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Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

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Nano Research 2023年第5期16卷 7459-7469页

作者： Liding Zhang Ying Su Xiaohan Liang Kai Cao Qingming Luo Haiming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)Wuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical EngineeringHainan UniversityHaikou 570228China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical SciencesHUST-Suzhou Institute for BrainsmaticsJiangsu Industrial Technology Research Institute(JITRI)Suzhou 215123China

Phosphorylation of tau at Ser(396,404)(p-tau^(396,404))is one of the earliest phosphorylation events,plasma p-tau^(396,404) level appears to be a potentially promising biomarker of Alzheimer’s disease(AD).The low abundance and easy degradation of p-tau in the plasma make the lateral flow assay(LFA)a suitable choice for point-of-care detection of plasma p-tau^(396,404) levels.Herein,based on our screening of a pair of p-tau^(396,404)-specific antibodies,we developed a colorimetric and surface-enhanced Raman scattering(SERS)dual-readout LFA for the rapid,highly sensitive,robust detection of plasma p-tau^(396,404) levels.This LFA realized a detection limit of 60 pg/mL by the naked eye or 3.8 pg/mL by SERS without cross-reacting with other tau species.More importantly,LFA rapidly and accurately differentiated AD patients from healthy controls,suggesting that it has the potential for clinical point-of-care application in AD diagnosis.This dual-readout LFA has the advantages of simple operation,rapid,ultra-sensitive detection,providing a new way for early AD diagnosis and intervention,especially in primary and community AD screening.

关键词： Alzheimer’s disease p-tau^(396,404) plasma detection surface-enhanced Raman scattering lateral flow assay

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Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer's disease

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 32-56页

作者： Liding Zhang Xiaohan Liang Zhihong zhang Haiming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China

The anti-amyloid-j(anti-Aβ)fibrils and soluble oligomers antibody aducanumab were approved to effectively slow down the progression of A lzheimer's disease(AD)at higher doses in 2019,reaffirming the therapeutic effects of targeting the core pathology of AD.A timely and accurate diagnosis in the prodromal or pre-dementia stage of AD is essential for patient recruitment,stratifcation,and monitoring of treat ment effects.A D core biomarkers amyloid-B(Aβ1-42),total tau(t-tau),and phosphorylated tau(p-tau)have been clinically validated to reflect AD-type pathological changes through cerebrospinal fuid(CSF)measurement or positron-emission to-mography(PET)and found to have high diagnostic performance for AD identification in the stage of mild cognitive impairment.The development of ultrasensitive immunoassay technology enables AD pathological proteins such as tau and neurofilament light(NFL)to be measured in blood samples.However,combined biomarker detection or targeting multiple biomarkers in immunoassays will increase detection sensitivity and specifcity and improve diagnostic accuracy..This review summarizes and analyzes the performance of current detection methods for early diagnosis of AD,and provides a concept of detection method based on multiple biomarkers instead of a single target,which may become a potential tool for early diagnosis of AD in the future.

关键词： Alzheimer's disease cerebrospinal fluid blood biomarkers bispecific antibody diagnosis.

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Identification on threshold and efficiency of rainfall replenishment to soil water in semi-arid loess hilly areas

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Science China Earth Sciences 2018年第3期61卷 292-301页

作者： Lei YANG Handan zhang liding CHEN State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Beijing 100085 China University of Chinese Academy of Sciences Beijing 100049 China

