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Cationic conjugated polymers for detection and inactivation of pathogens

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Science China Chemistry 2017年第12期60卷 1567-1574页

作者： Ping He Fengting Lv libing liu Shu Wang Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Conjugated polymers （CPs） are referred to a kind of fluorescent polymer materials with delocalized n-conjugated backbones. For the last decades, cationic CPs （CCPs） have been widely used in biosensor, imaging and biomedical fields due to their good photophysical properties and solubility in water medium resulting from side chain modification with ionized moieties. In this mini-review, we mainly introduced the applications of CCPs in detection and inactivation of pathogen with typical examples, and also briefly discussed the relevant mechanisms. We hold the expectation that this mini-review can offer researchers a general reference and inspire them to construct new systems with high performances of pathogen detection and antimicrobial activity.

关键词： conjugated polymers pathogen detection antimicrobial activity

Synthesis of amphiphilic poly(fluorene) derivatives for selective imaging of Staphylococcus aureus

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Science Bulletin 2018年第14期63卷 900-906页

作者： Ping He Fengting Lv libing liu Shu Wang Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences Beijing 100190 China College of Chemistry University of Chinese Academy of Sciences Beijing 100049 China

Three amphiphilic poly（fluorene-co-phenylene） derivatives with different side chains （PFP-I, PFP-2, PFP- 3） were designed and synthesized for exploring their detection and imaging of pathogens. Upon incuba- tion with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus oureus （S. aureus）. Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry （ITC） tests demonstrated that both electrostatic interactions and hydrophobic interac- tions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhi- bits great potential for specific imaging ors. aureus in a simple and rapid manner.

关键词： Conjugated polymers Pathogens S. aureus Selective imaging

Protein-assisted conjugated polymer microarray: Fabrication and sensing applications

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Chinese Science Bulletin 2013年第33期58卷 4039-4044页

作者： Lü FengTing FENG XuLi liu libing WANG Shu Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences

A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this *** water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm,which makes it compatible with a variety of commercial microarray *** is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without *** conjugated polymer microarray can be used for sensitive detection of picric acid(PA).A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray *** the simplicity of the preparation of the conjugated polymer microarray,it is anticipated that novel sensing platforms will be constructed by employing this versatile method.

关键词：共轭聚合物微阵列蛋白质传感制备应用聚合物芯片荧光信号

Oligo(p-phenylenevinylene)-rhodium complex as intracellular catalyst for enhancing biosynthesis of polyhydroxybutyrate biomaterials

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Science China Chemistry 2021年第1期64卷 143-150页

作者： Nan Dai Hao Zhao Wen Yu Fengting Lv libing liu Shu Wang Bejing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China College of Chemistry University of Chinese Academy of Sciences.Beijing 100049China

Microbial synthesis utilizes sustainable resources to produce valuable chemicals,as a potential alternative to petroleum-based chemical *** metabolic engineering is an efficient method to enhance the biosynthesis efficacy of microorganisms,it requires complicated biological ***,we report a facile intracellular catalysis system for augmenting the production of bio-based material in *** linking of oligo(p-phenylenevinylene)(OPV)and cyclopentadienyl rhodium(Ⅲ)bipyridine offers intracellular metal catalyst(OPV-Rh).The OPV-Rh complex displayed certain resistance to toxic biomolecules,which guaranteed its catalytic activity in complicated biological *** uptake by Gramnegative bacterium Ralstonia eutropha H16(*** H16),the OPV-Rh complex promotes the transformation of intracellular NADP+to NADPH,which further enhances the biosynthesis of polyhydroxybutyrate(PHB)by this *** work demonstrates that synthetic metal catalyst can be employed for regulating microbial biosynthesis intracellularly.

关键词： microbial synthesis rhodium complex NADPH PHB

STUDY ON NEW METHOD OF IDENTIFYING GEOMETRIC ERROR PARAMETERS FOR NC MACHINE TOOLS

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Chinese Journal of Mechanical Engineering 2001年第3期14卷 198-202,206页

作者： Yun Jintian,Wang Shuxin,liu libing,liu Youwu (College of Mechanical Engineering, Tianjin University) 天津大学机械学院天津

The methods of identifying geometric error parameters for NC machine tools are introduced. According to analyzing and comparing the different methods, a new method-displacement method with 9 lines is developed based on the theories of the movement errors of multibody system (MBS). A lot of experiments are also made to obtain 21 terms geometric error parameters by using the error identification software based on the new method.

