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Science China(Life Sciences) 2014年第5期57卷 539-548页

作者： LI XinRong zhang ZhiShan TAN HuiJuan GAO YanHong LIU lichao WANG XinPing Shapotou Desert Research and Experiment Station Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province

The main prevention and control area for wind-blown sand hazards in northern China is about 320000 km2 in size and includes sandlands to the east of the Helan Mountain and sandy deserts and desert-steppe transitional regions to the west of the Helan Mountain.Vegetation recovery and restoration is an important and effective approach for constraining wind-blown sand hazards in these areas.After more than 50 years of long-term ecological studies in the Shapotou region of the Tengger Desert,we found that revegetation changed the hydrological processes of the original sand dune system through the utilization and space-time redistribution of soil water.The spatiotemporal dynamics of soil water was significantly related to the dynamics of the replanted vegetation for a given regional precipitation condition.The long-term changes in hydrological processes in desert areas also drive replanted vegetation succession.The soil water carrying capacity of vegetation and the model for sand fixation by revegetation in aeolian desert areas where precipitation levels are less than 200 mm are also discussed.

关键词：腾格里沙漠土壤水分植被恢复风沙危害中国北方生态修复时空动力学能力

全基因组水平金银花TCP基因家族的鉴定及表达模式分析

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中草药 2024年第5期55卷 1665-1676页

作者：谭政委郭水柱苏小雨孙瑶余永亮李磊张利超许兰杰鲁丹丹安素妨李春明梁慧珍王子君河南省农业科学院中药材研究所河南郑州450002 河南省农业科学院芝麻研究中心河南郑州450002 仲景宛西制药股份有限公司河南南阳474550 承德市中药材绿色生态种植技术服务中心河北承德067000 驻马店市种子服务站河南驻马店463000

目的对金银花Lonicera japonica TCP(LjTCP)基因家族进行鉴定分析,以期为进一步研究LjTCPs的功能机制奠定基础。方法以金银花基因组数据为基础,通过生物信息学系统分析TCP基因家族在染色体上的分布、系统进化、基因结构、启动子元件及... 详细信息

目的对金银花Lonicera japonica TCP(LjTCP)基因家族进行鉴定分析,以期为进一步研究LjTCPs的功能机制奠定基础。方法以金银花基因组数据为基础,通过生物信息学系统分析TCP基因家族在染色体上的分布、系统进化、基因结构、启动子元件及其表达模式。结果共鉴定出17个LjTCPs,其中16个LjTCPs分布在9条染色体上,LjTCP17未定位到染色体上,基于系统进化树和多重序列比对,LjTCP基因家族可以分为PCF、CIN和CYC/TB13个亚家族,分别包含9、6、2个LjTCPs。基因组内共线性分析表明,全基因组复制和片段性复制在LjTCP基因家族进化中发挥了重要作用。LjTCP基因家族启动子包含许多与植物生长发育、激素响应,以及非生物和生物胁迫相关的调控元件。表达模式分析表明,LjTCP基因在金银花花发育初期表达量较高,随着发育进程表达量呈现下降趋势,并且LjTCP05、LjTCP13、LjTCP14、LjTCP16和LjTCP17基因在花青素含量不同的品种中表达量存在差异。对6个具有低温响应元件的LjTCPs在冷胁迫下的基因表达研究表明,大部分基因在冷处理后基因表达呈现上升趋势。结论金银花TCP基因家族包含17个成员,各成员的分子特征和表达模式存在差异。

关键词：金银花 TCP转录因子基因家族共线性分析系统进化表达模式

新时代江河湖库消落带生态修复技术体系研发、实践与成效

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中国水土保持 2024年第6期 8-11页

作者：张利超于长俊叶玉成李梅冯激金志伟周广天吴桐菲南昌工程学院水土保持学院江西南昌330099 景德镇市水利局江西景德镇333000 江西省水文监测中心江西南昌330002 景德镇市赣皖土木工程规划设计有限责任公司江西景德镇333000

近年来江河湖库消落带出现了包括水土流失、植被退化、近岸水体水质富营养化等生态功能明显退化问题,严重影响了江河湖库生态系统的功能。南昌工程学院张利超博士团队依托国家水利风景区、国家湿地公园及大中型水库工程建设,在江西及全... 详细信息

