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Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research

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Stroke & Vascular Neurology 2022年第2期7卷 114-123页

作者： Elisabetta Patorno Sebastian Schneeweiss Mary G George Xin Tong Jessica M Franklin Ajinkya Pawar Helen Mogun lidia M V R Moura Lee H Schwamm Division of Pharmacoepidemiology and Pharmacoeconomics Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBostonMassachusettsUSA Division for Heart Disease and Stroke Prevention NCCDPHPCenters for Disease Control and PreventionAtlantaGeorgiaUSA Epilepsy and Neurophysiology Division Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Fireman Vascular Center and Stroke Division Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA

Background Non-interventional large-scale research on real-world patients who had a stroke requires the use of multiple data sources ensuring access to longitudinal data from large populations with clinically-detailed *** sought to establish a framework for longitudinal research on patients hospitalised with stroke by linking information-rich,deidentified inpatient data from the Paul Coverdell National Acute Stroke Program(PCNASP)to commercial and Medicare Advantage longitudinal claims *** All stroke admissions in PCNASP between 2008 and 2015 were evaluated for linkage to longitudinal claims from a commercial insurer using an algorithm based on six available common data fields(patient age,gender,admission date,discharge date,discharge diagnosis and state)and a hospital *** evaluated the linkage quality(via the percentage of unique records in the linked dataset)and the representativeness of the linked *** also described medical history,stroke severity and patterns of medication use among the PCNASP-claims linked *** The linkage produced uniqueness equal to 99.1%.We identified 5644 linked and 98896 unlinked patients who had an ischaemic stroke hospitalisation in claims *** patients were younger than unlinked(69.7 vs 72.5 years),but otherwise similar by medical history,prestroke medication use or lab *** severity was mild and most patients were discharged *** and discharge use of antihypertensive and statins in the PCNASP were greater than their use as measured by filled prescriptions in *** High-quality linkage between the PCNASP and commercial claims data is *** linkage identified differences between reported or recommended versus actual out-of-hospital medication utilisation,highlighting the importance of longitudinal data availability for research aimed to improve the care of patients who had a stroke.

关键词： linkage claims younger

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Problems and Challenges of Conservation Multiculturalism

Problems and Challenges of Conservation Multiculturalism

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北京论坛（2011）文明的和谐与共同繁荣--传统与现代、变革与转型

作者： lidia Delgado Almeida Center for Chinese-Mexican Studies School of Economics National Autonomous University of Mexico

Tradition and modernity are two aspects which human is linked in the actual *** traditions represent the cultural heritage that their ancestors have left and provide identity,a way of thinking,values and the structure of the society in which he *** the other hand, modernity is synonymous of change,innovation and *** implies the human search to change the world that he lives in a better ***,science and technology have played an important role in the modernization of ***,modernity sometimes implies social inequality and the deterioration of the *** and tradition at first sight are opposed, but they are present in the society for long time ***,like China is characterized by a rich multicultural and multiethnic,but it has been affected by the impact of *** paper explores the importance of multi-ethnicity and multiculturalism as a source of identity. It also study the situation in China and Mexico,as well as the strategies they have been taken in order to maintain the identity of their *** main objective of this work is to find a perspective that allows modernization not as synonymous of the lost of human.

关键词： Multiculturalism,ethnicity,languages,traditions.

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机动车细微颗粒物及气体污染物排放的隧道实测研究

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环境污染与防治 2010年第5期32卷 19-25页

作者：朱春张旭 Morawska lidia 同济大学机械工程学院上海200092 昆士兰科技大学物理化学系

利用隧道实验法对澳洲Vulturestreet公交专用隧道的细微颗粒物和气体污染物进行连续4d实测,分析了自然通风和纵向通风下隧道内NOX、细微颗粒物数目浓度以及细微颗粒物粒度分布特征。结果表明,隧道内细微颗粒物粒径谱呈双峰分布,峰值区... 详细信息

利用隧道实验法对澳洲Vulturestreet公交专用隧道的细微颗粒物和气体污染物进行连续4d实测,分析了自然通风和纵向通风下隧道内NOX、细微颗粒物数目浓度以及细微颗粒物粒度分布特征。结果表明,隧道内细微颗粒物粒径谱呈双峰分布,峰值区段细微颗粒物粒径分别在19～25、70～105nm,判定为低硫柴油公交车和CNG公交车共同作用结果。隧道内NO2/NOX比值与NOX具有很强的相关性(R2=0.8320),当NOX大于1.000×10-6时,NO2/NOX渐进于(0.088±0.001),同时,NOX与细微颗粒物数目浓度、细微颗粒物总体积(VFP)呈明显的线性相关关系。柴油公交车和CNG公交车的混合条件下,细微颗粒物数目浓度、NOX平均排放因子分别为(2.48±1.53)×1014个/km、(12.8±5.1)g/km,柴油车和CNG公交车细微颗粒物数目浓度排放因子和NO排放因子没有明显差异。

关键词：细微颗粒物数目浓度粒度分布 NOX

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Real-world data on the infliximab biosimilar CT-P13 (Remsima®) in inflammatory bowel disease