关键词： NC machine tools Geometric error Parameter identification Multibody system

A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy

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Chinese Chemical Letters 2022年第10期33卷 4605-4609页

作者： Yunxia Wang Chuangxin Zhang Hui Zhang Liheng Feng libing liu School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China Department of Nutrition and Health China Agricultural UniversityBeijing 100193China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China

It is of great significance to develop effective antibacterial agents and methods to combat drug resistant bacterial infections due to its increasing threaten to human health and the ineffectiveness of ***,a multifunctional hybrid nano-assembly(M1-Fe NPs)based on conjugated oligomer and ferrous ion was engineered with favorable bactericidal activity for synergetic antibacterial *** chelation of ferrous ion not only enhances the photothermal conversion efficiency of M1 but also endows the nano-assembly with catalytic capability of transferring H_(2)O_(2) into stronger oxidant hydroxyl radicals(·OH).Meanwhile,the generated heat can further promote the Fenton reaction *** generating cytotoxic heat and oxidative·OH,M1-Fe NPs can effectively kill Staphylococcus aureus in vitro and in vivo with the aid of low dosage of H_(2)O_(2).The work provides a new multifunctional platform for combinational drug resistant antibacterial therapy and even antitumor therapy.

关键词： Conjugated oligomer Nano-assembly Fenton reaction Photothermal therapy Bacterial infections

Conjugated Polymer Nanomaterials for Phototherapy of Cancer

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Chemical Research in Chinese Universities 2020年第2期36卷 237-242页

作者： FU Xuancheng BAI Haotian LYU Fengting liu libing WANG Shu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China College of Chemistry University of Chinese Academy of SciencesBeijing 100049P.R.China

Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past *** to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination *** this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological ***,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine.

关键词： Conjugated polymer nanomaterial Cancer therapy Photodynamic therapy Photothermal therapy Combi nation therapy

MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers

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Chinese Science Bulletin 2013年第22期58卷 2762-2766页

作者： FENG XuLi Lü FengTing liu libing WANG Shu Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences

A cationic dendritic polyfluorene (PFP) is examined as a siRNA delivery vector. This material was designed to facilitate the nucleic acid binding, encapsulation and efficient cellular uptake. PFP can effectively protect siRNA against nuclease degradation, which is necessary for gene carriers. PFP can be used for multidrug resistance gene-targeted siRNA delivery in doxorubicin (Dox)-resistant human breast cancer cells (MCF7) cells. As a siRNA transfection agent, PFP can efficiently achieve the reversal of drug resistance and enhance the drug sensitivity. These new features and capabilities represent a major step toward conjugated polymers that can function for therapeutic application.

关键词： siRNA 共轭聚合物阳离子 MDRL 树突传递多药耐药基因人乳腺癌细胞

Efficient purification of Al_(30) by organic complexation method

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Journal of Environmental Sciences 2019年第6期31卷 240-247页

作者： libing liu Qinxue Yang Pin Wang Feng Xiao Ruyuan Jiao Guangyu An Dongsheng Wang University of Chinese Academy of Sciences State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Faculty Materials Science and Chemistry China University of Geosciences

A method was developed for preparing high purity Al30O8(OH)56(H2O)_(24)^(18)+(Al30) through elimination of impurities by *** chloride II(PAC_(30))with Al_(c )content of 75%was adopted as the source of Al_(30).The PAC_(30)was prepared under conditions of total aluminum concentration 0.1 mol/L and OH^-/Al ratio 2.2 to obtain the highest content of Al_(30).A precipitation/metathesis method,organic solvent precipitation method and organic complexation method were examined to separate and purify Al_(30).It was found that only by the organic complexation method could high purity Al_(30)products be obtained in large yield *** the experiments,benzoic acid was used as the coordinating reagent to decompose the main impurity AlO_4Al_(12)(OH)_(24)(H_2O)_(12)^(7+)(Al_(13)),and the Al_(30)product could be obtained by precipitation and metathesis *** was noteworthy that the decomposition of impurities by benzoic acid could be completed in 2 *** Al_(30)product was characterized by Ferron assay,^(27)Al-NMR,SEM,XRD and *** results showed that the purity of the Al_(30)product could exceed 92%.

关键词： Polyaluminum chloride(PAC) Al13 Al30 Organic complexation Precipitation/metathesis