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A Novel Nonlinear Parameter Estimation Method of Soft Tissues

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Genomics, Proteomics & Bioinformatics 2017年第6期15卷 371-380页

作者： Qianqian Tong Zhiyong yuan Mianlun Zheng Xiangyun liao Weixu Zhu Guian zhang School of Computer Wuhan University Shenzhen Key Laboratory of Virtual Reality and Human Interaction Technology Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

The elastic parameters of soft tissues are important for medical diagnosis and virtual surgery simulation. In this study, we propose a novel nonlinear parameter estimation method for soft tissues. Firstly, an in-house data acquisition platform was used to obtain external forces and their corresponding deformation values, To provide highly precise data for estimating nonlinear param- eters, the measured forces were corrected using the constructed weighted combination forecasting model based on a support vector machine （WCFM_SVM）. Secondly, a tetrahedral finite element parameter estimation model was established to describe the physical characteristics of soft tissues, using the substitution parameters of Young＇s modulus and Poisson＇s ratio to avoid solving compli- cated nonlinear problems. To improve the robustness of our model and avoid poor local minima, the initial parameters solved by a linear finite element model were introduced into the parameter estimation model. Finally, a self-adapting Levenberg-Marquardt （LM） algorithm was presented, which is capable of adaptively adjusting iterative parameters to solve the established parameter estimation model. The maximum absolute error of our WCFM SVM model was less than 0.03 Newton, resulting in more accurate forces in comparison with other correction models tested. The maximum absolute error between the calculated and measured nodal displacements was less than 1.5 mm, demonstrating that our nonlinear parameters are precise.

关键词： Nonlinear parameter estimation Finite element method Substitution parameters Force correction Self-adapting Levenberg-Marquardt algorithm

Static and dynamic finite element analysis of 304 stainless steel rod and wire hot continuous rolling process

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Journal of University of Science and Technology Beijing 2008年第3期15卷 324-329页

作者： Siyu yuan Liwen zhang Shulun liao Mao Li Min Qi Yu Zhen Shuqi Guo School of Materials Science and Engineering Dalian University of Technology Dalian 116023 China State Key Laboratory of Materials Modification by Laser Ion and Electron Beams Dalian University of Technology Dalian 116023 China Dongbei Special Steel Group Corporation Dalian 116031 China

Three-dimensional finite element models were developed to analyze 304 stainless steel rod and wire hot continuous rolling process with the help of *** software. The entire 30-pass deformation process and the actual parameters of production line were taken into account. Static and dynamic procedures were used to study the continuous rolling process with the aid of the thermo-mechanical coupled FEM of elastic-plasticity. The properties of billets, such as deformation, temperature field and rolling force, were mainly discussed. The simulation results of temperature agree well with the measured values. Comparisons of the analysis results obtained using static implicit method and dynamic implicit method were presented. It is shown that static implicit procedure is more accurate than dynamic implicit procedure and is able to simulate the rolling process with a lower speed, such as a roughing mill. Whereas, dynamic analysis shows a higher efficiency than static analysis and is fit for simulating the rolling process with a higher speed, such as a finishing mill.

关键词： 304 stainless steel static implicit dynamic implicit three-dimensional simulation continuous rolling

Enhancing the performance of poly(3-hexylthiophene)/ZnO nanorod arrays based hybrid solar cells through incorporation of a third component

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Science China(Physics,Mechanics & Astronomy) 2014年第7期57卷 1289-1298页

作者： ZHONG Peng QUE WenXiu zhang Jin yuan yuan liao YuLong YIN XingTian KONG LingBing HU Xiao Electronic Materials Research Laboratory School of Electronic and Information Engineering Xi'an Jiaotong University International Center for Dielectric Research Xi'an Jiaotong University School of Materials Science and Engineering Nanyang Technological University

Sparse ZnO nanorod arrays(NRAs)are fabricated on transparent conducting oxide coated glass substrates by using a modified liquid phase epitaxial growth *** adjusting the polymer concentrations and the spin-coating parameters,full infiltration of poly(3-hexylthiophene)(P3HT)into the as-prepared ZnO NRAs is achieved at 130°C in vacuum.A third component is incorporated into the P3HT/ZnO NRAs ordered bulk heterojunctions(BHJs)either through ZnO surface modification with N719dye or CdS shell layer or by inclusion of a fullerene derivative into the P3HT *** results indicate that performances of the hybrid solar cells are improved greatly with the incorporation of a third ***,the working principles of these third components differ from one another,according to morphology,structure,optical property,charge transfer and interfacial properties of the composite *** ideal device architecture for hybrid solar cells based on P3HT/ZnO NRAs ordered BHJs is proposed,which can be used as a guidance to further increase the power conversion efficiency of such solar cells.