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World Journal of Clinical Cases 2021年第36期9卷 11285-11299页

作者： Jose María Huguet Xavier Cortés Marta Maia Bosca-Watts Marian Aguas Nuria Maroto lidia Martí Cirilo Amorós Jose María Paredes Department of Gastroenterology General University Hospital of ValenciaValencia 46014Spain Department of Gastroenterology Hospital de SaguntoSagunto 46520Spain Department of Gastroenterology Hospital Clinico Universitario de ValenciaValencia 46010Spain Department of Gastroenterology Hospital Universitario y Politecnico la Fe de ValenciaValencia 46026Spain Department of Gastroenterology Hospital de ManisesManises 46940Spain Department of Gastroenterology Hospital Comarcal Francesc de BorjaGandia 46702Spain Department of Gastroenterology Hospital Arnau de Vilanova de ValenciaValencia 46015Spain Department of Gastroenterology Hospital Universitario Doctor Peset de ValenciaValencia 46017Spain

BACKGROUND In recent years,biological therapies have revolutionized the management of inflammatory bowel disease(IBD);however,they are *** development of biosimilar products has allowed us to reduce healthcare costs and improve patients’access to these *** various studies support the similarity between infliximab and its biosimilar CT-P13 in terms of efficacy and safety,there are unmet needs regarding research on these agents in the context of *** To analyze clinical response rates to CT-P13 and adverse events in IBD patients treated in real-life *** An observational,prospective,multicenter study of IBD patients treated with CTP13 in clinical practice who were naïve to biological treatments or failed to respond to other anti-tumor necrosis factor drugs or had switched from infliximab originator was carried *** diagnostic or follow-up interventions were conducted on patients outside usual clinical *** primary endpoints were clinical response rates and number of adverse *** primary efficacy variable was the proportion of patients who were in clinical remission and/or had a clinical response at 3,6,9,and 12 *** A total of 220 IBD patients treated with CT-P13(Remsima®)were included in the study:87(40%)with ulcerative colitis and 133(60%)with Crohn’s *** age of the patients was 41.47(SD 15.74)years,and 58%were ***(9%)patients started treatment with CT-P13 after switching from *** the remaining 201 patients,142(65%)were naïve to biologic *** baseline,68.6%(n=138/201)of patients presented with active *** 12 mo of treatment,14.8%(n=12/81)presented with active disease,and 64.2%(n=52/81)were in clinical remission without *** 3 mo,75.5%(n=115/152)had a clinical response or achieved clinical remission,which was sustained for 12 mo(85.2%;n=69/81).There was a decrease in specific IBD indices at 3,6,9,and 12 mo(P<0.001).A total of 34 adverse events

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Infliximab Biosimilar CT-P13

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Characterization of Avian-like Influenza A (H4N6)Virus Isolated from Caspian Seal in 2012

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Virologica Sinica 2018年第5期33卷 449-452页

作者： Marina Gulyaeva Ivan Sobolev Kirill Sharshov Olga Kurskaya Alexander Alekseev lidia Shestopalova Anna Kovner Yuhai Bi Weifeng Shi Michael Shchelkanov Alexander Shestopalov Novosibirsk State University NovosibirskRussia 630090 Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine" NovosibirskRussia 630117 School of Biomedicine Far Eastern Federal UniversityVladvostokRussia 690090 Federal Scientific Center of East Asia Terrestrial Biodiverslty Far Eastern Branch of Russian Academy of SciencesVladivostokRussia 690022 CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning (CASCIRE)Chinese Academy of SciencesBeijing 100101China Key Laboratory of Etiology and Epidermology of Emerging Infectious Diseases in Universiues of Shandong Taishan Medical CollegeTaian 271000China

Dear Editor Marine mammals are widely distributed and can be found almost in all coastal waters and coastlines around the *** interface areas between marine and terrestrial environments provide natural habitats for aquatic and semiaquatic mammals as well as for reservoir species of avian influenza viruses (AIV)(Runstadler et al.2013).

关键词： Caspian Seal Avian-like Influenza

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地下机动车道空气质量标准和设计通风量计算方法

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暖通空调 2009年第9期39卷 132-136页

作者：朱春张旭 lidia Morawska 同济大学昆士兰科技大学

分析了机动车排放的主要污染物,探讨了地下机动车道可借鉴应用的空气质量标准。通过分析机动车在地下车道内的运行特点,研究了地下车道的分类及不同分类下的通风量计算指标。给出了地下车道设计通风量的计算公式,通过实例论证了地下空... 详细信息

分析了机动车排放的主要污染物,探讨了地下机动车道可借鉴应用的空气质量标准。通过分析机动车在地下车道内的运行特点,研究了地下车道的分类及不同分类下的通风量计算指标。给出了地下车道设计通风量的计算公式,通过实例论证了地下空间采用稀释污染物计算方法的必要性。

关键词：地下机动车道空气质量设计通风量

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Construction of <i>k</i>-Variate Survival Functions with Emphasis on the Case <i>k</i>= 3

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Applied Mathematics 2020年第7期11卷 678-697页

