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Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping Wang Shijun Shen jia Zhao Zhiyi Lin jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen lichen ji Xuguang Zhang jiqing Yin Hong Wang Zhiyang Chen Zhenyu Ju Cizhong jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of Animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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轮廓法测试残余应力中的数据处理

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中国机械工程 2017年第15期28卷 1778-1783页

作者：谢国贞吴运新龚海李晨刘瑶琼姬浩张伟中南大学机电工程学院长沙410083 高性能复杂制造国家重点实验室长沙410083 有色金属先进结构材料与制造协同创新中心长沙410083 中国航空工业集团公司第一飞机设计研究院西安710000

使用轮廓法测量铝合金T形构件淬火残余应力,重点研究了测量误差的数据处理。采用包络处理、左右轮廓平均、Gauss混合模型拟合以及节点插值处理后,得到最终轮廓值,并将其作为边界条件反向加载到应力重构有限元模型中,得到待测面应力场。... 详细信息

使用轮廓法测量铝合金T形构件淬火残余应力,重点研究了测量误差的数据处理。采用包络处理、左右轮廓平均、Gauss混合模型拟合以及节点插值处理后,得到最终轮廓值,并将其作为边界条件反向加载到应力重构有限元模型中,得到待测面应力场。使用X射线衍射法对待测面边界处应力进行修正。将测量结果和有限元模拟淬火结果进行对比,利用统计学方法分析对比结果。结果表明:轮廓法和X射线衍射法结合可以很准确地描述T形构件淬火残余应力场。T形构件淬火残余应力最大拉应力出现在筋条和腹板交界处,靠近腹板一侧。

关键词：轮廓法数据处理铝合金 T形构件残余应力

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基于光学数字计算空间振幅编码图形法的光学并行阵列逻辑

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中国激光 1991年第1期18卷 56-62页

作者：钟立晨张戟刘薇薇郭奕理周炳琨清华大学无线电电子学系 100084

本文给出了执行光学并行阵列逻辑的一种新的空间振幅编码图形法的原理和特性。为了设计高速并行复合运算,本文还给出了系统的算法,并澄清了AND和OR阵列门的物理意义。也给出了在8f相干光学处理系统中执行的16种复合逻辑运算的结果。

关键词：光学阵列逻辑激光计算编码图形

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Improved complex filter applied in enhancing EFT/B immunity at a coal mine monitoring substation

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Journal of China University of Mining and Technology 2008年第1期18卷 22-26页

作者： SUN ji-ping MA Feng-ying lichen State Key Laboratory of Coal Resources and Safe Mining China University of Mining ＆ Technology Beijing 100083 China College of Electronic Information and Control Engineering Shandong Institute of Light Industry Jinan Shandong 250100 China

A monitoring system is an important guarantee of safety in a production mine. However, not all monitoring substations pass the electrical fast transient/burst （EFT/B） immunity test and the explosion-proof test simultaneously. To enhance the immunity, the values of capacitance and inductance should be increased, which are actually limited by coal mine explosion-proof standards. Hence, for the first time, an active filter was applied in an electromagnetic interference （EMI） output filter. As a result, the interference within 30 MHz clearly weakened, but the frequency spectrum had a wide range. An EMI input filter and ferrite beads were adopted to restrain higher frequency interference. An output interference spectrogram of the substation was obtained with an analyzer. The results indicate that the improved complex filtering markedly help to control interference. With the support of improved complex filtering and other enhancing immunity means about I/O ports, the substation managed to pass both the EFT/B immunity test and the explosion-proof test synchronously. We conclude that improved complex filtering is of vital importance in enhancing the electromagnetic compatibilitv （EMC） of the coal mine monitoring system.

关键词： EFT/B coal mine monitoring substation immunity complex filter EMC

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Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

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Nano Research 2019年第5期12卷 999-1008页

作者： Yongjuan Li jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong ji jinlin He lichen Yin Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow UniversitySuzhou 215123China Department of Biomedical Engineering University of Groningen and University Medical Center GroningenAntonius Deusinglaan 19713 AV Groningen The Netherlands Department of Cardiothoracic Surgery Wuxi Peoples Hospital Affiliated to Nanjing Medical UniversityWuxi 214023China

Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug ***,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle *** tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle *** such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic *** study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy.

关键词： core-cross-linked micelles on-demand drug release photodynamic therapy reactive oxygen species (ROS) responsiveness synergistic an ti-cancer therapy

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Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury

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Nano Research 2022年第10期15卷 9125-9134页

作者： Min Lan Mengying Hou jing Yan Qiurong Deng Ziyin Zhao Shixian Lv Juanjuan Dang Mengyuan Yin Yong ji lichen Yin Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Department of Cardiothoracic Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023China

Myocardial ischemia reperfusion(IR)injury is closely related to the overwhelming inflammation in the ***,cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species(ROS)-ultrasensitive co-delivery of dexamethasone(Dex)and RAGE small interfering RNA(siRAGE)to attenuate myocardial ***,a ROSdegradable polycation based on PGE2-modified,PEGylated,ditellurium-crosslinked polyethylenimine(PEI)was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles(MSNs),which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex *** intravenous injection to IR-injured rats,the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE2-assisted recognition of over-expressed E-series of prostaglandin(EP)receptors on the cell ***,the over-produced ROS degraded PPTP into small segments,promoting the release of siRAGE and Dex to mediate effective RAGE silencing(72%)and cooperative antiinflammatory *** a consequence,the nanotherapeutics notably suppressed the myocardial fibrosis and apoptosis,ultimately recovering the systolic ***,the current nanotherapeutics represent an effective example for the codelivery and on-demand release of nucleic acid and chemodrug payloads,and might find promising utilities toward the synergistic management of myocardial inflammation.

