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Hydrothermal Synthesis and Structure of [(PbCl_2)(μ-Pyz)_(1/2)]_n (Pyz = Pyrazine)

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Chinese Journal of Structural Chemistry 2006年第7期25卷 789-792页

作者： liao Qiu-Xia zhang Jian QIN Ye-Yan YAO yuan-Gen State Key Laboratory of Structural Chemistry Fujian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

A novel 2-D lead-containing hybrid compound, [（PbCl2）（μ-Pyz）1/2], （Pyz = pyrazine） 1, has been synthesized by the hydrothermal assembly of pyrazine with lead chloride. Elemental analysis and X-ray crystal structure analyses were carded out for the structural determination and characterization of the title compound. Compound 1 crystallizes in orthorhombic, space group lbam, with a = 19.5558（18）, b = 7.1939（6）, c = 7.5449（6） A, V = 1061.44（16） .A^3, C2H2Cl2NPb, Mr= 318.14, Z = 8, Dc= 3.982 g/cm^3, μ = 32.63 mm^-1, F（000） = 1096.0, R = 0.0368 and wR = 0.0901 for 623 observed reflections （I 〉 2σ（I））.

关键词： crystal structure lead chloride pyrazine

Dynamics-based optimization of rolling schedule aiming at dual goals of chatter suppression and speed increase for a 5-stand cold tandem rolling mill

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Journal of Iron and Steel Research International 2021年第2期28卷 168-180页

作者： Zhi-ying Gao Bo Tian Yang Liu Li-yuan zhang Mao-lin liao School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the process of cold tandem rolling,chatter instability leads to serious impacts on enhancing rolling speed,improving product quality,reducing production cost and realizing *** occurs with the rolling speed up to a certain threshold value,but the critical speed is determined by both product specifications and rolling schedules.A 5-stand cold tandem rolling mill whose first three stands and subsequent two stands,respectively,have four and six rolls was investigated by formulating its dynamic equations with the corresponding structure-process *** applying the stability-based calculation model about the critical rolling speed in each stand,the system dynamic responses around the critical rolling speed were simulated,and the system eigenvalues which represent instability and characteristic frequencies were figured ***,via combining the critical rolling speeds with the system dynamic behavior,a dynamics-based optimization model of rolling schedule for the 5-stand cold tandem system was proposed for the purposes of both the chatter suppression and rolling speed *** the optimization model,eight rolling technique parameters(four strip thicknesses and four tensions between the upstream and downstream stands)were taken as design variables,and the constraint conditions were set as no chatter instability in all five stands,and the optimization goal was to maximize the outlet speed of the final *** pattern search method was introduced to solve the optimization *** applying such a dynamics-based optimization model for the 5-stand cold tandem rolling process,the chatter instability was suppressed effectively and the rolling efficiency was improved considerably;therefore,such an optimization model is expected to be valuable for intelligent manufacturing of rolling process.

关键词： Cold tandem rolling Chatter Critical rolling speed Rolling schedule Dynamics-based optimization Stability

艾灸调节circ Pan3/mi R-667-5p/Ghrelin信号通路减轻膝骨关节炎大鼠的软骨病变

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中国组织工程研究 2025年第12期29卷 2475-2483页

作者：廖晴曾静陈峻袁立霞刘刚南方医科大学中医药学院广东省广州市510000 南方科技大学医院广东省深圳市518000 南方医科大学南方医院康复科广东省广州市510000