As one critical source of water for maintaining ecosystems in arid and semi-arid regions, rainfall replenishment to soil water can determine vegetation growth and ecosystem functions. However, the limited rainfall resources were often not used effectively in the semi-arid loess hilly areas due to random temporal and spatial distribution of rainfall and specific vegetation features. Thus, it is highly significant to determine the threshold and efficiency of rainfall replenishment to soil water under different vegetation types. The threshold and efficiency can offer scientific evidence for rehabilitating vegetation and improving efficiency of using rainfall resources. In this study, the efficiency and threshold of rainfall replenishment to soil water were determined under natural grassland, wheat, artificial grassland, sea buckthorn shrubland and Chinese pine forestland based on consecutive measurements. The results indicated that the lag-time, rate, efficiency of rainfall replenishment to soil water were closely related to vegetation type, with significant differences existing among different vegetation types. The lag-time for natural grassland in the soil horizon of 20 cm was the shortest one(26.4 h), followed by wheat(27.8 h), sea buckthorn(41.8 h), artificial grassland(50.0 h) and Chinese pine(81.8 h).The value of replenishment rate, followed the order of wheat(0.40 mm h^(-1))> natural grassland(0.30 mm h(-1))> sea buckthorn(0.17 mm h(-1))> artificial grassland(0.14 mm h(-1))> Chinese pine(0.09 mm h(-1)). As for the efficiency of rainfall replenishment to soil water, natural grassland was the most efficient one(35.1%), followed by wheat(29.2%), sea buckthorn(16.8%), artificial grassland(11.5%), Chinese pine(4.2%). At last, it was found that wheat had the lowest threshold(6.8 mm) of rainfall replenishment to soil water, which was followed by natural grassland(10.5 mm), sea buckthorn(20.5 mm), artificial grassland(22.6 mm) and Chinese pine(26.4 mm). These results implied that soil water in natural grassland was s

关键词：降雨资源土壤水半干旱阀值黄土生态系统功能植被生长鉴定

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The deformed Hermitian-Yang-Mills equation on almost Hermitian manifolds

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Science China Mathematics 2022年第1期65卷 127-152页

作者： liding Huang Jiaogen zhang Xi zhang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

In this paper,we consider the deformed Hermitian-Yang-Mills equation on closed almost Hermitian manifolds.In the case of the hypercritical phase,we derive a priori estimates under the existence of an admissible C-subsolution.As an application,we prove the existence of solutions for the deformed Hermitian-Yang-Mills equation under the condition of existence of a supersolution.

关键词： deformed Hermitian-Yang-Mills equation almost Hermitian manifold maximum principle a priori estimates

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Regional-scale Identification of Three-dimensional Pattern of Vegetation Landscapes

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Chinese Geographical Science 2014年第1期24卷 104-112页

作者： SUN Ranhao zhang Baiping CHEN liding State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of Sciences State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

The altitudinal pattern of vegetation is usually identified by field surveys,however,these can only provide discrete data on a local mountain.Few studies identifying and analyzing the altitudinal vegetation pattern on a regional scale are available.This study selected central Inner Mongolia as the study area,presented a method for extracting vegetation patterns in altitudinal and horizontal directions.The data included a vegetation map at a 1∶1 000 000 scale and a digital elevation model at a 1∶250 000 scale.The three-dimensional vegetation pattern indicated the distribution probability for each vegetation type and the transition zones between different vegetation landscapes.From low to high elevations,there were five vegetation types in the southern mountain flanks,including the montane steppe,broad-leaved forest,coniferous mixed forest,montane dwarf-scrub and sub-alpine shrub-meadow.Correspondingly,only four vegetation types were found in the northern flanks,except for the montane steppe.This study could provide a general model for understanding the complexity and diversity of mountain environment and landscape.

关键词：植被景观立体图案亚高山灌丛识别垂直分布格局植被格局数字高程模型植被类型

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Analysis and assessment of heavy metal contamination in surface water and sediments： a case study from Luan River, Northern China

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Frontiers of Environmental Science & Engineering 2015年第2期9卷 240-249页

作者： Zhaoming WANG Ranhao SUN Haiping zhang liding CHEN State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China University of Chinese Academy of Sciences Beijing 100049 China

