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Could zinc dipicolinate be used to“smuggle”zinc into prostate cancer cells?

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 209-213页

作者： Mark F.McCarty Simon Iloki Assanga lidianys lewis lujan Catalytic Longevity Foundation San DiegoCA 92109USA Department of Research and Postgraduate in Food University of SonoraHermosillo 83210Mexico

Although prostate epithelium concentrates zinc for the purpose of promoting citrate secretion,it loses its capacity to import zinc while undergoing malignant *** exclusion of zinc may be necessary for the viability of prostate cancer,as measures which increase the intracellular zinc content of prostate cancers lead to cell death,oxidative stress,and a marked reduction in ATP,suggestive of mitochondrial *** anti-fungal drug clioquinol,which can act as a zinc ionophore,can markedly slow the growth of human prostate cancer in nude mice,and has been proposed as a clinical therapy for prostate ***,clioquinol is currently only available as a topical agent,as it was linked to subacute myelo-optic neuropathy with oral use.A more practical option for promoting zinc transport may be offered by the nutraceutical zinc dipicolinate,a stable chelate in which four coordination positions of zinc are occupied by two molecules of the tryptophan metabolite picolinic *** dipicolinate is a highly effective supplemental source of zinc that has been shown to be more potent than soluble zinc salts for alleviating the symptoms of acrodermatitis enteropathica,a genetic zinc deficiency disorder reflecting homozygous loss of functional ZIP4 zinc importers in *** suggests that the zinc dipicolinate complex is sufficiently stable and lipophilic to transfer zinc across cellular *** so,it may have potential for“smuggling”zinc into prostate cancer ***,cell culture and rodent studies to evaluate the impact of zinc dipicolinate on human prostate cancer are warranted.

关键词： Prostate cancer zinc clioquinol picolinic acid ZIP4

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