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghre... 详细信息

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghrelin信号通路探究艾灸对大鼠膝骨关节炎软骨的影响。方法:SD大鼠随机分为假手术组、模型组和艾灸组(n=10),对后2组大鼠行右后肢膝关节前交叉韧带横断和内侧半月板部分切除术建立膝骨关节炎大鼠模型;假手术组大鼠仅接受关节囊切开术。6周后,艾灸组大鼠每日艾灸“足三里”“肾俞”穴区20 min,持续4周,其余2组不予以特殊处理。4周后通过组织病理学染色观察膝关节滑膜病变和软骨损伤程度,通过酶联免疫吸附实验检测血清中炎症因子白细胞介素6和肿瘤坏死因子α的变化。此外,取上述3组大鼠右侧膝关节软骨细胞分为:正常对照组、模型组和艾灸组,通过Western blot和qRT-PCR检测各组细胞中软骨基质合成代谢分子(Ⅱ型胶原蛋白和Sox9)、基质降解分子(基质金属蛋白酶13和ADAMTS5)、自噬标志物(ATG5、Beclin-1、微管相关蛋白1轻链3)、Ghrelin、CircPan3以及miR-667-5P的表达水平。结果与结论:①治疗4周后,相对于假手术组,模型组大鼠滑膜显著增厚,炎症细胞浸润显著,关节间隙狭窄,软骨表面粗糙不平,变薄,软骨细胞数量减少,滑膜炎和OARSI评分显著升高,白细胞介素6和肿瘤坏死因子α水平明显上调(P<0.0001);与模型组相比,艾灸组滑膜增厚减轻,炎症细胞浸润减少,关节间隙增宽,软骨更光滑完整、变厚,软骨细胞数量增多,滑膜炎和OARSI评分降低,白细胞介素6和肿瘤坏死因子α水平显著降低(P<0.0001)。②体外实验结果表明,与正常对照组相比,模型组软骨细胞基质金属蛋白酶13、ADAMTS5和miR-667-5P表达增多,Ⅱ型胶原蛋白、Sox9、自噬标志物、Ghrelin和Circpan3表达减少(P<0.01);与模型组相比,艾灸可逆转上述指标改变(P<0.01)。③结果说明艾灸可能通过调节circPan3/miR-667-5p/Ghrelin信号通路增强软骨细胞自噬,抑制膝骨关节炎炎症和软骨破坏,对软骨发挥保护作用。

关键词：膝骨关节炎艾灸 ghrelin 软骨自噬大鼠信号通路

Freeze-Drying Formulations Increased the Adenovirus and Poxvirus Vaccine Storage Times and Antigen Stabilities

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Virologica Sinica 2021年第3期36卷 365-372页

作者： Ye Chen Qibin liao Tianyue Chen Yuchao zhang Weien yuan Jianqing Xu Xiaoyan zhang Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 201508China Engineering Research Center of Cell and Therapeutic Antibody Ministry of Educationand School of PharmacyShanghai Jiao Tong UniversityShanghai 200000China

Successful vaccines induce specific immune responses and protect against various viral and bacterial infections. Noninactivated vaccines, especially viral vector vaccines such as adenovirus and poxvirus vaccines, dominate the vaccine market because their viral particles are able to replicate and proliferate in vivo and produce lasting immunity in a manner similar to natural infection. One challenge of human and livestock vaccination is vaccine stability related to the antigenicity and infectivity. Freeze-drying is the typical method to maintain virus vaccine stability, while cold chain transportation is required for temperatures about 2 °C–8 °C. The financial and technological resource requirements hinder vaccine distribution in underdeveloped areas. In this study, we developed a freeze-drying formula consisting of bovine serum albumin(BSA), L-glutamic acid(L-Glu), polyethylene glycol(PEG), and dextran(DEX) to improve the thermal stability and activity of viral vaccines, including vaccinia recombinant vaccine(rTTV-OVA) and adenovirus vaccine(Ad5-ENV). We compared a panel of five different formulations(PEG: DEX: BSA: L-GLU = 50:9:0:0(#1), 50:5:4:0(#2), 50:10:9:0(#3),50:0:0:9(#4), and 50:1:0:8(#5), respectively) and optimized the freeze-drying formula for rTTV-OVA and Ad5-ENV. We found that the freeze-drying formulations #2 and #3 could maintain rTTV-OVA infectivity at temperatures of 4 °C and25 °C and that r TTV-OVA immunogenicity was retained during lyophilization. However, formulations #4 and #5 maintained Ad5-ENV infectivity under the same conditions, and Ad5-ENV immunogenicity had maximum retention with freeze-drying formulation #4. In summary, we developed new freeze-drying formulations that increased virus vaccine storage times and retained immunogenicity at an ambient temperature.

