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Journal of electromagnetic Analysis and Applications 2016年第1期8卷 1-7页

作者： Silverio Soto Alvarez lidia flor.e. huerta Alma Verónica Vargas Jaime López Jesus Gabriel Silva César A. González Universidad del ejército y FAM/eMGS Laboratorio Multidisciplinario de Investigación Mexico D.F. Mexico Instituto Politécnico Nacional Escuela Superior de Medicina SEPI Mexico D.F. Mexico

The effectiveness of breast cancer ablation by radiofrequency (RF) has been associated to the capacity of concentrating the electromagnetic energy in the tumor region, our group has proposed that this condition could be modulated by appropriate RF exposure cycle times as well as modification of tissue electrical conductivity. The aim of this work was to evaluate analytical and experimental optimal exposure cycle times to induce tissue ablation by RF assisted with magnetic nanoparticles. The study was conducted both analytically by multiphysics simulation of the induced currents in cancer tissue given a magnetron source and experimentally by the observation of hyperthermic effects induced in agar phantoms by a magnetron device by the use of RF assisted with magnetic nanoparticles. The temperature showed significant increases in short periods of time, and was clearly higher under the condition with nanoparticles. Appropriate RF exposure cycle times as well as modification of tissue electrical conductivity by magnetic nanoparticles seems suitable factors to modulate the electromagnetic energy in tumoral regions.

关键词： Breast Cancer Radiofrequency Ablation Multiphysics Simulation Magnetic Nanoparticles

Minimally Invasive Surgery for Necrotizing Pancreatitis: A Case Report

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Surgical Science 2024年第9期15卷 514-521页

作者： Néstor Veriel Méndez huerta Luis Fernando Zorrilla Núñez Noelia Obregón Gaxiola César Jair Treviño Arizmendi Gerardo Iván Muñoz Morales Marco Alejandro Arizmendi Villarreal Pamela Denisse Valdez Navarro Marco Antonio Hernández Guedea Gerardo enrique Muñoz Maldonado Service of General Surgery Hospital Universitario Dr. Jos Eleuterio Gonzlez Universidad Autnoma de Nuevo Len Monterrey Mxico

Introduction: Necrotizing pancreatitis management is complex and varies significantly among clinicians. Minimally invasive approaches like transgastric necrosectomy via laparoscopy are emerging as effective treatment options. This case report underscores the technique’s efficacy, clinical outcomes, and role in reducing complications. Clinical Observation: A 59-year-old male with a history of smoking and alcoholism presented with severe abdominal pain, nausea, and vomiting. Over the following weeks, he developed symptoms including asthenia, weight loss, and melena. Diagnostic workup revealed severe anemia and Balthazar e necrotizing pancreatitis, with significant intra-abdominal fluid collections and signs of infection. After initial conservative management, the patient underwent transgastric necrosectomy via laparoscopy due to deteriorating clinical status. The procedure involved removing necrotic tissue and performing a cystogastroanastomosis and jejunostomy. Postoperative care included fasting, parenteral nutrition, broad-spectrum antibiotics, and enzymatic replacement. The patient recovered well, with reduced necrotic tissue on follow-up imaging, and was discharged twelve days post-surgery [1]. Conclusion: Transgastric necrosectomy by laparoscopy is a valuable first-line surgical option for patients with symptomatic necrotizing pancreatitis, particularly in cases without prior interventions. This minimally invasive technique helps reduce major complications and mortality, offering a less invasive alternative to traditional open necrosectomy. The multidisciplinary approach and careful postoperative management were crucial to the patient’s favorable outcome. The case highlights the potential of transgastric necrosectomy as an effective treatment strategy in managing complex pancreatitis cases, including those with associated duodenal perforation [2].

