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Study on the Correlation between IL-6,SAA,CRP and Exertional Heat Stroke in Rats

Chinese Journal of Biomedical Engineering(English Edition) 2023年第3期32卷 109-115页

作者： QUE Guo-wen liao yu-qin Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China

Objective:To investigate the correlation between interleukin-6(IL-6),serum amyloid A(SAA),C-reactive protein(CRP)and exertional heat stroke in ***:A total of 90 adult Sprague-Dawley rats without specific pathogens were randomly divided into three groups:control group,classical group and exertion group,with 30 rats in each *** control group was maintained at a temperature of(26±1)℃and humidity of(60±5)%,while the classical and exertion groups were exposed to a temperature of(40±0.5)℃and humidity of(70±5)%.Additionally,the exertion group underwent treadmill running under these *** levels of IL-6,SAA,and CRP in the three groups were assessed and compared at various time points:before modeling,immediately after onset,and at 2,4,and 8 h after ***,Spearman correlation analysis was employed to ***:The findings from the repeated measures analysis of variance indicated significant variations in the levels of IL-6,SAA,and CRP across the three groups(P<0.05).Both the classic and exertion groups exhibited higher levels of IL-6,SAA,and CRP compared to the control group,with the exertion group demonstrating even higher levels than the classic group(P<0.05).Additionally,Spearman correlation analysis revealed a positive correlation between the onset of heat stroke and the levels of IL-6,SAA,and CRP at the onset,as well as at 2,4,and 8 h post-onset(P<0.05).Furthermore,the types of heat stroke were found to be positively correlated with the levels of IL-6,SAA and CRP(P<0.05).Conclusion:The initiation and nature of heat stroke in rats are significantly associated with the concentrations of IL-6,SAA,and *** concentrations of IL-6,SAA,and CRP within 8 h of onset can reliably forecast the occurrence of heat stroke in rats,serving as a basis for distinguishing classical heat stroke from exertional heat ***,the predictive and differentiating efficacy may diminish as the onset time prolongs.

关键词： exertional heat stroke rat experiment interleukin-6(IL-6) serum amyloid A(SAA) C-reactive protein(CRP)

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SYNERGIC EFFECT OF POLYMER-ANCHORED BIMETALLICTALYSTS IN THE CARBONYLATION OF ALLYL CHLORIDE

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Chinese Journal of Catalysis 1995年第1期 7-8页

作者： yu, Zheng-kun Xu, yun liao, Shi-jian and yu, Dao-rong(Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023)

Homogeneous and polymer-anchored multimetallic catalysis has attract-ed much attention in recent years,since enhanced reacton rates,selectivitiesand new types of reaction are expected to arise from cooperative or succes-sive participation of two or more kinds of metal atom[1-3].Because of numer-ous possible combinations,bimetallic catalysts demonstrate great potentialto be tailored with respect to activity,selectivity and stability which some-times might not be achieved by a monometallic *** carbonylation

关键词： synergic effect polymer-anchored bimetallic catalyst carbonylation atmospheric pressure

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CircRNA_Maml2 promotes the proliferation and migration of intestinal epithelial cells after severe burns by regulating the miR-93-3p/FZD7/Wnt/β-catenin pathway

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Burns & Trauma 2022年第1期10卷 699-714页

作者： Wenwen Zhang yu liao Jiaqi Lou Mengmeng Zhuang Hao Yan Qi Li yuequ Deng Xiaohu Xu Dandan Wen Yong Sun Department of Burn Surgery the Affiliated Huaihai Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Burn Surgery the 71st Group Army Hospital of PLAXuzhou 221004Jiangsu ProvinceChina

Background:Circular RNA(circRNA)plays key regulatory roles in the development of many *** the biological functions and potential molecular mechanisms of circRNA in the injury and repair of intestinal mucosa in mice after severe burns are yet to be ***:Cell counting kit-8(CCK-8),5-ethynyl-2-deoxyuridine(EdU),wound healing and transwell assays were used to detect cell proliferation and migration ***-time quantitative PCR was used to identify the expression of circRNA,microRNA and messenger *** and cytoplas-mic separation experiments were employed to perceive the location of circRNA_***,in vitro and in vivo experiments were conducted to study the repairing effect of circRNA_Maml2 on the intestinal mucosa of mice after severe ***:When compared with the control group,the expression of circRNA_Maml2 was sig-nificantly reduced in the severe burn ***,overexpression of circRNA_Maml2 promoted the proliferation and migration of *** cells in vivo and the repair of damaged intestinal mucosa in ***_Maml2 acted as a sponge adsorption molecule for miR-93-3p to enhance the expression of frizzled class receptor 7 and activate the downstream Wnt/β-catenin pathway,thereby promoting the repair of the intestinal ***:Our findings demonstrate that circRNA_Maml2 regulates the miR-93-3p/FZD7/Wnt/β-catenin pathway and promotes the repair of damaged intestinal ***,circRNA_Maml2 is a potential therapeutic target to promote intestinal mucosal repair.