关键词： Adenovirus vaccine Poxvirus vaccine Freeze-drying formulation Stability Immunogenicity

Wide area measurements based fault detection and location method for transmission lines

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Protection and Control of Modern Power Systems 2019年第1期4卷 53-64页

作者： Wen Fan yuan liao Department of Electrical and Computer Engineering University of KentuckyLexingtonKY40506USA

Electric power grids are critical infrastructure for delivering energy from generation stations to load centers. To maximize utilization of assets, it is desirable to increase the power transferred over transmission systems. Reliable protection of transmission systems is essential for safeguarding the integrity and reliability of the power grid. Distance protection is the most widely used scheme for protecting transmission lines. Most existing protection systems use local measurements to make a decision while pilot protection is used in some circumstances. Distance protection may fail under stressed operating conditions, which could lead to cascading faults. This paper proposes a system integrity protection scheme by utilizing wide area measurements. The scheme partitions the system into subnetworks or protection zones and employs current measurements to derive a fault identification vector indicating the faulted zone. Then the fault location is pinpointed based on wide area measurements and network data. The proposed method is able to deal with multiple, simultaneous faults, and is applicable to both transposed and untransposed lines. Evaluation studies based on simulation studies are presented.

关键词： System integrity protection scheme Fault location Transmission systems

Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(Life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng yuan Xihao liao Shuang Li Xin-Hui Xing Chong zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

Leaching behavior of zinc and copper from zinc refinery residue and filtration performance of pulp under the hydrothermal process

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 21-32页

作者： Lei Cao Ya-long liao Gong-chu Shi Yu zhang Mu-yuan Guo Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology

This study aims to investigate the leaching behavior and filtration performance of zinc refinery residue under hydrothermal conditions. The relationships between the structure and morphology of silicon in the leaching residue and the pulp filtration performance were explored by determining the pulp filtration speed, analyzing quantitatively the silicon content in the leachate, and characterizing the leaching residue structure. The results show that hydrothermal leaching induces the coagulation–hydrolysis of the silicon in solution, consequently altering the microstructure of the leaching residue, and that silicon oxygen tetrahedra([SiO_4]^(4-)) form the main skeleton structure of the residue. The results obtained also show that the leaching rates of zinc and copper are 98.1% and 98.7%, respectively, and that the filtration speed is 526.32 L/(m^2·h) under the conditions of sulfuric acid concentration of 140 g/L, leaching temperature of 160°C, leaching time of 3.0 h, oxygen partial pressure of 0.75 MPa, stirring speed of 600 r/min, and a liquid-to-solid ratio of 10 mL/g.

关键词： zinc refinery residue hydrothermal leaching filtration performance mesoporous structure

Astrocytes in depression and Alzheimer’s disease

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Frontiers of Medicine 2021年第6期15卷 829-841页

作者： Yang liao Qu Xing Qianqian Li Jing zhang Ruiyuan Pan Zengqiang yuan The Brain Science Center Beijing Institute of Basic Medical SciencesBeijing 100850China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Astrocytes are an abundant subgroup of cells in the central nervous system(CNS)that play a critical role in controlling neuronal circuits involved in emotion,learning,and *** clinical cases,multiple chronic brain diseases may cause psychosocial and cognitive impairment,such as depression and Alzheimer’s disease(AD).For years,complex pathological conditions driven by depression and AD have been widely perceived to contribute to a high risk of disability,resulting in gradual loss of self-care ability,lower life qualities,and vast burden on human ***,correlational research on depression and AD has shown that depression might be a prodrome of progressive degenerative neurological *** a kind of multifunctional glial cell in the CNS,astrocytes maintain physiological function via supporting neuronal cells,modulating pathologic niche,and regulating energy *** evidence has shown that astrocytic dysfunction is involved in the progression of depression and *** herein review the current findings on the roles and mechanisms of astrocytes in the development of depression and AD,with an implication of potential therapeutic avenue for these diseases by targeting astrocytes.

关键词： astrocytes depression Alzheimer’s disease roles mechanisms

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda zhang Weimin yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$