关键词： Necrotizing Transgastric Pancreatic Necrosectomy Pancreatitis Case Report

Fuzzy Logic for elimination of Redundant Information of Microarray Data

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Genomics, Proteomics & Bioinformatics 2008年第2期6卷 61-73页

作者： edmundo Bonilla huerta B'eatrice Duval LeRIA Universit'e d'Angers 2 Boulevard Lavoisier 49045 Angers France

Gene subset selection is essential for classification and analysis of microarray data. However, gene selection is known to be a very difficult task since gene expression data not only have high dimensionalities, but also contain redundant information and noises. To cope with these difficulties, this paper introduces a fuzzy logic based pre-processing approach composed of two main steps. First, we use fuzzy inference rules to transform the gene expression levels of a given dataset into fuzzy values. Then we apply a similarity relation to these fuzzy values to define fuzzy equiva- lence groups, each group containing strongly similar genes. Dimension reduction is achieved by considering for each group of similar genes a single representative based on mutual information. To assess the usefulness of this approach, exten- sive experimentations were carried out on three well-known public datasets with a combined classification model using three statistic filters and three classifiers.

关键词： fuzzy processing gene selection dimension reduction classification

Canopy Roughness:A New Phenotypic Trait to estimate Aboveground Biomass from Unmanned Aerial System

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Plant Phenomics 2020年第1期2卷 419-428页

作者： Monica Herrero-huerta Alexander Bucksch eetu Puttonen Katy M.Rainey Department of Agronomy Purdue UniversityWest LafayetteINUSA Department of Cartographic and Land engineering Higher Polytechnic School of AvilaUniversity of SalamancaAvilaSpain Institute for Plant Sciences College of AgriculturePurdue UniversityWest LafayetteINUSA Department of Plant Biology University of GeorgiaAthensGAUSA Warnell School of Forestry and Natural Resources University of GeorgiaAthensGAUSA Institute of Bioinformatics University of GeorgiaAthensGAUSA Finnish Geospatial Research Institute National Land Survey of FinlandMasalaFinland

Cost-effective phenotyping methods are urgently needed to advance crop genetics in order to meet the food,fuel,and fiber demands of the coming ***,characterizing plot level traits in fields is of particular *** developments in highresolution imaging sensors for UAS(unmanned aerial systems)focused on collecting detailed phenotypic measurements are a potential *** introduce canopy roughness as a new plant plot-level *** tested its usability with soybean by optical data collected from UAS to estimate *** validate canopy roughness on a panel of 108 soybean[Glycine max(L.)Merr.]recombinant inbred lines in a multienvironment trial during the R^(2) growth stage.A senseFly eBee UAS platform obtained aerial images with a senseFly *** digital *** a structure from motion(SfM)technique,we reconstructed 3D point clouds of the soybean experiment.A novel pipeline for feature extraction was developed to compute canopy roughness from point *** used regression analysis to correlate canopy roughness with field-measured aboveground biomass(AGB)with a leave-one-out ***,our models achieved a coefficient of determination(R^(2))greater than 0.5 in all ***,we found that canopy roughness has the ability to discern AGB variations among different *** test trials demonstrate the potential of canopy roughness as a reliable trait for high-throughput phenotyping to estimate *** such,canopy roughness provides practical information to breeders in order to select phenotypes on the basis of UAS data.

关键词： soybean Biomass roughness

Photoelectrochemical activity of ZnO:Ag/rGO photo-anodes synthesized by two-steps sol-gel method

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Chinese Physics B 2022年第5期31卷 691-702页

作者： D Ben Jemia M Karyaoui M A Wederni A Bardaoui M V Martinez-huerta M Amlouk R Chtourou Laboratory of Nanomaterials and Renewable energy Systems LANSeR Research and Technology Center of EnergyBorj-Cedria Science and Technology ParkBP 952050 Hammam-LifTunisia Faculty of Science of Tunis University of Tunis El ManarTunisia Laboratory of Physics of Materials and Nanomaterials Applied to the environment(LaPhyMNe) Faculty of Sciences of GabesCite ErriadhUniversity of Gabes6079 GabesTunisia lnstitute of Catalysis and Petrochemistry CSICin MadridSpain Laboratory of Nanomaterials Nanotechnology and Energy(L2NE)University of Tunis El ManarTunisia