近年来江河湖库消落带出现了包括水土流失、植被退化、近岸水体水质富营养化等生态功能明显退化问题,严重影响了江河湖库生态系统的功能。南昌工程学院张利超博士团队依托国家水利风景区、国家湿地公园及大中型水库工程建设,在江西及全国率先系统性地成功构建了一整套基于多维立体林草复合生态修复与重建理论的新时代“江河湖库消落带多维立体林草复合生态修复体系(林泽系统)”,在江西及全国首次系统性地成功研发并实地应用了修复效果显著、成本低廉、推广性强的“江河湖库消落带多维立体林草复合生态修复与重建关键技术体系”,让生态退化的消落带变成了色彩缤纷美丽的“水上森林”景观带,在江西省成功建成了四大技术应用示范点,取得了显著的应用示范成效,可为国家生态文明试验区(江西)、生态鄱阳湖流域、南方红壤区等区域生态环境复苏、实现“碳达峰、碳中和”的“双碳”目标提供重要的科技支撑。

关键词：消落带江河湖库水土保持水生态修复治理 “双碳”目标新时代

流程化VTE预防质量控制管理在妇科恶性肿瘤患者围术期血栓预防中的应用效果

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临床医学研究与实践 2024年第14期9卷 156-159页

作者：刘红杰张凯刘秋瑾郭迎迎边蓉蓉侯丽超郑州大学第三附属医院成人重症医学科河南郑州450052

目的探讨流程化静脉血栓栓塞症(VTE)预防质量控制管理在妇科恶性肿瘤患者围术期血栓预防中的应用效果。方法选取2019年5月至2022年5月我院收治的70例妇科恶性肿瘤患者,按照干预方案不同将其分为对照组和研究组,各35例。对照组给予常规管... 详细信息

目的探讨流程化静脉血栓栓塞症(VTE)预防质量控制管理在妇科恶性肿瘤患者围术期血栓预防中的应用效果。方法选取2019年5月至2022年5月我院收治的70例妇科恶性肿瘤患者,按照干预方案不同将其分为对照组和研究组,各35例。对照组给予常规管理,研究组开展流程化VTE预防质量控制管理。比较两组的下肢静脉血流速度、疼痛评分、下肢静脉血栓发生情况、凝血功能指标及知信行(KAP)评分。结果干预前,两组的下肢静脉血流速度及视觉模拟评分法(VAS)评分比较,差异无统计学意义(P>0.05);干预后,研究组的下肢静脉血流速度大于对照组,VAS评分低于对照组,差异具有统计学意义(P0.05);干预后,研究组的凝血酶原时间长于对照组,纤维蛋白原、D-二聚体水平及血小板计数低于对照组,差异具有统计学意义(P<0.05)。研究组的KAP各维度评分高于对照组,差异具有统计学意义(P<0.05)。结论流程化VTE预防质量控制在妇科恶性肿瘤患者围手术期中的应用效果显著,能够改善凝血功能,加速下肢静脉血流速度,缓解疼痛,并提高患者的知信行水平,值得临床推广和应用。

关键词：妇科恶性肿瘤流程化静脉血栓栓塞症预防质量控制管理血流速度下肢静脉血栓疼痛

GRP78 stimulates EMT and cell-matrix adhesion via TGF-β 1signaling

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GRP78 stimulates EMT and cell-matrix adhesion via TGF-β 1si...

Hot deformation behavior of Mg-7.22Gd-4.84Y-1.26Nd-0.58Zr magnesium alloy

中国生物化学与分子生物学会第十一次会员代表大会暨201...

作者： lichao zhang Zongwei Li Zhuoyu Li Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of EducationShanxi University