Concentrations of the heavy metals Cu, Ni, Pb, Zn, Cd, and Cr were examined in surface water and sediment from the Luan River inChina,. With a decline in Cu and Ni concentration found in surface water at downstream stations. This finding suggests that water currents are a major explanatory factor in heavy metal contamination. The abundance of Cr, Pb, and Cd observed in the middle reaches of the river indicates heavy metal contamination in local areas, although there was an obvious decrease in concentrations in the water downstream of the Daheiting Reservoir. The significant rising trend in Cu, Pb, and Ni seen the sediment farther away from the river also suggests that anthropogenic activities contribute to heavy metal pollution Sediments were therefore used as environmental indicators, with sediment assessment was conducted using the geo-accumulation index （Igeo） and the potential ecological risk index （R/）. The Igeo values revealed that Cd （3.13） and Cr （2.39） had accumulated significantly in the Luan River. The R/values for most （89%） of the sampling stations were higher than 300, suggesting that sediment from the Luan River poses a severe ecological risk, with the potential ecological risks downstream higher than that in the upper and middle streams. Good correlations among Pb/Ni, Pb/Cd, Cu/Pb, and Cu/Cd in the water and Cr/Ni in the sediment were observed. Cluster analysis suggested that Cd may have various origins, being derived from anthropogenic sources.

关键词： tion index heavy metal water sediment geo-accumula- Luan River

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Diagnostic assays for COVID-19:a narrative review

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Journal of Bio-X Research 2020年第4期3卷 123-134页

作者： Liding Zhang Xiaohan Liang Yanqing Li Hua Zheng Wensheng Qu Baofeng Wang Haiming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering Sciences Department of Anesthesiology and Pain Medicine Tongji HospitalTongji Medical College Department of Neurology Tongji HospitalTongji Medical College Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Coronavirus disease 2019(COVID-19)is a newly emerged infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The number of COVID-19 cases is continuously increasing and no effective drugs or vaccines are currently available.Accurate and efficient diagnostic testing methods are desperately needed for the detection of SARS-CoV-2 and antiviral antibodies in infected individuals.Various assay techniques,including nucleic acid tests[eg,polymerase chain reaction(PCR),reverse transcription-PCR,real-time loop-mediated isothermal amplification,and CRISPR-Cas-based detection],serological tests[eg,immunoglobulin(Ig)A,IgM/G],imaging tests(eg,computed tomography and positron-emission tomography),and nanoparticle-based detections have been reported for COVID-19 diagnosis.This review aims to present the current diagnostic tools for SARS-CoV-2 and their performance characteristics to inform the appropriate selection of diagnostic and surveillance technologies at optimal testing times.We also describe the advantages of detection using combined nucleic acid and imaging tests,or serological testing and point-of-care diagnostics.Developing reliable protein biomarkers targeting the conserved proteins of SARS-CoV-2 rather than IgA,IgM,or IgG would be useful to manage SARS-CoV-2.

关键词： COVID-19 imaging tests nucleic acid tests point-of-care diagnostics serological tests

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“三融”视域下促进科技成果转化为现实生产力的天津实践

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天津市社会主义学院学报 2023年第3期 18-22页

作者：张立鼎中共天津市委党校天津300350

党的二十大报告强调“统筹职业教育、高等教育、继续教育协同创新,推进职普融通、产教融合、科教融汇,优化职业教育类型定位。”在新征程上,统筹“三教”协同创新,推进“三融”系统改革为推进科技成果转化为现实生产力提供了保障。本文... 详细信息

党的二十大报告强调“统筹职业教育、高等教育、继续教育协同创新,推进职普融通、产教融合、科教融汇,优化职业教育类型定位。”在新征程上,统筹“三教”协同创新,推进“三融”系统改革为推进科技成果转化为现实生产力提供了保障。本文分析研究推进“三融”是促进科技成果转化的内在要求,同时对推进“三融”视域下科技成果转化为现实生产力的困境进行了分析,总结提出整体推进“三融”视域下科研成果在津落地转化的思路,以推动天津教育、科技和经济社会发展深度融合,打通成果转化的通道,以释放创新活力。

关键词： “三融” 科技成果转化现实生产力天津实践

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Differing migration patterns and year-round habitat-use of allopatric nesting Eastern Tundra Bean Geese(Anser fabalis serrirostris)in East Asia

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Avian Research 2022年第4期13卷 415-423页

