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Protein S-Nitrosylation in plants: Current progresses and challenges

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Journal of Integrative Plant Biology 2019年第12期61卷 1206-1223页

作者： Jian Feng lichao chen Jianru Zuo Sainsbury Laboratory University of CambridgeCambridge CB21LRUK State Key Laboratory of Plant Genomics and National Center for Plant Gene Research CAS Center for Excellence in Molecular Plant SciencesInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China The University of Chinese Academy of Sciences Beijing 100049China

Nitric oxide(NO)is an important signaling molecule regulating diverse biological processes in all living organisms.A major physiological function of NO is executed via protein S-nitrosylation,a redox-based the past decade,significant progress has been made in functional characterization of S-nitrosylated proteins Inviteposttranslational modification by covalently adding a NO molecule to a reactive cysteine thiol of a target protein.S-nitrosylation is an evolutionarily conserved mechanism modulating multiple aspects of cellular signaling.Duringin plants.Emerging evidence indicates that protein Snitrosylation is ubiquitously involved in the regulation of plant development and stress responses.Here we review current understanding on the regulatory mechanisms of protein S-nitrosylation in various biological processes in plants and highlight key challenges in this field.

关键词： field. adding conserved

基于无监督学习模型的前列腺超高b值DWI图像生成与临床评估

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现代仪器与医疗 2024年第3期30卷 40-47页

作者：陈立超杨瑜冰陈哲宇吴霖曹达王伟南京医科大学生物医学工程与信息学院南京医科大学第一附属医院放射科

目的探讨超高b值DWI图像采集在前列腺癌诊断中的独特优势，并解决其存在的采集时间长和易发生伪影等问题。方法通过临床采集高b值磁共振图像与超高b值图像，并利用无监督学习两个域之间的特征关系生成前列腺超高b值DWI图像，以提高对... 详细信息

目的探讨超高b值DWI图像采集在前列腺癌诊断中的独特优势，并解决其存在的采集时间长和易发生伪影等问题。方法通过临床采集高b值磁共振图像与超高b值图像，并利用无监督学习两个域之间的特征关系生成前列腺超高b值DWI图像，以提高对比度和前列腺疾病检测的敏感度。评估模型的临床性能，辅助年轻医师提高前列腺癌诊断能力。结果生成的前列腺超高b值DWI图像具有足够的对比度，提高了前列腺疾病检测的敏感度，且模型在临床性能评估中表现良好。结论基于无监督学习的超高b值DWI图像生成技术不仅具有突出的技术优势，而且在临床实践中显示出一定的应用潜力。该技术有望成为前列腺疾病影像诊断领域的重要辅助工具，为医疗实践带来重要的进展和改善。

关键词：前列腺磁共振图像医学图像生成无监督学习计算机辅助诊断

创新是一个过程——自然与真实建造的设计策略

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世界建筑 2024年第5期 28-33页

作者：陆文宇陈立超宋曙华业余建筑工作室中国美术学院建筑艺术学院

以杭州国家版本馆的设计与建造为例,从场地设计、材料体系、建造工艺及景观造园等面临的设计问题展开,探讨如何将自然与真实建造的设计策略与解决方案,贯穿于从概念方案到建设实施的全过程。

关键词：自然真实材料体系建造体系实施控制

Rational Design of Plasmonic Nanoparticle-Molecule Complexes for Chirality Sensing

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Chinese Journal of Chemistry 2024年第8期42卷 903-919页

作者： chen Wang Dandan Lu lichao Sun Qingfeng Zhang College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,Sensing the chirality of molecules is of great importance to fields such as enantioselective synthesis,pharmaceutical industry,and biomedicine.Plasmonic nanoparticles are ideal candidates for molecular sensing due to their inherent plasmonic properties that significantly enhance their sensitivity to surrounding molecules.Developing plasmonic nanoparticle-molecule complexes for chirality sensing has drawn enormous attention in recent years due to their intriguing properties and potential applications.Thus,in this review,we believe it is timely to circumnavigate the rational design of plasmonic nanoparticle-molecule complexes and widen the scope of their emerging applications in chirality sensing.First,we present different fundamental mechanisms for plasmon-based chirality that are built on the system of plasmonic nanoparticle-molecule complexes.Second,we review the typical applications of plasmonic nanoparticle-molecule complexes in chirality sensing.Third,we discuss the emerging biomedical applications that the plasmon-based chirality has attracted enormous interest.Finally,we provide an outlook on the challenges and opportunities in the field of plasmonic approaches for chirality sensing.