This work investigated the influence of silver plasmon and reduced graphene oxide(r GO)on the photoelectrochemical performance(PeC)of Zn O thin films synthesized by the sol-gel *** physicochemical properties of the obtained photo-anodes were systematically studied by using several characterization *** x-ray diffraction analysis showed that all samples presented hexagonal wurtzite structure with a polycrystalline *** and energy dispersive x-ray(eDX)studies confirmed the existence of both Ag and r GO in Zn O:Ag/r GO thin *** estimated grain size obtained from scanning electron microscopy(SeM)analysis decreased with Ag doping,then increased to a maximum value after r GO *** UV-vis transmission spectra of the as-prepared Zn O:Ag and Zn O:Ag/r GO thin films have shown a reduction in the visible range with a redshift at the absorption *** bandgaps were estimated to be around 3.17 e V,2.7 e V,and 2.52 e V for Zn O,Zn O:Ag,and Zn O:Ag/r GO,***,the electrical measurements revealed that the charge exchange processes were enhanced at the Zn O:Ag/r GO/electrolyte interface,accompanied by an increase in the(PeC)performance compared to Zn O and Zn O:Ag ***,the photocurrent density of Zn O:Ag/r GO(0.2 m A·cm^(-2)) was around 4 and 2.22 times higher than photo-anodes based on undoped Zn O(0.05 m A·cm^(-2)) and Zn O:Ag(0.09 m A·cm^(-2)),***,from the flat band potential and donor density,deduced from the Mott-Schottky,it was clear that all the samples were n-type semiconductors with the highest carrier density for the Zn O:Ag/r GO photo-anode.

关键词： zinc oxide reduced graphene oxide silver doping sol-gel photoelectrochemical performance

Degradation of duloxetine: Identification of transformation products by UHPLC-eSI(+)-HRMS/MS,in silico toxicity and wastewater analysis

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Journal of environmental Sciences 2019年第8期31卷 113-123页

作者： Rodrigo A.Osawa Ana P.Carvalho Olinda C.Monteiro M.Conceicao Oliveira M.Helena florêncio Centro de Química e Bioquímica Faculdade de Ciências Universidade de Lisboa Laboratório de FTICR e espectrometria de Massa estrutural Faculdade de Ciências Universidade de Lisboa Centro de Química estrutural Instituto Superior Técnico Universidade de Lisboa

Duloxetine(DUL), an antidepressant drug, has been detected in surface water and wastewater effluents, however, there is little information on the formation of its transformation products(TPs). In this work, hydrolysis, photodegradation(UV irradiation) and chlorination experiments were performed on spiked distillated water, under controlled experimental conditions to simulate abiotic processes that can occur in the environment and wastewater treatment plants(WWTPs). eleven TPs, nine from reaction with UV light and two from chlorine contact, were formed and detected by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, and nine of them had their chemical structures elucidated upon analyses of their fragmentation patterns in MS/MS spectra. The formation and degradation of the TPs were observed. The parent compound was completely degraded after30 min in photodegradation and after 24 hr in chlorination. Almost all TPs were completely degraded in the experiments. The ecotoxicity and mutagenicity of the TPs were predicted based on several in silico models and it was found that a few of these products presented more ecotoxicity than DUL itself and six TPs showed positive mutagenicity. Finally, wastewater samples were analyzed and DUL and one TP, possibly formed by chlorination process, were detected in the effluent, which showed that WWTP not only did not remove DUL, but also formed a TP.