关键词： CircRNA_Maml2 Severe burn miR-93-3p FZD7 Wnt/β-catenin pathway Proliferation Migration

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Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

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Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han liao Kun-yu CHEN Ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma *** Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of *** growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 *** cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH *** PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

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High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling liao Quanhong Yang Nianjun Yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Polymer membrane electrodes

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Identification of milestone papers in physics via reference publication year spectroscopy

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Data Science and Informetrics 2021年第2期1卷 1-18页

作者： yu liao Zhesi Shen Liying Yang National Science Library Chinese Academy of SciencesBeijingChina Department of Library Information and Archives Management School of Economics and ManagementUniversity of Chinese Academy of SciencesBeijingChina

In the modern time of the high speed development of physics,the citation analysis facilitates us to trace the brilliant ideas and works in the *** we use the Reference Publication Year Spectroscopy(RPYS)to identify the historical roots that announce significant discoveries in physics and compare them with the milestone papers selected by *** the 123 milestones,64 milestone papers are successfully identified by *** papers are identified simultaneously in multiple subfields,implying their broad impact across the fields of *** RPYS analysis shows promise in detecting the historical roots and identifying fundamental *** are still some open questions that need to be investigated.

关键词： Reference Publication Year Spectroscopy RPYS Milestone Papers Citation Analysis

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Citrate versus unfractionated heparin for anticoagulation in continuous renal replacement therapy

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Chinese Medical Journal 2013年第7期126卷 1344-1349页

作者： liao yu-jie ZHANG Ling ZENG Xiao-xi FU Ping Division of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China

Background Unfractionated heparin is the most commonly used anticoagulant in continuous renal replacement therapy （CRRT）, but it can increase the risk of bleeding. Citrate is a promising substitute. Our study was to assess the efficacy and safety of citrate versus unfractionated heparin in CRRT. Methods We searched the MEDLINE, the EMBASE, the Cochrane Central Register of Controlled Trials, and the China National Knowledge Infrastructure Database until up to November 2011 for randomized controlled trials comparing citrate with unfractionated heparin in adult patients with acute kidney injury prescribed CRRT. The primary outcome was mortality and the secondary outcomes included circuit survival, control of uremia, risk of bleeding, transfusion rates, acid-base statuses, and disturbance of sodium and calcium homeostasis. Results Four trials met the inclusion criteria. Meta-analysis found no significant difference between two anticoagulants on mortality. Less bleeding and more hypocalcemic episodes were with citrate. Citrate was superior or comparable to unfractionated heparin in circuit life. Conclusions Citrate anticoagulation in CRRT seems to be superior in reducing bleeding risk and with a longer or similar circuit life, although there is more metabolic derangement. Mortality superiority has not been approved.

关键词： continuous renal replacement therapy anticoagulation citrate unfractionated heparin meta-analysis

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Calibration of X-ray telescope prototypes at PANTER

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Research in Astronomy and Astrophysics 2019年第12期19卷 199-206页

作者： Ying-yu liao Zheng-Xiang Shen Jun yu Qiu-Shi Huang Bin Ma Zhong Zhang Xiao-Qiang Wang Kun Wang Chun Xie Vadim Burwitz Gisela Hartner Marlis-Madeleine La Caria Carlo Pelliciari Zhan-Shan Wang Key Laboratory of Advanced Micro-Structured Materials Ministry of EducationTongji UniversityShanghai 200092China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Mechanical Engineering Tongji UniversityShanghai 200092China Sino-German College of Applied Sciences Tongji UniversityShanghai 200092China Max-Planck-Institute for Extraterrestrial Physics Giessenbachstr85748 GarchingGermany

We report on a ground X-ray calibration of two X-ray telescope prototypes at the PANTER X-ray Test Facility, operated by the Max-Planck-Institute for Extraterrestrial Physics, in Neuried, *** X-ray telescope prototypes were developed by the Institute of Precision Optical Engineering(IPOE)of Tongji University, in a conical Wolter-I configuration, using thermal glass slumping *** #1 with three layers and Prototype #2 with 21 layers were tested to assess the prototypes’ onaxis imaging performance. The measurement of Prototype #1 indicates a Half Power Diameter(HPD) of 82′′ at 1.49 keV. As for Prototype #2, we performed more comprehensive measurements of on-axis angular resolution and effective area at several energies ranging from 0.5–10 keV. The HPD and effective area are111′′ and 39 cm^2 at 1.49 keV, respectively, at which energy the on-axis performance of the prototypes is our greatest concern.