关键词： small interfering RNA(siRNA)delivery reactive oxygen species(ROS)responsiveness ditellurium-crosslinked polyethylenimine(PEI) myocardial ischemia reperfusion injury anti-inflammation

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采用多态机制的未来态配电网模型管理方案

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电力系统自动化 2018年第9期42卷 201-206页

作者：陈宇星马志斌李晨黄文英周济张小娇国网福建省电力有限公司福建省福州市350003 南瑞集团(国网电力科学研究院)有限公司江苏省南京市211106 北京科东电力控制系统有限责任公司北京市100192 国家电力调度控制中心北京市100031

配电网模型的频繁变更和数据质量问题对配电自动化主站系统实时监控类应用会产生较大干扰,而主站新的建设模式对多用户并发维护提出更高的性能要求。提出基于多态机制的未来态配电网模型管理方案,在独立的环境下开展基于异动单的模型维... 详细信息

配电网模型的频繁变更和数据质量问题对配电自动化主站系统实时监控类应用会产生较大干扰,而主站新的建设模式对多用户并发维护提出更高的性能要求。提出基于多态机制的未来态配电网模型管理方案,在独立的环境下开展基于异动单的模型维护、遵循IEC 61970/61968标准的图模接入和校验、全量模型和增量模型相结合的版本管理,以及自动化调试工作,与在线运行环境适当解耦,同时解决了多用户并发维护的效率问题。通过配电自动化系统和省级集中监管系统的运用案例,实践证明基于多态机制的未来态模型管理方案可满足配电网模型管理的多源端、多用户、自动化离线调试的需求。

关键词：未来态 IEC 61970/61968标准配电网模型管理版本管理异动单

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Zn/Fe bimetallic modified Spartina alterniflora-derived biochar heterostructure with superior catalytic performance for the degradation of malachite green

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Biochar 2023年第1期5卷 506-518页

作者： Hua jing Lili ji Zilong Li Zhen Wang Ran Li Kaixuan Ju Ocean College Zhejiang UniversityZhoushanZhejiang 310058China National Marine Facilities Aquaculture Engineering Technology Research Center Zhejiang Ocean UniversityZhoushanZhejiang 316022China Zhejiang lichen New Material Technology Co. LtdShaoxing 313100China

In this study,the synchronous magnetized carbonization method was utilized for preparing photocatalysis ZnO-Fe@SC heterostructure,which exhibited degradation efficiency 99.14%(60 min)for malachite green(200 mg/L)and could still maintain good performance after 5 *** prepared ZnO-Fe@SC was analyzed using UV-Vis DRS,PL,SEM,TEM,BET,FTIR,XPS and VSM,and LC-MS for degradation *** results indicate that photocatalyst has favorable magnetic properties,chemical stability and low charge carriers(e^(−)/h^(+))recombination *** modification of bimetals enables the composite photocatalyst to enhance the intensity of photogenerated electron ***,quenching experiment revealed that the photo-generated holes(h^(+))and superoxide radicals(·O_(2)^(−))were the dominant active species during the photocatalytic process,which degraded malachite green into small molecules by demethylation,deamination,ring-opening reactions as deducted from LC-MS ***-Fe@SC was prepared using a green,safe,low cost and operable synthetic method,which has a broad market potential in the field of environmental remediation.

关键词： Bimetallic heterostructure Nano-ZnO Green synthesis Photocatalytic degradation

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Biomedical polymers: synthesis, properties, and applications

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Science China Chemistry 2022年第6期65卷 1010-1075页

作者： Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang jinqiang Wang Lei Wang Meng-Hua Xiong lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He jian ji Xiqun jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan UniversityWuhan430072China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Ministry of EducationBeijing Laboratory of Biomedical MaterialsCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai UniversityTianjin300071China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China jinhua Institute of Zhejiang University Jinhua321299China Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai200438China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nano-scienceNational Center for Nanoscience and Technology(NCNST)Beijing100190China School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou510006China Institute of Functional Nano and So

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

关键词： biomedical polymer nanomedicine cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity biocompatibility

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基于离散元的平行双裂隙砂岩破裂特征和失稳机理研究

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矿业研究与开发 2024年第8期44卷 182-189页

作者：孙立臣娄培杰李成杰姬鹏辉安徽理工大学土木建筑学院安徽淮南市232001 中国矿业大学煤炭精细勘探与智能开发全国重点实验室江苏徐州市221116

研究双裂隙对岩体稳定性及破坏特征的影响有助于理解裂隙间的互相作用机制。运用PFC2D建立含不同空间分布的平行双裂隙砂岩试样数值模型,对其进行单轴压缩试验,分析其受载损伤特征、微裂纹演变和应力场分布,并结合宏观破坏特征,探讨试... 详细信息

研究双裂隙对岩体稳定性及破坏特征的影响有助于理解裂隙间的互相作用机制。运用PFC2D建立含不同空间分布的平行双裂隙砂岩试样数值模型,对其进行单轴压缩试验,分析其受载损伤特征、微裂纹演变和应力场分布,并结合宏观破坏特征,探讨试样的失稳机理。结果表明:3种双裂隙的不同空间分布使砂岩的渐进损伤过程和力学性质产生差异,并影响了微裂纹分布、数量和倾角,对岩桥破坏程度差异显著,进而形成不同的破裂区域;采用等效应力云图对不同模型峰值应力分布进行对比,并结合宏观破坏特征,从受外力角度探讨了裂隙的不同空间分布结构对试样的受力承载面和压应力传递路径的影响。研究成果可为工程实践和岩石力学研究提供参考价值。

关键词：平行双裂隙离散元损伤特征应力场失稳机理

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