作者： Jerzy K. Filus lidia Z. Filus Dept. of Mathematics and Computer Science Oakton College Des Plaines USA Dept. of Mathematics Northeastern Illinois University Chicago USA

The purpose of this paper is to present a general universal formula for k-variate survival functions for arbitrary k = 2, 3, ..., given all the univariate marginal survival functions. This universal form of k-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case k = 2 and the main results for the case

关键词： Construction of Multivariate Probability Distributions via Joiners Joiner versus Copula Methodology A Possible Fusion of the Two Construction Methods k -Variate Survival Function Scheme k = 3 Case

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The Characteristics of the Violence against Women in Mozambique

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Health 2014年第13期6卷 1589-1601页

作者： Germano Vera Cruz lidia Domingos Aniceto Sabune Education Faculty Eduardo Mondlane University Maputo Mozambique Psychology Faculty University of Toulouse II Toulouse France

The purpose of this study is to identify the main characteristics of violence against women in the context of a) intimate partner relationships and b) non-partner relationships in Mozambique, using the Revised Conflict Tactics Scale (CTS2);measure the occurrence during lifetime or the past 12 months, and examine the association between intimate partner violence (IPV)/non-partner violence (NPV) types and predictor variables (demographic, socio-economic and lifestyle factors). A total of 1200 women (aged 15 - 45?years) were recruited to participate in this study. Results show that in Mozambique, generally, the rates of IPV and NPV are higher compared to those of other Sub-Saharan Africa countries (except when it comes to sexual assault). It seems that there is more violence against women within intimate partner relationship than in non-partner relationship. Adolescent, single young adults and women who experience the financial strain or use frequently alcohol are more vulnerable to be abused.

关键词： Mozambique Relationship Violence against Women

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Treatments Comparison of Mineral and Bio Fertilizers in the Apple and Sour Cherry Organic Nursery

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Journal of Life Sciences 2014年第11期8卷 889-898页

作者： Zygmunt Stanislaw Grzyb Wojciech Piotrowski lidia Sas Paszt Department of Pomology Research Institute of Horticulture Konstytucji 3 Maja 1/3 Skierniewice 96-100 Poland

Maiden trees of apple cultivars ＇Topaz＇ and ＇Ariwa＇ grafted on M26 rootstock and of sour cherry cultivars ＇Debreceni Botermo and ＇Sabina＇ on mahaleb cherry （Prunus mahaleb L.） were fertilized with bioproducts such as： Fertigo-granulated manure, Micosat-microbial inoculum consisting of mycorrhizal fungi; Humus UP-an extract from vermicompost; Humus Active ＋ Aktywit PM-an extract from vermicomposts with PM （Positive Microorganism）; BioFeed Amin--a plant extract reinforced with amino acids; BioFeed Quality-a seaweed extract reinforced with humic and fulvic acids; Tytanit-titanium; Vinassa-molasses residue from yeast production; Florovit Eko-composed of many environmentally-friendly products. Control maidens were fertilized with mineral fertilizers containing mainly NPK. The maiden trees fertilized with the preparations Tytanit and Humus UP grew less vigorously and produced smaller increases in the length of lateral shoots than those fertilized with mineral fertilizers. On the other hand, bio preparations such as BF Amin, BF Quality, Micosat and Vinassa promoted tree branching and intensified the growth of lateral shoots, stimulating tree growth to a greater extent than the mineral fertilizers.

关键词： Organic nursery bioproducts fertilization maidens fruit tree quality.

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Quick and Simple Spectrophotometric Method of Identification of the Thermal State of Meat on the Basis of Composition and Content of Free Nucleotides

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Food and Nutrition Sciences 2018年第5期9卷 572-583页

作者： Magomed Dibirasulaev Georgy Belozerov Leonid Arkhipov lidia Stoyanova All-Russian Scientific Research Institute of Refrigeration Industry Branch of V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Science Moscow Russia M. V. Lomonosov Moscow State University Moscow Russia

At present, there is no method for identifying meat frozen in a thermal state acceptable for production control. The role of free nucleotides in the processes of refrigeration and storage of meat, affecting the structural and mechanical properties of muscle tissue, the formation of taste and its biological value is known. In this article we compared methods for identifying the thermal state of meat based on the determination of the composition and content of free nucleotides by high-performance liquid chromatography (HPLC) and spectrophotometry [SF]. High-purity reference substances were used: free nucleotides—ATP, ADP, AMP, IMP and nucleosides-inosine and hypoxanthine. It has been experimentally established that the characteristic peaks of the absorption spectra for extracts of free nucleotides of meat frozen depended from thermal state of meat. The content of ATP is 21.8 times higher in meat frozen in a fresh state, and the amount of IMF is 12.3 times lower than in meat frozen after cooling. The results of studies of meat frozen using the HPLC method and the developed SF method show the adequacy of the data obtained by both methods. SF-method based on the determination of the optical density of the extracts of free nucleotides is recommended to justify the choice of technological process meat defrost modes.

关键词： Thermal State of Meat Free Nucleotides and Nucleosides HPLC and Spectrophotometric Methods Defrost Modes

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