Coloretal cancer(CRC)is the human digestive system malignancy and its incidenceis increasing with years.Metastasis of colon cancer is the main reason of the therapyfailure.Glucose regulated protein 78(GRP78),also referred to as immunoglobulin heavychain binding protein(Bip),is a member of the heat shock protein 70(Hsp70)family.Innormal cells,GRP78 is mainly located in the endoplasmic reticulum(ER),inducing new proteinfolding as a molecular chaperone.In addition,GRP78 can be induced by ER stress,such as glucose deprivation,hypoxia and acidosis,which frequently happen in solid tumorsdue to poor vascularization and shortage of nutrition.Several lines of evidence have indicatedthat GRP78expression is higher in colon cancer than that in colon adenoma and normaltissue,and that high level of GRP78 is closely associated with colorectal metastasis.However,few reports have elaborated on the molecular mechanisms by which GRP78promotestumor metastasis.In order to investigate the impact of GRP78 on cell migration,we constructed lentiviralvectors mediated stable overexpressed and knockdown GRP78 cell lines in the DLD1 coloncancer cell.As the change of cell-ECM adhesion is the early step in tumor cell metastasis,we performed cell adhesion assay,and found that overexpressed GRP78 facilitates the adhesionbetween DLD1 cells and extracellular matrix through the activation of integrin-β1and FAK.In addition,migration of epithelial cells is often accompanied by the process ofEMT.In contrast to the epithelial morphology of GFP-expressed DLD1 cells,GFPGRP78-expressed DLD1 cells displayed a mesenchymal spindle-shaped morphology,and the mesenchymalmarker,α-smooth muscle actin(α-SMA)was upregulated.To further uncover the regulatory mechanism of adhesion change and EMT,we examinedthe activation of several metastasisrelated signaling pathways,and found that the phosphorylatedform of Smad2/3,downstream protein of TGF-βsignaling pathway,was increasedin GRP78-overexpressed DLD1,and decreased in GRP78-knockdown DLD1.Moreover,the amount of TGF-βi

关键词： GRP78 cell-ECM adhesion EMT TGF-β

来源： cnki会议评论

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Rare Metals 2011年第1期30卷 87-93页

作者： zhang Kui MA Minglong LI Xinggang LI Yongjun LIANG lichao BING Mengfen State Key Lab of Non-ferrous Metals and Processes General Research Institute for Nonferrous Metals Beijing 100088 China CNGC Shenyang Dong Ji Industries Group Corporation Shenyang 110045 China

The behavior evolvement of Mg-7.22Gd-4.84Y-1.26Nd-0.58Zr（GWN751K） magnesium alloy during the hot deformation process was discussed.The flow stress behavior of the magnesium alloy over the strain rate range of 0.002 to 2.000 s^-1 and in the temperature range of 623 to 773 K was studied on a Gleeble-1500D hot simulator under the maximum deformation degree of 60%.The experimental results showed that the relationship between stress and strain was obviously affected by strain rate and deformation temperature.The flow stress of GWN751K magnesium alloy during high temperature deformation could be represented by the Zener-Hollomon parameter in the hyperbolic Arrhenius-type equation.The stress exponent n and deformation activation energy Q were evaluated by linear regression analysis.The stress exponent n was fitted to be 3.16.The hot deformation activation energy of the alloy during hot deformation was 230.03 kJ/mol.The microstructures of hot deformation were also influenced by strain rate and compression temperature strongly.It was found that the alloy could be extruded at 723 K with the mechanical properties of σ0.2 = 260 MPa,σb = 320 MPa,and δ = 18%.

关键词： magnesium alloys rare earth elements microstructure activation energy deformation hot working

Multimaterial additive manufacturing manipulator for fabricating magnetoelectric pressure sensors

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Science China(Technological Sciences) 2022年第11期65卷 2542-2550页

作者： LIU ZhuFeng LI ZhaoQing WANG Qi WANG Yan YANG Lei NIE Xiang GENG Peng WU ZhenHua TANG SiHan YANG Lei WU HongZhi SHI YunSong CHEN Peng SU Bin zhang lichao YAN ChunZe SHI YuSheng State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and Technology Wuhan 430074China State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and TechnologyWuhan 430074China Schol of Materials Science and Enginering Wuhan Insitute of TechnologyWuhan 430205Chinai School of Transportation and Logisis Engineering Wuhan University of TechnologyWuhan 430063China Deparment of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030China

The simultaneous placement of different types of materials including polymers,ceramics,and metals,in their desired positions could be adopted to manufacture end-use devices/apparatuses with diverse functionalities and significantly reduce the fabrication cost and time.However,existing additive manufacturing(AM)approaches can only treat one material species at a time due to their intrinsic working mechanisms.Here we develop an AM manipulator for manufacturing a wide variety of material species,including polymers,ceramics,and metals,through a multifilament transport strategy assisted by laser power.The six-jaw manipulator contains three pairs of filament delivering/cutting systems for transporting diverse materials and a beam of tunable laser as the thermal source.The whole apparatus is integrated into a robotic manipulator to create a multifreedom manufacturing platform.With this innovation,products with multiple material species and desired complex geometries can be fabricated on demand.Furthermore,we synthesize a multimaterial(polymer/ceramic/metal)printed magnetoelectric pressure sensor that can convert applied mechanical forces to electricity and maintain efficiency even after undergoing 10000 cycles of pressure/recovery.With this multimaterial filament transport and laser manufacturing strategy,our AM manipulator exhibits promising application in the advanced manufacturing of embedded electronics,sensors,soft robotics,and customizable medical devices.