关键词： High resolution mass spectrometry Duloxetine Degradation processes Transformation products Wastewater analysis In silico toxicity

Differential expression of Leptin and Leptin Receptor mRNA in Obese and Non-Obese Women across the Menstrual Cycle Title

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Food and Nutrition Sciences 2014年第22期5卷 2265-2273页

作者： María-Raquel huerta-Franco e. R. huerta-Franco F. M. Vargas-Luna Department of Sciences Applied to the Work University of Guanajuato Leon México Department of Dentistry University of Guadalajara Guadalajara México Department of Physical engineering University of Guanajuato Leon México

OBJeCTIVe: The aim of this study was to investigate the messenger ribonucleic acid expression of leptin (L-mRNA) and the leptin receptor (OB-RmRNA) in subcutaneous fat tissue and to determine their relationship with leptin and testosterone and steroid serum levels over the course of the menstrual cycle (MC), in obese (OBW) and non-obese women (NOW). DeSIGN: Observational study investigating mRNA transcript expression of leptin and the leptin receptor from human subcutaneous fat specimens, as well as leptin serum levels, both in relation to the testosterone and sex hormones during the MC in obese and non-obese women. MeTHODS: Nineteen women, thirteen with a body mass index (BMI) > 25 Kg/m2 and 6 with BMI 2 were included. RT-PCR was used to detect L-mRNA transcripts of leptin and its receptor in samples from 28 fat biopsies taken from seven volunteers (20 from OW and 8 from NOW). The serum concentrations of leptin and steroid hormones were measured throughout the MC using radioinmuno analysis. ReSULTS: The percentages of women expressing leptin L-mRNA during the phases of the MC were: early follicular (eF), 14.3%;late follicular (LF), 28.6%;early luteal (eL), 14.3%;and late luteal (LL), 42.9%. The percentages of OB-RmRNA were: eF, 71.4%;LF, 14.3%;eL, 28.6%;and LL, 71.4%. Leptin serum levels were directly related to BMI (p estosterone (p ectly to SHBG (p e L-mRNA expression and its receptor in subcutaneous human tissue are regulated throughout the MC in a periodic manner. The physiological role of testosterone in regulation of expression L-mRNA and OB-RmRNA during the secretory phase of the MC in obese women requires further investigation.

关键词： Steroid Hormones Leptin Leptin Receptor Menstrual Cycle

Progress in breeding for resistance to Ug99 and other races of the stem rust fungus in CIMMYT wheat germplasm

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Frontiers of Agricultural Science and engineering 2019年第3期6卷 210-224页

作者： Sridhar BHAVANI David PHODSON Julio huerta-eSPINO Mandeep SRANDHAWA Ravi PSINGH International Maize and Wheat Improvement Center Texcoco56237Mexico Campo experimental Valle de México INIFAP Chapingo56230Mexico International Maize and Wheat Improvement Center ICRAF CampusNairobi00100Kenya

Races belonging to the Ug99(TTKSK) lineage of the wheat stem rust fungus, carrying complex virulence combinations, and their migration to countries in Africa,Middle east and Asia continue to pose a significant threat to global wheat *** rapid spread of additional races, e.g., TKTTF or the Digalu lineage, in several countries causing localized epidemics reminds us of the vulnerability of wheat germplasm to stem rust disease, a formidable foe referenced as early as biblical times.A global rust monitoring system reflecting increased surveillance efforts has identified 13 races within the Ug99 lineage in 13 countries and unrelated lineages are emerging, spreading and posing serious threats to wheat *** TKTTF has caused localized epidemics in ethiopia and its variants have been recently implicated in stem rust outbreaks in *** research efforts have resulted in the identification of several new resistance genes and gene combinations for use in *** multiple adult plant resistance(APR) genes in high-yielding backgrounds and discovery of new quantitative trait loci conferring stem rust resistance has progressed in the recent years, enhancing the durability of *** gene stewardship and new generation breeding materials and cultivars that combine multiple race-specific or minor to intermediate effect APR genes,complemented by active surveillance and monitoring, have helped to limit major epidemics and increase grain yield potential in key target environments.

