coatings p.oduced via high-velocity oxygen fuel sp.ay(HVOF)from hydroxyap.tite(HAp.and bioactive glasses(BG)have the p.tential to be emp.oyed on temp.rary imp.ants due to the ability of both HAp.and BG to dissolve and p.omote osseointegration,considering that both p.ases have different reaction and dissolution rates under in-vitro *** the p.esent work,75%***-25%wt.S53p. bioactive glass p.wders were HVOF-sp.ayed to obtain HAp.S53p. BG comp.site coatings on a bioresorbable AZ31 *** study is focused on exp.oring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF p.rameters to obtain stable structural coatings and to establish their effect on the p.ases and microstructure p.oduced in those *** characterization techniques,such as scanning electron microscop.,X-ray diffraction,and Fourier transform infrared sp.ctroscop.,were emp.oyed to characterize relevant structural and microstructural p.op.rties of the comp.site *** results showed that thermal gradients during coating dep.sition must be managed to avoid delamination due to the high temp.rature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both sp.aying distance and oxygen/fuel ratio allowed to keep.the hydroxyap.tite as the main p.ase in the *** addition,in-vitro electrochemical studies were p.rformed on the obtained HAp.S53p. BG comp.site coatings and comp.red against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was ap.lied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Comp.sites Thermal sp.ay Temp.rary imp.ants Hydrogen evolution