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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong zhuan liao Yangyan Qian Xin Song Li Sui Lianzhong Ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

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Food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian zhuan liao Hui Zhang Lianzhong Ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China Department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is *** major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging *** result showed that pretreatment with *** AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme *** D-galactose induced aging mice,*** AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant *** analysis shown that gavage of *** AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic *** results were also confirmed in H_(2)O_(2)-treated HepG2 *** indicated that *** AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative *** AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 D-galactose Oxidative stress ER stress

A comprehensive review of recent advances in chronic pancreatitis

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胰腺病学杂志(英文) 2024年第1期7卷 45-52页

作者： Mao Sheng-Han Zou Wen-Bin Mao Xiao-Tong Li Zhao-Shen liao zhuan Department of Gastroenterology Changhai Hospital The Naval Medical University Shanghai China Shanghai Institute of Pancreatic Diseases Shanghai China

Chronic pancreatitis (CP) is a multifaceted disorder influenced by environmental and genetic factors, with smoking and alcohol consumption being major contributors. Recent developments encompass the advent of innovative transgenic models and the identification of susceptibility genes, shedding light on the genetic aspect of CP. The pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction, inflammatory reactions, and fibrosis. Current research delves into understanding these molecular mechanisms. Pain, a pivotal symptom of CP, has been increasingly studied to develop effective therapeutic interventions. Diagnostic advancements, including endoscopic ultrasound, radiomics, and blood-based markers, have shown potential in enhancing early CP detection. Moreover, recent clinical trials have optimized treatment approaches, such as pancreatic stone fragmentation, stent placement, and decision-making between endoscopic and surgical procedures. Emerging therapies, including chemical pancreatectomy and gene therapy, present promising opportunities for improved CP management.

关键词： Chronic pancreatitis Diagnosis Endoscopy Etiology Mechanism Surgery

新型便携式内镜系统用于动物腹部战创伤救治的可行性与安全性研究

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中华消化内镜杂志 2024年第1期41卷 25-29页

作者：张婷邹文斌姜春晖王震蔡丽萍李兆申廖专海军军医大学第一附属医院消化内科上海200433 海军军医大学第一附属医院肝胆胰脾外科上海200433 海军军医大学第一附属医院临床教学中心上海200433

目的比较新型便携式内镜系统和常规电子内镜系统用于动物腹部战创伤探查与紧急治疗的可行性与安全性。方法将3头健康巴马猪分别编为1号、2号、3号, 术前禁食水8 h。实验前进行诱导麻醉, 从巴马猪的中腹壁逐层切开进入腹腔, 利用腹腔镜... 详细信息

目的比较新型便携式内镜系统和常规电子内镜系统用于动物腹部战创伤探查与紧急治疗的可行性与安全性。方法将3头健康巴马猪分别编为1号、2号、3号, 术前禁食水8 h。实验前进行诱导麻醉, 从巴马猪的中腹壁逐层切开进入腹腔, 利用腹腔镜气腹机建立人工气腹, 置入子弹模型1枚, 建立子弹创伤模型;取出子弹模型后置入弹片模型1枚, 建立弹片创伤模型。分别应用新型便携式内镜系统和常规电子内镜系统对1号巴马猪进行子弹模型和弹片模型的探查及取出操作。上述操作结束后, 两种内镜系统分别对2号、3号巴马猪进行同样操作过程。两种内镜操作的先后顺序根据随机数表法进行分配。分别记录两种内镜系统的手术成功情况、手术时间、内镜管道通畅性、内镜操作满意情况、不良事件和器械缺陷发生情况。结果使用新型便携式内镜系统和常规电子内镜系统进行手术各3次, 手术均成功。新型便携式内镜系统发现及取出子弹模型、发现及取出弹片模型的时间分别为(232.33±11.68)s、(300.33±57.70)s、(170.00±44.44)s、(52.67±2.52)s;常规电子内镜系统相应时间分别为[(232.67±21.20)s, t=-0.054, P=0.962]、[(256.67±67.00)s, t=0.880, P=0.472]、[(176.00±52.42)s, t=-0.111, P=0.922]、[(58.67±14.84)s, t=-0.832, P=0.493], 差异无统计学意义(P>0.05)。实验过程中, 两种内镜系统管道均通畅, 操作者对两种内镜系统的内镜操作过程均满意。两组均无不良事件和器械缺陷发生。结论新型便携式内镜系统用于动物腹部战创伤的救治操作成功情况与常规电子内镜系统相当, 初步证实该系统用于动物腹部战创伤救治安全可行。