关键词： Chirality Surface plasmon resonance Nanoparticles Chiral molecules Chirality sensing

Mitochondrial dysfunction: A promising therapeutic target for liver diseases

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Genes & Diseases 2024年第3期11卷 324-337页

作者： Ping chen lichao Yao Mengqin Yuan Zheng Wang Qiuling Zhang Yingan Jiang Lanjuan Li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430060China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310003China

The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the mitochondria.Liver tissues of pa-tients with alcohol-related or non-alcohol-related liver diseases contain ultrastructural mito-chondrial lesions,mitochondrial DNA damage,disturbed mitochondrial dynamics,and compromised ATP production.Overproduction of mitochondrial reactive oxygen species in-duces oxidative damage to mitochondrial proteins and mitochondrial DNA,decreases mito-chondrial membrane potential,triggers hepatocyte inflammation,and promotes programmed cell death,all of which impair liver function.Mitochondrial DNA may be a poten-tial novel non-invasive biomarker of the risk of progression to liver cirrhosis and hepatocellular carcinoma in patients infected with the hepatitis B virus.We herein present a review of the mechanisms of mitochondrial dysfunction in the development of acute liver injury and chronic liver diseases,such as hepatocellular carcinoma,viral hepatitis,drug-induced liver injury,alcoholic liver disease,and non-alcoholic fatty liver disease.This review also discusses mito-chondrion-centric therapies for treating liver diseases.

关键词： Chronic diseases Liverdamage Mesenchymalstem cell Mitochondrial dysfunction Oxidativestress

Hypertension and NAFLD risk:Insights from the NHANES 2017-2018 and Mendelian randomization analyses

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Chinese Medical Journal 2024年第4期137卷 457-464页

作者： Mengqin Yuan Jian He Xue Hu lichao Yao Ping chen Zheng Wang Pingji Liu Zhiyu Xiong Yingan Jiang Lanjuan Li Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhanHubei 430000China Department of Gastroenterology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510010China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Centre for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310000China

Background:Hypertension and non-alcoholic fatty liver disease(NAFLD)share several pathophysiologic risk factors,and the exact relationship between the two remains unclear.Our study aims to provide evidence concerning the relationship between hypertension and NAFLD by analyzing data from the National Health and Nutrition Examination Survey(NHANES)2017-2018 and Mendelian randomization(MR)analyses.Methods:Weighted multivariable-adjusted logistic regression was applied to assess the relationship between hypertension and NAFLD risk by using data from the NHANES 2017-2018.Subsequently,a two-sample MR study was performed using the genome-wide association study(GWAS)summary statistics to identify the causal association between hypertension,systolic blood pressure(SBP),diastolic blood pressure(DBP),and NAFLD.The primary inverse variance weighted(IVW)and other supplementary MR approaches were conducted to verify the causal association between hypertension and NAFLD.Sensitivity analyses were adopted to confirm the robustness of the results.Results:A total of 3144 participants were enrolled for our observational study in NHANES.Weighted multivariable-adjusted logistic regression analysis suggested that hypertension was positively related to NAFLD risk(odds ratio[OR]=1.677;95%confidence interval[CI],1.159-2.423).SBP≥130 mmHg and DBP≥80 mmHg were also significantly positively correlated with NAFLD.Moreover,hypertension was independently connected with liver steatosis(β=7.836[95%CI,2.334-13.338]).The results of MR analysis also supported a causal association between hypertension(OR=7.203[95%CI,2.297-22.587])and NAFLD.Similar results were observed for the causal exploration between SBP(OR=1.024[95%CI,1.003-1.046]),DBP(OR=1.047[95%CI,1.005-1.090]),and NAFLD.The sensitive analysis further confirmed the robustness and reliability of these findings(all P>0.05).Conclusion:Hypertension was associated with an increased risk of NAFLD.

关键词： Hypertension Non-alcoholic fatty liver disease National Health and Nutrition Examination Survey Mendelian randomization analysis Causality

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图像分割算法在医学图像中的应用综述

现代仪器与医疗 2024年第2期30卷 59-68页

作者：孙淑婷刘铖枨周广茵韩锐陈立超羊月褀许玥南京医科大学生物医学工程与信息学院南京医科大学第一附属医院(江苏省人民医院)临床医学工程处

医学图像分割是计算机辅助诊断领域的一项关键技术，其主要任务是将特定的器官、组织或异常区域从图像中准确地识别出来。但是医学图像的质量易受到其复杂纹理和成像设备限制(如噪声和边界不清晰)的影响，故传统的医学图像分割方法已难... 详细信息

医学图像分割是计算机辅助诊断领域的一项关键技术，其主要任务是将特定的器官、组织或异常区域从图像中准确地识别出来。但是医学图像的质量易受到其复杂纹理和成像设备限制(如噪声和边界不清晰)的影响，故传统的医学图像分割方法已难以满足现实临床需求。随着深度学习技术的进步，基于这一领域的算法已经取得了显著的进展。本文首先回顾了七种传统的医学图像分割策略，并重点介绍了两种当前主流的深度学习方法：全卷积神经网络和U-Net,最后文章探讨了目前深度学习技术所面临的挑战及其可能的解决策略。

关键词：深度学习医学图像分割全卷积神经网络 U-Net

A Novel Approach of Components Retrieval in Large-scale Component Repositories

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A Novel Approach of Components Retrieval in Large-scale Comp...