关键词： hybrid solar cell zinc oxide conjugated polymer surface modification bulk heterojunction power conversion efficiency

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柳州市葡萄产业现状与优势及发展对策

气象研究与应用 2017年第3期38卷 77-80页

作者：刘永裕赵志晖刘梅唐国敏廖媛章柳州市农业气象试验站广西柳州545003 柳州市柳北区农业服务中心广西柳州545001 柳州市气象局广西柳州545001

为了保障柳州市葡萄产业的稳步发展,对柳州市葡萄产业发展现状以及优势条件进行分析,找出限制双季葡萄的制约因素,提出葡萄产业未来发展的相关对策。

关键词：柳州双季葡萄优势限制因素对策

Identification and quantification of the bioactive components in Osmanthus fragrans roots by HPLC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第3期11卷 299-307页

作者： Xiaoyan liao yuan Hong Zilin Chen Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsSchool of Pharmaceutical SciencesWuhan UniversityWuhan430071China State Key Laboratory of Transducer Technology Chinese Academy of SciencesBeijing100080China

The roots of O. fragrans are also a valuable resource in addition to its flowers and fruits. In this study, the HPLC-MS/MS method used for analyzing the chemical constituents in O. fragrans roots extract was developed, which showed high sensitivity for both qualitative and quantitative analyses. Thirty-two compounds were first discovered in O. fragrans roots, one compound of which was reported for the first time. The simultaneous determination method for acteoside, isoacteoside, oleuropein and phillyrin was validated to be sensitive and accurate. Then it was applied to determine the content of bioactive components in O. fragrans roots from different cultivars. The content of oleuropein and phillyrin in the twelve batches was relatively stable, while the content of acteoside and isoacteoside varied ***, the therapeutic material basis and mechanism of O. fragrans roots exerting its traditional pharmacodynamics were analyzed by network pharmacology. The results showed that O. fragrans roots might be effective for the treatment of inflammation, cardiovascular diseases, cancer, and rheumatoid arthritis, which is consistent with the traditional pharmacodynamics of O. fragrans roots. This work can provide an analytical method for the comprehensive development of O. fragrans roots.

关键词： Osmanthus fragrans roots HPLC-MS/MS Identification Quantitation Bioactive constituents Network pharmacology

A New Method for Deriving High-Vertical-Resolution Wind Vector Data from the L-Band Radar Sounding System in China

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Advances in Atmospheric Sciences 2024年第11期41卷 2192-2202页

作者： Fang yuan Zijiang ZHOU Jie liao National Meteorological Information Center China Meteorological AdministrationBeijing 100081China

High-vertical-resolution radiosonde wind data are highly valuable for describing the dynamics of the meso-and microscale atmosphere. However, the current algorithm used in China's L-band radar sounding system for calculating highvertical-resolution wind vectors excessively smooths the data, resulting in significant underestimation of the calculated kinetic energy of gravity waves compared to similar products from other countries, which greatly limits the effective utilization of the data. To address this issue, this study proposes a novel method to calculate high-vertical-resolution wind vectors that utilizes the elevation angle, azimuth angle, and slant range from L-band radar. In order to obtain wind data with a stable quality, a two-step automatic quality control procedure, including the RMSE-F(root-mean-square error F) test and elemental consistency test are first applied to the slant range data, to eliminate continuous erroneous data caused by unstable signals or radar malfunctions. Then, a wind calculation scheme based on a sliding second-order polynomial fitting is utilized to derive the high-vertical-resolution radiosonde wind vectors. The evaluation results demonstrate that the wind data obtained through the proposed method show a high level of consistency with the high-resolution wind data observed using the Vaisala Global Positioning System and the data observed by the new Beidou Navigation Sounding System. The calculation of the kinetic energy of gravity waves in the recalculated wind data also reaches a level comparable to the Vaisala observations.

