检索结果-南通市图书馆

Laparoscopic radical prostatectomy： oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

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Asian Journal of Andrology 2009年第5期11卷 548-556,I0001,I0002页

作者： Xin Gao Jian-Hua Zhou liao-yuan li Jian-Guang Qiu Xiao-Yong Pu Department of Urology The Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

In this study we evaluate the oncological and functional results of the largest cohort of patients in China treated by laparoscopic radical prostatectomy （LRP） and with at least 3 years of follow-up. 126 inconsecutive patients （range 56-78 years, median 62.5） who had an LRP were retrospectively analyzed. The mean prostate specific antigen level and Gleason score was 13.4 ng mL^-1 and 6.4, respectively. Twenty-seven patients had unilateral or bilateral nerve preservation and 29 had pelvic lymphadenectomy. Multivariate analysis was used to adjust for differences in clinical and pathological features when comparing the risk for biochemical progression-free survival （bPFS）. Urinary continence was assessed by incontinence questionnaire and erectile function by the Sexual Health Inventory for Men score. The mean operative duration was 250 min and blood loss 354 mL. Five patients received blood transfusion and nine had complications, including rectal injury （two）, ureteral injury （one）, active bleeding （one）, bladder neck stenosis （two）, paralytic ileus （one）, subcutaneous hematoma （one） and port-site hernia （one）. The overall positive surgical margin rate was 20.6% and correlated with pathological stage and Gleason score respectively （P = 0.03, P 〈 0.001 respectively）. All patients had 〉 3 years of follow-up （range 3-6.75 years, mean 4.6, median 4.75）. At 3 years of follow-up, the overall survival rate was 100% and the bPFS was 81.0% in all patients; 124 patients （98.4%） were continent; 22 of 27 patients （81.5%） who underwent nerve preservation retained erectile function. Our series confirms that LRP is an effective, safe and precise technique at Chinese institution.

关键词： complication follow-up laparoscopic surgery prostate cancer prostatectomy survival

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^(68)Ga-PSMA ligand PET/CT integrating indocyanine green-guided salvage lymph node dissection for lymph node metastasis after radical prostatectomy

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Asian Journal of Andrology 2022年第1期24卷 97-101页

作者： Teng-Cheng li Yu Wang Chu-Tian Xiao Ming-Zhao li Xiao-Peng liu Wen-Tao Huang liao-yuan li Ke li Jin-Ming Di Xing-Qiao Wen Xin Gao Department of Urology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

To efficiently remove all recurrent lymph nodes(rLNs)and minimize complications,we developed a combination approach that consisted of ^(68)Gallium prostate-specific membrane antigen(PSMA)ligand positron emission tomography(PET)/computed tomography(CT)and integrated indocyanine green(ICG)-guided salvage lymph node dissection(sLND)for rLNs after radical prostatectomy(RP).Nineteen patients were enrolled to receive such treatment.^(68)Ga-PSMA ligand PET/CT was used to identify rLNs,and 5 mg of ICG was injected into the space between the rectum and bladder before *** laparoscopy was used to perform *** extensive LN dissection was performed at level I,another 5 mg of ICG was injected via the intravenous route to intensify the fluorescent signal,and laparoscopy was introduced to intensively target stained LNs along levels I and II,specifically around suspicious LNs,with ^(68)Ga-PSMA ligand PET/***,both lateral peritonea were exposed longitudinally to facilitate the removal of fluorescently stained LNs at levels III and *** total,pathological analysis confirmed that 42 nodes were *** 145 positive LNs stained with ICG,24 suspicious LNs identified with ^(68)Ga-PSMA ligand PET/CT were *** sensitivity and specificity of ^(68)Ga-PSMA ligand PET/CT for detecting rLNs were 42.9%and 96.6%,*** ICG,the sensitivity was 92.8%and the specificity was 39.1%.At a median follow-up of 15(interquartile range[IQR]:6–31)months,15 patients experienced complete biochemical remission(BR,prostate-specific antigen[PSA]line in the PSA level,but it remained>0.2 ng ml−***,^(68)Ga-PSMA ligand PET/CT integrating ICG-guided sLND provides efficient sLND with few complications for patients with rLNs after RP.