关键词： multiple materials additive manufacturing laser manipulator magnetoelectric

经皮冠状动脉介入治疗后残余血管病变及冠状动脉临界病变患者应用硝酸异山梨酯缓释片与单硝酸异山梨酯片的疗效对比研究

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中国循环杂志 2024年第4期39卷 386-391页

作者：郝一莼曾谷雨赵立超陈艳宋莹袁德山汪沛志宋雷张茵高立建陈珏刘海波袁晋青赵雪燕许晶晶中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院冠心病中心北京100037

目的:探讨长效硝酸异山梨酯和单硝酸异山梨酯在经皮冠状动脉介入治疗(PCI)后残余血管病变以及冠状动脉临界病变患者中的疗效与安全性。方法:选取中国医学科学院阜外医院2022年7月至2023年2月收治的PCI后残余血管病变以及冠心病临界病变... 详细信息

目的:探讨长效硝酸异山梨酯和单硝酸异山梨酯在经皮冠状动脉介入治疗(PCI)后残余血管病变以及冠状动脉临界病变患者中的疗效与安全性。方法:选取中国医学科学院阜外医院2022年7月至2023年2月收治的PCI后残余血管病变以及冠心病临界病变患者435例,依据随机数字表法分为硝酸异山梨酯缓释片组(n=217)和单硝酸异山梨酯片组(n=218),分别口服两种药物20 mg每日两次。比较两组患者治疗前和治疗后1、2、3个月西雅图心绞痛问卷(SAQ)评分(包括活动受限程度、心绞痛稳定性、心绞痛发作频率、治疗满意度、疾病认知度)以及治疗后主要不良心脑血管事件(MACCE,包括全因死亡、心肌梗死、再次血运重建、脑卒中)、药物不良反应的发生率等。结果:治疗后两组患者的SAQ五个部分评分以及SAQ总分等均显著增加(P_(trend)均<0.001),非劣效检验结果显示两组患者SAQ评分无明显差异(P<0.001)。3个月后两组MACCE发生率差异无统计学意义(1.4%vs. 4.6%,P=0.067)。治疗后两组患者中均有头痛等药物不良反应发生,硝酸异山梨酯缓释片组患者中低血压发生率低于单硝酸异山梨酯片组(0.9%vs. 4.1%,P=0.033),两组患者因不良反应所致的停药率差异无统计学意义(3.2%vs. 3.7%,P=0.916)。结论:硝酸异山梨酯缓释片能有效改善PCI后残余血管病变以及冠状动脉临界病变患者生活质量,治疗效果、MACCE发生率、药物不良反应、停药率等与单硝酸异山梨酯片相似,且低血压的发生率更低。

关键词：硝酸异山梨酯缓释片单硝酸异山梨酯冠状动脉临界病变经皮冠状动脉介入治疗心绞痛西雅图生活质量评分

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硒缓解水稻镉胁迫的研究进展

宁夏农林科技 2024年第2期65卷 9-13页

作者：邓邦骏张利超邱进陈洁宁郭修远胡盛明崔龄胡良南昌工程学院流域生态智能监测与综合治理江西省重点实验室江西南昌330099 江西益洁环保技术有限公司江西南昌330036

Cd污染问题对现代农业可持续发展和农产品质量安全构成严重威胁,稻米Cd污染防治是全面推进乡村振兴重点工作的任务之一,已成为迫切需要解决的重大生态环境问题。Se是人与动物必需的微量元素之一,Se对重金属可以产生拮抗作用,阻挡重金属... 详细信息

Cd污染问题对现代农业可持续发展和农产品质量安全构成严重威胁,稻米Cd污染防治是全面推进乡村振兴重点工作的任务之一,已成为迫切需要解决的重大生态环境问题。Se是人与动物必需的微量元素之一,Se对重金属可以产生拮抗作用,阻挡重金属对植物的危害,被誉为“重金属的天然解毒剂”。施用Se肥能减轻Cd对水稻生长的毒害,降低水稻对Cd的吸收,然而其机理机制尚无定论。针对Cd对水稻的危害、Se对水稻中Cd含量的影响作用进行分析,总结并论述现阶段Se对水稻Cd胁迫的缓解作用,以期制定相应措施降低Cd对水稻的毒害,进而提升稻米品质,保障人民身体健康。

关键词： Se Cd 水稻胁迫