关键词： L-band radar sounding system upper air high-vertical-resolution radiosonde wind vectors quality control polynomial fitting

Determination of bioactive components in the fruits of Cercis chinensis Bunge by HPLC-MS/MS and quality evaluation by principal components and hierarchical cluster analyses

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Journal of Pharmaceutical Analysis 2021年第4期11卷 465-471页

作者： yuan Hong Xiaoyan liao Zilin Chen Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsSchool of Pharmaceutical SciencesWuhan UniversityWuhan430071China State Key Laboratory of Transducer Technology Chinese Academy of SciencesBeijing100080China

The fruits of leguminous plants Cercis Chinensis Bunge are still overlooked although they have been reported to be antioxidative because of the limited information on the phytochemicals of *** fruits.A simple,rapid and sensitive HPLC-MS/MS method was developed for the identification and quantitation of the major bioactive components in *** *** polyphenols were identified,which are first reported in *** ***,ten components were simultaneously *** validated quantitative method was proved to be sensitive,reproducible and ***,it was applied to analyze batches of *** fruits from different phytomorph and *** principal components analysis(PCA)realized visualization and reduction of data set dimension while the hierarchical cluster analysis(HCA)indicated that the content of phenolic acids or all ten components might be used to differentiate *** fruits of different phytomorph.

关键词： C.chinensis fruits HPLC-MS/MS Polyphenols Principal components analysis Hierarchical cluster analysis

Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy:advances and perspectives

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1253-1278页

作者： yuan Fang Guochao liao Bin Yu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China International Institute for Translational Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou 510006China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Blocking the MDM2/X-P53 protein-protein interaction has been widely recognized as an attractive therapeutic strategy for the treatment of *** small-molecule MDM2 inhibitors have been reported since the release of the structure of the MDM2-P53 interaction in 1996,SAR405838,NVP-CGM097,MK-8242,RG7112,RG7388,DS-3032 b,and AMG232 currently undergo clinical evaluation for cancer *** review is intended to provide a comprehensive and updated overview of MDM2 inhibitors and proteolysis targeting chimera(PROTAC)degraders with a particular focus on how these inhibitors or degraders are identified from starting points,strategies employed,structure-activity relationship(SAR)studies,binding modes or co-crystal structures,biochemical data,mechanistic studies,and preclinical/clinical ***,we briefly discuss the challenges of designing MDM2/X inhibitors for cancer therapy such as dual MDM2/X inhibition,acquired resistance and toxicity of P53 activation as well as future directions.

关键词： MDM2/X-P53 interaction MDM2/X inhibitors PROTAC degraders Cancer therapy

Age Structure of Two Species of Odorous Frogs(Odorrana margaretae and Odorrana grahami)

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Asian Herpetological Research 2021年第3期12卷 308-314页

作者： LIANJU yuan MAOJUN ZHONG WENBO liao Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchong 637009SichuanChina Key Laboratory of Artificial Propagation and Utilization in Anurans of Nanchong City China West Normal UniversityNanchong 637009SichuanChina Institute of Eco-adaptation in Amphibians and Reptiles China West Normal UniversityNanchong 637009SichuanChina

Variation in age structure and body size benefits are identified to understand the evolution of life ***,we estimated the age structure and body size of two species of odorous frogs(Odorrana margaretae and Odorrana grahami)by using *** ages at sexual maturity of *** and *** in both sexes were 1 and 2 years,*** both sexes,the maximum age observed in *** was six *** ***,the maximum age observed in males and females were 4 and 5 years,*** and females did not differ in mean age in the two *** average body size of both species considerably differed between sexes,with females being larger than *** body size of females was also larger than that of males when the effect of age was *** also found positive correlations between body size and age within each sex in ***,but only for female in *** female-biased sexual size dimorphism of the two species suggested that fecundity selection for larger female size may increase the reproductive output.

关键词： age structure body size odorous frogs skeletochronology