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Combining Transcriptomics and Metabolomics to Uncover the Effects of High-Energy Lithium-Ion Beam Irradiation on Capsicum annuum L.

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 2947-2964页

作者： libo xie Xue Wang Luxiang Liu Chunmei Xu Yongdun xie Hongchun Xiong Xinchun Han Mu Guo Horticultural Sub-Academy Heilongjiang Academy of Agricultural SciencesHarbin150069China Institute of Crop Science Chinese Academy of Agricultural Sciences National Center of Space Mutagenesis for Crop ImprovementBeijing10008China Heihe Agricultural and Rural Bureau Heihe164300China

Hot pepper(Capsicum annuum L.)is consumed as one of the oldest domesticated crops all over the *** mutation breeding using radiation has been performed in hot peppers,little is known about the comparative analysis of mutagenic effects at the molecular level by ion beam *** comprehend the response mechanism of hot pepper to the ion beam,we used a mutant with favorable economic characteristics induced by lithium-ion beam irradiation to investigate the biological *** results indicated that the lithium-ion beam had a positive effect on important agronomic traits,particularly yield unit,but had a negligible effect on the photosynthetic rate of hot pepper,with a specific influence on chlorophyll b rather than chlorophyll *** RNA-Seq analysis,671 up-regulated and 376 down-regulated genes were identified as differentially expressed genes(DEGs)between irradiated and unirradiated hot *** on GO and KEGG network analysis,the auxin metabolic process was the common pathway in these two networks.A total of 118 potential reactive oxygen species(ROS)scavenging genes and 262 signal transduction genes were identified,suggesting a balance between antioxidant enzymes and enhanced ROS *** amounts of 15 metabolite,involved in GABA pathways,secondary metabolism,carbohydrate metabolism,shikimate pathways,TCA cycles,nitrogen metabolism,glycerol metabolism and acetate pathways,were significantly changed in the ion beam irradiated *** results highlighted that the enriched pathways could play important roles in response to ion beam irradiation in hot pepper *** summary,these data provide valuable information for future research on ion beam irradiation and genomic studies in hot pepper.

关键词： Capsicum annuum L physiology transcriptomics metabolomics lithium-ion beam

基于全长转录组的蛇足石杉ARF基因家族鉴定分析

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广西植物 2024年第6期44卷 1091-1104页

作者：李海波史济东张恺谢锂波化阳光曹禹李俊怡汪得凯余姚市种子种苗管理站浙江宁波315499 余姚市鹿亭乡农业农村办浙江宁波315434 浙江理工大学生命科学与医药学院杭州310018

生长素响应因子(ARF)是介导生长素信号传导并调节多种生物学过程的转录因子家族。为探究蛇足石杉ARF基因家族成员及其在高温和干旱胁迫响应中的作用,该研究利用全长转录组和RNA-seq数据,分析蛇足石杉ARF基因家族成员的系统发育及表达模... 详细信息

生长素响应因子(ARF)是介导生长素信号传导并调节多种生物学过程的转录因子家族。为探究蛇足石杉ARF基因家族成员及其在高温和干旱胁迫响应中的作用,该研究利用全长转录组和RNA-seq数据,分析蛇足石杉ARF基因家族成员的系统发育及表达模式,并通过生物信息学分析,对ARF基因家族的理化性质、结构域、保守基序、系统发育、组织表达模式及高温和干旱胁迫下的表达模式进行分析。结果表明:(1)在蛇足石杉全长转录组中共筛选出24个ARF家族成员,均为酸性蛋白且均为亲水蛋白。(2)亚细胞定位预测显示,所有24个HsARF均定位于细胞核。(3)系统发育分析发现,HsARF与被子植物拟南芥和水稻亲缘关系较远,与高等开花植物只有2个共同的ARF祖先。(4)结构域分析发现,除HsARF18/23/24外,大多数HsARF有B3结构域。二级结构分析发现,HsARF蛋白占比最多的为无规卷曲,其次为延伸链和α-螺旋。24个HsARF蛋白中所用的三级结构模型只有4种。(5)RNA-seq分析显示,7个HsARF在所有检测的组织中表达量均较高,10个HsARF在茎中的表达量高于根和叶,而HsARF13和HsARF14在叶中的表达量低于根和茎。(6)HsARF在高温和干旱胁迫下表达量发生显著变化,其中18个HsARF基因不同程度高温胁迫诱导,有7个HsARF基因响应干旱胁迫,其中有3个HsARF基因受干旱诱导,有4个HsARF基因受干旱抑制。该研究结果为蛇足石杉HsARF基因的功能和生物育种提供了理论参考。