作者： Fanjuan Meng Jing zhang Chang Li Qingshan Zhao Diana Solovyeva Hansoo Lee liding Chen Lei Cao Anthony David Fox State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China University of Chinese Academy of Sciences Beijing100049China Institute of Biological Problems of the North Far Eastern Branch of the Russian Academy of SciencesMagadan685000Russia Korea Institute of Environmental Ecology Yuseong-guDaejeonSouth Korea Department of Ecoscience Aarhus UniversityC.F.Møllers Vej 8DK-8000AarhusDenmark

Sympatric Chinese-wintering Eastern Tundra Bean Geese(Anser fabalis serrirostris,ETBG)breed in two widely separated Arctic areas(Central Russian Arctic and Anadyr region);South Korean-wintering birds(Chaun-South Korea)breed in a third discrete area between these two.Such winter/summer segregation likely structures the population,potentially resulting in distinct migration patterns and habitat-use throughout the annual cycle.We tracked individuals using GPS-GSM transmitters from all three of these geographically discrete ETBG subpopulations to see whether this was the case,testing for differences in migration patterns,seasonal and diurnal habitat-use using remotely sensed land-cover mapping.Mean migration distance of Central Arctic-China and Chaun-South Korea individuals did not differ significantly,but Anadyr-China birds travelled 15–24%further(mean:1140 km,P<0.001).Despite this,mean spring migration durations were longest among Central ArcticChina ETBG,significantly longer than Anadyr-China geese,due to significantly longer stopovers,which were significantly longer than Chaun-South Korea birds.Autumn migration duration of Central Arctic-China and Chaun-South Korea individuals was significantly shorter than in spring,with fewer,shorter stopovers.Lack of significant differences in migration and stopover duration or numbers of stopovers between spring and autumn among Anadyr-China ETBG confirms this is a plastic trait,differing between subpopulations responding to prevailing conditions.Migration patterns and habitat-use differed significantly between all three ETBG subpopulations,although all tended to use wetlands more at night and croplands more in daytime in winter,suggesting specific adaptations and responses to differing conditions encountered along their different migration routes.Although untestable,we speculate that differences in habitat-use may affect fitness levels and genetic exchange between subpopulations,but based on our observations,conclude clear differences in migration and foraging ecology be

关键词： Cropland feeding Diurnal habitat-use GPS/GSM Telemetry Migration duration Migration stopovers

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Effect of Agricultural Land Use Changes on Soil Nutrient Use Efficiency in an Agricultural Area,Beijing,China

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Chinese Geographical Science 2011年第4期21卷 392-402页

作者： CHEN liding QI Xin zhang Xinyu LI Qi zhang Yanyan State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Institute of Geographical Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 101101China Department of Environmental Science and Engineering Nanjing University of Information Science and TechnologyNanjing 210044China

Agricultural land use and management practices may affect soil properties,which play a critical role in sustaining crop production.Since the late 1970s,several new agricultural land use types had been introduced in the rural areas of China.The purpose of this study is to evaluate the effect of these land use changes on the soil properties,nu-trient absorption rate,and nutrient use economic efficiency ratio in an agricultural area of Beijing.Specifically,the cropland,the orchard and the vegetable field were examined.Results of this study suggest that land use and farming management practices significantly affect the content of soil organic carbon (SOC),total nitrogen (TN),total phos-phorus (TP),and available phosphorus in the surface layer of 0-25 cm (p<0.05) in the Yanqing Basin,northwestern Beijing.Soil nutrients in each agricultural land use type decrease rapidly with the increasing soil depth.Orchard and vegetable field tend to have higher soil nutrients than the cropland does.However,the soil nutrient-absorption rate (NAR) of the orchard and vegetable field is lower than that of the cropland,even though orchard and vegetable field may provide much higher economic benefit.While increasing SOC,TN,and TP in the orchard and vegetable field by intensive farming may be a valuable option to improve soil quality,potential increase in the risk of nutrient loss,or agricultural non-point source pollution can be a tradeoff if the intensive practices are not managed appropriately.

关键词：养分利用效率土壤性质北京中国农业土地利用土地利用类型农业非点源污染农地

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