煤层气直井压裂效果及其对产能影响——以窑街矿区为例

2012 IEEE 3rd International Conference on Software Engineering and Service Science（ICSESS 2012）

作者： Lei Zhang lichao chen Lihu Pan Yingjun Zhang School of Computer Science and Technology Taiyuan University of Science and Technology Taiyuan Shanxi Province China

For improving the retrieval performance of large-scale component repositories,a novel approach of components retrieval,Automatic Tags Extraction（ATE） retrieval,is proposed in this paper.In this method,component tags are extracted automatically from application domain terms,high-frequency terms,high-weight terms and facet terms in description document of component at first,and then the improved VSM （Vector Space Mode） similarity algorithm is used to retrieve on the tags.Our experiments show that,compared with some common retrieval methods,the ATE retrieval is more feasible and efficient.

关键词： software component component retrieval automatic tags extraction web services

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煤炭科学技术 2023年第6期51卷 130-136页

作者：马代兵陈立超甘肃煤田地质局一四九队甘肃兰州730020 煤与煤层气共采国家重点实验室山西晋城048204

煤层气藏作为典型缝控气藏,压裂造缝规模及裂缝充填效果对气井产能具有决定性控制。为探究煤层气直井水力压裂效果对气井产能效果的影响机制,以甘肃窑街海石湾矿区为例,重点报道直井开发形式下煤储层压裂改造效果及其对产能制约方面认识... 详细信息

煤层气藏作为典型缝控气藏,压裂造缝规模及裂缝充填效果对气井产能具有决定性控制。为探究煤层气直井水力压裂效果对气井产能效果的影响机制,以甘肃窑街海石湾矿区为例,重点报道直井开发形式下煤储层压裂改造效果及其对产能制约方面认识,结果表明:①煤层气井破裂压力主要反馈井筒固井水泥环特征而非煤储层力学性能,从该井压裂曲线看破裂压力不明显,表明井筒环空固井水泥环厚度适中,水力压裂期间固井水泥环破裂相对容易,能量消耗低,注入压裂液能量主要用于撑开煤岩裂缝;②从压裂曲线看出,该井压裂裂缝延伸压力较高,表明地下煤储层结构较为破碎且发育煤粉源集合体,煤粉对压裂裂缝的延展具有关键制约作用。而且在压裂曲线裂缝延展阶段出现多个波动形态特征,指示多条次级裂缝撑开,整体上该井压裂裂缝形态较为复杂,推测为主干压裂裂缝两侧发育枝状次级裂缝形式;③该井注砂后发生严重砂堵,主要原因是煤储层压裂液滤失造成近井地带压裂裂缝内支撑剂脱砂形成楔体,导致后续支撑剂注入困难,同时也与煤储层原生裂缝煤粉源及少量构造煤粉源集合体发育有关;④压裂微震监测数据显示该井煤储层主干压裂裂缝走向为NE 50°,其中在北东方向上煤岩微震事件更活跃,指示该方向上煤储层天然裂隙系统更发育;结合煤储层压裂裂缝矿井观测结果,提出压裂裂缝有效支撑区、实际破裂区及岩体扰动区的划分方案,认为微震监测得出的压裂裂缝半长实际为岩体扰动范围,难以准确反映储层实际改造效果。综合该井后期产能规律及晋城矿区煤储层压裂裂缝矿井观测结果,认为该井煤储层实际压裂裂缝半长在20 m以内,有效支撑压裂裂缝半长不足5 m,压裂液注入液量少、压裂液滤失诱导支撑剂脱砂形成楔体以及煤粉聚集造成砂堵等是该井煤储层压裂裂缝较短的主要因素;⑤结合煤层气产能规律,认为该井气藏管控和排采制度较为合理,但煤储层有效支撑压裂裂缝过短,煤储层内煤粉运移导致近井压裂裂缝导流能力快速衰减是气井产能低下的关键制约机制,建议后期煤储层水力压裂加大压裂液注入液量,适当增大压裂液排量,降低支撑剂砂比,重点防控压裂液滤失、防止脱砂楔体形成。该区煤储层埋深大、应力高,实现裂缝大范围加砂是煤储层压裂改造的关键。同时考虑储层干燥,压裂液滤失严重的实际情况,有条件可开展CO_(2)前置压裂试验。

关键词：煤层气直井压裂效果天然裂隙系统压裂液滤失甘肃窑街矿区