关键词：蛇足石杉生长素反应因子(ARF) 系统发育分析全长转录组非生物胁迫

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Reduced dose of Bacillus Calmette-Guérin versus full dose of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer after transurethral resection bladder tumor： a meta-analysis of randomized controlled trials

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Chinese Medical Journal 2014年第22期127卷 3970-3974页

作者： Qin Xin Wu Keming xie libo Zhao Sixiu Lu Yiping Department of Urology West China Hospital Sichuan UniversityChengdu Sichuan 610041 China

Background Bladder cancer is widely known as the most common malignant tumor in the urinary tract,with 75％-85％ of patients suffering from nonmuscle invasive bladder cancer （NMIBC）.However,the optimal dose of Bacillus Calmette-Guérin （BCG） remains *** aim of this study was to compare the therapeutic efficacy of full dose （FD） with the reduced dose （RD） of *** Randomized controlled trials （RCTs） were selected through the Cochrane Library,PubMed and Embase and were supplemented by hand searching of *** end points include overall survival rate,recurrence rate,progression rate and side *** Five RCTs that included a total of 1 473 patients （727 in the reduced dose group vs 746 in the full dose group）,with a median follow-up period from 33.5 month to 7.1 *** in 80 of 687 （11.6％） patients assigned to the RD group progress to the muscular layer or distant metastasis,compared with 81 of 698 （11.6％） patients assigned to the FD group （RR=1.02; 95％ CI,0.77-1.36; P=0.89）.The incidence of recurrence at three year was reported in all five studies to be 41.1％（299 of 727） and 36.1％（269 of 746） in the RD and FD groups,respectively （RR=1.13; 95％ CI,1.00-1.29; P=0.05）.The 5-year survival rate was 75.9％（502 of 662） in the RD group,and 75.8％（510 of 673） in the FD *** the RD group 41 of 655 （6.3％） patients and 56 of 663 （8.7％） patients in the FD group did not complete the treatment due to systemic or local side effects （RR=0.75; 95％ CI,0.51-1.10; P=0.14） Conclusions In general,the results of our study demonstrate a trend towards a reduction of the toxicity in reduced dose group without affecting the efficacy of treatment when compared with full *** trials with large sample size are still necessary to explore the prognosis of the patients with high risk of tumor in different dose group.

关键词： Bacillus Calmette-Guérin instillation therapy

波浪作用下液化场地高桩码头动力响应试验研究

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上海交通大学学报 2023年第11期57卷 1442-1454页

作者：毕建巍苏雷解立波张昱凌贤长青岛理工大学土木工程学院山东青岛266520 大连理工大学海岸与近海工程国家重点实验室辽宁大连116024 哈尔滨工业大学土木工程学院哈尔滨150090

高桩码头广泛应用于深水港口工程建设中,且大多位于可液化场地,波浪作用对液化场地高桩码头工作性能的影响不可忽视,但鲜有研究报道.进行液化场地高桩码头模型波浪水槽试验,考虑波浪、码头和土层三者之间的相互作用,真实再现高桩码头使... 详细信息

高桩码头广泛应用于深水港口工程建设中,且大多位于可液化场地,波浪作用对液化场地高桩码头工作性能的影响不可忽视,但鲜有研究报道.进行液化场地高桩码头模型波浪水槽试验,考虑波浪、码头和土层三者之间的相互作用,真实再现高桩码头使用环境,探索波浪作用下码头内部响应差异,分析波浪作用下码头桩基和土层动力响应,探讨波高变化对各动力响应的影响规律.结果表明:高桩码头面板加速度和位移响应随波浪作用时间增加先逐渐变大最终保持相对稳定;群桩内各桩受到的动水压力和变形差异明显,其变化规律与桩位置有直接联系;自由场和桩周土层孔压响应幅值随埋深增大而减小,群桩的存在会降低桩周土层孔压的响应,增大土层加速度的响应;波高的增加对土层的影响随深度的增加而减小.上述研究成果可为波浪作用下类似高桩码头试验提供参考,为高桩码头合理化设计和防波浪侵袭提供支持.