关键词：创伤和损伤便携式内镜腹部战创伤动物实验

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导管通路在慢性胰腺炎致病机制中的作用进展

生物医学转化 2024年第1期5卷 66-71页

作者：杜甑衎王元辰邹文斌廖专海军军医大学附属长海医院上海200433 上海市胰腺疾病研究所上海200433

慢性胰腺炎(CP)是一种遗传和环境等多因素作用下的进行性纤维性胰腺炎性疾病。目前,CP遗传致病机制主要分为胰蛋白酶依赖性通路、蛋白错误折叠通路和导管通路。胰腺导管上皮细胞作为胰腺外分泌部的一种重要细胞类型,可以产生H2O和HCO_(3... 详细信息

慢性胰腺炎(CP)是一种遗传和环境等多因素作用下的进行性纤维性胰腺炎性疾病。目前,CP遗传致病机制主要分为胰蛋白酶依赖性通路、蛋白错误折叠通路和导管通路。胰腺导管上皮细胞作为胰腺外分泌部的一种重要细胞类型,可以产生H2O和HCO_(3)^(-),负责碱化、稀释和输送消化酶。当导管通路相关的易感基因发生功能障碍时,将会导致导管内离子浓度失衡与消化酶转运障碍,促进CP的发生与发展。既往导管通路相关致病基因较少,近年来对其认知逐步加深,新型易感基因陆续被发现。本文主要针对导管通路相关基因及其主要致病机制展开论述,以加深对CP发生机制的认识。

关键词：慢性胰腺炎易感基因导管通路致病机制

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胰管结石患者内镜治疗体验及需求的质性研究

现代消化及介入诊疗 2024年第5期29卷 519-522,527页

作者：陶红曹裕陈佳云赵琪许方蕾廖专同济大学医学院 200092 海军军医大学第一附属医院消化内科 200092 同济大学附属同济医院 200092

目的深入探究胰管结石患者在接受内镜治疗的感受及需求,为制定个性化方法提供依据。方法采用目的抽样法,选取2023年2-4月在上海市某三甲医院消化内科接受治疗的15例患者进行半结构式访谈,运用colaizzi 7步分析法对资料进行编码和总结,... 详细信息

目的深入探究胰管结石患者在接受内镜治疗的感受及需求,为制定个性化方法提供依据。方法采用目的抽样法,选取2023年2-4月在上海市某三甲医院消化内科接受治疗的15例患者进行半结构式访谈,运用colaizzi 7步分析法对资料进行编码和总结,以提炼出主题。结果患者治疗体验及需求归纳为4个主题。①治疗前疼痛认知及应对管理不足:以持续性或间歇性腹痛为特征;起病位置隐匿,易被误诊;应对方式无效;影响日常生活,降低生活质量。②诊治期生理舒适度的改变:腹部软组织损伤;术后并发症。③治疗后态度发生改变:诊治前期待治疗;未达到预期时失落与怀疑;症状改善后坚定信念;④治疗期间的需求:专业人员的指导;延续性护理支持。结论胰管结石患者在内镜治疗前对疼痛认知不足,治疗过程中态度可能转变,并寻求外部支持。医护人员需关注其生理、心理及社会需求的动态变化,采取相应措施减轻疼痛,提升舒适度,促进患者康复。

关键词：内镜治疗胰管结石体验需求质性研究

Clinical application of magnetically controlled capsule gastroscopy in gastric disease diagnosis: recent advances

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Science China(Life Sciences) 2018年第11期61卷 1304-1309页

作者： zhuan liao Wenbin Zou Zhao-Shen Li Department of Gastroenterology Changhai Hospital the Second Military Medical University

Magnetically controlled capsule gastroscopy(MCCG) is a novel system primarily used for the diagnosis of gastric disease. It consists of an endoscopic capsule with magnetic material inside, external guidance magnet equipment, data recorder and computer workstation. Several clinical trials have demonstrated that MCCG is comparable in accuracy in diagnosing gastric focal disease when compared to conventional gastroscopy. Further clinical studies are needed to test the diagnostic accuracy and improve the functioning of MCCG. This novel MCCG system could be a promising alternative for screening for gastric diseases,with the advantages of no anesthesia required, comfort and high acceptance across populations.