关键词： X-ray telescopes thermal slumping technology X-ray calibration PANTER

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异基因脐血间充质干细胞移植治疗Emery-Dreifuss型肌营养不良1例(英文)

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中国组织工程研究与临床康复 2009年第27期13卷 5393-5396页

作者：廖瑜南京医科大学附属无锡第二医院神经内科江苏省无锡市214002

2008-02南京医科大学附属无锡第二医院神经内科收治的男性患者1例,32岁,体质量38kg,四肢无力、肌萎缩18年,突发头晕、呕吐3d后入院,经基因分析和肌肉活检确诊为Emery-Dreifus型肌营养不良并发小脑梗死。经HLA配型在上海市脐血库中寻找... 详细信息

2008-02南京医科大学附属无锡第二医院神经内科收治的男性患者1例,32岁,体质量38kg,四肢无力、肌萎缩18年,突发头晕、呕吐3d后入院,经基因分析和肌肉活检确诊为Emery-Dreifus型肌营养不良并发小脑梗死。经HLA配型在上海市脐血库中寻找到一个与受者非血源相关、HIA全相合、Rh血型相合、ABO血型主侧不合的脐血供体,于入院后第9天采用白消安+环磷酰胺+兔抗胸腺淋巴细胞球蛋白预处理后,通过外周静脉移植异基因脐血间充质干细胞悬液40mL,10滴/min,实际输入的有核细胞数为31.98×108。细胞移植5周后,患者头晕消失,吞咽困难、饮水呛咳症状明显好转,可连续饮水,双手协调动作较移植前好转,可操作电脑,体质量约增长4kg;移植后半年,血清肌酸磷酸激酶由移植前35.79μkat/L降至9.55μkat/L,血清肌酸磷酸激酶同工酶由移植前18.20μkat/L降至4.78μkat/L,肌红蛋白由移植前413.50μg/L降至213.20μg/L,功能独立性评分由71分提高至101分,未见免疫排斥反应及致瘤趋性。提示脐血间充质干细胞移植后能在短期内使血清肌酸磷酸激酶水平下降,改善运动功能,有助于Emery-Dreifuss型肌营养不良的治疗,近期安全性可靠。

关键词：脐血间充质干细胞移植 Emery-Dreifuss型肌营养不良

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Effects of Ligustrum robustum on gut microbes and obesity in rats

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World Journal of Gastroenterology 2015年第46期21卷 13042-13054页

作者： Zhi-Mei Xie Tao Zhou Hong-yu liao Qian Ye Shan Liu Lu Qi Jing Huang Hao-Jiang Zuo Xiao-Fang Pei Department of Laboratory Science of Public Health West China School of Public HealthSichuan University Sichuan Provincial Disease Prevention and Control Center Department of Clinical Laboratory Sichuan Provincial People’s Hospital Department of Nutrition Harvard School of Public Health Channing Laboratory Department of MedicineBrigham and Women’s Hospital Harvard Medical School Boston Department of Chemistry of Medicinal Natural Products West China School of PharmacySichuan University

AIM: To investigate the anti-obesity and antibacterial effects of Ligustrum robustum(L. robustum) in vivoand in vitro and its possible mechanisms. METHODS: The effects of L. robustum aqueous extract(LR) on various gut bacteria in vitro were evaluated. The effects of LR on high-fat diet-fed(HFD) rats in vivo were also assessed. Culture methods,quantitative polymerase chain reaction,and terminalrestriction fragment length polymorphism were used to analyze the effects of LR on gut bacteria. Biochemical tests were also performed to detect the changes in obesity-related indicators after LR treatment. RESULTS: LR treatment lowered adipose weight and decreased Lee's index,blood glucose,total cholesterol,and lipid in the tested groups relative to control(P < 0.05). To determine the reasons for these changes,we assessed the potential bacteriostatic and bactericidal effects of LR on specific bacterial species in vitro. LR affected the richness,diversity,and evenness of gut bacteria,increased fecal Lactobacillus,and decreased Enterococci in HFD rats(P < 0.05). CONCLUSION: L. robustum may be a safe and effective food for weight loss and obesity control,and the effects of L. robustum might be mediated by the regulation of gut bacteria.

关键词： Gut bacteria Ligustrum robustum Culture methods Qu

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