关键词： indocyanine green prostate cancer recurrent lymph node salvage lymph node dissection

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Loupe-assisted versus microscopic varicocelectomy： s there an intraoperative anatomic difference？

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Asian Journal of Andrology 2014年第1期16卷 112-114页

作者： Hao Zhang Xiao-Peng liu Xiao-Jian Yang Wen-Tao Huang Xing-Xing Ruan Heng-Jun Xiao liao-yuan li Xin Gao Yan Zhang Department of Urology The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China

The aim of this study was to compare the intraoperative difference in anatomic details between Ioupe-assisted and microscopic varicocelectomy within the same spermatic cord. Between April 2011 and August 2011, 26 men with 33 sides containing grade 2-3 varicocele were enrolled in this study. First, one surgeon performed the open inguinal varicocelectomy under x 3.5 Ioupe magnification. The presumed vascular channels and lymphatics were isolated and marked without ligation. Another surgeon then microsurgically dissected and checked the same spermatic cord using an operating microscope to judge the results in terms of the ligation of the internal spermatic veins and the preservation of the arteries and lymphatics. There were significant differences in the average number of internal spermatic arteries （1.51 vs 0.97）, internal spermatic veins （5.70 vs 4.39） and lymphatics （3.52 vs 1.61） between the microscope and Ioupe-assisted procedures （P 〈 0.001, P 〈 0.001, P 〈 0.001, respectively）. Meanwhile, in varicocele repair with Ioupe magnification, an average of 1.30 β± 1.07 （43/33） internal spermatic veins per side were missed, among the overlooked veins, 1.12 ± 0.93 （37/33） were adhered to the preserved testicular artery, as well as 0.55 ± 0.79 lymphatics and 0.36 ± 0.55 arteries that were to be ligated. In conclusion, microscopic varicocelectomy could preserve more internal spermatic arteries and lymphatics and could ligate more veins than the Ioupe-assisted procedure. To some degree, Ioupe magnification is inadequate for the reliable identification and dissection of the tiny vessels of the spermatic cord, as most of the overlooked veins were adhered to the preserved testicular artery.

关键词： intraoperative difference Ioupe-assisted microscopic varicocelectomy

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The influence of autophagy on mouse inflammatory responses caused by Salmonella enterica serovar Typhimurium with spv genes

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微生物与感染 2011年第4期6卷 205-213页

作者： li yuan-yuan WU Shu-Yan CHU yuan-yuan liao li li Qiong HUANG Rui Department of Medical Microbiology Medical School of Soochow University Suzhou 215123 China

An investigation into the effects of Salmonella plasmid virulence genes (spv) on autophagy, apoptosis, and inflammation was carried out in mice, using a strain of Salmonella enterica serovar Typhimurium (S. typhimurium) SR-11 carrying spv. Strain BRD509 without spv was used as a control. Results showed that the expression of autophagy protein Beclin-1 in the livers and spleens in the SR-11 group was lower than that in the BRD509 group, while the apoptosis protein, Caspase-3, was higher in the SR-11 group. Inflammatory cytokine levels [interleukin 12 (IL-12) and interferon γ (IFN-γ)] were higher in the SR-11 group compared with those in the BRD509 group since 4 d post-infection. In addition, we found an increase in severe pathological changes and larger viable bacterial amounts in livers and spleens in the SR-11 group. After intervention with autophagy agonist rapamycin (RAPA), Beclin-1 expression increased in both groups, while Caspase-3 expression was different between the two groups: Caspase-3 decreased in the SR-11 group but increased in the BRD509 group. Moreover, RAPA decreased cytokine levels, bacterial quantity and organ-related injury in the SR-11 group whereas RAPA increased cytokine levels and aggravated organ injury in the BRD509 group. Results from these studies suggest that S. typhimurium with spv genes may exacerbate infection by inhibiting autophagy and affecting the production of inflammatory cytokines. RAPA-enhanced autophagy may improve the secretion of cytokines in order to protect the host from damaging by Salmonella infection. Our study suggests that the regulation of cellular autophagy may play a role in the prevention and control of certain infectious diseases.