关键词： adult plant resistance black rust race-specific resistance Triticum aestivum

Body Composition, Gynecologic-Obstetric Variables, and Prolactin Levels in Patients with Breast Cancer

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Food and Nutrition Sciences 2023年第4期14卷 315-327页

作者： Luis-Alfredo Jiménez-huerta María-del-Corazón-de-Jesús huerta-Franco Ángel-Haziel Vargas-huerta Francisco-Miguel Vargas-Luna María-Raquel huerta-Franco Department of General Surgery Mexican Institute of Social Security HGZ 1 of Colima Colima Mexico Division of Social Sciences and Technology Center for Industrial Technical Education (CETI) Guadalajara Mexico Division of engineering and Sciences Technological Institute of Higher Studies of Monterrey (ITESM) Monterrey Mexico Department of Physical engineering University of Guanajuato Leon Mexico Department of Applied Sciences to Work University of Guanajuato Leon Mexico

Objective: The aim of this study was to determine body composition, gynecological, and obstetric data, sex hormones, and prolactin serum levels in pre- (PReW) and postmenopausal women (PMW) with breast cancer (BC) and compare them with a control group (CG) of healthy women. Methodology: BC patients without treatment or use of hormone replacement therapy, or hormonal birth control, and without data of metastasis were included. CG was matched for age, BMI, and menstrual cycle status. FSH, LH, e2, progesterone, testosterone, and prolactin (PRL) were measured using radioimmunoassay kits. Comparisons between BC and CG were made with “t” tests, and with the Mann-Whitney U-test;χ2 test was used to compare the qualitative variables between the groups. Results: Seventy-two patients with BC, and 74 CG women were evaluated. Both groups presented overweight data, BMI (kg/mt2) = 27.21 ± 5.51 vs. 28.40 ± 4.66, p = ns, for BC patients and CG, respectively. In PReW, the age at menarche was later in BC patients compared to the CG (13.3 ± 1.36 years vs. 12.41 ± 1.27 years, p = 0.005). The PMW with BC presented a higher age at menarche and menopause compared to the women of the CG (13.51 ± 1.48 vs. 12.91 ± 1.41, p = 0.09, and 49.03 ± 2.86 vs. 45.5 ± 8.78, p = 0.03, respectively). PRL levels were significantly higher in PMW with BC, in comparison with the CG;median and minimum and maximum values (min-max) were: 14.7 ng/mL (3.6 - 52.7) vs. 5.9 ng/mL (1.9 - 33.3), p = 0.005). A higher percentage of PMW with BC (26.0% vs. 7.1%, χ2 = 5.57, p = 0.01) presented hyperprolactinemia (PRL serum levels > 20 ng/mL), compared to the GC. Conclusions: The higher levels of PRL in PMW with BC compared with CG, suggest a proliferative effect of this hormone in the affected breast tissue. This study demonstrates the need to use biological markers such as PRL to determine the risk of BC in PMW.

关键词： Breast Cancer Sex Hormones Prolactin Postmenopausal Women

Smart bioadhesives for wound healing and closure

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Bioactive Materials 2023年第1期19卷 360-375页

作者： Jia Zhu Honglei Zhou ethan Michael Gerhard Senhao Zhang flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng Department of engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA16802USA AML Department of Engineering MechanicsTsinghua UniversityBeijing100084China Institute of Flexible electronics Technology of THU ZhejiangJiaxing314000China Department of Biomedical engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Suzhou Institute of Biomedical engineering and Technology Chinese Academy of ScienceSuzhou215011PR China School of Materials and energy State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu610054PR China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA16802USA

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion,antibacterial effect,real-time sensing,wireless communication,and on-demand treatment *** with bio-inspired structures and chemicals have shown unprecedented adhesion strengths,as well as tunable optical,electrical,and bio-dissolvable *** wound healing has been achieved via directly released antibacterial and growth factors,material or drug-induced host immune responses,and delivery of curative *** recently,the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives,allowing real-time sensing of the physiological conditions(e.g.,pH,temperature,uric acid,glucose,and cytokine)with iterative feedback for drastically enhanced,stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged *** rapid advances in the burgeoning field,challenges still exist in the design and fabrication of integrated systems,particularly for chronic wounds,presenting significant opportunities for the future development of next-generation smart materials and systems.

关键词： Smart bioadhesives Immunomodulatory bioadhesives Mechanically/electrically active bioadhesives Closed-loop system On-demand treatments Wound healing and closure