关键词：波浪作用高桩码头动力响应液化场地模型试验

基于FLAC^(3D)液化场地桩基动力反应振动台试验数值分析方法

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防灾减灾工程学报 2022年第3期42卷 454-463页

作者：苏雷赵卓毕建巍解立波凌贤长青岛理工大学土木工程学院山东青岛266520 哈尔滨工业大学土木工程学院黑龙江哈尔滨150090 青岛双瑞海洋环境工程股份有限公司山东青岛266101

液化场地桩基动力响应是岩土地震工程领域重要的研究课题,而研究液化场地桩基动力响应有效的方法包括大型物理模型试验和数值模拟。鉴于此,针对已完成的振动台试验,采用FLAC^(3D)有限差分计算程序,建立了液化场地桩‑土动力相互振动台试... 详细信息

液化场地桩基动力响应是岩土地震工程领域重要的研究课题,而研究液化场地桩基动力响应有效的方法包括大型物理模型试验和数值模拟。鉴于此,针对已完成的振动台试验,采用FLAC^(3D)有限差分计算程序,建立了液化场地桩‑土动力相互振动台试验数值模型。在数值模拟中,承台采用实体单元,桩采用桩单元,柱墩采用梁单元,考虑液化效应的饱和砂土采用Finn模型,粘土采用Mohr‑Coulomb模型。模型边界采用自由场边界,采用弹簧‑滑块‑裂缝单元模拟桩‑土界面。通过对比振动台试验结果表明:建立的有限差分数值模型能够再现结构和地基的动力响应,进而验证了数值模型的可靠性。同时,分析了引起数值计算结果与试验结果差异的主要原因。所采用的数值分析方法对类似布置的桩‑土相互作用数值分析提供参考与借鉴。

关键词：桩基动力反应有限差分振动台试验液化场地

Mesenchymal stem cells ameliorate renal fibrosis by Galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat

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解剖学杂志 2021年第S1期44卷 220-221页

作者： Tang Huajun Zeng Lianlin Zhang Peiyue Zhao Yu xie libo Chen Bo Department of Human Anatomy School of Basic Medical SciencesSouthwest Medical UniversityLuzhou 646000 Department of Urology Sichuan Clinical Research Center for Nephropathythe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical University

Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney *** stromal cells(MSCs)have been verified with significant improvement i the therapy of fibrosis diseases,but the mechanism is still *** attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal *** model was induced by adenine *** marrow derived MSCs was injected by tail vein after modeling.

关键词： GSK3β renal diseases

Mesenchymal stem cells ameliorate renal fibrosis by Galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat

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Mesenchymal stem cells ameliorate renal fibrosis by Galectin...

中国解剖学会2021年年会

作者： Tang Huajun Zeng Lianlin Zhang Peiyue Zhao Yu xie libo Chen Bo Department of Human Anatomy School of Basic Medical SciencesSouthwest Medical University Department of Urology Sichuan Clinical Research Center for Nephropathythe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical University

Tubulointerstitial fibrosis (TIF) is one of the main pathological features of various progressive renal damages and chronic kidney *** stromal cells (MSCs) have been verified with significant improvement in the therapy of fibrosis diseases, but the mechanism is still *** attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal proteomics.

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古风·知足常乐

宝藏 2017年第1期 109-110页

作者：杨栋 xie libo 不详

赫然禹迹印，脚踏遍神州。治水丰功建，云根一足留。

关键词：常乐古风收藏美文词赋照片

Stilamin in the treatment of lymphatic leaks after living-related renal transplantation

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Stilamin in the treatment of lymphatic leaks after living-re...