关键词：沙门氏菌质粒蛋白质微生物临床分析

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我国图书馆空间研究演进的可视化分析

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情报科学 2018年第12期36卷 106-110页

作者：廖远丽罗瑞林中南财经政法大学中韩新媒体学院湖北武汉430074 内蒙古农业大学图书馆内蒙古呼和浩特010018

【目的/意义】本文从文献发文量、关键词频次、关键词聚类等方面,研究我国图书馆空间的研究热点、主题演进情况,为今后该方向的科学研究与实际工作提供借鉴。【方法/过程】以中国知网期刊数据库为数据来源,以图书馆空间期刊论文为研究对... 详细信息

【目的/意义】本文从文献发文量、关键词频次、关键词聚类等方面,研究我国图书馆空间的研究热点、主题演进情况,为今后该方向的科学研究与实际工作提供借鉴。【方法/过程】以中国知网期刊数据库为数据来源,以图书馆空间期刊论文为研究对象,利用文献计量学方法与可视化方法对论文进行分析。【结果/结论】我国图书馆空间的研究热点层次较为分明,宏观主题与微观主题并存,主题演进阶段性特征明显。图书馆空间研究热点主题偏向于具体空间类型的实践类借鉴与总结,应进一步加强基础性理论的研究和思考。

关键词：图书馆空间研究热点主题演进

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雷帕霉素对伤寒沙门菌质粒pR_(ST98)与巨噬细胞相互作用的影响

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现代免疫学 2010年第4期30卷 276-281页

作者：李琼吴淑燕储元元廖莉李嫄渊黄瑞苏州大学医学部基础医学与生物科学学院苏州215123

研究自噬诱导剂雷帕霉素(RAPA)对伤寒沙门菌质粒pRST98与巨噬细胞相互作用的影响。用加入RAPA和未加药的RPMI1640培养巨噬细胞J774A.1后,分别与携带pRST98的伤寒沙门菌ST8,无质粒的伤寒沙门菌ST10和鼠伤寒沙门菌标准毒株SR-11共作用,观... 详细信息

研究自噬诱导剂雷帕霉素(RAPA)对伤寒沙门菌质粒pRST98与巨噬细胞相互作用的影响。用加入RAPA和未加药的RPMI1640培养巨噬细胞J774A.1后,分别与携带pRST98的伤寒沙门菌ST8,无质粒的伤寒沙门菌ST10和鼠伤寒沙门菌标准毒株SR-11共作用,观察细胞自噬和凋亡情况。结果显示,MDC染色后2h和4h细胞自噬泡的数量SR-11组lin-1表达量在2hSR-11组ST8组>ST10组,RAPA干预后ST8组凋亡率下降,ST10组凋亡率升高(P<0.05);电镜下2～4h可见部分细菌被双层膜包裹,8h起可见凋亡改变。RAPA作用后,ST8组细胞破坏减轻,ST10组加重。提示伤寒沙门菌质粒pRST98与细胞自噬有关,在早期可抑制自噬,其诱导的巨噬细胞凋亡可被RAPA减轻,而RAPA能使ST10诱导的巨噬细胞凋亡增强。

关键词：雷帕霉素伤寒沙门菌巨噬细胞自噬凋亡

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng Cai Shengjun Miao yuan li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao li Zhao Yajun Zhang Zhe yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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基于嵌入式linux的网络电视终端的实时性开发及HTML控制方法

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计算机工程与应用 2002年第13期38卷 210-213页

作者：廖渊李明树中科院软件所计算机科学开放实验室北京100080

linux诸多优点,和国际自由软件组织的努力,使基于linux的开发的嵌入式产品越来越多。由于Web技术的普及,怎样在嵌入式产品上实现性能优异的Web功能成为了当前的一个研究热点。该文深入探讨在进行嵌入式应用开发过程中遇到的问题并给出... 详细信息

linux诸多优点,和国际自由软件组织的努力,使基于linux的开发的嵌入式产品越来越多。由于Web技术的普及,怎样在嵌入式产品上实现性能优异的Web功能成为了当前的一个研究热点。该文深入探讨在进行嵌入式应用开发过程中遇到的问题并给出了相应的解决方法。并以网络电视终端为例,详细论述具体嵌入式产品中各部分的设计和实现。

关键词：嵌入式linux 网络电视终端实时性 HMTL控制

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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