关键词： magnetically controlled capsule endoscopy gastric diseases screening conventional gastroscopy diagnostic accuracy

Study on chronic pancreatitis and pancreatic cancer using MRS and pancreatic juice samples

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World Journal of Gastroenterology 2011年第16期17卷 2126-2130页

作者： Jian Wang Chao Ma zhuan liao Bing Tian Jian-Ping Lu Department of Radiology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Gastroenterology Changhai HospitalThe Second Military Medical University Shanghai 200433 China

AIM:To investigate the markers of pancreatic diseases and provide basic data and experimental methods for the diagnosis of pancreatic ***:There were 15 patients in the present study,among whom 10 had pancreatic cancer and 5,chronic *** all patients,pancreatic cancer or chronic pancreatitis was located on the head of the ***-thology da-ta-of a-ll p-a-tients wa-s confirmed by biopsy and *** the 10 patients with pancreatic cancer,3 people had a medical history of longterm alcohol *** 5 patients with chronic pancreatitis,4 men suffered from alcoholic chronic *** juice samples were obtained from patients by endoscopic retrograde *** resonance spectroscopyn was performed on an 11.7-T scanner (Bruker DRX-500) using Call-Purcell-Meiboom-Gill pulse *** parameters were as follows:spectral width,15 KHz;time domain,64 K;number of scans,512;and acquisition time,2.128 ***:The main component of pancreatic juice included leucine,iso-leucine,valine,lactate,alanine,acetate,aspartate,lysine,glycine,threonine,tyrosine,histidine,tryptophan,and *** performing 1D 1H and 2D total correlation spectroscopy,we found a triplet peak at the chemical shift of 1.19 ppm,which only appeared in the spectra of pancreatic juice obtained from patients with alcoholic chronic *** triplet peak was considered the resonance of the methyl of ethoxy group,which may be associated with the metabolism of alcohol in the ***:The triplet peak,at the chemical shift of 1.19 ppm is likely to be the characteristic metabolite of alcoholic chronic pancreatitis.

关键词：胰腺癌胰腺炎慢性胰液 MRS 二维相关光谱样品化学位移

Meta-analysis of capsule endoscopy in patients diagnosed or suspected with esophageal varices

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World Journal of Gastroenterology 2009年第10期15卷 1254-1258页

作者： Yi Lu Rui Gao zhuan liao Liang-Hao Hu Zhao-Shen Li Department of Gastroenterology Changhai Hospital SecondMilitary Medical University 168 Changhai Road Shanghai200433 China

AIM:To review the literature on capsule endoscopy(CE) for detecting esophageal varices using conventional esophagogas troduodenoscopy(EGD)as the standard. METHODS:A strict literature search of studies comparing the yield of CE and EGD in patients diagnosed or suspected as having esophageal varices was conducted by both computer search and manual *** were extracted to estimate the pooled diagnostic sensitivity and specificity. RESULTS:There were seven studies appropriate for meta-analysis in our study,involving 446 patients. The pooled sensitivity and specificity of CE for detecting esophageal varices were 85.8%and 80.5%, *** subgroup analysis,the pooled sensitivity and specificity were 82.7%and 54.8%in screened patients,and 87.3%and 84.7%in the screened/ patients under surveillance,respectively. CONCLUSION:CE appears to have acceptable sensitivity and specificity in detecting esophageal ***,data are insufficient to determine the accurate diagnostic value of CE in the screen/ surveillance of patients alone.

关键词：食管静脉曲张 Meta分析胶囊内镜内镜诊断特异性检测诊断敏感性疑似 CE认证

Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients

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World Journal of Gastroenterology 2010年第21期16卷 2669-2676页

作者： liao, zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen Second Mil Med Univ Changhai Hosp Dept Gastroenterol Capsule Endoscopy Study Grp Shanghai 200433 Peoples R China Jianshan Sci & Technol Grp Co Ltd Chongqing 401120 Peoples R China

AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese ***:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology *** capsule endoscopy *** patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and ***:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy *** thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic *** overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with ***,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 *** overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER.

关键词： OMOM capsule endoscopy Obscure gastrointestinal bleeding Small bowel