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Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

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Open Journal of Gastroenterology 2019年第11期9卷 203-210页

作者： Aklesso Bagny Late Mawuli Lawson-Ananissoh Oumboma Bouglouga lidawu Kogoe Rafiou El Hadji-Yakoubou Debohoma Redah Datouda Redah Hepatology and Gastroenterology Department of Campus Teaching Hospital of Lome Lome Togo Gastroenterology Unit of Teaching Hospital of Kara Kara Togo

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, as well as in Togo, where it is a major public health problem. HCC is the third most common cause of death from cancer. Chronic infection with HBV and HCV is the most important cause of HCC. Objective: To determine the epidemiological, diagnostic and evolutionary aspects of HCC in the hepatology and gastroenterology department of Campus Teaching Hospital of Lomé. Patients and method: Descriptive and analytical study, conducted from January 1, 2013 to December 31, 2017, on all patients admitted in the hepatology and gastroenterology department of Campus Teaching Hospital of Lome for hepatocellular carcinoma. The statistical analysis was done using Stata 13 software. The significance threshold was used for p Findings: A total of 250 patients were retained. Hospital prevalence was 6.1%. There was a male predominance with a sex ratio of 2.84. The average age was 47.15 ± 13.85 (extreme: 20 - 85 years). The average duration of symptoms was 67.08 ± 82.59 days. Pain in the right hypochondrium was the most common reason for consultation (64.6%). The average AFP value was 24,062 ± 33,318 ng/ml. Ultrasound found more than two nodules in 74.75% of cases and a portal thrombosis in 64.97% of cases. The main etiologies found were chronic hepatitis B (55%) and C (8%) virus infections. The majority (89.20%) of patients were in the BCLC D stage. Survival at 6 months was 45%. Factors associated with death were: chronic ethylism (OR = 16.87, p = 0.002), jaundice (OR = 341.57, p = 0.004), rupture of esophageal varices (OR = 42.45, p = 0.008) and a BCLC D score (OR = 9.82, p = 0.041). Conclusion: Young adults were the most affected by HCC, whose etiologies are dominated in our context by hepatitis B and C viruses. The majority of our patients consulted late and was found at the terminal stage of the disease, limiting any therapeutic possibility. In this situation, the best attitude remains

关键词： Hepatocellular Carcinoma Diagnosis Survival Togo

Hematological Profile of Anemia in Hospitalized Cirrhotics in the Hepato-Gastroenterology Unit of the University Hospital Campus of Lome (Togo)

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Open Journal of Gastroenterology 2021年第10期11卷 194-202页

作者： Laté Mawuli Lawson-Ananissoh lidawu Roland-Moïse Kogoe Venceslas Debehoma Redah Oumboma Bouglouga Rafiou El-Hadji Yakoubou Laconi Kaaga Aklesso Bagny Hepatogastroenterology Unit University Hospital Campus Lomé Togo Hepatogastroenterology Unit University Hospital of Kara Kara Togo

Background: Anemia is multifactorial and very frequently observed in the evolution of cirrhosis. Only biological investigations can clarify its mechanisms. Objective: To determine the frequency of anemia in cirrhosis patients and to identify the different types of anemia encountered. Patients and Methods: Descriptive and analytical study based on the retrospective collection of data was carried out over 12 months in the hepato-gastroenterology unit of the University Hospital Campus of Lome (Togo). This study included hospitalized cirrhotic patients with a complete medical file including a blood count and presenting anemia. Results: During the study period, we collected 253 cases of cirrhosis, of which 153 patients had anemia (60.5%);there was a male predominance of 73.2%. The mean age was 51 ± 13 years. The B viral origin of cirrhosis was the most common (60.1%). Oedemato-ascitic decompensation (82.4%) and hepatocellular carcinoma (34%) were the main complications

关键词： Anemia Blood Count Cirrhosis Hepatitis B Virus Togo

Comparison of Prognostic Scores for Upper Gastrointestinal Bleeding in the Hepato-Gastro-Enterology Department of Campus Teaching Hospital of Lome

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Open Journal of Gastroenterology 2021年第9期11卷 161-171页

作者： Aklesso Bagny lidawu Roland-Moïse Kogoe Late Mawuli Lawson-Ananissoh Laconi Yeba Kaaga Debehoma Redah Mawunyo Henoc Gbolou Yendoukoa Yves Kanake Departement of Gastroenterology Teaching Hospital Campus of Lome Lome Togo Departement of Gastroenterology University of Lome Lome Togo

Objective: To evaluate and compare the prognostic contribution of different UGIB prognostic scores. Patients and Method: Descriptive cross-sectional study with retrospective collection conducted from January 2014 to December 2019. Patients hospitalized in the Gastroenterology Department of Campus Teaching Hospital of Lome for upper gastrointestinal hemorrhage were included. The analytical component of this study had consisted of an evaluation of the sensitivity and specificity of different prognostic scores (GBS, mGBS, FRS, CRS, AIMS65) in predicting the occurrence of death and/or re-bleeding within 42 days. These different scores were compared using ROC (Receiver Operating Characteristic) curves. Results: We included 314 patients in our study. The male to female sex ratio was 2.48. Fibroscopy found non-related portal hypertension UGIB in 70.94% of the cases. The “FRS” was the most accurate score in predicting death or re-bleeding in all patients. The “FRS” was the most precise score in predicting the occurrence of spotting in all patients. The “FRS” was the most accurate score in predicting death among all patients. The mortality of patients at low risk of death (below the threshold value) was 2.2% for the “FRS”, 9.3% for the “CRS”, 0% for the “GBS” (p = 0.565), 50% for the “mGBS” and 11.4% for the “AIMS65”. Scores were more accurate for non-related portal hypertension UGIB. Conclusion: The “FRS” and the “CRS” are two precise scores in predicting the occurrence of an incident in the event of upper gastrointestinal hemorrhage. However, these scores were less effective in related portal hypertension UGIB.

关键词： Upper Gastrointestinal Bleeding Prognostic Scores Rockall Glas-gow-Blatchford AIMS65 Lome

Interest of Serum-Ascites Albumin Concentration Gradient in the Diagnosis of Portal Hypertension in Cirrhotic Patients

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Open Journal of Gastroenterology 2019年第1期9卷 13-21页

作者： Laté Mawuli Lawson-Ananissoh Aklesso Bagny Oumboma Bouglouga Ismael Mahaman Salissou Ganbobo Rafiou El-Hadji Yakoubou lidawu Kogoe Laconi Kaaga Datouda Redah Hepatogastroenterology Unit University Hospital Campus Lome Togo Hepatogastroenterology Unit University Hospital of Kara Kara Togo

Objective: To find a more accessible and less restrictive mean such as serum-ascites albumin gradient (SAAG) to predict esophageal varices (EV) in cirrhotics with ascit. Patients and methods: Descriptive and analytical studies based on the retrospective collection of data on 125 patients’ records in the hepatogastroenterology unit of the University Hospital Campus of Lome (Togo) from January 1, 2008 to March 31, 2018 were included. Cirrhotic patients aged 15 years and older had performed cytochemical analysis of ascites fluid and upper gastrointestinal fibroscopy and had a protidogram. Statistical analysis was done by R Studio Software 3.4.2. Results: The mean age was 48.70 years;there was a male predominance (70.40%) with a sex ratio of 2.38. Protein levels in ascitic fluid was Conclusion: Our study noted that at an upper threshold of 1.10 g/dl, the SAAG significantly predicted the presence of EV.

关键词： Esophageal Varices Serum-Ascit Albumin Gradient Cirrhosis Togo